NASA Spaceline Current Awareness 25 November 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Jeong SM, Shibata S, Levine BD, Zhang R.
Exercise plus volume loading prevents orthostatic intolerance, but not reduction in cerebral blood flow velocity after bed rest.
Am J Physiol Heart Circ Physiol. 2011 Nov 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22081705
(PI: B.D. Levine)
NOTE: Bed rest studies.

2
Clarke MS.
Proteomic analysis of skeletal muscle tissue using SELDI-TOF MS: Application to disuse atrophy.
Methods Mol Biol. 2012;818:131-41.
http://www.ncbi.nlm.nih.gov/pubmed/22083821

3
Pelch KE, Carleton SM, Phillips CL, Nagel SC.
Developmental exposure to low dose xenoestrogens alters femur length and tensile strength in adult mice.
Biol Reprod. 2011 Nov 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22088916
(PI: S.M. Carleton, NSBRI Postdoctoral Fellowship Program)
NOTE: This article may temporarily be obtained online without charge.

4
Datta K, Suman S, Trani D, Doiron K, Rotolo JA, Kallakury BV, Kolesnick R, Cole MF, Fornace AJ.
Accelerated hematopoietic toxicity by high energy 56Fe radiation.
Int J Radiat Biol. 2011 Nov 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22077279
(PIs: A.J. Fornace; A.J. Fornace/K. Datta/NSCOR; D. Trani, NSBRI Postdoctoral Fellowship Program)

5
Valerie NC, Casarez EV, DaSilva JO, Dunlap-Brown ME, Parsons SJ, Amorino GP, Dziegielewski J.
Inhibition of neurotensin receptor 1 selectively sensitizes prostate cancer to ionizing radiation.
Cancer Res. 2011 Nov 1;71(21):6817-26. Epub 2011 Sep 8.
http://www.ncbi.nlm.nih.gov/pubmed/21903767
(PI: J. Dziegielewski)

6
Nicholson WL, Ricco AJ, Agasid E, Beasley C, Diaz-Aguado M, Ehrenfreund P, Friedericks C, Ghassemieh S, Henschke M, Hines JW, Kitts C, Luzzi E, Ly D, Mai N, Mancinelli R, McIntyre M, Minelli G, Neumann M, Parra M, Piccini M, Rasay RM, Ricks R, Santos O, Schooley A, Squires D, Timucin L, Yost B, Young A.
The O/OREOS mission: First science data from the Space Environment Survivability of Living Organisms (SESLO) payload.
Astrobiology. 2011 Nov 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22091486
NOTE: Cubesat/nanosatellite preliminary results.

7
Dilda V, MacDougall HG, Curthoys IS, Moore ST.
Effects of Galvanic vestibular stimulation on cognitive function.
Exp Brain Res. 2011 Nov 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22076407
(PI: S.T. Moore)
NOTE: This article may temporarily be obtained online without charge.

8
Hamorsky KT, Ensor CM, Pasini P, Daunert S.
A protein switch sensing system for the quantification of sulfate.
Anal Biochem. 2011 Oct 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22067979

Other papers of interest:

1
Dabertrand F, Porte Y, Macrez N, Morel JL.
Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension.
J Appl Physiol. 2011 Nov 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22096120
NOTE: ISS, STS-118 results. There is a fun drawing highlighting physical inactivity on the cover of the October-December issues of this journal: http://jap.physiology.org/content/111/5.cover-expansion

2
Wilson MH, Imray CH, Hargens AR.
The headache of high altitude and microgravity? Similarities with clinical syndromes of cerebral venous hypertension.
High Alt Med Biol. 2011 Nov 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22087727
NOTE: This article may be obtained online without charge.

3
Convertino VA, Rickards CA, Ryan KL.
Autonomic mechanisms associated with heart rate and vasoconstrictor reserves.
Clin Auton Res. 2011 Nov 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22083580

4
Khandelwal E, Jaryal AK, Deepak KK.
Cardiovascular autonomic functions & cerebral autoregulation in patients with orthostatic hypotension.
Indian J Med Res. 2011 Oct;134(4):463-9.
http://www.ncbi.nlm.nih.gov/pubmed/22089608
NOTE: This article may be obtained online without charge.

5
Truijen J, Kim YS, Krediet CT, Stok WJ, Koelgen RS, Colier WN, Secher NH, van Lieshout JJ.
Orthostatic leg blood volume changes assessed by near-infrared spectroscopy.
Exp Physiol. 2011 Nov 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22090063

6
Allan ME, Storey KB.
Expression of NF-B and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels, Spermophilus tridecemlineatus.
Cell Biochem Funct. 2011 Nov 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22086848

7
Xu J, Hwang JC, Lees HA, Wohlgemuth S, Knutson MD, Judge AR, Dupont-Versteegden E, Marzetti E, Leeuwenburgh C.
Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.
Exp Gerontol. 2011 Nov 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22085543

8
Karsenty G, Oury F.
Biology without walls: The novel endocrinology of bone.
Annu Rev Physiol. 2011 Nov 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22077214
NOTE: Review of this topic, with nice graphics.

9
Jaemsae T, Ahola R, Korpelainen R.
Measurement of osteogenic exercise – how to interpret accelerometric data?
Front Physiol. 2011;2:73. Epub 2011 Oct 18.
http://www.ncbi.nlm.nih.gov/pubmed/22028693
NOTE: This article may be obtained online without charge.

10
Wysocki A, Butler M, Shamliyan T, Kane RL.
Whole-body vibration therapy for osteoporosis: State of the science.
Ann Intern Med. 2011 Nov 15;155(10):680-6.
http://www.ncbi.nlm.nih.gov/pubmed/22084334
NOTE: Critical review of this subject.

11
Slatkovska L, Alibhai SM, Beyene J, Hu H, Demaras A, Cheung AM.
Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: A randomized trial.
Ann Intern Med. 2011 Nov 15;155(10):668-79.
http://www.ncbi.nlm.nih.gov/pubmed/22084333
NOTE: This article may be obtained online without charge.

12
Riddle RC, Leslie JM, Gross TS, Clemens TL.
Hypoxia inducible factor-1 is a negative regulator of load-induced bone formation.
J Biol Chem. 2011 Nov 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22081627
NOTE: This article may temporarily be obtained online without charge.

13
Tu X, Rhee Y, Condon KW, Bivi N, Allen MR, Dwyer D, Stolina M, Turner CH, Robling AG, Plotkin LI, Bellido T.
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.
Bone. 2012 Jan;50(1):209-17. Epub 2011 Oct 29.
http://www.ncbi.nlm.nih.gov/pubmed/22075208

14
Kazama Y, Hirano T, Saito H, Liu Y, Ohbu S, Hayashi Y, Abe T.
Characterization of highly efficient heavy-ion mutagenesis in Arabidopsis thaliana.
BMC Plant Biol. 2011 Nov 15;11:161. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22085561
NOTE: This article may be obtained online without charge.

15
Nikjoo H, Girard P.
A model of the cell nucleus for DNA damage calculations.
Int J Radiat Biol. 2011 Nov 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22081899

16
Suarez H, Geisinger D, Ferreira E, Suarez A, San Roman C, Sotta G.
Visual gravitational vertical perception in peripheral vestibular hypofunction.
Acta Otolaryngol. 2011 Nov 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22073979

17
Tsutsumi T, Ikeda T, Watanabe K, Kikuchi S.
Changes in Listing plane thickness caused by vestibular schwannoma: A parameter for evaluating the accuracy of the gravity-oriented internal model.
Otol Neurotol. 2011 Dec;32(9):1513-7.
http://www.ncbi.nlm.nih.gov/pubmed/22072267

18
Tanaka K, Abe C, Sakaida Y, Aoki M, Iwata C, Morita H.
Subsensory galvanic vestibular stimulation augments arterial pressure control upon head-up tilt in human subjects.
Auton Neurosci. 2011 Nov 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22088942

19
Shahin K, Doran PM.
Tissue engineering of cartilage using a mechanobioreactor exerting simultaneous mechanical shear and compression to simulate the rolling action of articular joints.
Biotechnol Bioeng. 2011 Nov 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22095592

20
Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK.
NASA-approved rotary bioreactor enhances proliferation of human epidermal stem cells and supports formation of 3D epidermis-like structure.
PLoS One. 2011;6(11):e26603. Epub 2011 Nov 9.
http://www.ncbi.nlm.nih.gov/pubmed/22096490
NOTE: This article may be obtained online without charge.

21
Tan C, Wang H, Zhang Y, Qi B, Xu G, Zheng H.
A proteomic approach to analyzing responses of Arabidopsis thaliana root cells to different gravitational conditions using an agravitropic mutant, pin2 and its wild type.
Proteome Sci. 2011 Nov 16;9:72. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22085406
NOTE: This article may be obtained online without charge.

Some recent books:

1
Phillips RW.
Grappling with gravity. How will life adapt to living in space?
New York: Springer, 2012. 271 p.
http://dx.doi.org/10.1007/978-1-4419-6899-9
http://www.springer.com/astronomy/extraterrestrial+physics%2C+space+scie…
NOTE: The front and back matter of this book are available online without charge.

2
Vernikos, J.
Sitting kills, moving heals: How simple everyday movement will prevent pain, illness and early death – and exercise alone won’t.
Linden Publishing, Quill Driver Books, 2011. 144 p.
http://www.quilldriverbooks.com/sitting_kills/about_sitting_kills.htm
NOTE: This book, by the former director of life sciences at NASA, draws on Dr. Vernikos’ and others’ space life sciences research. It emphasizes the earthly benefits and includes a chapter on using gravity as therapy.

3
Vakoch DA, ed.
Psychology of space exploration: Contemporary research in historical perspective.
Washington, DC: NASA, Office of Communications, History Program Office, 2011. 264 p. NASA SP-2011-4411. NASA History Series.
http://cot.ag/nyCekB
NOTE: This volume may be obtained online without charge at: http://history.nasa.gov/SP-4411.pdf