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NASA Spaceline Current Awareness List #984 28 January 2022 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 28, 2022


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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Bisserier M, Saffran N, Brojakowska A, Sebastian A, Evans AC, Coleman MA, Walsh K, Mills PJ, Garikipati VNS, Arakelyan A, Hadri L, Goukassian DA.
Emerging role of exosomal long non-coding RNAs in spaceflight-associated risks in astronauts.
Front Genet. 2022 Jan 17;12:812188.
PI: D.A. Goukassian
Note: From the abstract: "In this perspective article, we provide new insights into the potential role of exosomal lncRNA after spaceflight. We analyzed the transcriptional profile of exosomes isolated from peripheral blood plasma of three astronauts who flew on various Shuttle missions between 1998–2001 by RNA-sequencing. Computational analysis of the transcriptome of these exosomes identified 27 differentially expressed lncRNAs with a Log2 fold change, with molecular, cellular, and clinical implications." This article is part of Research Topic "RNA-Chromatin Interactions: Biology, Mechanism, Disease and Therapeutics" (https://www.frontiersin.org/research-topics/25076/rna-chromatin-interactions-biology-mechanism-disease-and-therapeutics#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.599
Funding: "This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (to DG), the Translational Research Institute for Space Health funds FIP0005 (to DG.), National Aeronautics and Space Administration grant 80NSSC19K1079 (to DG), American Heart Association Career Development Award 18CDA34110277 and startup funds from the Ohio State University Medical Center (to VG.), National Institutes of Health grant R01 HL133554 and American Heart Association 18IPA34170321 (to LH), NIH 5T32HL007824-22, and the Cardiovascular Medical Research and Education Fund (CMREF) (to LH and MB). Work was also performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344."
 
2
Parker CW, Teixeira MM, Singh NK, Raja HA, Cank KB, Spigolon G, Oberlies NH, Barker BM, Stajich JE, Mason CE, Venkateswaran K.
Genomic characterization of Parengyodontium torokii sp. nov., a biofilm-forming fungus isolated from Mars 2020 Assembly Facility.
J Fungi (Basel). 2022 Jan 9;8(1):66.
Note: Mars rover mission results. This article is part of Special Issue "Diversity and Classification of Environmental Fungi" (https://www.mdpi.com/journal/jof/special_issues/Environmental_fungi). This article may be obtained online without charge.
Journal Impact Factor: 5.816
Funding: "The research described in this manuscript was funded by the NNH18ZDA001N-PPR award 18-PPR18-0011 to K.V."
 
3
Demmig-Adams B, López-Pozo M, Polutchko SK, Fourounjian P, Stewart JJ, Zenir MC, Adams WW 3rd.
Growth and nutritional quality of Lemnaceae viewed comparatively in an ecological and evolutionary context.
Plants (Basel). 2022 Jan 6;11(2):145. Review.
PI: B. Demmig-Adams
Note: This article is part of Special Issue "Duckweed: Research Meets Applications" (https://www.mdpi.com/journal/plants/special_issues/duckweed). The Special Issue also includes an article from previous Current Awareness List #970 https://doi.org/10.3390/plants10091896. This article may be obtained online without charge.
Journal Impact Factor: 3.935
Funding: "This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, the National Science Foundation award number IOS-1907338, and the University of Colorado."
 
4
Demmig-Adams B, Polutchko SK, Zenir MC, Fourounjian P, Stewart JJ, López-Pozo M, Adams WW 3rd.
Intersections: Photosynthesis, abiotic stress, and the plant microbiome.
Photosynthetica. 2022 Jan;60:57-67. Review.
PI: B. Demmig-Adams
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.189
Funding: "This work was supported by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, National Science Foundation award number IOS-1907338, and the University of Colorado."
 
5
Pena D, Suescun J, Schiess M, Ellmore TM, Giancardo L.
Toward a multimodal computer-aided diagnostic tool for Alzheimer's disease conversion.
Front Neurosci. 2022 Jan 3;15:744190.
PI: L. Giancardo
Note: This article is part of Research Topic "Machine Learning in Neuroscience, Volume II" (https://www.frontiersin.org/research-topics/19158/machine-learning-in-neuroscience-volume-ii#articles). This article may be obtained online without charge.
Journal Impact Factor: 4.677
Funding: "…LG was supported by a Learning Healthcare Award funded by the UTHealth Center for Clinical and Translational Science (CCTS), the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A, NIH grants UL1TR003167 and R01NS121154, and a Cancer Prevention and Research Institute of Texas grant (RP 170668)."
 
6
Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, Shin SA, Dayal D, Martin P, Mann C, Amanat F, Julg B, Nilles EJ, Musk ER, Menon AS, Krammer F, Saphire EO, Carfi A, Alter G.
mRNA-1273 vaccine-induced antibodies maintain Fc-effector functions across SARS-CoV-2 variants of concern.
Immunity. 2022 Jan 5. Online ahead of print.
PI: A.S. Menon
Note: This article may be obtained online without charge.
Journal Impact Factor: 31.745
Funding: "…We acknowledge support from the Ragon Institute of MGH, MIT, and Harvard, the Massachusetts Consortium on Pathogen Readiness (MassCPR), the NIH (3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, 1U01CA260476 – 01, CIVIC75N93019C00052), the Gates Foundation Global Health Vaccine Accelerator Platform funding (OPP1146996 and INV-001650), Translational Research Institute for Space Health through NASA Cooperative Agreement (NNX16AO69A), and the Musk Foundation."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Chen S, Hatch J, Luck A, Nichols NM, Geason EJ, Martin K, Foley KD, Copeland DS, Kraves S, Saavedra EA.
Detection of DNA microsatellites using multiplex polymerase chain reaction aboard the International Space Station.
Gravit Space Res. 2021 Dec 30;9(1):164-70.
Note: ISS results. This article may be obtained online without charge.
 
2
Kornilova LN.
Orientation in space, vestibular function, and ocular tracking in a changed gravitational environment.
Hum Physiol. 2021 Dec;47(7):803-9. Review.
Note: ISS, Russian Mir space station, and dry immersion results.
 
3
Proshchina A, Gulimova V, Kharlamova A, Krivova Y, Barabanov V, Saveliev S.
Cytoskeleton markers in the spinal cord and mechanoreceptors of thick-toed geckos after prolonged space flights.
Life (Basel). 2022 Jan 11;12(1):100.
Note: Russian Foton-M3 and Bion-M1 space mission results. This article is part of Special Issue "Space Flight Factors and Cytoskeleton Organization" (https://www.mdpi.com/journal/life/special_issues/Space_flight). This article may be obtained online without charge.
 
4
Alekseev VR, Hwang JS, Levinskikh MA.
Effect of space flight factor on dormant stages in aquatic organisms: A review of International Space Station and terrestrial experiments.
Life (Basel). 2022 Jan;12(1):47. Review.
Note: ISS results. From the abstract: "This work is a review of the experiments carried out in the Russian segment of the ISS (inside and outside) from 2005 to 2016 on the effect of the space flight factor on the resting stages of organisms. In outer space, ultraviolet, a wide range of high and low temperatures, cosmic radiation, altered gravity, modified electromagnetic field, vacuum, factors of technical origin, ultrasound, microwave radiation, etc. and their combination determine the damaging effect on living organisms." This article may be obtained online without charge.
 
5
Nijhuis J, Schmidt S, Tran NN, Hessel V.
Microfluidics and macrofluidics in space: ISS-proven fluidic transport and handling concepts.
Front Space Technol. 2022 Jan 24;2:779696.
Note: From the abstract: "Recently, three different microfluidics-suitable fluid behavior phenomena have been studied on the ISS that might further facilitate the manipulation of fluids in space: capillary-driven flow, thermocapillary Marangoni forces, and electrolytic gas evolution-driven flow. Furthermore, attention is drawn for strategies to eliminate unwanted bubbles from liquid bodies in space, as they can damage sensitive equipment: Mesh-screen capillarity and open wedge channels have been identified as promising approaches. Finally, the relevance of fluid handling in space is illustrated with everyday activities during space missions, such as drinking, plant watering, and gathering biometric data." This article is part of Research Topic "Technologies for handling, preparation, and liquid-based analysis of fluidic samples in space" (https://www.frontiersin.org/research-topics/18491/technologies-for-handling-preparation-and-liquid-based-analysis-of-fluidic-samples-in-space#articles). The Research Topic also includes an article from previous Current Awareness List #981 https://doi.org/10.3389/frspt.2021.797518. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
6
Bogomolov VV, Polyakov AV, Matsnev EI, Popova II, Kovachevich IV, Alferova IV, Repenkova LG, Sigaleva EE.
Diagnosis and treatment of ENT diseases in Russian cosmonauts during missions to the Orbital Station MIR and ISS.
Hum Physiol. 2021 Dec;47(7):810-4. Review.
Note: From the abstract: "We reviewed diagnosis and treatment of the ENT cases among Russian cosmonauts during 83 main missions to the orbital station Mir and ISS."
 
7
Baran R, Marchal S, Garcia Campos S, Rehnberg E, Tabury K, Baselet B, Wehland M, Grimm D, Baatout S.
The cardiovascular system in space: Focus on in vivo and in vitro studies.
Biomedicines. 2022 Jan;10(1):59. Review.
Note: From the abstract: "This review summarizes all known cardiovascular diseases related to human spaceflight and focusses on the cardiovascular changes related to human spaceflight (in vivo [e.g., head-down bed rest studies]) as well as cellular and molecular changes (in vitro [e.g., random positioning machine])." This article and the two articles below (Cortés-Sánchez et al. and Hammer et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). The Topic also includes articles from previous Current Awareness List #970 https://doi.org/10.3390/ijms22189997 and https://doi.org/10.3390/biomedicines9091205, and #976 https://doi.org/10.3390/ijms222111759. Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
 
8
Cortés-Sánchez JL, Callant J, Krüger M, Sahana J, Kraus A, Baselet B, Infanger M, Baatout S, Grimm D.
Cancer studies under space conditions: Finding answers abroad.
Biomedicines. 2021 Dec 28;10(1):25. Review.
Note: From the abstract: "In this review article, we discuss the current state of knowledge in cancer research under real and simulated microgravity conditions and point out further research directions in this field. Outer space is an extremely hostile environment for human life, with radiation, microgravity, and vacuum posing significant hazards." This article, the article above (Baran et al.), and the article below (Hammer et al.), are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.
 
9
Hammer A, Cerretti G, Ricciardi DA, Schiffmann D, Maranda S, Kummer R, Zumbühl C, Rattenbacher-Kiser KF, von Arx S, Ammann S, Strobl F, Berkane R, Stolz A, Stelzer EHK, Egli M, Schleiff E, Wuest SL, Böhmer M.
Retrograde analysis of calcium signaling by CaMPARI2 shows cytosolic calcium in chondrocytes is unaffected by parabolic flights.
Biomedicines. 2022 Jan;10(1):138.
Note: Parabolic flight results. This article and the two articles above (Baran et al. and Cortés-Sánchez et al.) are part of Topic "Translation from Microgravity Research to Earth Application" (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.
 
10
Hughes L, Hackney KJ, Patterson SD.
Optimization of exercise countermeasures to spaceflight using blood flow restriction.
Aerosp Med Hum Perform. 2022 Jan;93(1):32-45. Review.
Note: From the abstract: "Blood flow restriction exercise is a low intensity exercise strategy that requires minimal equipment and can elicit positive training benefits across multiple physiological systems. This method of exercise training has potential as a strategy to optimize exercise countermeasures during spaceflight and reconditioning in terrestrial and partial gravity environments. The possible applications of blood flow restriction exercise during spaceflight are discussed herein."
 
11
Levik YS.
Space research and new concepts in the physiology of movements.
Hum Physiol. 2021 Dec;47(7):785-95. Review.
 
12
Shafirkin AV.
New outlook on the space radiation risk paradigm for remote beyond-magnetosphere missions to the Moon and Mars.
Hum Physiol. 2021 Dec;47(7):757-66.
 
13
Moors KA, Ott E, Weckwerth W, Milojevic T.
Proteomic response of Deinococcus radiodurans to short-term real microgravity during parabolic flight reveals altered abundance of proteins involved in stress response and cell envelope functions.
Life (Basel). 2022 Jan;12(1):23.
Note: Parabolic flight results. This article is part of Special Issue "Frontiers in Extremophiles: From Life at Edge on Earth to Space Exploration" (https://www.mdpi.com/journal/life/special_issues/CEE2022). Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.
 
14
Shi S, Li J, Li E, Guo W, He Y, Wang J, Zhang Y, Yue L, Wei L.
Simulated microgravity increases the permeability of HUVEC monolayer through up-regulation of Rap1GAP and decreased Rap2 activation.
Int J Mol Sci. 2022 Jan 6;23(2):630.
Note: A rotating wall vessel was used in this study. This article is part of Special Issue "Recent Advances in Microgravity and Cell Adherence" (https://www.mdpi.com/journal/ijms/special_issues/Microgravity_Cell). The Special Issue also includes an article from previous Current Awareness List #948 https://doi.org/10.3390/ijms22094550 and #957 https://doi.org/10.3390/ijms22136951. This article may be obtained online without charge.
 
15
Singh R, Singh RP.
Study of rotary cell culture system-induced microgravity effects on cancer biomarkers.
Methods Mol Biol. 2022;2413:77-96.
Note: Rotary cell culture system study.
 
16
Kozlovskaya IB, Lapin BA, Miller NV, Badakva AM.
Vestibular studies of primates in biosatellite flights.
Hum Physiol. 2021 Dec;47(7):796-802. Review.
Note: Biosatellite flight results.
 
17
Shenkman BS, Mirzoev TM, Kozlovskaya IB.
Tonic activity and gravitational control of the postural muscle.
Hum Physiol. 2021 Dec;47(7):744-56. Review.
 
18
Tomilovskaya ES, Rukavishnikov IV, Amirova LE, Shigueva TA, Saveko AA, Kitov VV, Vassilieva GY, Ponomarev SA, Smirnova TA, Kozlovskaya IB, Orlov OI.
21-day dry immersion: Schedule of investigations and major results.
Hum Physiol. 2021 Dec;47(7):735-43.
Note: Dry immersion study.
 
19
Oyabu M, Takigawa K, Mizutani S, Hatazawa Y, Fujita M, Ohira Y, Sugimoto T, Suzuki O, Tsuchiya K, Suganami T, Ogawa Y, Ishihara K, Miura S, Kamei Y.
FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
FASEB J. 2022 Feb;36(2):e22152.
Note: This research comprehensively identifies novel FOXO1 target genes in skeletal muscle and clarifies the pathophysiological role of FOXO1, a master regulator of skeletal muscle atrophy.
 
20
Parker E, Khayrullin A, Kent A, Mendhe B, Youssef El Baradie KB, Yu K, Pihkala J, Liu Y, McGee-Lawrence M, Johnson M, Chen J, Hamrick M.
Hindlimb immobilization increases IL-1β and Cdkn2a expression in skeletal muscle fibro-adipogenic progenitor cells: A link between senescence and muscle disuse atrophy.
Front Cell Dev Biol. 2022 Jan 3;9:790437.
Note: Hindlimb unloading study. This article is part of Research Topic "Skeletal Muscle – From Developmental Concepts to Therapy" (https://www.frontiersin.org/research-topics/23627/skeletal-muscle---from-developmental-concepts-to-therapy#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
21
Pierantozzi E, Szentesi P, Paolini C, Dienes B, Fodor J, Oláh T, Colombini B, Rassier DE, Rubino EM, Lange S, Rossi D, Csernoch L, Bagni MA, Reggiani C, Sorrentino V.
Impaired intracellular Ca2+ dynamics, M-band and sarcomere fragility in skeletal muscles of obscurin KO mice.
Int J Mol Sci. 2022 Feb 1;23(3):1319.
Note: This article is part of Section "Molecular Biology" (https://www.mdpi.com/journal/ijms/sections/Molecular_Biology). This article may be obtained online without charge.
 
22
Thurston T, Dolan JP, Husein F, Stroud A, Funk K, Borzy C, Zhu X.
Assessment of muscle activity and fatigue during laparoscopic surgery.
Surg Endosc. 2022 Jan 16. Online ahead of print.
Note: NASA Task Load Index assessment.
 
23
Tay JRH, Ng E, Lu XJ, Lai WMC.
Healing complications and their detrimental effects on bone gain in vertical-guided bone regeneration: A systematic review and meta-analysis.
Clin Implant Dent Relat Res. 2022 Jan 19. Review. Online ahead of print.
 
24
Zarka M, Haÿ E, Cohen-Solal M.
YAP/TAZ in bone and cartilage biology.
Front Cell Dev Biol. 2022 Jan 4;9:788773. Review.
Note: This article is part of Research Topic "Identification of New Molecular Mechanisms of Bone Disease" (https://www.frontiersin.org/research-topics/21262/identification-of-new-molecular-mechanisms-of-bone-disease#articles). This article may be obtained online without charge.
 
25
Pohjoismäki JLO, Goffart S.
Adaptive and pathological outcomes of radiation stress induced redox signaling.
Antioxid Redox Signal. 2022 Jan 19. Online ahead of print.
 
26
Sproull M, Nishita D, Chang P, Moroni M, Citrin DE, Shankavaram U, Camphausen K.
Comparison of proteomic expression profiles after radiation exposure across four different species.
Radiat Res. 2022 Jan 24. Online ahead of print.
 
27
Pei S, Wang S, Martinez JR, Parajuli A, Kirn-Safran CB, Farach-Carson MC, Lu XL, Wang L.
Osteocytic Pericellular Matrix (PCM): Accelerated degradation under in vivo loading and unloading conditions using a novel imaging approach.
Genes (Basel). 2021 Dec 28;13(1):72.
Note: Hindlimb unloading study. This article is part of Special Issue "Craniofacial Bone and Dental Genetics, Metabolism, Aging, and Disorders" (https://www.mdpi.com/journal/genes/special_issues/Bone_Genetics). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
28
Joushomme A, Garenne A, Dufossée M, Renom R, Ruigrok HJ, Chappe YL, Canovi A, Patrignoni L, Hurtier A, Poulletier de Gannes F, Lagroye I, Lévêque P, Lewis N, Priault M, Arnaud-Cormos D, Percherancier Y.
Label-free study of the global cell behavior during exposure to environmental radiofrequency fields in the presence or absence of pro-apoptotic or pro-autophagic treatments.
Int J Mol Sci. 2022 Jan 8;23(2):658.
Note: This article is part of Special Issue "Apoptosis Studies in In Vivo/In Vitro Experimental Models of Non-ionizing Radiation" (https://www.mdpi.com/journal/ijms/special_issues/Non-ionizing_Radiation). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
29
Ma H, Li L, Yan J, Zhang Y, Ma X, Li Y, Yuan Y, Yang X, Yang L, Guo J.
The resonance and adaptation of Neurospora crassa circadian and conidiation rhythms to short light-dark cycles.
J Fungi (Basel). 2022 Jan;8(1):27.
Note: This article is part of Section "Environmental and Ecological Interactions of Fungi" (https://www.mdpi.com/journal/jof/sections/environmental_ecological_interactions_fungi). This article may be obtained online without charge.
 
30
Machida M, Sweeten BLW, Adkins AM, Wellman LL, Sanford LD.
The basolateral amygdala mediates the role of rapid eye movement sleep in integrating fear memory responses.
Life (Basel). 2022 Jan;12(1):17.
Note: This article is part of Section "Life Sciences" (https://www.mdpi.com/journal/life/sections/life_sciences). This article may be obtained online without charge.
 
31
Biranje SS, Sun J, Cheng L, Cheng Y, Shi Y, Yu S, Jiao H, Zhang M, Lu X, Han W, Wang Q, Zhang Z, Liu J.
Development of cellulose nanofibril/casein-based 3D composite hemostasis scaffold for potential wound-healing application.
ACS Appl Mater Interfaces. 2022 Jan 26;14(3):3792-808.
Note: From the abstract: "In this work, a 3D composite scaffold is designed using bioprinting technology and synergistic hemostasis mechanisms of cellulose nanofibrils (TCNFs), chitosan, and casein to control blood loss in traumatic hemorrhage."

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