NASA Spaceline Current Awareness 12 January 2012 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Shi Y, Zhang X, Tang X, Wang P, Wang H, Wang Y.
MiR-21 is continually elevated long-term in the brain after exposure to ionizing radiation.
Radiat Res. 2012 Jan;177(1):124-8. Epub 2011 Oct 28.
http://www.ncbi.nlm.nih.gov/pubmed/22034847
(PIs: H. Wang; Y. Wang/H. Wang/NSCOR; Y. Wang)

2
Hlatky L.
Double-strand break motions shift radiation risk notions?
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):351-2. Epub 2011 Dec 30.
http://www.ncbi.nlm.nih.gov/pubmed/22210116
(PI: L. Hlatky)
NOTE: This article is a comment on the NASA-supported paper by Neumaier et al. that appeared in last week’s list: http://www.ncbi.nlm.nih.gov/pubmed/22184222
The paper is highlighted on the cover of this issue of PNAS.

3
Kondrachuk AV, Boyle RD.
The density difference of cupula and endolymph changes the mechanics of semicircular canals.
Microgravity Sci Technol. 2011 Nov;23(4):433-8.
http://dx.doi.org/10.1007/s12217-011-9265-6
(PI: R.D. Boyle)

4
Goel N, Banks S, Lin L, Mignot E, Dinges DF.
Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.
PLoS One. 2011;6(12):e29283. Epub 2011 Dec 27.
http://www.ncbi.nlm.nih.gov/pubmed/22216231
(PI: D.F. Dinges)
NOTE: This article may be obtained online without charge.

5
Damron FH, Owings JP, Okkotsu Y, Varga JJ, Schurr JR, Goldberg JB, Schurr MJ, Yu HD.
Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN.
J Bacteriol. 2011 Dec 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22210761
(PI: F.H. Damron, NASA Graduate Student Researcher Program)

6
Wise SS, Wise JP Sr.
Chromium and genomic stability.
Mutat Res. 2011 Dec 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22192535
(PI: J.P. Wise)

7
Nickerson CA, Ott CM, Castro SL, Garcia VM, Molina TC, Briggler JT, Pitt AL, Tavano JJ, Byram JK, Barrila J, Nickerson MA.
Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders.
PLoS One. 2011;6(12):e28906. Epub 2011 Dec 19.
http://www.ncbi.nlm.nih.gov/pubmed/22205979
(PIs: S.L. Castro, NASA student grant; C.A. Nickerson)
NOTE: This article may be obtained online without charge.

8
Osterlund J, Lawrence B.
Virtual reality: Avatars in human spaceflight training.
Acta Astronaut. 2012 Feb-Mar;71:139-50.
http://dx.doi.org/10.1016/j.actaastro.2011.08.011
NOTE: As with some other articles, figures from this article can be viewed at the publisher’s abstract.

Other papers of interest:

1
Goel R, Kaderka J, Newman D.
Modeling the benefits of an artificial gravity countermeasure coupled with exercise and vibration.
Acta Astronaut. 2012 Jan-Feb;70:43-51.
http://dx.doi.org/10.1016/j.actaastro.2011.07.021
NOTE: This article may be obtained online without charge if accessed via the Table of Contents (click on volume 70 in the publisher’s abstract).

2
Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X.
Agonistic autoantibodies as vasodilators in orthostatic hypotension: A new mechanism.
Hypertension. 2012 Jan 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22215709

3
Koelegard R, Eiken O.
Distensibility in human veins as affected by 5 weeks of repeated elevations of local transmural pressure.
Eur J Appl Physiol. 2011 Dec;111(12):3119-25. Epub 2011 Apr 3.
http://www.ncbi.nlm.nih.gov/pubmed/21461927

4
Launius RD.
Why go to the moon? The many faces of lunar policy.
Acta Astronaut. 2012 Jan-Feb;70:165-75.
http://dx.doi.org/10.1016/j.actaastro.2011.07.013
NOTE: This article may be obtained online without charge if accessed via the Table of Contents (click on volume 70 in the publisher’s abstract).

5
Landau D, Strange NJ.
This way to Mars.
Sci Am. 2011 Dec;305(6):58-65.
http://www.ncbi.nlm.nih.gov/pubmed/22214130
NOTE: Title subheading: “By adapting ideas from robotic planetary exploration, the human space program could get astronauts to asteroids and Mars cheaply and quickly.” The article may be obtained online without charge at the publisher’s site: http://www.scientificamerican.com/article.cfm?id=this-way-to-mars

6
Chennimalai Kumar N, Dantzig JA, Jasiuk IM.
Modeling of cortical bone adaptation in a rat ulna: Effect of frequency.
Bone. 2011 Dec 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22210383

7
Civitelli R, Ziambaras K.
Calcium and phosphate homeostasis: Concerted interplay of new regulators.
J Endocrinol Invest. 2011 Jul;34(7 Suppl):3-7.
http://www.ncbi.nlm.nih.gov/pubmed/21985972

8
Gershovich PM, Gershovich JG, Zhambalova AP, Romanov YA, Buravkova LB.
Cytoskeletal proteins and stem cell markers gene expression in human bone marrow mesenchymal stromal cells after different periods of simulated microgravity.
Acta Astronaut. 2012 Jan-Feb;70:36-42.
http://dx.doi.org/10.1016/j.actaastro.2011.07.028
NOTE: This article may be obtained online without charge if accessed via the Table of Contents (click on volume 70 in the publisher’s abstract).

9
Nomura S, Kami K, Kawano F, Oke Y, Nakai N, Ohira T, Fujita R, Terada M, Imaizumi K, Ohira Y.
Effects of hindlimb unloading on neurogenesis in the hippocampus of newly weaned rats.
Neurosci Lett. 2011 Dec 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22206837

10
Mitra A, Mitra SS, Tsien RW.
Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
Nat Neurosci. 2011 Dec 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22179109

11
Knab AM, Nieman DC, Broman-Fulks JJ, Canu WH, Sha W.
Exercise frequency is related to psychopathology but not neurocognitive function.
Med Sci Sports Exerc. 2012 Jan 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22217563
NOTE: Huh?

12
Obara T, Matsumoto H, Koga K.
Space environment measurements by JAXA satellites and ISS/JEM.
Acta Astronaut. 2012 Feb-Mar;71:1-10.
http://dx.doi.org/10.1016/j.actaastro.2011.08.009
NOTE: Includes ISS results.

13
Gang B.
The simulation of radiation effects to astronauts due to solar energetic particles in deep space.
Acta Astronaut. 2012 Feb-Mar;71:32-7.
http://dx.doi.org/10.1016/j.actaastro.2011.08.007

14
Drobyshev SG, Benghin VV.
Estimation of the effect of orientation of International Space Station on the dose rate in Station’s Service Module when passing through the South-Atlantic anomaly region.
Cosmic Res. 2011 Oct;49(5):399-406.
http://dx.doi.org/10.1134/S0010952511050054
NOTE: ISS results. This paper is a translation in English of the Russian original published in Kosmicheskie Issledovaniya 2011;49(5):411-8.

15
Kartashov DA, Shurshakov VA, Kolomenskii AV.
Optimization of radiation exposures during extravehicular activity using the effect of the West-East asymmetry of the fluxes of trapped protons.
Cosmic Res. 2011 Dec;49(6):504-9.
http://dx.doi.org/10.1134/S0010952511060050
NOTE: This paper is a translation in English of the Russian original published in Kosmicheskie Issledovaniya 2011;49(6):520-5.

16
Mukherjee D, Coates PJ, Lorimore SA, Wright EG.
The in vivo expression of radiation-induced chromosomal instability has an inflammatory mechanism.
Radiat Res. 2012 Jan;177(1):18-24. Epub 2011 Nov 3.
http://www.ncbi.nlm.nih.gov/pubmed/22050452

17
Hu B, Grabham P, Nie J, Balajee AS, Zhou H, Hei TK, Geard CR.
Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells.
Radiat Res. 2012 Jan;177(1):25-34. Epub 2011 Nov 11.
http://www.ncbi.nlm.nih.gov/pubmed/22077336

18
Kalanxhi E, Dahle J.
Genome-wide microarray analysis of human fibroblasts in response to radiation and the radiation-induced bystander effect.
Radiat Res. 2012 Jan;177(1):35-43. Epub 2011 Oct 28.
http://www.ncbi.nlm.nih.gov/pubmed/22034846

19
Trainor C, Butterworth KT, McGarry CK, Liberante F, O’Sullivan JM, Hounsell AR, Prise KM.
Cell survival responses after exposure to modulated radiation fields.
Radiat Res. 2012 Jan;177(1):44-51. Epub 2011 Oct 26.
http://www.ncbi.nlm.nih.gov/pubmed/22029841

20
Northum JD, Guetersloh SB, Braby LA.
FLUKA capabilities for microdosimetric analysis.
Radiat Res. 2012 Jan;177(1):117-23. Epub 2011 Nov 3.
http://www.ncbi.nlm.nih.gov/pubmed/22050453

21
Aoki M, Sakaida Y, Tanaka K, Mizuta K, Ito Y.
Evidence for vestibular dysfunction in orthostatic hypotension.
Exp Brain Res. 2011 Dec 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22205233

22
zu Eulenburg P, Caspers S, Roski C, Eickhoff SB.
Meta-analytical definition and functional connectivity of the human vestibular cortex.
Neuroimage. 2011 Dec 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22209784

23
Pinter IJ, van Soest AJ, Bobbert MF, Smeets JB.
Do we use a priori knowledge of gravity when making elbow rotations?
Exp Brain Res. 2011 Dec 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22205232
NOTE: This article may be obtained online without charge.

24
Gushin V, Shved D, Vinokhodova A, Vasylieva G, Nitchiporuk I, Ehmann B, Balazs L.
Some psychophysiological and behavioral aspects of adaptation to simulated autonomous Mission to Mars.
Acta Astronaut. 2012 Jan-Feb;70:52-7.
http://dx.doi.org/10.1016/j.actaastro.2011.07.020
NOTE: Mars 105 experiment results. This article may be obtained online without charge if accessed via the Table of Contents (click on volume 70 in the publisher’s abstract).

25
Hill RJ, Larkin OJ, Dijkstra CE, Manzano AI, de Juan E, Davey MR, Anthony P, Eaves L, Medina FJ, Marco R, Herranz R.
Effect of magnetically simulated zero-gravity and enhanced gravity on the walk of the common fruitfly.
J R Soc Interface. 2012 Jan 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22219396
NOTE: This article may be obtained online without charge. The University of Nottingham had a press release for this paper, which includes a link to a video: http://www.nottingham.ac.uk/news/pressreleases/2012/january/magnetically…

26
Kuranova IP, Smirnova EA, Abramchik YA, Chupova LA, Esipov RS, Akparov VK, Timofeev VI, Kovalchuk MV.
Crystal growth of phosphopantetheine adenylyltransferase, carboxypeptidase t, and thymidine phosphorylase on the International Space Station by the capillary counter-diffusion method.
Crystallogr Rep. 2011 Sep;56(5):884-91.
http://dx.doi.org/10.1134/S1063774511050154
NOTE: ISS results. This paper is a translation in English of the Russian original published in Kristallografiya 2011;56(5):944-51.

27
Pietsch J, Bauer J, Weber G, Nissum M, Westphal K, Egli M, Grosse J, Schoenberger J, Eilles C, Infanger M, Grimm D.
Proteome analysis of thyroid cancer cells after long-term exposure to a random positioning machine.
Microgravity Sci Technol. 2011 Nov;23(4):381-90.
http://dx.doi.org/10.1007/s12217-011-9258-5

28
Monici M, Cialdai F, Romano G, Fusi F, Egli M, Pezzatini S, Morbidelli L.
An in vitro study on tissue repair: Impact of unloading on cells involved in the remodelling phase.
Microgravity Sci Technol. 2011 Nov;23(4):391-401.
http://dx.doi.org/10.1007/s12217-011-9259-4
NOTE: Used random positioning machine.

29
Wang Y, An L, Jiang Y, Hang H.
Effects of simulated microgravity on embryonic stem cells.
PLoS One. 2011;6(12):e29214. Epub 2011 Dec 21.
http://www.ncbi.nlm.nih.gov/pubmed/22216215
NOTE: Used 3D clinostat. This article may be obtained online without charge.

30
Fernandez P, Maier M, Lindauer M, Kuffer C, Storchova Z, Bausch AR.
Mitotic spindle orients perpendicular to the forces imposed by dynamic shear.
PLoS One. 2011;6(12):e28965. Epub 2011 Dec 29.
http://www.ncbi.nlm.nih.gov/pubmed/22220200
NOTE: This article may be obtained online without charge.

31
Margadant F, Chew LL, Hu X, Yu H, Bate N, Zhang X, Sheetz M.
Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin.
PLoS Biol. 2011 Dec;9(12):e1001223. Epub 2011 Dec 20.
http://www.ncbi.nlm.nih.gov/pubmed/22205879
NOTE: This article may be obtained online without charge.

32
Kiyohara S, Honda H, Shimizu N, Ejima C, Hamasaki R, Sawa S.
Tryptophan auxotroph mutants suppress the superroot2 phenotypes, modulating IAA biosynthesis in Arabidopsis.
Plant Signal Behav. 2011 Sep;6(9):1351-5.
http://www.ncbi.nlm.nih.gov/pubmed/22216462