NASA Spaceline Current Awareness 6 January 2012 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Conkin J.
PH2O and simulated hypobaric hypoxia.
Aviat Space Environ Med. 2011 Dec;82(12):1157-8.
http://www.ncbi.nlm.nih.gov/pubmed/22195399

2
Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S, Costes SV.
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells.
Proc Natl Acad Sci U S A. 2011 Dec 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22184222
(PIs: M. Barcellos-Hoff/S.V. Costes/NSCOR; D.J. Chen)
NOTE: This article may be obtained online without charge.

3
Azzam EI, Jay-Gerin JP, Pain D.
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury.
Cancer Lett. 2011 Dec 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22182453
(PI: E.I. Azzam)

4
Plante I, Cucinotta FA.
Model of the initiation of signal transduction by ligands in a cell culture: Simulation of molecules near a plane membrane comprising receptors.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5-1):051920. Epub 2011 Nov 28.
http://www.ncbi.nlm.nih.gov/pubmed/22181457
(PI: F.A. Cucinotta)

5
Newton J, Oldham M, Thomas A, Li Y, Adamovics J, Kirsch DG, Das S.
Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques.
Med Phys. 2011 Dec;38(12):6754.
http://www.ncbi.nlm.nih.gov/pubmed/22149857
(PI: D.G. Kirsch/NSCOR)

6
Allen JD, Wang S, Chen M, Girard L, Minna JD, Xie Y, Xiao G.
Probe mapping across multiple microarray platforms.
Brief Bioinform. 2011 Dec 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22199380
(PI: J.D. Minna/L. Girard/NSCOR)

7
Wang Q, Vlkolinsky R, Xie M, Obenaus A, Song SK.
Diffusion tensor imaging detected optic nerve injury correlates with decreased compound action potentials following murine retinal ischemia.
Invest Ophthalmol Vis Sci. 2011 Dec 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22159023
(PI: G. Nelson/R. Vlkolinsky/A. Obenaus/S.K. Song/NSCOR)

Other papers of interest:

1
McBeth PB, Keaney M, Ball CG, Saary J, Broderick TJ, Kock V, Kirkpatrick AW.
Aeromobile modular critical care, resuscitation, and surgical suites for
operational medicine.
J Trauma. 2011 Nov;71(5 Suppl 1):S494-500.
http://www.ncbi.nlm.nih.gov/pubmed/22072009
NOTE: From paper: “As there is a need to provide capable and robust OM [operational medicine] platforms, the purpose of this article is to outline the design and development of a Modular Critical Care, Resuscitation and Surgical Suite (MCCRSS) for OM use during microgravity in parabolic flight. The development process, system capabilities, lessons learned, and potential applicability to other OM environments are further reviewed.”

2
Rai B, Kaur J, Foing BH.
Evaluation by an aeronautic dentist on the adverse effects of a six-week period of microgravity on the oral cavity.
Int J Dent. 2011;2011:548068. Epub 2011 Dec 10.
http://www.ncbi.nlm.nih.gov/pubmed/22190932
NOTE: Bed rest study. This article may be obtained online without charge via PubMed Central and at the publisher’s site.

3
Castillo M.
Imaging in space exploration.
AJNR Am J Neuroradiol. 2011 Dec 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22173771
NOTE: This ‘Perspective,” by the journal’s editor, provides an overview of medical issues in space with some discussion of imaging in space flight. He concludes: “In reality, I think that there will be very little, if any, use for neuroimaging in space. If images are generated, we certainly can interpret them down here on earth.”

4
Protheroe CL, Dikareva A, Menon C, Claydon VE.
Are compression stockings an effective treatment for orthostatic presyncope?
PLoS One. 2011;6(12):e28193. Epub 2011 Dec 16.
http://www.ncbi.nlm.nih.gov/pubmed/22194814
NOTE: This article may be obtained online without charge.

5
Fogt DL, Cooke WH, Kalns JE, Michael DJ.
Linear mixed-effects modeling of the relationship between heart rate variability and fatigue arising from sleep deprivation.
Aviat Space Environ Med. 2011 Dec;82(12):1104-9.
http://www.ncbi.nlm.nih.gov/pubmed/22195390

6
Gagnon DD, Pullinen T, Karinen H, Rintamaeki H, Kyroelaeinen H.
Recovery of hormonal, blood lipid, and hematological profiles from a North Pole expedition.
Aviat Space Environ Med. 2011 Dec;82(12):1110-7.
http://www.ncbi.nlm.nih.gov/pubmed/22195391

7
Guadagno AG, Morgagni F, Vicenzini E, Davi L, Appiani GC, Tomao E.
Cerebral vascular response in airmen exposed to hypobaric hypoxia.
Aviat Space Environ Med. 2011 Dec;82(12):1138-42.
http://www.ncbi.nlm.nih.gov/pubmed/22195395

8
Woodrow AD, Webb JT, Wier GS.
Recollection of hypoxia symptoms between training events.
Aviat Space Environ Med. 2011 Dec;82(12):1143-7.
http://www.ncbi.nlm.nih.gov/pubmed/22195396

9
Kordi M, Cardoso RB, Russomano T.
A preliminary comparison between methods of performing external chest compressions during microgravity simulation.
Aviat Space Environ Med. 2011 Dec;82(12):1161-3.
http://www.ncbi.nlm.nih.gov/pubmed/22195400
NOTE: This article, in the ‘Science and Technology Watch’ section of the journal, may be obtained online without charge: http://www.ingentaconnect.com/content/asma/asem/2011/00000082/00000012/a…

10
Kolomiytseva IK.
Lipids in mammalian hibernation and artificial hypobiosis.
Biochemistry (Mosc). 2011 Dec;76(12):1291-9.
http://www.ncbi.nlm.nih.gov/pubmed/22150274
NOTE: This paper is a translation in English of the Russian original published in Biokhimiya 2011;76(12):1604-14.

11
Otis JP, Sahoo D, Drover VA, Yen CL, Carey HV.
Cholesterol and lipoprotein dynamics in a hibernating mammal.
PLoS One. 2011;6(12):e29111. Epub 2011 Dec 15.
http://www.ncbi.nlm.nih.gov/pubmed/22195001
NOTE: This article may be obtained online without charge.

12
Vikhlyantsev IM, Okuneva AD, Shpagina MD, Shumilina YV, Molochkov NV, Salmov NN, Podlubnaya ZA.
Changes in isoform composition, structure, and functional properties of titin from Mongolian gerbil (Meriones unguiculatus) cardiac muscle after space flight.
Biochemistry (Mosc). 2011 Dec;76(12):1312-20.
http://www.ncbi.nlm.nih.gov/pubmed/22150276
NOTE: Foton M3 results. This paper is a translation in English of the Russian original published in Biokhimiya 2011;76(12):1629-39.

13
Ren JC, Fan XL, Song XA, Zhao XH, Chen MX, Shi L.
Prolonged hindlimb unloading leads to changes in electrophysiological properties of L5 dorsal root ganglion neurons in rats after 14 days.
Muscle Nerve. 2012 Jan;45(1):65-9.
http://www.ncbi.nlm.nih.gov/pubmed/22190309

14
Ohnishi YI, Iwatsuki K, Shinzawa K, Nakai Y, Ishihara M, Yoshimine T.
Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury.
Neuroreport. 2011 Dec 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22182976

15
Sato S, Shirato K, Tachiyashiki K, Imaizumi K.
Muscle plasticity and (2)-adrenergic receptors: Adaptive responses of (2)-adrenergic receptor expression to muscle hypertrophy and atrophy.
J Biomed Biotechnol. 2011;2011:729598. Epub 2011 Nov 15.
http://www.ncbi.nlm.nih.gov/pubmed/22190857
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site.

16
Ko CY, Hyun Seo D, Sung Kim H.
Deterioration of bone quality in the tibia and fibula in growing mice during skeletal unloading: Gender-related differences.
J Biomech Eng. 2011 Nov;133(11):111003.
http://www.ncbi.nlm.nih.gov/pubmed/22168735

17
Green DE, Adler BJ, Chan ME, Rubin CT.
Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity.
J Bone Miner Res. 2011 Dec 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22190044

18
Del Fattore A, Teti A, Rucci N.
Bone cells and the mechanisms of bone remodelling.
Front Biosci (Elite Ed). 2012 Jan 1;4:2302-21.
http://www.ncbi.nlm.nih.gov/pubmed/22202038
NOTE: This article may be obtained online without charge: http://www.bioscience.org/2012/v4e/af/543/fulltext.htm

19
Himeno-Ando A, Izumi Y, Yamaguchi A, Iimura T.
Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities.
Biochem Biophys Res Commun. 2011 Dec 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22198435

20
Kulkarni RN, Bakker AD, Gruber EV, Chae TD, Veldkamp JB, Klein-Nulend J, Everts V.
MT1-MMP modulates the mechanosensitivity of osteocytes.
Biochem Biophys Res Commun. 2011 Dec 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22202174

21
Shuryak I, Brenner DJ, Ullrich RL.
Radiation-induced carcinogenesis: Mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA.
PLoS One. 2011;6(12):e28559. Epub 2011 Dec 14.
http://www.ncbi.nlm.nih.gov/pubmed/22194850
NOTE: This article may be obtained online without charge.

22
Aziz K, Nowsheen S, Pantelias G, Iliakis G, Gorgoulis V, Georgakilas AG.
Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy.
Pharmacol Ther. 2011 Dec 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22197993

23
Franken NA, Hovingh S, Ten Cate R, Krawczyk P, Stap J, Hoebe R, Aten J, Barendsen GW.
Relative biological effectiveness of high linear energy transfer -particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells.
Oncol Rep. 2012 Mar;27(3):769-74. Epub 2011 Dec 21.
http://www.ncbi.nlm.nih.gov/pubmed/22200791

24
Clement G, Demel M.
Perceptual reversal of bi-stable figures in microgravity and hypergravity during parabolic flight.
Neurosci Lett. 2012 Jan 24;507(2):143-6. Epub 2011 Dec 13.
http://www.ncbi.nlm.nih.gov/pubmed/22188656
NOTE: Parabolic flight results.

25
Horii A, Nakagawa A, Uno A, Kitahara T, Imai T, Nishiike S, Takeda N, Inohara H.
Implication of substance P neuronal system in the amygdala as a possible mechanism for hypergravity-induced motion sickness.
Brain Res. 2011 Dec 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22192410

26
Groves AK, Fekete DM.
Shaping sound in space: The regulation of inner ear patterning.
Development. 2012 Jan 15;139(2):245-57.
http://www.ncbi.nlm.nih.gov/pubmed/22186725

27
Kazmierczak P, Mueller U.
Sensing sound: Molecules that orchestrate mechanotransduction by hair cells.
Trends Neurosci. 2011 Dec 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22177415

28
Katsumata H, Russell DM.
Prospective versus predictive control in timing of hitting a falling ball.
Exp Brain Res. 2011 Nov 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22120106

29
Zhang Y, Lai C, Duan J, Guan N, Ullah K, Deng Y.
Simulated microgravity affects semicarbazide-sensitive amine oxidase expression in recombinant Escherichia coli by HPLC-ESI-QQQ analysis.
Appl Microbiol Biotechnol. 2011 Dec 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22170102
NOTE: Microgravity was simulated with a double-axis clinostat developed in China. The authors apparently use the terms ‘clinostat’ and ‘bioreactor’ interchangeably.

30
Okajima R, Chiba S.
How does life adapt to a gravitational environment? The outline of the terrestrial gastropod shell.
Am Nat. 2011 Dec;178(6):801-9. Epub 2011 Oct 20.
http://www.ncbi.nlm.nih.gov/pubmed/22089873

31
Martinac B.
Bacterial mechanosensitive channels as a paradigm for mechanosensory transduction.
Cell Physiol Biochem. 2011;28(6):1051-60. Epub 2011 Dec 16.
http://www.ncbi.nlm.nih.gov/pubmed/22178995
NOTE: This article may be obtained online without charge.

32
Hanein D, Horwitz AR.
The structure of cell-matrix adhesions: The new frontier.
Curr Opin Cell Biol. 2011 Dec 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22196929