NASA Spaceline Current Awareness 3 August 2012 (Recent Space Life Science Research Results)

Next list: August 17, 2012

Papers deriving from NASA support:

1 Gibson CR, Mader TH, Schallhorn SC, Pesudovs K, Lipsky W, Raid E, Jennings RT, Fogarty JA, Garriott RA, Garriott OK, Johnston SL.
Visual stability of laser vision correction in an astronaut on a Soyuz mission to the International Space Station.
J Cataract Refract Surg. 2012 Aug;38(8):1486-91.
http://www.ncbi.nlm.nih.gov/pubmed/22814056
NOTE: ISS results. There is a comment on this article that may be obtained online without charge: http://www.jcrsjournal.org/article/S0886-3350(12)00805-X/fulltext
This topic is featured on the cover of the journal: http://www.jcrsjournal.org/home or go to the table of contents of the issue.

2 Meyers VE, Garcia HD, Monds K, Cooper BL, James JT.
Ocular toxicity of authentic lunar dust.
BMC Ophthalmol. 2012 Jul 20;12:26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22817808
(PI: J.T. James/Wyle)
NOTE: Apollo 14 lunar samples were used. This article may be obtained online without charge.

3 Marzban C, Illian PR, Morison D, Moore A, Kliot M, Czosnyka M, Mourad PD.
A method for estimating zero-flow pressure and intracranial pressure.
J Neurosurg Anesthesiol. 2012 Jul 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22824923
(PI: P.D. Mourad)

4 Hu M, Cheng J, Qin YX.
Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model.
Bone. 2012 Jul 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22820398
(PI: Y.X. Qin)

5 Zhao L, Dodge T, Ledet E, Yokota H.
Knee loading stimulates bone formation in tail-suspended mouse hindlimb.
Biol Sci Space. 2011 Dec;25(2-4):77-82.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502010/_pdf
(PI: H. Yokota)
NOTE: This article may be obtained online without charge.

6 Zhang P, Jiang C, Ledet E, Yokota H.
Loading- and unloading-driven regulation of phosphorylation of eIF2.
Biol Sci Space. 2011 Apr;25(1):3-6.
https://www.jstage.jst.go.jp/article/bss/25/1/25_3/_pdf
(PI: H. Yokota)
NOTE: This article may be obtained online without charge.

7 Wang M, Hada M, Saha J, Sridharan DM, Pluth JM, Cucinotta FA.
Protons sensitize epithelial cells to mesenchymal transition.
PLoS One. 2012;7(7):e41249. Epub 2012 Jul 23.
http://www.ncbi.nlm.nih.gov/pubmed/22844446
(PIs: J.M. Pluth, F.A. Cucinotta)
NOTE: This article may be obtained online without charge.

9 Zhang X, Ng WL, Wang P, Tian L, Werner E, Wang H, Doetsch P, Wang Y.
MicroRNA-21 modulates the levels of reactive oxygen species levels by targeting SOD3 and TNF.
Cancer Res. 2012 Jul 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22836756
(PI: Y. Wang/H. Wang/P. Doetsch/NSCOR)

10 Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D.
AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.
Int J Radiat Oncol Biol Phys. 2012 Jul 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22795803
(PI: S. Burma)

11 Kon T, Zhang X, Huang Q, Yang Z, Liu S, Yan B, Li F, Wang H, Li CY.
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.
Trans Cancer Res. 2012 Jun;1(1):6-14.
http://dx.doi.org/10.3978/j.issn.2218-676X.2012.05.02
(PI: C.Y. Li)
NOTE: This article, which may be obtained online without charge, is featured on the cover of the first issue of this new journal: http://www.thetcr.org/issue/view/36 and is addressed in a comment: http://www.thetcr.org/article/view/367/717

12 Putcha L, Taylor PW, Boyd JL.
Biopharmaceutical challenges of therapeutics in space: Formulation and packaging considerations.
Ther Deliv. 2011 Nov;2(11):1373-6.
http://www.ncbi.nlm.nih.gov/pubmed/22826869
(PI: L. Putcha)
NOTE: This article may be obtained online without charge: http://www.future-science.com/doi/pdf/10.4155/tde.11.115

Other papers of interest:

1 Santucci D, Kawano F, Ohira T, Terada M, Nakai N, Francia N, Alleva E, Aloe L, Ochiai T, Cancedda R, Goto K, Ohira Y.
Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days.
PLoS One. 2012;7(7):e40112. Epub 2012 Jul 9.
http://www.ncbi.nlm.nih.gov/pubmed/22808101
NOTE: ISS results. This article may be obtained online without charge.

2 Shi F, Wang YC, Zhao TZ, Zhang S, Du TY, Yang CB, Li YH, Sun XQ.
Effects of simulated microgravity on human umbilical vein endothelial cell angiogenesis and role of the PI3K-Akt-eNOS signal pathway.
PLoS One. 2012;7(7):e40365. Epub 2012 Jul 13.
http://www.ncbi.nlm.nih.gov/pubmed/22808143
NOTE: This article may be obtained online without charge.

3 Varenik EN, Lipina TV, Shornikova MV, Krasnov IB, Chentsov YS.
Electron microscope analysis of cardiomyocytes in the rat left ventricle under simulation of weightlessness effects and artificial gravitation.
Biol Bull. 2012 May;39(3):221-8.
http://dx.doi.org/10.1134/S1062359012030132
NOTE: This is an English translation of the Russian original published in Izvestiya Akademii Nauk, Seriya Biologicheskaya 2012 May-Jun;(3):270-8: http://www.ncbi.nlm.nih.gov/pubmed/22834310

4 Grant CC, Viljoen M, van Rensburg DC, Wood PS.
Heart rate variability assessment of the effect of physical training on autonomic cardiac control.
Ann Noninvasive Electrocardiol. 2012 Jul;17(3):219-29.
http://www.ncbi.nlm.nih.gov/pubmed/22816541

5 Tank J, Heusser K, Malehsa D, Hegemann K, Haufe S, Brinkmann J, Tegtbur U, Diedrich A, Bara C, Jordan J, Strueber M.
Patients with continuous-flow left ventricular assist devices provide insight in human baroreflex physiology.
Hypertension. 2012 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22824986

6 Gemignani T, Matos-Souza JR, Franchini KG, Nadruz W Jr.
Leg blood pressure measured in orthostatic posture is associated with left ventricular mass in normotensive subjects.
Am J Hypertens. 2012 Jul 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22810843

7 Deschenes MR, McCoy RW, Mangis KA.
Factors relating to gender specificity of unloading-induced declines in strength.
Muscle Nerve. 2012 Aug;46(2):210-7.
http://www.ncbi.nlm.nih.gov/pubmed/22806370
NOTE: Used modified unilateral lower limb suspension technique to produce unloading.

8 Roca-Rivada A, Al-Massadi O, Castelao C, Senin LL, Alonso J, Seoane LM, Garcia-Caballero T, Casanueva FF, Pardo M.
Muscle tissue as an endocrine organ: Comparative secretome profiling of slow-oxidative and fast-glycolytic rat muscle explants and its variation with exercise.
J Proteomics. 2012 Jul 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22800642

9 Segizbaeva MO, Pogodin MA, Aleksandrova NP.
Effects of body positions on respiratory muscle activation during maximal inspiratory maneuvers.
Adv Exp Med Biol. 2013;756:355-63.
http://www.ncbi.nlm.nih.gov/pubmed/22836654

10 Cheung AM, Giangregorio L.
Mechanical stimuli and bone health: What is the evidence?
Curr Opin Rheumatol. 2012 Jul 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22832826

11 Deere K, Sayers A, Rittweger J, Tobias JH.
A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females.
J Clin Endocrinol Metab. 2012 Jul 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22802090

12 Souzanchi MF, Palacio-Mancheno PE, Borisov Y, Cardoso L, Cowin SC.
Microarchitecture and bone quality in the human calcaneus; Local variations of fabric anisotropy.
J Bone Miner Res. 2012 Jul 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22807141

13 Smith MB, Akatov Y, Andrews HR, Arkhangelsky V, Chernykh IV, Ing H, Khoshooniy N, Lewis BJ, Machrafi R, Nikolaev I, Romanenko RY, Shurshakov V, Thirsk RB, Tomi L.
Measurements of the neutron dose and energy spectrum on the International Space Station during expeditions ISS-16 to ISS-21.
Radiat Prot Dosimetry. 2012 Jul 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22826353
NOTE: ISS results.

14 Wojcik A, Obe G, Lisowska H, Czub J, Nievaart V, Moss R, Huiskamp R, Sauerwein W.
Chromosomal aberrations in peripheral blood lymphocytes exposed to a mixed beam of low energy neutrons and gamma radiation.
J Radiol Prot. 2012 Sep;32(3):261-74.
http://www.ncbi.nlm.nih.gov/pubmed/22809710

15 Chapman KL, Al-Mayah AH, Bowler DA, Irons SL, Kadhim MA.
No influence of serotonin levels in foetal bovine sera on radiation-induced bystander effects and genomic instability.
Int J Radiat Biol. 2012 Jul 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22812666

16 Fazzari J, Mersov A, Smith R, Seymour C, Mothersill C.
Effect of 5-hydroxytryptamine (serotonin) receptor inhibitors on the radiation-induced bystander effect.
Int J Radiat Biol. 2012 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22823540

17 Kalanxhi E, Dahle J.
The role of serotonin and p53 status in the radiation-induced bystander effect.
Int J Radiat Biol. 2012 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22803606

18 Schmid TE, Multhoff G.
Non-targeted effects of photon and particle irradiation and the interaction with the immune system.
Front Oncol. 2012;2:80. Epub 2012 Jul 24.
http://www.ncbi.nlm.nih.gov/pubmed/22837986
NOTE: This article may be obtained online without charge.

19 Chakraborti A, Allen A, Allen B, Rosi S, Fike JR.
Cranial irradiation alters dendritic spine density and morphology in the hippocampus.
PLoS One. 2012;7(7):e40844. Epub 2012 Jul 16.
http://www.ncbi.nlm.nih.gov/pubmed/22815839
NOTE: This article may be obtained online without charge.

20 Haro KJ, Scott AC, Scheinberg DA.
Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells.
Blood. 2012 Jul 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22829630

21 Stoll E, Jaekel S, Katz J, Saenz-Otero A, Varatharajoo R.
SPHERES interact–Human-machine interaction aboard the International Space Station.
J Field Robotics. 2012 Jul-Aug;29(4):554-75.
http://dx.doi.org/10.1002/rob.21419
NOTE: ISS results. This article is in a Special Issue on Space Robotics, Part II.

22 Beraneck M, Bojados M, Le Seac’h A, Jamon M, Vidal PP.
Ontogeny of mouse vestibulo-ocular reflex following genetic or environmental alteration of gravity sensing.
PLoS One. 2012;7(7):e40414. Epub 2012 Jul 10.
http://www.ncbi.nlm.nih.gov/pubmed/22808156
NOTE: This article may be obtained online without charge.

23 Minetti AE, Ivanenko YP, Cappellini G, Dominici N, Lacquaniti F.
Humans running in place on water at simulated reduced gravity.
PLoS One. 2012;7(7):e37300. Epub 2012 Jul 18.
http://www.ncbi.nlm.nih.gov/pubmed/22815681
NOTE: This article may be obtained online without charge.

24 Ma CW, Zhang FX, Lai CH, Lai SK, Yung KK, Shum DK, Chan YS.
Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations.
J Comp Neurol. 2012 Jul 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22806574

25 Prsa M, Gale S, Blanke O.
Self-motion leads to mandatory cue fusion across sensory modalities.
J Neurophysiol. 2012 Jul 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22832567

26 Masani K, Sayenko DG, Vette AH.
What triggers the continuous muscle activity during upright standing?
Gait Posture. 2012 Jul 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22824676

27 Goodworth A, Chandan A, Chase H, Foster E, Francoeur H, Michaud J, Terry K.
Stance width influences frontal plane balance responses to centripetal
accelerations.
Gait Posture. 2012 Jul 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22819010

28 Smith PF.
Dyscalculia and vestibular function.
Med Hypotheses. 2012 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22819131

29 Pomplun M, Silva EJ, Ronda JM, Cain SW, Muench MY, Czeisler CA, Duffy JF.
The effects of circadian phase, time awake, and imposed sleep restriction on performing complex visual tasks: Evidence from comparative visual search.
J Vis. 2012 Jul 26;12(7). pii: 14. Print 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22836655
NOTE: This article may be obtained online without charge.

30 Zhang J, Gao W, Yan S, Zhao Y.
Effects of space flight on the chemical constituents and anti-inflammatory activity of licorice (Glycyrrhiza uralensis Fisch).
Iranian J Pharm Res. 2012 May;11(2):601-9.
http://ijpr.sbmu.ac.ir/?_action=articleInfo&article=1139
NOTE: Results from seeds flown on a Chinese satellite. This article may be obtained online without charge.

31 Hermann M, Wurm M, Lubei V, Pirkebner D, Draxl A, Margreiter R, Hengster P.
Keep on rolling: Optimizing human islet transport conditions using a perfused rotary system.
Islets. 2012 Mar-Apr;4(2):152-7.
http://www.ncbi.nlm.nih.gov/pubmed/22627172
NOTE: The rotary system used is based on the rotating wall vessel system originally developed by NASA.

32 Brykov VO, Shugaev AG, Generozova IP.
Ultrastructure and metabolic activity of pea mitochondria under clinorotation.
Cytol Genet. 2012 May;46(3):144-9.
http://dx.doi.org/10.3103/S0095452712030036
NOTE: This is a translation in English of the original Russian paper published in Tsitologiya i Genetika 2012;46(3):20-6.

33 Mammoto A, Mammoto T, Ingber DE.
Mechanosensitive mechanisms in transcriptional regulation.
J Cell Sci. 2012 Jul 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22797927
NOTE: This article and the following article are part of a “Minifocus on Mechanotransduction” section to appear in this journal. The other articles are PubMed IDs 22797926, 22797913, 22797912, and one not yet published.

34 Sukharev S, Sachs F.
Molecular force transduction by ion channels – diversity and unifying principles.
J Cell Sci. 2012 Jul 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22797911

35 Vedula SR, Leong MC, Lai TL, Hersen P, Kabla AJ, Lim CT, Ladoux B.
Emerging modes of collective cell migration induced by geometrical constraints.
Proc Natl Acad Sci U S A. 2012 Jul 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22814373
NOTE: This article may be obtained online without charge.

36 Dabiri BE, Lee H, Parker KK.
A potential role for integrin signaling in mechanoelectrical feedback progress in biophysics and molecular biology.
Prog Biophys Mol Biol. 2012 Jul 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22819851

37 Gilmore SJ, Vaughan BL Jr, Madzvamuse A, Maini PK.
A mechanochemical model of striae distensae.
Math Biosci. 2012 Jul 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22796062
NOTE: Test question: What are striae distensae? (answer: see abstract)

The following 47 citations (and 2 in the NASA section) represent recent and earlier articles dating back to 2007 from the Japanese journal Biological Sciences in Space. They are entered here for completeness. The articles are available online without charge. The publisher’s online site, listing all issues, is: https://www.jstage.jst.go.jp/browse/bss

1 Kato M, Itoh Y, Shimizu J, Naga S, Takabayashi A, Nagaoka S.
Psychological and physiological influences of a head-down tilted condition.
Biol Sci Space. 2010 Oct;24(2):91-4.
https://www.jstage.jst.go.jp/article/bss/24/2/24_91/_pdf

2 Yoshioka M, Yamaguchi T, Gyotoku J, Ochiai T, Ohta H.
Effect of parabolic flight on plasma arginine vasopressin as a sensitive marker for psychophysiological stress in humans.
Biol Sci Space. 2010 Oct;24(2):95-100.
https://www.jstage.jst.go.jp/article/bss/24/2/24_95/_pdf
NOTE: Parabolic flight results.

3 Kitamura KI, Nemoto T, Sato N, Chen W.
Development of a new accelerometer-based physical activity-monitoring system using a high-frequency sampling rate.
Biol Sci Space. 2009 Jul;23(2):77-84.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_77/_pdf

4 Ohira Y, Kawano F, Wang XD, Nakai N, Ohira T, Okabe H, Naito H, Goto K.
Role(s) of mechanical load and satellite cells in the regulation of the size of soleus muscle fiber in rats.
Biol Sci Space. 2010 Dec;24(3-4):135-44.
https://www.jstage.jst.go.jp/article/bss/24/3_4/24_135/_pdf

5 Oguro-Ando A.
[Gravity response and disuse atrophy in skeletal muscle: Understanding from extracellular matrix-collagen and its molecular chaperon HSP47]
Biol Sci Space. 2008 Dec;22(4):167-71. Japanese.
https://www.jstage.jst.go.jp/article/bss/22/4/22_4_167/_pdf
NOTE: This article is one of eight articles (all are in Japanese) in an issue on the topic of “Gravitational Health Sciences – A New Science Field”: https://www.jstage.jst.go.jp/browse/bss/22/4/_contents

6 Kitamura KI, Chen W, Zhu X, Suzuki N, Yano S, Nemoto T.
Acceleration-based study of optimum exercise for human weight-bearing bones enhancement.
Biol Sci Space. 2010 Oct;24(2):83-90.
https://www.jstage.jst.go.jp/article/bss/24/2/24_83/_pdf

7 Suzuki N, Kitamura KI, Omori K, Nemoto T, Satoh Y, Tabata MJ, Ikegame M, Yamamoto T, Ijiri K, Furusawa Y, Kondo T, Takasaki I, Tabuchi Y, Wada S, Shimizu N, Sasayama Y, Endo M, Takeuchi T, Nara M, Somei M, Maruyama Y, Hayakawa K , Shimazu T, Shigeto Y, Yano S, Hattori A.
Response of osteoblasts and osteoclasts in regenerating scales to gravity loading.
Biol Sci Space. 2009 Dec;23(4):211-7.
https://www.jstage.jst.go.jp/article/bss/23/4/23_4_211/_pdf

8 Suzuki N, Omori K, Nakamura M, Tabata MJ, Ikegame M, Ijiri K, Kitamura KI, Nemoto T, Shimizu N, Kondo T, Matsuda K, Ando H, Kasahara H, Nagase M, Nara M, Hattori A.
Scale osteoblasts and osteoclasts sensitively respond to low-gravity loading by centrifuge.
Biol Sci Space. 2008 Sep;22(1):3-7.
https://www.jstage.jst.go.jp/article/bss/22/1/22_1_3/_pdf

9 Izumi R, Oishi H, Higashibata A, Yoshizaki R, Ito I, Murase H, Inoue M, Kato K, Kawashima H, Soya H, Ishioka N.
Development of basic technologies for drop-tower experiments on vertebrates.
Biol Sci Space. 2009 Jul;23(2):85-97.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_85/_pdf

10 Yoo W, Lee K, Gwag T, Ju H, Yamashita M, Choi I.
Seasonal proteomic plasticity in the brain of a mammalian hibernator.
Biol Sci Space. 2008 Nov;22(3):99-111.
https://www.jstage.jst.go.jp/article/bss/22/3/22_3_99/_pdf

11 Hoson T, Takahashi A, Nikawa T, Fukui K, Ogawa S, Higashitani A.
Toward future space experiments for life sciences.
Biol Sci Space. 2011 Apr;25(1):21-4.
NOTE: Report of a workshop held at the 24th annual meeting of the Japanese Society for Biological Sciences in Space.

12 Higashitani A, Hashizume T, Sugimoto T, Mori C, Nemoto K, Etheridge T, Higashitani N, Takanami T, Suzuki H, Fukui K, Yamazaki T, Ishioka N, Szewczyk N, Higashibata A.
C. elegans RNAi space experiment (CERISE) in Japanese Experiment Module KIBO.
Biol Sci Space. 2009 Dec;23(4):183-7.
https://www.jstage.jst.go.jp/article/bss/23/4/23_4_183/_pdf
NOTE: Describes ISS experiment underway at the time.

13 Harada-Sukeno A, Kohno S, Nakao R, Hirasaka K, Higashibata A, Yamazaki T, Ishioka N, Suzuki H, Shimazu T, Maita A, Okumura Y, Nikawa T.
“Myo Lab”: A JAXA Cell Biology Experiment in “Kibo (JEM)” of the International Space Station.
Biol Sci Space. 2009 Dec;23(4):189-93.
https://www.jstage.jst.go.jp/article/bss/23/4/23_4_189/_pdf
NOTE: About future ISS experiment.

14 Takahashi A, Nagamatsu A, Su X, Suzuki M, Tsuruoka C, Omori K, Suzuki H, Shimazu T, Seki M, Hashizume T, Iwasaki T, Ishioka N, Ohnishi T.
The first life science experiments in ISS: Reports of “Rad Gene”-Space radiation effects on human cultured cells-
Biol Sci Space. 2010 Apr;24(1):17-41.
https://www.jstage.jst.go.jp/article/bss/24/1/24_1_17/_pdf
NOTE: ISS results.

15 Ohnishi T, Takahashi A, Suzuki H, Omori K, Shimazu T, Ishioka N.
Expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment.
Biol Sci Space. 2009 May;23(1):3-9.
https://www.jstage.jst.go.jp/article/bss/23/1/23_1_3/_pdf
NOTE: Describes ISS experiment.

16 Yatagai F, Takahashi A, Honma M, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Enomoto S, Ohnishi T, Ishioka N.
LOH analyses for biological effects of space radiation: Human cell culture in “Kibo” of International Space Station.
Biol Sci Space. 2009 May;23(1):11-6.
https://www.jstage.jst.go.jp/article/bss/23/1/23_1_11/_pdf
NOTE: Describes ISS experiment.

17 Miura Y.
Proteomic approach for biomarker discovery in radioadaptive responses -Age-dependent variations of cell response to low-dose radiation –
Biol Sci Space. 2009 May;23(1):17-22.
https://www.jstage.jst.go.jp/article/bss/23/1/23_1_17/_pdf

18 Majima HJ, Indo HP, Tomita K, Iwashita Y, Suzuki H, Masuda D, Shimazu T, Tanigaki F, Umemura S, Yano S, Fukui K, Higashibata A, Yamazaki TQ, Kameyama M, Suenaga S, Sato T, Yen HC, Gusev O, Okuda T, Matsui H, Ozawa T, Ishioka N.
Bio-assessment of RISK in long-term manned space exploration – Cell death factors in space radiation and/or microgravity: A review-
Biol Sci Space. 2009 Jul;23(2):43-53.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_43/_pdf

19 Tsuruoka C.
Difference in biological effectiveness due to the endpoints and radiation quality.
Biol Sci Space. 2011 Apr;25(1):13-7.
https://www.jstage.jst.go.jp/article/bss/25/1/25_13/_pdf

20 Yoshida K, Yoshida S, Eguchi-Kasai K, Morita T.
Study of the effects of space radiation on mouse ES cells.
Biol Sci Space. 2010 Apr;24(1):11-5.
https://www.jstage.jst.go.jp/article/bss/24/1/24_1_11/_pdf
NOTE: Ground research related to future ISS experiment.

21 Hamada N.
The bystander response to heavy-ion radiation: Intercellular signaling between irradiated and non-irradiated cells.
Biol Sci Space. 2009 Dec;23(4):195-201.
https://www.jstage.jst.go.jp/article/bss/23/4/23_4_195/_pdf

22 Tsuruoka C, Suzuki M, Furusawa Y, Anzai K, Okayasu R.
The influence of mutation induction in normal human fibroblasts irradiated with X rays and iron ions.
Biol Sci Space. 2009 Jul;23(2):55-60.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_55/_pdf

23 Hamada N, Ni M, Funayama T, Sakashita T, Sora S, Nakano T, Kobayashi Y.
A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of -rays and energetic heavy ions.
Biol Sci Space. 2008;22(2):41-5.
https://www.jstage.jst.go.jp/article/bss/22/2/22_2_41/_pdf

24 Hamada N, Hara T, Omura-Minamisawa M, Ni M, Funayama T, Sakashita T, Sora S, Nakano T, Kobayashi Y.
Heavy-ion microbeam irradiation induces bystander killing of human cells.
Biol Sci Space. 2008;22(2):46-53.
https://www.jstage.jst.go.jp/article/bss/22/2/22_2_46/_pdf

25 Sora S, Hamada N, Hara T, Funayama T, Sakashita T, Yokota Y, Nakano T, Kobayashi Y.
Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation.
Biol Sci Space. 2008;22(2):54-8.
https://www.jstage.jst.go.jp/article/bss/22/2/22_2_54/_pdf

26 Hayatsu K, Hareyama M, Kobayashi S, Yamashita N, Miyajim M, Sakurai K, Hasebe N.
Radiation doses for human exposed to galactic cosmic rays and their secondary products on the lunar surface.
Biol Sci Space. 2008;22(2):59-66.
https://www.jstage.jst.go.jp/article/bss/22/2/22_2_59/_pdf

27 Watanabe-Asaka T, Mukai C, Mitani H.
Technologies and analyses using medaka to evaluate effects of space on health.
Biol Sci Space. 2010 Apr;24(1):3-9.
https://www.jstage.jst.go.jp/article/bss/24/1/24_1_3/_pdf

28 Furusawa T, Nojima K, Ichida M, Nagaoka S, Sugimura Y, Suzuki E, Sumida M, Suzuki H, Simazu T, Omori K, Ishioka N, Fujii H, Nagaoka S.
Introduction to the proposed space experiments aboard the ISS using the silkworm, Bombyx mori.
Biol Sci Space. 2009 Jul;23(2):61-9.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_61/_pdf
NOTE: Describes STS-84 experiment as a prelude to an ISS experiment.

29 Hosoya C, Akiyama A, Kage A, Baba SA, Mogami Y.
Reverse bioconvection of Chlamydomonas in the hyper-density medium.
Biol Sci Space. 2010 Dec;24(3-4):145-51.
https://www.jstage.jst.go.jp/article/bss/24/3_4/24_145/_pdf

30 Nishimura T, Koshiba T.
Indole-3-acetic acid biosynthesis and gravitropic response in maize coleoptiles.
Biol Sci Space. 2011 Dec;25(2-4):37-43.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502006/_pdf

31 Biswas KK, Oono Y.
New insights to auxin signaling through the use of small molecules.
Biol Sci Space. 2011 Dec;25(2-4):45-55.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502007/_pdf

32 Miyamoto K, Uheda E, Oka M, Ueda J.
Auxin polar transport and automorphosis in plants.
Biol Sci Space. 2011 Dec;25(2-4):57-68.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502008/_pdf

33 Ueda J, Miyamoto K, Uheda E, Oka M.
Auxin transport and a graviresponse in plants: Relevance to ABC proteins.
Biol Sci Space. 2011 Dec;25(2-4):69-75.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502009/_pdf

34 Soga K.
Gravity resistance in plants.
Biol Sci Space. 2010 Dec;24(3-4):129-34.
https://www.jstage.jst.go.jp/article/bss/24/3_4/24_129/_pdf

35 Sasagawa-Saito Y, Kitazawa D, Miyazawa Y, Fujii N, Takahashi H.
Differential accumulation of CsARF5 protein during peg formation in cucumber seedlings.
Biol Sci Space. 2010 Dec;24(3-4):153-61.
https://www.jstage.jst.go.jp/article/bss/24/3_4/24_153/_pdf

36 Karahara I, Tamaoki D, Nishiuchi T, Schreiber L, Kamisaka S.
Effects of altered gravity conditions on lignin and secondary wall formation in herbaceous dicots and woody plants.
Biol Sci Space. 2009 Dec;23(4):177-82.
https://www.jstage.jst.go.jp/article/bss/23/4/23_4_177/_pdf

37 Kamada M, Omori K, Yokoyama R, Nishitani K, Hoson T, Shimazu T, Ishioka N.
Preparation and outline of space-based studies on gravity responses and cell wall formation in plants.
Biol Sci Space. 2009 Sep;23(3):115-20.
https://www.jstage.jst.go.jp/article/bss/23/3/23_3_115/_pdf
NOTE: Some ISS results.

38 Nishitani K, Yokoyama R, Koizumi K.
Cell wall-related genes involved in supporting tissue formation and transcriptional regulation in Arabidopsis thaliana.
Biol Sci Space. 2009 Sep;23(3):121-9.
https://www.jstage.jst.go.jp/article/bss/23/3/23_3_121/_pdf

39 Hoson T, Soga K, Wakabayashi K.
Role of the cell wall-sustaining system in gravity resistance in plants.
Biol Sci Space. 2009 Sep;23(3):131-6.
https://www.jstage.jst.go.jp/article/bss/23/3/23_3_131/_pdf

40 Wakabayashi K, Soga K, Hoson T.
Modification of cell wall architecture in gramineous plants under altered gravity conditions.
Biol Sci Space. 2009 Sep;23(3):137-42.
https://www.jstage.jst.go.jp/article/bss/23/3/23_3_137/_pdf

41 Kotake T, Hirata N, Kitazawa K, Soga K, Tsumuraya Y.
Arabinogalactan-proteins in the evolution of gravity resistance in land plants.
Biol Sci Space. 2009 Sep;23(3):143-9.
https://www.jstage.jst.go.jp/article/bss/23/3/23_3_143/_pdf

42 Hoson T, Matsumoto S, Soga K, Wakabayashi K, Hashimoto T, Sonobe S, Muranaka T, Kamisaka S, Kamada M, Omori K, Ishioka N, Shimazu T.
Growth and cell wall properties in hypocotyls of Arabidopsis tua6 mutant under microgravity conditions in space.
Biol Sci Space. 2009 Jul;23(2):71-5.
https://www.jstage.jst.go.jp/article/bss/23/2/23_2_71/_pdf
NOTE: ISS results.

43 Soga K, Kotake T, Wakabayashi K, Kamisaka S, Hoson T.
The transcript level of katanin gene is increased transiently in response to changes in gravitational conditions in azuki bean epicotyls.
Biol Sci Space. 2009 May;23(1):23-8.
https://www.jstage.jst.go.jp/article/bss/23/1/23_1_23/_pdf

44 Nakano S, Soga K, Wakabayashi K, Hoson T.
Different cell wall polysaccharides are responsible for gravity resistance in the upper and the basal regions of azuki bean epicotyls.
Biol Sci Space. 2007 Dec;21(4):113-6.
https://www.jstage.jst.go.jp/article/bss/21/4/21_4_113/_pdf
NOTE: There are three articles in this issue, in Japanese, under a special issue topic “Fundamentals of Space Agriculture”: https://www.jstage.jst.go.jp/browse/bss/21/4/_contents

45 Motohashi K, Tomita-Yokotani K, Sato S, Baba K, Suzuki T, Sakurai N, Hashimoto H, Yamashita M, Tree RT.
The differences between upright and weeping type of Prunus sp. on the acoustic vibration analysis.
Biol Sci Space. 2011 Dec;25(2-4):93-7.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502012/_pdf

46 Kitaya Y, Hirai H, Shibuya T.
Important role of air convection for plant production in space farming.
Biol Sci Space. 2010 Dec;24(3-4):121-8.
https://www.jstage.jst.go.jp/article/bss/24/3_4/24_121/_pdf
NOTE: Summarizes parabolic flight results.

47 Takahashi Y, Hashimoto H, Nakagawa T, Shibata S.
Survivability of moss and fungal spores in tests simulating conditions of the ISS outer wall.
Biol Sci Space. 2011 Dec;25(2-4):83-92.
https://www.jstage.jst.go.jp/article/bss/25/2_4/25_112502011/_pdf
NOTE: Ground research in support of ISS experiment.