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NASA Spaceline Current Awareness List #982 14 January 2022 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 14, 2022

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
In case you missed it: SpaceRef website ran an article titled, "NASA Space Station On-Orbit Status Report 10 January, 2021 - Space Agriculture," providing a status report of the many on-orbit agriculture studies that are currently being conducted. From the article: "Growing plants in space is critical to keeping crews healthy as NASA and its international partners plan human missions to the Moon, Mars and beyond. Just like humans living in space, microgravity affects plants and scientists want to learn how to successfully grow crops in space to sustain crews with less support from Earth." To view the full article go to http://spaceref.com/international-space-station/nasa-space-station-on-orbit-status-report-10-january-2021--.html.
 
Papers deriving from NASA support:
 
1
Martin D, Makedonas G, Crucian B, Peanlikhit T, Rithidech K.
The use of the Multidimensional Protein Identification Technology (MudPIT) to analyze plasma proteome of astronauts collected before, during, and after spaceflights.
Acta Astronautica. 2022 Apr 1;193:9-19.
https://doi.org/10.1016/j.actaastro.2021.12.054
PI: K. Rithidech
Note: ISS results.
Journal Impact Factor: 2.413
Funding: "This research was supported by the National Aeronautics and Space Administration (NASA) Grant # NNX16AH80G."
 
2
Garcia HD.
Acceptable limits for n-hexane in spacecraft atmospheres.
Aerosp Med Hum Perform. 2021 Dec 1;92(12):956-61. Review.
https://pubmed.ncbi.nlm.nih.gov/34986934
Note: From the abstract: "The Spacecraft Maximum Allowable Concentrations (SMACs) for C2-C9 alkanes set by NASA in 2008 under the guidance and approval of the National Research Council specifically excluded SMACs for n-hexane. Unlike other C2-C9 alkanes, n-hexane can cause polyneuropathy after metabolism in humans or rodents and so requires more stringent SMACs than the other members of this group do. This document reviews the relevant published studies of n-hexane toxicity to develop exposure duration-specific SMACs for n-hexane of 200 ppm for 1 hour, 30 ppm for 24 hours, and 2.4 ppm for 7 days, 30 days, 180 days, and 1000 days."
Journal Impact Factor: 0.889
Funding: "This study was supported by Toxicology, Human Health and Performance Contract #NNJ15HK11B, KBR, NASA Johnson Space Center, Houston, TX, USA."
 
3
Diaz-Artiles A, Wang Y, Davis MM, Abbott R, Keller N, Kennedy DM.
The influence of altered-gravity on bimanual coordination: Retention and transfer.
Front Physiol. 2022 Jan 7;12:794705.
https://doi.org/10.3389/fphys.2021.794705
PI: A. Diaz-Artiles
Note: Head-down and head-up tilt results. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: "This work was supported by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) (Grant 80NSSC20K1499)."
 
4
Santomartino R, Zea L, Cockell CS.
The smallest space miners: Principles of space biomining.
Extremophiles. 2022 Jan 6;26(1):7. Review.
https://pubmed.ncbi.nlm.nih.gov/34993644
PI: L. Zea
Note: From the abstract: "As we aim to expand human presence in space, we need to find viable approaches to achieve independence from terrestrial resources. Space biomining of the Moon, Mars and asteroids has been indicated as one of the promising approaches to achieve in-situ resource utilization by the main space agencies. Structural and expensive metals, essential mineral nutrients, water, oxygen and volatiles could be potentially extracted from extraterrestrial regolith and rocks using microbial-based biotechnologies. The use of bioleaching microorganisms could also be applied to space bioremediation, recycling of waste and to reinforce regenerative life support systems." This article may be obtained online without charge.
Journal Impact Factor: 2.395
Funding: "Rosa Santomartino and Charles S. Cockell were supported by United Kingdom Science and Technology Facilities Council under grants ST/R000875/1 and ST/V000586/1. Luis Zea was supported by the National Aeronautics and Space Administration under Grant No. 80NSSC18K1486, by BioServe Space Technologies, and by the University of Colorado Boulder’s Research Innovation Ofce (RIO) Seed Grant funding."
 
5
Tolsma J, Ryan K, Torres J, Richards J, Richardson Z, Land E, Perera I, Doherty C.
The circadian-clock regulates the Arabidopsis gravitropic response.
Gravit Space Res. 2021 Dec 30;9(1):170-85.
https://doi.org/10.2478/gsr-2021-0014
PI: C. Doherty
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "Funding was made possible for this work from NASA 80NSSC18K1466. We would like to thank Anna Maria J Ruby, Simon Gilroy, the Microgravity Simulation Support Facility, and Kennedy Space Center staff for their assistance and technical knowledge during the RPM experiments. Jigar Desai and Tomas Pierce helped teach the basics of raspbian and Grant Scarboro provided expertise in optics and imaging."
 
6
Shuryak I, Loucas BD, Cornforth MN.
Robbing Peter to pay Paul: Competition for radiogenic breaks during rejoining diminishes curvature in the dose response for simple chromosome exchanges.
Radiat Res. 2021 Aug 1;196(2):147-55.
https://pubmed.ncbi.nlm.nih.gov/34019659
PIs: B.D. Loucas, M.N. Cornforth
Journal Impact Factor: 2.841
Funding: "This work supported by the National Aeronautics and Space Administration (NASA grant nos. NNX15AG74G to MC and 80NSSC18K0864 to BL) and the National Institute of Allergy and Infectious Diseases (NIAID grant no. 2U19AI067773-16 to IS)."
 
7
Yamazaki EM, Rosendahl-Garcia KM, Casale CE, MacMullen LE, Ecker AJ, Kirkpatrick JN, Goel N.
Left ventricular ejection time measured by echocardiography differentiates neurobehavioral resilience and vulnerability to sleep loss and stress.
Front Physiol. 2022 Jan 11;12:795321.
https://doi.org/10.3389/fphys.2021.795321
PI: N. Goel
Note: This article, and two article below in the "Other" section (Shoshina et al. and Watanabe et al.) are part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; #976 https://doi.org/10.3389/fphys.2021.770502; #977 https://doi.org/10.3389/fphys.2021.782860; and #979 https://doi.org/10.3389/fncir.2021.750176. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: "This work was supported by National Aeronautics and Space Administration (NASA) [grant numbers NNX14AN49G and 80NSSC20K0243 (to NG)]. This work was also partially supported from National Institutes of Health [grant number NIH R01DK117488 (to NG)]."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Pastushkova L, Goncharov IN, Koloteva MI, Goncharova AG, Kashirina DN, Nosovsky AM, Glebova TM, Kononikhin AS, Nikolaev EN, Larina IM.
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions.
Life Sciences in Space Research. 2022 Jan 14. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.01.001
Note: The spaceflight information is not evident in the available abstract.
 
2
Pavletić B, Runzheimer K, Siems K, Koch S, Cortesão M, Ramos-Nascimento A, Moeller R.
Spaceflight virology: What do we know about viral threats in the spaceflight environment?
Astrobiology. 2022 Jan 3. Mini review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34981957
Note: From the abstract: "In this mini review, we focus on the International Space Station (ISS) as the only current human habitat in space that has a diverse range of viral genera that infect microorganisms from bacteria to eukaryotes. Thus, we have reviewed the literature on the physical conditions of space habitats that have an impact on both virus transmissibility and interaction with their host, which include UV radiation, ionizing radiation, humidity, and microgravity." This article may be obtained online without charge.
 
3
Cordasco KM, Watson T, Glassman P.
When lightning hits your spaceship: The power and peril of habits in aerospace and patient safety.
J Gen Intern Med. 2022 Jan 3;1-3. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34981343
Note: This article may be obtained online without charge.
 
4
Forti A, van Veelen MJ, Squizzato T, Dal Cappello T, Palma M, Strapazzon G.
Mechanical cardiopulmonary resuscitation in microgravity and hypergravity conditions: A manikin study during parabolic flight.
Am J Emerg Med. 2022 Mar;53:54-8.
https://pubmed.ncbi.nlm.nih.gov/34979409
Note: Parabolic flight results. This article may be obtained online without charge.
 
5
Kashirina DN, Brzhozovskiy AG, Sun W, Pastushkova LK, Popova OV, Rusanov VB, Nikolaev EN, Larina IM, Kononikhin AS.
Proteomic characterization of dry blood spots of healthy women during simulation the microgravity effects using dry immersion.
Front Physiol. 2022 Jan 11;12:753291.
https://doi.org/10.3389/fphys.2021.753291
Note: Dry immersion study. This article is part of the Research Topic "Cardio-vascular Dysfunction and Physiological Manifestations Induced by Environmental Conditions, Volume II" (https://www.frontiersin.org/research-topics/17903/cardio-vascular-dysfunction-and-physiological-manifestations-induced-by-environmental-conditions-vol#articles). The Research Topic also includes articles from previous Current Awareness Lists #959 https://doi.org/10.3389/fphys.2021.699493 and #976 https://doi.org/10.3389/fphys.2021.760875, https://doi.org/10.3389/fphys.2021.656527, and https://doi.org/10.3389/fphys.2021.712422. This article may be obtained online without charge.
 
6
Shoshina I, Zelenskaya I, Karpinskaia V, Shilov Y, Tomilovskaya E.
Sensitivity of visual system in 5-day "dry" immersion with high-frequency electromyostimulation.
Front Neural Circuits. 2021 Dec 24;15:702792
https://doi.org/10.3389/fncir.2021.702792
Note: Dry immersion study. This article, an article above in the "NASA" section (Yamazaki et al.), and the article directly below (Watanabe et al.) are part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). This article may be obtained online without charge.
 
7
Watanabe H, Saito S, Washio T, Bailey DM, Ogoh S.
Acute gravitational stress selectively impairs dynamic cerebrovascular reactivity in the anterior circulation independent of changes to the central respiratory chemoreflex.
Front Physiol. 2022 Jan 6;12:749255.
https://doi.org/10.3389/fphys.2021.749255
Note: This article, an article above in the "NASA" section (Yamazaki et al.), and the article directly above (Shoshina et al.) are part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). This article may be obtained online without charge.
 
8
Li W, Wang B, Wang Y, Liu X, Feng W, Liu T, Sun Z, Liu Y, Liu S, Fan Y.
Variations of human cerebral and ocular blood flow during exposure to multi-axial accelerations : A mathematical modeling study.
Med Biol Eng Comput. 2022 Jan 8. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34997405
Note: From the abstract: "This model was firstly validated by using experimental data from experiment of posture change and centrifuge tests of +Gz accelerations, and then applied to analyze human hemodynamic responses to typical multi-axial accelerations."
 
9
Ma L, Kong F, Sun K, Wang T, Guo T.
From classical radiation to modern radiation: Past, present, and future of radiation mutation breeding.
Front Public Health. 2021 Dec 21;9:768071. Review.
https://pubmed.ncbi.nlm.nih.gov/34993169
Note: This article is part of Research Topic "Medical Application and Radiobiology Research of Particle Radiation" (https://www.frontiersin.org/research-topics/14492/medical-application-and-radiobiology-research-of-particle-radiation#articles). The Research Topic also includes articles from previous Current Awareness List #977 https://doi.org/10.3389/fpubh.2021.733337 and https://doi.org/10.3389/fpubh.2021.759236. This article may be obtained online without charge.
 
10
Zhang X, Li X, Zheng C, Yang C, Zhang R, Wang A, Feng J, Hu X, Chang S, Zhang H.
Ferroptosis, a new form of cell death defined after radiation exposure.
Int J Radiat Biol. 2022 Jan 4;1-9. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34982648
 
11
Barodia K, Cheruku SP, Kanwal A, Menon A, Rajeevan R, Rukade A, Kumar Shenoy RU, Prabhu C, Sharma V, Divya KP, Sumalatha S, Nayak Y, Kumar N.
Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles.
J Ayurveda Integr Med. 2021 Dec 30;100503. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34974956
Note: This article may be obtained online without charge.
 
12
Padilha CS, Figueiredo C, Deminice R, Krüger K, Seelaender M, Rosa-Neto JC, Lira FS.
Costly immunometabolic remodeling in disused muscle buildup through physical exercise.
Acta Physiol (Oxf). 2022 Jan 6;e13782. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34990078
 
13
Kawao N, Kawaguchi M, Ohira T, Ehara H, Mizukami Y, Takafuji Y, Kaji H.
Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice.
J Cachexia Sarcopenia Muscle. 2022 Jan 7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34997830
Note: This article may be obtained online without charge.
 
14
Lee SS, Laganenka L, Du X, Hardt WD, Ferguson SJ.
Silicon nitride, a bioceramic for bone tissue engineering: A reinforced cryogel system with antibiofilm and osteogenic effects.
Front Bioeng Biotechnol. 2021 Dec 15;9:794586.
https://pubmed.ncbi.nlm.nih.gov/34976982
Note: From the abstract: "Silicon nitride (SiN [Si3N4]) is a promising bioceramic for use in a wide variety of orthopedic applications. Over the past decades, it has been mainly used in industrial applications, such as space shuttle engines, but not in the medical field due to scarce data on the biological effects of SiN. More recently, it has been increasingly identified as an emerging material for dental and orthopedic implant applications. Although a few reports about the antibacterial properties and osteoconductivity of SiN have been published to date, there have been limited studies of SiN-based scaffolds for bone tissue engineering. Here, we developed a silicon nitride reinforced gelatin/chitosan cryogel system (SiN-GC) by loading silicon nitride microparticles into a gelatin/chitosan cryogel (GC), with the aim of producing a biomimetic scaffold with antibiofilm and osteogenic properties." This article may be obtained online without charge.
 
15
Wang B, Wang H, Li Y, Song L.
Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages.
Lipids Health Dis. 2022 Jan 7;21(1):5. Review.
https://pubmed.ncbi.nlm.nih.gov/34996476
Note: This article may be obtained online without charge.
 
16
Wu J, Liu F, Wang Z, Liu Y, Zhao X, Fang C, Leung F, Yeung KWK, Wong TM.
The development of a magnesium-releasing and long-term mechanically stable calcium phosphate bone cement possessing osteogenic and immunomodulation effects for promoting bone fracture regeneration.
Front Bioeng Biotechnol. 2022 Jan 11;9:803723.
https://doi.org/10.3389/fbioe.2021.803723
Note: This article is part of Research Topic "Bioactive Bone Regenerative Materials and Bionic Prosthesis Interfaces" (https://www.frontiersin.org/research-topics/26062/bioactive-bone-regenerative-materials-and-bionic-prosthesis-interfaces#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
17
Pradhan GN, Ottestad W, Meland A, Kåsin JI, Høiseth L, Cevette MJ, Stepanek J.
Oculometric feature changes during acute hypoxia in a simulated high-altitude airdrop scenario.
Aerosp Med Hum Perform. 2021 Dec 1;92(12):928-36.
https://pubmed.ncbi.nlm.nih.gov/34986930
 
18
Schlicher J, Metsker MT, Shah H, Demirkan H.
From NASA to healthcare: Real-time data analytics (Mission Control) is reshaping healthcare services.
Perspect Health Inf Manag. 2021 Fall;18(4):1g. Available online 1 October 2021.
https://pubmed.ncbi.nlm.nih.gov/34975356
Note: From the abstract: "This is a case study of the implementation of a data and analytics-enabled Mission Control at one of the largest healthcare service providers in the state of Washington. Using data analytics and artificial intelligence, CHI-Franciscan (one of the largest healthcare organizations in state of Washington) is able to coordinate patient care more effectively and efficiently, improving safety for all its patients. This case study demonstrates tangible evidence from quantitative and qualitative analysis for return on investment for such a large project." This article may be obtained online without charge.
 
19
Jiong Guo J, Du J, Xu Y, Liu A, Yang HL.
Catching the circadian rhythm of intervertebral disc and association with clinical outcomes by twice-a-day magnetic resonance imaging.
Eur J Radiol. 2021 Dec 27;147:110130.
https://pubmed.ncbi.nlm.nih.gov/34974366
 
20
Klett NJ, Cravetchi O, Allen CN.
Long-term imaging reveals a circadian rhythm of intracellular chloride in neurons of the suprachiasmatic nucleus.
J Biol Rhythms. 2022 Jan 7;7487304211059770. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34994231
 
21
Kong X, Ota SM, Suchecki D, Lan A, Peereboom AI, Hut RA, Meerlo P.
Chronic social defeat stress shifts peripheral circadian clocks in male mice in a tissue-specific and time-of-day dependent fashion.
J Biol Rhythms. 2022 Jan 7;7487304211065336. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34994236
Note: This article may be obtained online without charge.
 
22
Lu X, Zhou M, Liu N, Zhang C, Zhao Z, Cai D.
Synaptic protein phosphorylation networks are associated with electroacupuncture-induced circadian control in the suprachiasmatic nucleus.
Front Genet. 2021 Dec 16;12:762557.
https://pubmed.ncbi.nlm.nih.gov/34976011
Note: This article is part of Research Topic "Time, Genetics and Complex Disease" (https://www.frontiersin.org/research-topics/14670/time-genetics-and-complex-disease#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
23
Greenlund IM, Carter JR.
Sympathetic neural responses to sleep disorders and insufficiencies.
Am J Physiol Heart Circ Physiol. 2022 Jan 7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34995163
 
24
Klerman EB, Barbato G, Czeisler CA, Wehr TA.
Can people sleep too much? Effects of extended sleep opportunity on sleep duration and timing.
Front Physiol. 2021 Dec 22;12:792942.
https://pubmed.ncbi.nlm.nih.gov/35002775
Note: This article may be obtained online without charge.
 

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