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NASA Spaceline Current Awareness List #977 3 December 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, December 3, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
In case you missed it: The astrobiology web website features an article titled, "Researchers Put Space Garden Microbes Under the Microscope," discussing how NASA scientists are carefully monitoring the microbiome of the International Space Station with two goals in mindto map and keep track of microbes present through time, and to discover any patterns of microbial growth that could potentially affect the crew's health and safety—in order to determine whether or not the station itself creates conditions that spur microbial growth. Further reading is available at http://astrobiology.com/2021/12/researchers-put-space-garden-microbes-under-the-microscope.html.
 
Papers deriving from NASA support:
 
1
Haveman NJ, Schuerger AC.
Diagnosing an opportunistic fungal pathogen on spaceflight-grown plants using the MinION sequencing platform.
Astrobiology. 2021 Nov 18. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34793258
PI: N.J. Haveman, NASA Space Biology Postdoctoral Fellowship
Note: ISS results. From the abstract: "In this study, we show how the MinION sequencing platform can be used to diagnose the opportunistic pathogen, Fusarium oxysporum sensu lato; a fungal infection on Zinnia hybrida (zinnia) plants that were grown on the International Space Station (ISS) in 2015–2016."
Journal Impact Factor: 4.335
Funding: "This study was supported in part by NASA Space Biology Postdoctoral Fellowship (80NSSC19K0520) awarded to N.J.S."
 
2
Koller DP, Kasanin V, Flynn-Evans EE, Sullivan JP, Dijk DJ, Czeisler CA, Barger LK.
Altered sleep spindles and slow waves during space shuttle missions.
npj Microgravity. 2021 Nov 18;7(1):48.
https://pubmed.ncbi.nlm.nih.gov/34795291
Note: From the abstract: "This study extends previous findings by analyzing how spaceflight affects characteristics of sleep spindles and slow waves, two sleep oscillations associated with sleep quality and quantity, in four astronauts before, during and after two Space Shuttle missions." This article may be obtained online without charge.
Journal Impact Factor: 4.415
Funding: "We thank the Space Shuttle crew members who participated in this study; Dr. Leopold Summerer and ESA’s Advanced Concepts Team for their help in initiating and running this study; Dr. R. Hughes for his role in the original study; NASA’s LSDA, LSAH, and IRB teams, as well as Inês Antunes, ESA’s Human Research Science Coordinator, for their continuous support. Dr. Flynn-Evans was supported by the NASA Human Research Program. Drs. Barger and Czeisler and Mr. Sullivan were supported in part by R01OH011773."
 
3
Bretl KN, Clark TK.
Predicting individual acclimation to the cross-coupled illusion for artificial gravity.
J Vestib Res. 2021 Nov 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34806642
Note: From the abstract: "Eleven subjects were exposed to the CC illusion for up to 50 25-minute acclimation sessions. The metric of acclimation rate was calculated as the slope of each subject's linear increase in spin rate across sessions. As potential predictors of acclimation rate, we gathered age, gender, demographics, and activity history, and measured subjects' vestibular perceptual thresholds in the yaw, pitch, and roll rotation axes."
Journal Impact Factor: 2.435
Funding: "The funding for this research was provided via a NASA Space Technology Research Fellowship, Grant Number 80NSSCK0085."
 
4
Kiffer FC, Luitel K, Tran FH, Patel RA, Guzman CS, Soler I, Xiao R, Shay JW, Yun S, Eisch AJ.
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.
Behav Brain Res. 2022 Feb 15;419:113677.
https://pubmed.ncbi.nlm.nih.gov/34818568
PIs: J.W. Shay, S. Yun, A.J. Eisch, F.C. Kiffer, TRISH Postdoctoral Program Fellowship
Journal Impact Factor: 3.332
Funding: "This work was supported by NASA grants 80NSSC17K0060 (Eisch), 80NSSC21K0814 (Yun), NNX16AE08G (Shay); by the Translational Research Institute for Space Health through NASA cooperative agreement NNX16AO69A (Kiffer); NIH MH107945 (Eisch and Yun); the University of Pennsylvania McCabe Fund (Yun); the NARSAD Brain & Behavior Research Foundation award for Young Investigators (Yun); the Children’s Hospital of Philadelphia Department of Anesthesiology and Critical Care Development Fund (Eisch)."
 
5
De Martino E, Hides J, Elliott JM, Hoggarth MA, Zange J, Lindsay K, Debuse D, Winnard A, Beard D, Cook JA, Salomoni SE, Weber T, Scott J, Hodges PW, Caplan N.
Intramuscular lipid concentration increased in localized regions of the lumbar muscles following 60-day bedrest.
Spine J. 2021 Nov 20;S1529-9430(21)01028-7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34813960
Note: Head-down tilt bedrest study. This article may be obtained online without charge.
Journal Impact Factor: 4.166
Funding: "The AGBRESA study was funded by the German Aerospace Center, the European Space Agency (contract number: 4000113871/15/NL/PG), and the National Aeronautics and Space Administration (contract number: 80JSC018P0078). The study was performed at the ":envihab" research facility of the DLR Institute of Aerospace Medicine. Funding for this ESA-selected project (ESA-HSO-U-LE-0629) was received from the STFC/UK Space Agency (ST/R005753/1)."
 
6
Yamazaki EM, Antler CA, Casale CE, MacMullen LE, Ecker AJ, Goel N.
Cortisol and C-reactive protein vary during sleep loss and recovery but are not markers of neurobehavioral resilience.
Front Physiol. 2021 Nov 29;12:782860.
https://doi.org/10.3389/fphys.2021.782860
PI: N. Goel
Note: This article and an article below in the "Other" section (Guillon et al.) are part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; and #976 https://doi.org/10.3389/fphys.2021.770502. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: "This work was supported by the National Aeronautics and Space Administration (NASA) [grant numbers NNX14AN49G and 80NSSC20K0243 (to NG)]. This work was also partially supported from National Institutes of Health [grant number NIH R01DK117488 (to NG)]."
 
7
Plante I, Poignant F, Slaba T.
Track structure components: Characterizing energy deposited in spherical cells from direct and peripheral HZE ion hits.
Life (Basel). 2021 Oct 20;11(11):1112.
https://pubmed.ncbi.nlm.nih.gov/34832988
Note: From the abstract: "To understand the biological effects of radiation, it is important to determine how ionizing radiation deposits energy in micrometric targets. The energy deposited in a target located in an irradiated tissue is a function of several factors such as the radiation type and the irradiated volume size. We simulated the energy deposited by energetic ions in spherical targets of 1, 2, 4, and 8 µm radii encompassed in irradiated parallelepiped volumes of various sizes using the stochastic radiation track structure code Relativistic Ion Tracks (RITRACKS)." This article and an article below in the "Other" section (Calvaruso et al.) are part of Special Issue "Space Radiobiology" (https://www.mdpi.com/journal/life/special_issues/space_radiobiology). The Special Issue also includes an article from previous Current Awareness List #968 https://doi.org/10.3390/life11080849. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.817
Funding: "This work was supported by NASA Human Health and Performance (HHPC) contract number NNJ15HK11B (I.P.) and by the NASA Langley Cooperative Agreement 80LARC17C0004 (F.P.). This work is supported by the Human Research Program under the Human Exploration and Operations Mission Directorate at NASA (T.S.)."
 
8
Roberts DR, Collins HR, Al Kasab S.
The importance of the intracranial compartment in the development of spaceflight-associated neuro-ocular syndrome.
JAMA Ophthalmol. 2021 Nov 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34817563
PI: D.R. Roberts
Note: This article is a comment on an article from previous Current Awareness List #951 https://pubmed.ncbi.nlm.nih.gov/34014272.
Journal Impact Factor: 7.4
Funding: "Dr. Roberts reported grants from NASA during the conduct of the study."
 
9
Marshall-Goebel K, Kramer LA, Macias BR.
The importance of the intracranial compartment in the development of spaceflight-associated neuro-ocular syndrome-reply.
JAMA Ophthalmol. 2021 Nov 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34817558
PIs: K. Marshall-Goebel, L.A. Kramer, B.R. Macias
Note: This article is the reply to the comment article above on an article from previous Current Awareness List #951 https://pubmed.ncbi.nlm.nih.gov/34014272.
Journal Impact Factor: 7.4
Funding: "Drs. Marshall-Goebel, Kramer, and Macias reported grants from NASA during the conduct of the study."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Blokhinа TM, Yashkina EI, Belyaeva AG, Perevezentsev AA, Shtemberg AS, Osipov AN.
Long-term persistence of increased number of γH2AX+ peripheral blood lymphocytes in monkeys exposed to negative factors of space flights: Ionizing radiation and simulated hypogravity.
Bull Exp Biol Med. 2021 Nov;172(1):81-4.
https://pubmed.ncbi.nlm.nih.gov/34791560
Note: The method of simulated hypogravity is not evident in the available abstract. This article may be obtained online without charge.
 
2
Basirun C, Ferlazzo ML, Howell NR, Liu GJ, Middleton RJ, Martinac B, Narayanan SA, Poole K, Gentile C, Chou J.
Microgravity × radiation: A space mechanobiology approach toward cardiovascular function and disease.
Front Cell Dev Biol. 2021 Oct 29;9:750775. Mini review.
https://pubmed.ncbi.nlm.nih.gov/34778261
Note: From the abstract: "This mini review aims to identify the impact of microgravity and radiation on the cardiovascular system. Being able to understand the effect that comes with deep space explorations, including that of microgravity and space radiation, may also allow us to get a deeper understanding of the heart and ultimately our own basic physiological processes." This article and an article below (Rosenstein et al.) are part of Research Topic "Space Mechanobiology and Medicine" (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). The Research Topic also includes articles from previous Current Awareness List #963 https://doi.org/10.3389/fcell.2021.672098, https://doi.org/10.3389/fcell.2021.689662, and https://doi.org/10.3389/fcell.2021.707470; and #971 https://doi.org/10.3389/fcell.2021.732370. This article may be obtained online without charge.
 
3
Rosenstein AH, Walker VK.
Fidelity of a bacterial DNA polymerase in microgravity, a model for human health in space.
Front Cell Dev Biol. 2021 Nov 29;9:702849.
https://doi.org/10.3389/fcell.2021.702849
Note: This article and the article above (Basirun et al.) are part of Research Topic "Space Mechanobiology and Medicine" (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). You may also view a write-up promoting this article on the astrobiology web website at http://astrobiology.com/2021/12/cells-replication-of-dna-is-more-error-prone-in-microgravity.html. This article may be obtained online without charge.
 
4
Mohanta TK, Mishra AK, Mohanta YK, Al-Harrasi A.
Space breeding: The next-generation crops.
Front Plant Sci. 2021 Oct 27;12:771985. Review.
https://pubmed.ncbi.nlm.nih.gov/34777452
Note: From the abstract: "This review aims to elucidate the detailed molecular mechanisms and genetic mutations found in plants used in recent space crop projects and how these can be applied in space breeding programs in the future." This article is part of the Research Topic "Enviromics in Plant Breeding" (https://www.frontiersin.org/research-topics/17196/enviromics-in-plant-breeding#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
5
Strigari L, Strolin S, Morganti AG, Bartoloni A.
Dose-effects models for space radiobiology: An overview on dose-effect relationships.
Front Public Health. 2021 Nov 8;9:733337. Review.
https://pubmed.ncbi.nlm.nih.gov/34820349
Note: This article is part of the Research Topic "Medical Application and Radiobiology" (https://www.frontiersin.org/research-topics/14492/medical-application-and-radiobiology-research-of-particle-radiation#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
6
Calvaruso M, Militello C, Minafra L, La Regina V, Torrisi F, Pucci G, Cammarata FP, Bravatà V, Forte GI, Russo G.
Biological and mechanical characterization of the Random Positioning Machine (RPM) for microgravity simulations.
Life (Basel). 2021 Nov 5;11(11):1190.
https://pubmed.ncbi.nlm.nih.gov/34833068
Note: From the abstract: "In our study, we aimed to characterize, at the biological and mechanical level, a Random Positioning Machine in order to simulate microgravity in an in vitro model of Triple-Negative Breast Cancer (TNBC)." This is article and an article above in the "NASA" section (Plante et al.) are part of Special Issue "Space Radiobiology" (https://www.mdpi.com/journal/life/special_issues/space_radiobiology). This article may be obtained online without charge.
 
7
Guillon L, Kermorgant M, Charvolin T, Bonneville F, Bareille M-P, Cassol E, Beck A, Beaurain M, Péran P, Lotterie J-A, Traon AP-L, Payoux P.
Reduced regional cerebral blood flow measured by 99mTc-hexamethyl propylene amine oxime single-photon emission computed tomography in microgravity simulated by 5-day dry immersion.
Front Physiol. 2021 Nov 22;12:789298.
https://doi.org/10.3389/fphys.2021.789298
Note: Dry immersion results. This article and an article above in the "NASA" section (Yamazaki et al.) are part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
8
Richter C, Braunstein B, Staeudle B, Attias J, Suess A, Weber T, Mileva KN, Rittweger J, Green DA, Albracht K.
Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities.
Sci Rep. 2021 Nov 19;11(1):22555.
https://pubmed.ncbi.nlm.nih.gov/34799596
Note: From the abstract: "…this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility." This article may be obtained online without charge.
 
9
Abdelfattah OM, Sayed A, Elgendy IY, Munir M, Saleh Y, Kapadia SR, Abela GS, Jneid H.
Patent foramen ovale closure and decompression sickness among divers.
Cardiovasc Revasc Med. 2021 Nov 20;S1553-8389(21)00745-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34810112
 
10
Booker CN, Haga CL, Boregowda SV, Strivelli J, Phinney DG.
Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts.
npj Microgravity. 2021 Nov 26;7(1):49.
https://doi.org/10.1038/s41526-021-00178-0
Note: Hindlimb unloading study. This article may be obtained online without charge.
 
11
Kalashnikov VE, Tyganov SA, Turtikova OV, Kalashnikova EP, Glazova MV, Mirzoev TM, Shenkman BS.
Prochlorperazine withdraws the delayed onset tonic activity of unloaded rat soleus muscle: A pilot study.
Life (Basel). 2021 Nov;11(11):1161.
https://pubmed.ncbi.nlm.nih.gov/34833037
Note: Hindlimb unloading study. This article is part of Section "Physiology and Pathology" (https://www.mdpi.com/journal/life/sections/Physiology_and_Pathology). This article may be obtained online without charge.
 
12
Paramonova, II, Vilchinskaya NA, Shenkman BS.
HDAC4 is indispensable for reduced slow myosin expression at the early stage of hindlimb unloading in rat soleus muscle.
Pharmaceuticals (Basel). 2021 Nov 16;14(11):1167.
https://pubmed.ncbi.nlm.nih.gov/34832949
Note: Hindlimb unloading study. This article is part of Special Issue "Drug Insight: Histone Deacetylase (HDAC) Inhibitors" (https://www.mdpi.com/journal/pharmaceuticals/special_issues/HDAC_pharm). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
13
Sun L, An S, Zhang Z, Zhou Y, Yu Y, Ma Z, Fan X, Tang L, Guo J.
Molecular and metabolic mechanism of low-intensity pulsed ultrasound improving muscle atrophy in hindlimb unloading rats.
Int J Mol Sci. 2021 Nov 9;22(22):12112.
https://pubmed.ncbi.nlm.nih.gov/34829990
Note: Hindlimb unloading study. This article belongs to Section "Molecular Pathology, Diagnostics, and Therapeutics" (https://www.mdpi.com/journal/ijms/sections/Pathology_Diagnostics_Therapeutics). This article may be obtained online without charge.
 
14
Dolan CP, Imholt F, Yang TJ, Bokhari R, Gregory J, Yan M, Qureshi O, Zimmel K, Sherman K, Falck A, Yu L, Leininger E, Brunauer R, Suva LJ, Gaddy D, Dawson LA, Muneoka K.
Mouse digit tip regeneration is mechanical load-dependent.
J Bone Miner Res. 2021 Nov 16. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34783092
Note: Hindlimb unloading study.
 
15
Konosu A, Funato T, Matsuki Y, Fujita A, Sakai R, Yanagihara D.
A model of predictive postural control against floor tilting in rats.
Front Syst Neurosci. 2021 Nov 25;15:785366.
https://doi.org/10.3389/fnsys.2021.785366
Note: From the abstract: "Humans and animals learn the internal model of bodies and environments from their experience and stabilize posture against disturbances based on the predicted future states according to the internal model. We evaluated the mechanism of predictive control during standing, by using rats to construct a novel experimental system and comparing their behaviors with a mathematical model." This article is part of Research Topic "The Neural Basis of Hyper-Adaptability in Humans and Animals" (https://www.frontiersin.org/research-topics/18103/the-neural-basis-of-hyper-adaptability-in-humans-and-animals#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
16
Bodnyk KA, Kim DG, Pan X, Hart RT.
The long-term residual effects of low-magnitude mechanical stimulation on murine femoral mechanics.
J Biomech Eng. 2021 Nov 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34817049
Note: From the abstract: "As an alternative to drug treatments, low-magnitude mechanical stimulation (LMMS) may improve skeletal health without potential side effects from drugs. LMMS has been shown to increase bone health short term in both animal and clinical studies. Long term changes to the mechanical properties of bone from LMMS are currently unknown, so the objective of this research is to investigate the long-term effects of whole body vibration therapy on the elastic and viscoelastic properties of bone."
 
17
Harijanto C, Lim A, Vogrin S, Duque G.
Does whole-body vibration training have a concurrent effect on bone and muscle health? A systematic review and meta-analysis.
Gerontology. 2021 Nov 15;1-11. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34781288
 
18
Kohama I, Yanagawa T, Okamoto M, Ohno T, Chikuda H.
A risk factor analysis for local recurrence of bone and soft tissue sarcoma treated with carbon ion radiotherapy: A retrospective cohort study at a single institution.
Asia Pac J Clin Oncol. 2021 Nov 23. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34811886
 
19
MacDonald EA, Quinn TA.
What keeps us ticking? Sinoatrial node mechano-sensitivity: The grandfather clock of cardiac rhythm.
Biophys Rev. 2021 Sep 15;13(5):707-16. Review.
https://pubmed.ncbi.nlm.nih.gov/34777615
 
20
Harada T, Sugawara T, Ito T, Wada Y, Fukunaga M, Sadato N, Larroque SK, Demertzi A, Laureys S, Sakai H.
Vestibular morphological asymmetry associated with motion sickness susceptibility.
Front Neurosci. 2021 Nov 4;15:763040.
https://pubmed.ncbi.nlm.nih.gov/34803595
Note: This article may be obtained online without charge.
 
21
Nürnberger M, Klingner C, Witte OW, Brodoehl S.
Mismatch of visual-vestibular information in virtual reality: Is motion sickness part of the brains attempt to reduce the prediction error?
Front Hum Neurosci. 2021 Oct 29;15:757735.
https://pubmed.ncbi.nlm.nih.gov/34776909
Note: This article is part of Research Topic "The Brain Under Fatigue" (https://www.frontiersin.org/research-topics/18593/the-brain-under-fatigue#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
22
Sakai H, Harada T, Larroque SK, Demertzi A, Sugawara T, Ito T, Wada Y, Fukunaga M, Sadato N, Laureys S.
Left parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging.
Hum Brain Mapp. 2021 Nov 15. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34783415
Note: This article may be obtained online without charge.
 
23
Sudo D, Hosokawa M, Maeda Y.
Kinematic effects of different gait speeds during gait initiation movement.
J Phys Ther Sci. 2021 Nov;33(11):857-61.
https://pubmed.ncbi.nlm.nih.gov/34776623
Note: This article may be obtained online without charge.
 
24
Ming X, Wang W, Shahnazi K, Sun J, Zhang Q, Li P, Hong Z, Sheng Y.
Dosimetric comparison between carbon, proton and photon radiation for renal retroperitoneal soft tissue sarcoma recurrence or metastasis after radical nephrectomy.
Int J Radiat Biol. 2021 Nov 22:1-26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34802361
 

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