SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #974 5 November 2021

Status Report From: Spaceline
Posted: Friday, November 5, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Rosenberg MJ, Coker MA, Taylor JA, Yazdani M, Matheus MG, Blouin CK, Al Kasab S, Collins HR, Roberts DR.
Comparison of dural venous sinus volumes before and after flight in astronauts with and without spaceflight-associated neuro-ocular syndrome.
JAMA Netw Open. 2021 Oct 27;4(10):e2131465.
https://pubmed.ncbi.nlm.nih.gov/34705011
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 8.48
Funding: "This research was funded by grant number 20-EPSCoR 2020-0069 from National Aeronautics and Space Administration (NASA)."
 
2
Fajardo-Cavazos P, Nicholson WL.
Shelf life and simulated gastrointestinal tract survival of selected commercial probiotics during a simulated round-trip journey to Mars.
Front Microbiol. 2021 Oct 7;12:748950.
https://pubmed.ncbi.nlm.nih.gov/34690999
PI: W.L. Nicholson
Note: From the abstract: "Here we tested three commercial probiotics-Bifidobacterium longum strain BB536, Lactobacillus acidophilus strain DDS-1, and spores of Bacillus subtilis strain HU58-for their survival to some of the conditions expected to be encountered during a 3-year, round trip voyage to Mars. All probiotics were supplied as freeze-dried cells in capsules at a titer of >109 colony forming units per capsule. Parameters tested were survival to: (i) long-term storage at ambient conditions, (ii) simulated Galactic Cosmic Radiation and Solar Particle Event radiation provided by the NASA Space Radiation Laboratory, (iii) exposure to simulated gastric fluid, and (iv) exposure to simulated intestinal fluid." This article may be obtained online without charge.
Journal Impact Factor: 5.640
Funding: "This work was funded by grant 80NSSC20K1297 from the NASA Human Research Program."
 
3
Stahn AC, Kühn S.
Extreme environments for understanding brain and cognition.
Trends Cogn Sci. 2021 Oct 25;S1364-6613(21)00260-6. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34711517
Note: From the abstract: "We review characteristics of spaceflight and spaceflight analogues, such as bed rest, dry immersion, parabolic flights, and isolated and controlled confinement, and discuss the potential of utilizing these research settings to advance cognitive neuroscience."
Journal Impact Factor: 20.229
Funding: "This material is based upon work supported by the National Aeronautics and Space Agency (NASA), European Space Agency (ESA), and German Aerospace Center (DLR), including grants 50WB1225 and 50WB1519."
 
4
Slaba TC.
Historical reconstruction of astronaut cancer risk: Context for recent solar minima.
Space Weather. 2021 Oct;19(10):e2021SW002851.
https://doi.org/10.1029/2021SW002851
Journal Impact Factor: 4.46
Funding: "This work was supported by the Advanced Exploration Systems (AES) under the Human Exploration and Operations Mission Directorate of NASA."
 
5
Simonsen LC, Slaba TC.
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework.
Life Sci Space Res (Amst). 2021 Nov;31:14-28.
https://pubmed.ncbi.nlm.nih.gov/34689946
Journal Impact Factor: 2.082
Funding: "This work was performed by the Multi-Model Ensemble Risk Assessment (MERA) project at NASA Langley Research Center and is supported by the Human Research Program under the Human Exploration and Operations Mission Directorate at NASA."
 
6
McNulty MJ, Berliner AJ, Negulescu PG, McKee L, Hart O, Yates K, Arkin AP, Nandi S, McDonald KA.
Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry.
Front Microbiol. 2021 Oct 11;12:700863.
https://pubmed.ncbi.nlm.nih.gov/34707576
PI: K.A. McDonald
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.640
Funding: "This material is based upon work supported by NASA under grant or cooperative agreement award number NNX17AJ31G. This work was also supported by a NASA Space Technology Research Fellowship (NASA grant number 80NSSC18K1157). This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Aeronautics and Space Administration (NASA) or the Translational Research Institute for Space Health (TRISH)."
 
7
Nemec-Bakk AS, Sridharan V, Landes RD, Singh P, Cao M, Seawright JW, Liu X, Zheng G, Dominic P, Pathak R, Boerma M.
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model.
Life Sci Space Res (Amst). 2021 Nov;31:43-50.
https://pubmed.ncbi.nlm.nih.gov/34689949
PI: M. Boerma
Journal Impact Factor: 2.082
Funding: "This work supported by the National Space Biomedical Research Institute under grant RE03701 through NCC 9–58, NASA grants 80NSSC17K0425 and 80NSSC19K0437, and by the National Institute of General Medical Sciences under grant P20 GM109005. The authors wish to thank the BNL support group, the NSRL physicists, the UAMS Experimental Pathology Core, and the animal care staff at UAMS and BNL for their excellent technical support."
 
8
Soler I, Yun S, Reynolds RP, Whoolery CW, Tran FH, Kumar PL, Rong Y, DeSalle MJ, Gibson AD, Stowe AM, Kiffer FC, Eisch AJ.
Multi-domain touchscreen-based cognitive assessment of C57BL/6J female mice shows whole-body exposure to 56Fe particle space radiation in maturity improves discrimination learning yet impairs stimulus-response rule-based habit learning.
Front Behav Neurosci. 2021 Oct 11;15:722780. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34707486
PIs: S. Yun, A.J. Eisch, F.C. Kiffer, NASA Postdoctoral Program Fellowship
Journal Impact Factor: 3.558
Funding: "IS was supported by the UPenn Post Baccalaureate Research Education Program (PennPREP) which is supported by a grant from the NIH (R25GM071745, PI: K. L. Jordan-Sciutto) and additional funding from Biomedical Graduate Studies at the University of Pennsylvania. SY was supported by an NIH Institutional Training Grant (MH076690, PI: C. A. Tamminga), NNX15AE09G (PI AE), MH107945 (PI AE), a 2018 PENN McCabe Pilot grant, a 2019 IBRO travel grant, and is currently supported by 2019 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, a 2020 PENN Undergraduate Research Foundation grant, and a 2021 NASA HERO grant (80NSSC21K0814). CW was supported by an NIH Institutional Training grant (DA007290, PI AE). YR was supported by an Undergraduate Translational Research Internship Program under Penn’s Institute for Translational Medicine and Therapeutics which is supported by an NIH Institutional Clinical and Translational Science Award TR001878, PI: G. A. Fitzgerald). AS was supported by the American Heart Association (14SDG18410020), NIH/NINDS (NS088555), the Dana Foundation David Mahoney Neuroimaging Program, and The Haggerty Center for Brain Injury and Repair (UTSW). FK was supported by the Translational Research Institute for Space Health (TRISH) through NASA cooperative agreement NNX16AO69A. This research was also supported by NASA grants NNX07AP84G (co-I AE), NNX12AB55G (co-I AE), and NNX15AE09G (PI AE), NIH grants DA007290, DA023555, DA016765, and MH107945 to AE and R15 MH117628 (PI K. G. Lambert), and a pilot grant from the University of Pennsylvania Perelman School of Medicine Department of Radiation Oncology (co-PI with Y. Fan)."
 
9
Suman S, Kumar S, Moon BH, Angdisen J, Kallakury BVS, Datta K, Fornace AJ Jr.
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc1638N/+ mice.
Life Sci Space Res (Amst). 2021 Nov;31:85-91.
https://pubmed.ncbi.nlm.nih.gov/34689954
PI: A.J. Fornace Jr
Journal Impact Factor: 2.082
Funding: "This study is supported in part by NASA grant NNX09AU95G."
 
10
Lock R, Al Asafen H, Fleischer S, Tamargo M, Zhao Y, Radisic M, Vunjak-Novakovic G.
A framework for developing sex-specific engineered heart models.
Nat Rev Mater. 2021 Oct 20:1-19. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34691764
PI: G. Vunjak-Novakovic
Note: This article may be obtained online without charge.
Journal Impact Factor: 66.308
Funding: "The authors gratefully acknowledge the funding support of their cardiac research by NIH (HL076485, EB025765, EB027062), NSF (grant NSF16478) and NASA (NNX16AO69A)."
 
_______________________________________________________
 
 
Other papers of interest:
 
 
1
Cialdai F, Bolognini D, Vignali L, Iannotti N, Cacchione S, Magi A, Balsamo M, Vukich M, Neri G, Donati A, Monici M, Capaccioli S, Lulli M.
Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment.
Cell Mol Life Sci. 2021 Oct 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34714361
Note: ISS results.
 
2
Fujiwara D, Kawaguchi Y, Kinoshita I, Yatabe J, Narumi I, Hashimoto H, Yokobori SI, Yamagishi A.
Mutation analysis of the rpoB gene in the radiation-resistant bacterium Deinococcus radiodurans R1 exposed to space during the Tanpopo Experiment at the International Space Station.
Astrobiology. 2021 Oct 22. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34694920
Note: ISS results. This article may be obtained online without charge.
 
3
Greaves D, Guillon L, Besnard S, Navasiolava N, Arbeille P.
4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement.
npj Microgravity. 2021 Nov 2;7(1):43.
https://pubmed.ncbi.nlm.nih.gov/34728651
Note: Dry immersion study. This article may be obtained online without charge.
 
4
Liu H, Yao Z, Fu Y, Feng J.
Review of research into bioregenerative life support system(s) which can support humans living in space.
Life Sci Space Res (Amst). 2021 Nov;31:113-20. Review.
https://pubmed.ncbi.nlm.nih.gov/34689943
 
5
Marge M.
Preparing individuals with disabilities for space travel and habitation.
Disabil Health J. 2021 Oct 23;101228. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34711524
Note: This article may be obtained online without charge.
 
6
Rühle A, Ping D, Lopez Perez R, Strack M, Brons S, Yijia Q, Debus J, Wuchter P, Grosu AL, Huber PE, Nicolay NH.
Human mesenchymal stromal cells maintain their stem cell traits after high-LET particle irradiation - Potential implications for particle radiotherapy and manned space missions.
Cancer Lett. 2022 Jan;524:172-81. Available online 21 October 2021.
https://pubmed.ncbi.nlm.nih.gov/34688844
 
7
Tang Y, Dong W, Ai W, Zhang L, Li J, Yu Q, Guo S, Li Y.
Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform.
Life Sci Space Res (Amst). 2021 Nov;31:121-30.
https://pubmed.ncbi.nlm.nih.gov/34689944
 
8
Wu X, Yin Y, Liu J, Zhu Y, Fan Q, Zhao S, Wang J, Gao J, Liu Y, Jiao L, Li Y.
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways.
Life Sci Space Res (Amst). 2021 Nov;31:34-42.
https://pubmed.ncbi.nlm.nih.gov/34689948
Note: From the abstract: "During space flight, astronauts are exposed to various influences of extreme environments and susceptible to develop depression-like behavior. Thus, this study aims to explore the molecular biological mechanism of the cause of depression-like behavior and reveal the effect of Baoyuan Jieyu Formula (BYJYF) on ameliorating depression-like behavior."
 
9
Zeidler C, Woeckner G, Schöning J, Vrakking V, Zabel P, Dorn M, Schubert D, Steckelberg B, Stakemann J.
Crew time and workload in the EDEN ISS greenhouse in Antarctica.
Life Sci Space Res (Amst). 2021 Nov;31:131-49.
https://pubmed.ncbi.nlm.nih.gov/34689945
Note: This article may be obtained online without charge.
 
10
Sanavandi H, Guo W.
A magnetic levitation based low-gravity simulator with an unprecedented large functional volume.
npj Microgravity. 2021 Oct 29;7(1):40.
https://pubmed.ncbi.nlm.nih.gov/34716356
Note: This article may be obtained online without charge.
 
11
Wang H, Liu H, Wang X, Zhang C.
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity.
Life Sci Space Res (Amst). 2021 Nov;31:80-4.
https://pubmed.ncbi.nlm.nih.gov/34689953
Note: From the abstract: "During spaceflight, astronauts experience 1-1.5% bone loss per month, especially in the lumbar spine, pelvis and lower limbs. The bone loss leads to osteoporosis and increased the risk of fracture. Current researches focus on anti-osteoporosis under microgravity mainly by inhibiting bone resorption of osteoclasts and/or increasing bone formation of osteoblasts. However, studies on the effects of mass transfer in the bone lacunar-canalicular system (LCS) on osteoporosis are lacking. Osteocytes reside in the lacunae and communicate with other osteocytes, osteoblasts and osteoclasts through the LCS in the bone matrix. Osteocytes are mainly responsible for mechanosensing and signal regulation in bone, and the LCS is the basic structure for signaling, mass transfer and mechanical stimulation. Microgravity causes deficient mass transfer in the LCS, especially in the outer layer of osteon. Osteocytes far away from the Haversian canals are inhibited or accelerated apoptosis to stimulate osteoclasts which result in bone loss. Deficient mass transfer in the LCS may be a determinant of human osteoporosis under microgravity, which will open up a new way to treat osteoporosis in space."
 
12
Markina E, Alekseeva O, Andreeva E, Buravkova L.
Short-term reloading after prolonged unloading ensures restoration of stromal but not hematopoietic precursor activity in tibia bone marrow of C57Bl/6N mice.
Stem Cells Dev. 2021 Oct 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34714129
Note: Hindlimb unloading study.
 
13
Lund S, Yan M, D'Angelo J, Wang T, Hallbeck MS, Heller S, Zielinski M.
NASA-TLX assessment of workload in resident physicians and faculty surgeons covering trauma, surgical intensive care unit, and emergency general surgery services.
Am J Surg. 2021 Oct 19;S0002-9610(21)00610-3. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34689977
Note: The NASA Task Load Index was used in this study.
 
14
Zhang H, Zhang H, Xiong Y, Dong L, Li X.
Development of hierarchical porous bioceramic scaffolds with controlled micro/nano surface topography for accelerating bone regeneration.
Mater Sci Eng C Mater Biol Appl. 2021 Nov;130:112437.
https://pubmed.ncbi.nlm.nih.gov/34702522
 
15
Belykh ES, Velegzhaninov IO, Garmash EV.
Responses of genes of DNA repair, alternative oxidase, and pro-/antioxidant state in Arabidopsis thaliana with altered expression of AOX1a to gamma irradiation.
Int J Radiat Biol. 2021 Oct 29:1-14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34714725
 
16
Dobrzyńska MM, Gajowik A.
Protection and mitigation by resveratrol of DNA damage induced in irradiated human lymphocytes in vitro.
Radiat Res. 2021 Nov 1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34724059
 
17
Ekwealor JTB, Mishler BD.
Transcriptomic effects of acute ultraviolet radiation exposure on two Syntrichia mosses.
Front Plant Sci. 2021 Oct 28;12:752913.
https://doi.org/10.3389/fpls.2021.752913
Note: This article may be obtained online without charge.
 
18
Lee C-L, Wright AO, Lee JW, Brownstein J, Hasapis S, Satow S, Da Silva Campos L, Williams N, Ma Y, Luo L, Johnson T, Daniel AR, Harrison WT, Oldham M, Kirsch DG.
Sensitization of endothelial cells to ionizing radiation exacerbates delayed radiation myelopathy in mice.
Radiat Res. 2021 Nov 1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34724704
 
19
Semaida AI, El-Khashab MA, Saber AA, Hassan AI, Elfouly SA.
Effects of Sargassum virgatum extracts on the testicular measurements, genomic DNA & antioxidant enzymes in irradiated rats.
Int J Radiat Biol. 2021 Oct 25;1-48. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34694945
 
20
Sun T, Yu S, Song X, Zhang J, Bao Q, Mei Q, Shen Q, Wang D, Ni G.
Cold plasma irradiation regulates inflammation and oxidative stress in human bronchial epithelial cells and human non-small cell lung carcinoma.
Radiat Res. 2021 Oct 26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34700340
 
21
Yang X, Song G, Liu H, Hu D.
Microbial diversity formation and maintenance due to temporal niche differentiation caused by low-dose ionizing radiation in oligotrophic environments.
Life Sci Space Res (Amst). 2021 Nov;31:92-100.
https://pubmed.ncbi.nlm.nih.gov/34689955
 
22
Germonpré P, Lafère P, Portier W, Germonpré F-L, Marroni A, Balestra C.
Increased risk of decompression sickness when diving with a right-to-left shunt: Results of a prospective single-blinded observational study (the "Carotid Doppler" study).
Front Physiol. 2021 Oct 29;12:763408.
https://doi.org/10.3389/fphys.2021.763408
Note: This article may be obtained online without charge.
 
23
Huang H, Jiang N, Zhang YW, Lv JW, Wang HX, Lu C, Liu XM, Lu GH.
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment.
Life Sci Space Res (Amst). 2021 Nov;31:51-8.
https://pubmed.ncbi.nlm.nih.gov/34689950
 

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.