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NASA Spaceline Current Awareness List #981 7 January 2022 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 7, 2022

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
McGregor HR, Hupfeld KE, Pasternak O, Wood SJ, Mulavara AP, Bloomberg JJ, Hague TN, Seidler RD.
Case report: No evidence of intracranial fluid shifts in an astronaut following an Aborted Launch.
Front Neurol. 2021 Dec 9;12:774805. Case report.
https://pubmed.ncbi.nlm.nih.gov/34956056
PI: R.D. Seidler
Note: ISS and Russian Soyuz MS-10 mission results. From the abstract: "Here, we describe a case report of a Crewmember who experienced an Aborted Launch ('CAL'). CAL's launch and landing experience was dissociated from prolonged microgravity exposure. Using MRI, we show that hypergravity exposure during the aborted launch did not induce lasting ventricular enlargement or intracranial fluid shifts resembling those previously reported with spaceflight. This case study therefore rules out hypergravity during launch and landing as a contributing factor to previously reported long-lasting intracranial fluid changes following spaceflight." This article may be obtained online without charge.
Journal Impact Factor: 4.003
Funding: "This study was supported by NASA grant #NNX11AR02G awarded to RS, AM, SW, and JB. HM was supported by a NSERC postdoctoral fellowship and a NASA Human Research Program augmentation grant. KH was supported by a National Institute on Aging fellowship 1F99AG068440."
 
2
Nicholson WL, Fajardo-Cavazos P, Turner C, Currie TM, Gregory G, Jurca T, Weislogel M.
Design and validation of a device for mitigating fluid microgravity effects in Biological Research in Canister spaceflight hardware.
Front Space Technol. 2021 Dec 22;2:797518.
https://doi.org/10.3389/frspt.2021.797518
PIs: W.L. Nicholson, M. Weislogel
Note: ISS results. This article is part of Research Topic "Technologies for Handling, Preparation, and Liquid-Based Analysis of Fluidic Samples in Space." (https://www.frontiersin.org/research-topics/18491/technologies-for-handling-preparation-and-liquid-based-analysis-of-fluidic-samples-in-space#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "WN and PF-C were funded by the University of Florida Space Research Initiative (OR-DRPD-SRI2019) and NASA (NNX14AT38G and 80NSSC21K0319). CT and MW were supported in part through NASA Applied Capillary Fluidics Cooperative Agreement 80NSSC18K0436. TJ thanks the University of Central Florida Department of Chemistry, College of Science, and Faculty Cluster Initiative for startup funding."
 
3
Singh NK, Lavire C, Nesme J, Vial L, Nesme X, Mason CE, Lassalle F, Venkateswaran K.
Comparative genomics of novel Agrobacterium G3 strains isolated from the International Space Station and description of Agrobacterium tomkonis sp. nov.
Front Microbiol. 2021 Dec 6;12:765943.
https://pubmed.ncbi.nlm.nih.gov/34938279
PI: K. Venkateswaran
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 5.640
Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with National Aeronautics and Space Administration. This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the post-doctoral fellowships for NS. This research was funded in part to FL by the Wellcome Trust Grant (206194)."
 
4
Meier A, Essumang D, Hummerick M, Johnson C, Kruger M, Massa G, Engeling K.
Reviewing plasma seed treatments for advancing agriculture applications on Earth and into the final frontier.
Gravit Space Res. 2021 Dec 23;9(1):133-58. Review.
https://doi.org/10.2478/gsr-2021-0011
Note: From the abstract: "This review paper brings together the current state-of-the-art reported literature to aide in understanding plasma seed application apparatus, seed or crop performance pertaining to germination, growth, water interactions, inactivation of bacteria, and surface sanitization results." This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "Funding for this work was provided by the NASA KSC Independent Research and Technology Development (IR&TD) Program. The authors would like to thank inputs from the project team at Kennedy Space Center (KSC), including Dr. Ray Wheeler, intern Aniya Norvell, and Dr. Ryan Gott."
 
5
Reid CR, Charvat JM, McFarland SM, Norcross JR, Benson E, England S, Rajulu S.
Modeling occupational fingernail onycholysis disorders in the population of US astronauts who have engaged in extravehicular activity.
Hum Factors. 2021 Dec 27;187208211062299. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34961336
PI: J.R. Norcross
Note: From the article: "This paper was a secondary analysis from a larger retrospective EVA [extravehicular activity] glove injury data mining investigation conducted between 2012 and 2014, which focused on three decades of EVA training and spaceflight data. The goal of the larger study was to conduct a broad injury assessment of all injuries that occurred to the upper extremities between the fingernails and the elbow."
Journal Impact Factor: 2.888
Funding: "The authors thank Millennia Young and Caroline Schaefer of NASA's Lifetime Surveillance of Astronaut Health who assisted with the statistical analysis of the study. Additionally, we express sincere gratitude to Scott Cupples of the NASA JSC EVA Flight Office, who provided historical insight into the contextual changes and uses of EVA gloves over the three decades this study covered. Lastly, the authors thank Jane Krauhs for technical editing of the submission."
 
6
Sharma A, Clemens RA, Garcia O, Taylor DL, Wagner NL, Shepard KA, Gupta A, Malany S, Grodzinsky AJ, Kearns-Jonker M, Mair DB, Kim DH, Roberts MS, Loring JF, Hu J, Warren LE, Eenmaa S, Bozada J, Paljug E, Roth M, Taylor DP, Rodrigue G, Cantini P, Smith AW, Giulianotti MA, Wagner WR.
Biomanufacturing in low Earth orbit for regenerative medicine.
Stem Cell Reports. 2021 Dec 16;S2213-6711(21)00598-1. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34971562
PI: S. Gerecht
Note: From the abstract: "Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space." This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "The Biomanufacturing in Space Symposium and this report are funded by NSF /CMMI #2028635 (M.A.G.), an American Heart Association Career Development Award 856987 (A.S.), the Translational Research Institute through NASA #20-20TSRAD-2-0007 (D.-H.K.), and the NIH UH3TR003519 (D.-H.K.)."
 
7
Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA.
Long-term sex- and genotype-specific effects of 56Fe irradiation on wild-type and APPswe/PS1dE9 transgenic mice.
Int J Mol Sci. 2021 Dec 10;22(24):13305.
https://pubmed.ncbi.nlm.nih.gov/34948098
PI: C.A. Lemere
Note: This article is part of Special Issue "Molecular Research in Radiobiology" (https://www.mdpi.com/journal/ijms/special_issues/Radiobiology). This article may be obtained online without charge.
Journal Impact Factor: 5.924
Funding: "This research was funded by grants from the National Aeronautic and Space Administration (NASA): NNX14AI07G and 80NSSC18K0810 (both to CAL)."
 
8
Romsdahl J, Schultzhaus Z, Cuomo CA, Dong H, Abeyratne-Perera H, Hervey WJt, Wang Z.
Phenotypic characterization and comparative genomics of the melanin-producing yeast Exophiala lecanii-cornireveals a distinct stress tolerance profile and reduced ribosomal genetic content.
J Fungi (Basel). 2021 Dec 15;7(12):1078.
https://pubmed.ncbi.nlm.nih.gov/34947060
PI: Z. Wang
Note: This article is part of Special Issue "Yeast Biorefineries" (https://www.mdpi.com/journal/jof/special_issues/Yeast_Biorefineries). This article may be obtained online without charge.
Journal Impact Factor: 5.816
Funding: "This work was supported by the Defense Threat Reduction Agency Grant HDTRA-17-1-002 and NASA Grant NNK190B09A."
 
9
Uemura T, Wang J, Aratani Y, Gilroy S, Toyota M.
Wide-field, real-time imaging of local and systemic wound signals in Arabidopsis.
JoVE. 2021 Jun 6;(172):e62114.
https://dx.doi.org/10.3791/62114
PI: S. Gilroy
Note: From the abstract: "Here, we introduce a plant-wide, real-time imaging method to monitor the dynamics of both the Ca2+ signals and changes in apoplastic glutamate that occur in response to wounding. This approach uses a wide-field fluorescence microscope and transgenic Arabidopsis plants expressing Green Fluorescent Protein (GFP)-based Ca2+ and glutamate biosensors."
Journal Impact Factor: 1.4
Funding: "This work was supported by grants from the Japan Society for the Promotion of Science (17H05007 and 18H05491) to MT, the National Science Foundation (IOS1557899 and MCB2016177) and the National Aeronautics and Space Administration (NNX14AT25G and 80NSSC19K0126) to SG."
 
10
Hammond TG, Nislow C, Christov IC, Batuman V, Nagrani PP, Barazandeh M, Upadhyay R, Giaever G, Allen PL, Armbruster M, Raymond A, Birdsall HH.
Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells.
Sci Rep. 2021 Oct 29;11(1):21296.
https://pubmed.ncbi.nlm.nih.gov/34716334
PI: T.G. Hammond
Note: The Published Erratum titled, "Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells," can be found at https://pubmed.ncbi.nlm.nih.gov/34819606. This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: "NASA Grant 80NSSC19K0706 under solicitation NNH18ZTT001N-EM1 to the Institute for Medical Research supported these studies."
 
11
Coronado I, Abdelkhaleq R, Yan J, Marioni SS, Jagolino-Cole A, Channa R, Pachade S, Sheth SA, Giancardo L.
Towards stroke biomarkers on Fundus Retinal imaging: A comparison between vasculature embeddings and general purpose convolutional neural networks.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3873-6.
https://pubmed.ncbi.nlm.nih.gov/34892078
PI: L. Giancardo
Journal Impact Factor: 1.04
Funding: "This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A. This research has been conducted using the UK Biobank resource. Ivan Coronado is supported by a training fellowship from the Gulf Coast Consortia, on the NLM Training Program in Biomedical Informatics & Data Science (T15LM007093)."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Krivonosov YS, Gulimova VI, Buzmakov AV, Zolotov DA, Cedola A, Bukreeva I, Asadchikov VE, Saveliev SV.
Micro-CT study of Mongolian gerbil humeral bone after prolonged spaceflight based on a new algorithm for delimitation of long-bone regions.
Front Physiol. 2021 Dec 7;12:752893.
https://pubmed.ncbi.nlm.nih.gov/34950047
Note: Russian spacecraft Foton-M3 mission results. This article may be obtained online without charge.
 
2
Pantalone D, Faini GS, Cialdai F, Sereni E, Bacci S, Bani D, Bernini M, Pratesi C, Stefàno P, Orzalesi L, Balsamo M, Zolesi V, Monici M.
Robot-assisted surgery in space: Pros and cons. A review from the surgeon's point of view.
npj Microgravity. 2021 Dec 21;7(1):56. Review.
https://pubmed.ncbi.nlm.nih.gov/34934056
Note: This article may be obtained online without charge.
 
3
Pavez Loriè E, Baatout S, Choukér A, Buchheim JI, Baselet B, Dello Russo C, Wotring V, Monici M, Morbidelli L, Gagliardi D, Stingl JC, Surdo L, Yip VLM.
The future of personalized medicine in space: From observations to countermeasures.
Front Bioeng Biotechnol. 2021 Dec 13;9:739747. Review.
https://pubmed.ncbi.nlm.nih.gov/34966726
Note: This article is part of Research Topic "Space (Nano)Medicine" (https://www.frontiersin.org/research-topics/18488/space-nanomedicine#articles). The Research Topic also includes an article from previous Current Awareness List #950 https://doi.org/10.3389/fbioe.2021.666683. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
4
Barravecchia I, De Cesari C, Forcato M, Scebba F, Pyankova OV, Bridger JM, Foster HA, Signore G, Borghini A, Andreassi M, Andreazzoli M, Bicciato S, Pè ME, Angeloni D.
Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.
Cell Mol Life Sci. 2021 Dec 22;79(1):28. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34936031
Note: The method of simulated microgravity and the spaceflight information are not evident in the available abstract. From the abstract: "Microgravity and space radiation (SR) are two highly influential factors affecting humans in space flight (SF). Many health problems reported by astronauts derive from endothelial dysfunction and impaired homeostasis. Here, we describe the adaptive response of human, capillary endothelial cells to SF."
 
5
Li F, Ye Y, Lei X, Zhang W.
Effects of microgravity on early embryonic development and embryonic stem cell differentiation: Phenotypic characterization and potential mechanisms.
Front Cell Dev Biol. 2021 Dec 2;9:797167. Mini review.
https://pubmed.ncbi.nlm.nih.gov/34926474
Note: This article is part of Research Topic "The Regulating Mechanisms of Development, Growth, and Metabolism: From Ground to Space" (https://www.frontiersin.org/research-topics/22183/the-regulating-mechanisms-of-development-growth-and-metabolism-from-ground-to-space#articles). The Research Topic also includes an article from previous Current Awareness List #975 https://doi.org/10.3389/fcell.2021.739944. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
6
Amini K, Janabadi ED, Fayaz R.
Lighting and illumination investigation of long-term residence on Mars for the case of a set of designed Martian Habitat Units (MHUs).
Acta Astronautica. 2022 Mar;192:210-32.
https://www.sciencedirect.com/science/article/abs/pii/S009457652100655X
 
7
Baldry M, Gurieff N, Keogh D.
Imagining sustainable human ecosystems with power-to-X in-situ resource utilisation technology.
Acta Astronautica. 2022 Mar;192:190-8.
https://doi.org/10.1016/j.actaastro.2021.12.031
 
8
Delle Monache S, Indovina I, Zago M, Daprati E, Lacquaniti F, Bosco G.
Watching the effects of gravity. Vestibular cortex and the neural representation of "visual" gravity.
Front Integr Neurosci. 2021 Dec 1;15:793634. Review.
https://pubmed.ncbi.nlm.nih.gov/34924968
Note: This article is part of Research Topic "Role of the Vestibular System in the Perception of Time and Space" (https://www.frontiersin.org/research-topics/20823/role-of-the-vestibular-system-in-the-perception-of-time-and-space#articles). The Research Topic also includes an article from previous Current Awareness List #970 https://doi.org/10.3389/fnint.2021.742100. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
9
Ninokawa S, Nordham K.
Discovery of caisson disease: A dive into the history of decompression sickness.
Proc (Bayl Univ Med Cent). 2022;35(1):129-32. Available online 1 September 2021.
https://pubmed.ncbi.nlm.nih.gov/34970062
Note: This article may be obtained online without charge.
 
10
Tanaka M, Kanazashi M, Kondo H, Fujino H.
Time course of capillary regression and an expression balance between vascular endothelial growth factor-A and thrombospondin-1 in the soleus muscle of hindlimb unloaded rats.
Muscle Nerve. 2021 Dec 26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34957570
Note: Hindlimb unloading study.
 
11
Abbas SR, Khan RT, Shafique S, Mumtaz S, Khan AA, Khan AM, Hassan Z, Hussain SA, Abbas S, Abbas MR, Batool A, Safder MA.
Study of resveratrol against bone loss by using in-silico and in-vitro methods.
Braz J Biol. 2021 Dec 2;83:e248024.
https://pubmed.ncbi.nlm.nih.gov/34932613
Note: This article may be obtained online without charge.
 
12
Resendes C, Horan DJ, Robling AG, Gao B, Milne GL, Warman ML.
Transiently increased serotonin has modest or no effects on bone mass accrual in growing female C57BL6/J or growing male and female Lrp5A214V mice.
Bone. 2021 Dec 29:116307. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34973493
 
13
Luo N, Zhu W, Li X, Fu M, Peng X, Yang F, Zhang Y, Yin H, Yang C, Zhao J, Yuan X, Hu G.
Impact of gut microbiota on radiation-associated cognitive dysfunction and neuroinflammation in mice.
Radiat Res. 2022 Jan 4. Online ahead of print.
https://doi.org/10.1667/RADE-21-00006.1
 
14
Tanooka H.
Radiation cancer risk at different dose rates: New dose-rate effectiveness factors derived from revised A-bomb radiation dosimetry data and non-tumor doses.
J Radiat Res. 2021 Dec 20;rrab109. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34927198
Note: This article may be obtained online without charge.
 
15
Wei W, Bai H, Chen Y, Zhang T, Zhang Y, Hua J, He J, Ding N, Zhou H, Wang J.
Circulating tRNA-derived small RNAs as novel radiation biomarkers of heavy ion, proton and x-ray exposure.
Int J Mol Sci. 2021 Dec 15;22(24):13476.
https://pubmed.ncbi.nlm.nih.gov/34948273
Note: This article is part of Special Issue "miRNAs in the Era of Personalized Medicine: From Biomarkers to Therapeutics 2.0" (https://www.mdpi.com/journal/ijms/special_issues/miRNAs_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
16
Corken A, Ghosh SP, Du R, Boerma M, Ware J, Pathak R.
Platelet glycoprotein Ibα provides radiation protection.
Radiother Oncol. 2021 Dec 28;S0167-8140(21)09078-2. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34971661
 
17
Huang G.
Mechanobiology in wound healing.
Biophys J. 2021 Dec 14;S0006-3495(21)03907-2. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34953534
 
18
Smart LJ, Drew A, Hadidon T, Teaford M, Bachmann E.
Simulation and virtual reality using nonlinear kinematic parameters as a means of predicting motion sickness in real-time in virtual environments.
Hum Factors. 2021 Dec 20;187208211059623. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34930044
 
19
Zhang X, Sun Y.
The predictive role of ADRA2A rs1800544 and HTR3B rs3758987 polymorphisms in motion sickness susceptibility.
Int J Environ Res Public Health. 2021 Dec 14;18(24):13163.
https://pubmed.ncbi.nlm.nih.gov/34948773
Note: This article may be obtained online without charge.
 
20
Nordine M, Schwarz A, Bruckstein R, Gunga H-C, Opatz O.
The human dive reflex during consecutive apnoeas in dry and immersive environments: Magnitude and synchronicity.
Front Physiol. 2022 Jan 4;12:725361.
https://doi.org/10.3389/fphys.2021.725361
Note: This article is part of Research Topic "Physiology and Physiopathology of Breath-Holding Activity" (https://www.frontiersin.org/research-topics/17771/physiology-and-physiopathology-of-breath-holding-activity#articles). The Research Topic also includes an article from previous Current Awareness List #978 https://doi.org/10.3389/fphys.2021.712573. This article may be obtained online without charge.
 
21
Nosikova I, Riabova A, Amirova L, Kitov V, Tomilovskaya E.
NAIAD-2020: Characteristics of motor evoked potentials after 3-day exposure to dry immersion in women.
Front Hum Neurosci. 2021 Dec 1;15:753259.
https://pubmed.ncbi.nlm.nih.gov/34924980
Note: This article is part of Research Topic "Women in Neuroscience" (https://www.frontiersin.org/research-topics/19592/women-in-neuroscience#articles). The Research Topic also includes an article from previous Current Awareness List #975 https://doi.org/10.3389/fnhum.2021.756674. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
22
Rivera PM, Proppe CE, Beltran E, Hill EC.
Acute effects of local ischemic hypoxia and systemic hypoxemia on neuromuscular and cognitive function.
High Alt Med Biol. 2021 Dec 21. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34936812
 
23
Garnier YM, Lepers R, Canepa P, Martin A, Paizis C.
Effect of the knee and hip angles on knee extensor torque: Neural, architectural, and mechanical considerations.
Front Physiol. 2022 Jan 4;12:789867.
https://doi.org/10.3389/fphys.2021.789867
Note: This article may be obtained online without charge.
 

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