Note:ISS and Russian Soyuz MS-10 mission results. From the abstract: "Here, we describe a case report of a Crewmember who experienced an Aborted Launch ('CAL'). CAL's launch and landing experience was dissociated from prolonged microgravity exposure. Using MRI, we show that hypergravity exposure during the aborted launch did not induce lasting ventricular enlargement or intracranial fluid shifts resembling those previously reported with spaceflight. This case study therefore rules out hypergravity during launch and landing as a contributing factor to previously reported long-lasting intracranial fluid changes following spaceflight." This article may be obtained online without charge.
Journal Impact Factor:4.003
Funding:"This study was supported by NASA grant #NNX11AR02G awarded to RS, AM, SW, and JB. HM was supported by a NSERC postdoctoral fellowship and a NASA Human Research Program augmentation grant. KH was supported by a National Institute on Aging fellowship 1F99AG068440."
Journal Impact Factor:Not available for this journal
Funding:"WN and PF-C were funded by the University of Florida Space Research Initiative (OR-DRPD-SRI2019) and NASA (NNX14AT38G and 80NSSC21K0319). CT and MW were supported in part through NASA Applied Capillary Fluidics Cooperative Agreement 80NSSC18K0436. TJ thanks the University of Central Florida Department of Chemistry, College of Science, and Faculty Cluster Initiative for startup funding."
Note:ISS results. This article may be obtained online without charge.
Journal Impact Factor:5.640
Funding:"Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with National Aeronautics and Space Administration. This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the post-doctoral fellowships for NS. This research was funded in part to FL by the Wellcome Trust Grant (206194)."
4
Meier A, Essumang D, Hummerick M, Johnson C, Kruger M, Massa G, Engeling K.
Reviewing plasma seed treatments for advancing agriculture applications on Earth and into the final frontier.
Gravit Space Res. 2021 Dec 23;9(1):133-58. Review.
Note:From the abstract: "This review paper brings together the current state-of-the-art reported literature to aide in understanding plasma seed application apparatus, seed or crop performance pertaining to germination, growth, water interactions, inactivation of bacteria, and surface sanitization results." This article may be obtained online without charge.
Journal Impact Factor:Not available for this journal
Funding:"Funding for this work was provided by the NASA KSC Independent Research and Technology Development (IR&TD) Program. The authors would like to thank inputs from the project team at Kennedy Space Center (KSC), including Dr. Ray Wheeler, intern Aniya Norvell, and Dr. Ryan Gott."
5
Reid CR, Charvat JM, McFarland SM, Norcross JR, Benson E, England S, Rajulu S.
Modeling occupational fingernail onycholysis disorders in the population of US astronauts who have engaged in extravehicular activity.
Hum Factors. 2021 Dec 27;187208211062299. Online ahead of print.
Note:From the article: "This paper was a secondary analysis from a larger retrospective EVA [extravehicular activity] glove injury data mining investigation conducted between 2012 and 2014, which focused on three decades of EVA training and spaceflight data. The goal of the larger study was to conduct a broad injury assessment of all injuries that occurred to the upper extremities between the fingernails and the elbow."
Journal Impact Factor:2.888
Funding:"The authors thank Millennia Young and Caroline Schaefer of NASA's Lifetime Surveillance of Astronaut Health who assisted with the statistical analysis of the study. Additionally, we express sincere gratitude to Scott Cupples of the NASA JSC EVA Flight Office, who provided historical insight into the contextual changes and uses of EVA gloves over the three decades this study covered. Lastly, the authors thank Jane Krauhs for technical editing of the submission."
6
Sharma A, Clemens RA, Garcia O, Taylor DL, Wagner NL, Shepard KA, Gupta A, Malany S, Grodzinsky AJ, Kearns-Jonker M, Mair DB, Kim DH, Roberts MS, Loring JF, Hu J, Warren LE, Eenmaa S, Bozada J, Paljug E, Roth M, Taylor DP, Rodrigue G, Cantini P, Smith AW, Giulianotti MA, Wagner WR.
Biomanufacturing in low Earth orbit for regenerative medicine.
Stem Cell Reports. 2021 Dec 16;S2213-6711(21)00598-1. Review. Online ahead of print.
Note:From the abstract: "Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space." This article may be obtained online without charge.
Journal Impact Factor:Not available for this journal
Funding:"The Biomanufacturing in Space Symposium and this report are funded by NSF /CMMI #2028635 (M.A.G.), an American Heart Association Career Development Award 856987 (A.S.), the Translational Research Institute through NASA #20-20TSRAD-2-0007 (D.-H.K.), and the NIH UH3TR003519 (D.-H.K.)."
7
Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA.
Long-term sex- and genotype-specific effects of56Fe irradiation on wild-type and APPswe/PS1dE9 transgenic mice.
Funding:"This research was funded by grants from the National Aeronautic and Space Administration (NASA): NNX14AI07G and 80NSSC18K0810 (both to CAL)."
8
Romsdahl J, Schultzhaus Z, Cuomo CA, Dong H, Abeyratne-Perera H, Hervey WJt, Wang Z.
Phenotypic characterization and comparative genomics of the melanin-producing yeastExophiala lecanii-cornireveals a distinct stress tolerance profile and reduced ribosomal genetic content.
Note:From the abstract: "Here, we introduce a plant-wide, real-time imaging method to monitor the dynamics of both the Ca2+signals and changes in apoplastic glutamate that occur in response to wounding. This approach uses a wide-field fluorescence microscope and transgenicArabidopsisplants expressing Green Fluorescent Protein (GFP)-based Ca2+and glutamate biosensors."
Journal Impact Factor:1.4
Funding:"This work was supported by grants from the Japan Society for the Promotion of Science (17H05007 and 18H05491) to MT, the National Science Foundation (IOS1557899 and MCB2016177) and the National Aeronautics and Space Administration (NNX14AT25G and 80NSSC19K0126) to SG."
10
Hammond TG, Nislow C, Christov IC, Batuman V, Nagrani PP, Barazandeh M, Upadhyay R, Giaever G, Allen PL, Armbruster M, Raymond A, Birdsall HH.
Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells.
Note:The Published Erratum titled, "Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells," can be found athttps://pubmed.ncbi.nlm.nih.gov/34819606. This article may be obtained online without charge.
Journal Impact Factor:4.380
Funding:"NASA Grant 80NSSC19K0706 under solicitation NNH18ZTT001N-EM1 to the Institute for Medical Research supported these studies."
11
Coronado I, Abdelkhaleq R, Yan J, Marioni SS, Jagolino-Cole A, Channa R, Pachade S, Sheth SA, Giancardo L.
Towards stroke biomarkers on Fundus Retinal imaging: A comparison between vasculature embeddings and general purpose convolutional neural networks.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3873-6.
Funding:"This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A. This research has been conducted using the UK Biobank resource. Ivan Coronado is supported by a training fellowship from the Gulf Coast Consortia, on the NLM Training Program in Biomedical Informatics & Data Science (T15LM007093)."
Barravecchia I, De Cesari C, Forcato M, Scebba F, Pyankova OV, Bridger JM, Foster HA, Signore G, Borghini A, Andreassi M, Andreazzoli M, Bicciato S, Pè ME, Angeloni D.
Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.
Cell Mol Life Sci. 2021 Dec 22;79(1):28. Online ahead of print.
Note:The method of simulated microgravity and the spaceflight information are not evident in the available abstract. From the abstract: "Microgravity and space radiation (SR) are two highly influential factors affecting humans in space flight (SF). Many health problems reported by astronauts derive from endothelial dysfunction and impaired homeostasis. Here, we describe the adaptive response of human, capillary endothelial cells to SF."
5
Li F, Ye Y, Lei X, Zhang W.
Effects of microgravity on early embryonic development and embryonic stem cell differentiation: Phenotypic characterization and potential mechanisms.
Front Cell Dev Biol. 2021 Dec 2;9:797167. Mini review.
Note:This article may be obtained online without charge.
10
Tanaka M, Kanazashi M, Kondo H, Fujino H.
Time course of capillary regression and an expression balance between vascular endothelial growth factor-A and thrombospondin-1 in the soleus muscle of hindlimb unloaded rats.
Radiation cancer risk at different dose rates: New dose-rate effectiveness factors derived from revised A-bomb radiation dosimetry data and non-tumor doses.
J Radiat Res. 2021 Dec 20;rrab109. Online ahead of print.
Note:This article is part of Special Issue "miRNAs in the Era of Personalized Medicine: From Biomarkers to Therapeutics 2.0" (https://www.mdpi.com/journal/ijms/special_issues/miRNAs_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
16
Corken A, Ghosh SP, Du R, Boerma M, Ware J, Pathak R.