In case you missed it:Medical Xpress, a web-based medical and health news service that is part of the renowned Science X network, recently ran a story titled, "Spaceflight caused DNA to leak out of astronauts' cell powerhouse" by Thor Christensen which highlights article 1 in the "NASA" section below. To view the full story go tohttps://medicalxpress.com/news/2021-10-spaceflight-dna-leak-astronauts-cell.html.
Papers deriving from NASA support:
Bisserier M, Shanmughapriya S, Rai AK, Gonzalez C, Brojakowska A, Garikipati VNS, Madesh M, Mills PJ, Walsh K, Arakelyan A, Kishore R, Hadri L, Goukassian DA.
Cell-free mitochondrial DNA as a potential biomarker for astronauts' health.
Note:ISS results. This article may be obtained online without charge.
Journal Impact Factor:4.605
Funding:"This work was supported by the Translational Research Institute for Space Health award FIP0005 (to Dr Goukassian), National Aeronautics and Space Administration grant 80NSSC21K0549 (to Drs Goukassian and Walsh), American Heart Association Career Development Award 18CDA34110277 and start-up funds from the Ohio State University Medical Center (to Dr Garikipati), National Institutes of Health grant R01 HL133554 and American Heart Association 18IPA34170321 (to Dr Hadri), National Institutes of Health 5T32HL007824-22, and the Cardiovascular Medical Research and Education Fund (to Drs Hadri and Bisserier)."
Beheshti A, McDonald JT, Hada M, Takahashi A, Mason CE, Mognato M.
Genomic changes driven by radiation-induced DNA damage and microgravity in human cells.
Funding:"This research was funded by University of Padova (BIRD-DOR 2020) to M.M. A.B. was supported and funded by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and The Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404)."
Krukowski K, Grue K, Becker M, Elizarraras E, Frias ES, Halvorsen A, Koenig-Zanoff M, Frattini V, Nimmagadda H, Feng X, Jones T, Nelson G, Ferguson AR, Rosi S.
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures.
Note:This article may be obtained online without charge.
Journal Impact Factor:14.136
Funding:"This work was supported by NASA grants NNX14AC94G (S.R.) and 80NSSC19K1581 (S.R.). E.S.F. is supported by the National Institute for General Medicine (NIGMS) Initiative for Maximizing Student Development (R25GM056847) and the NSF Graduate Fellowship Program. A.H. was supported by the UCSF Summer Research Training Program. E.E. was supported by the Sally Casanova Pre-Doctoral Scholarship. NIH/NINDS: R01NS088475 (A.R.F.) and UG3NS106899 (A.R.F.); Department of Veterans Affairs: 1I01RX002245 (A.R.F.) and I01RX002787 (A.R.F.); Wings for Life and Craig H. Neilsen Foundation (A.R.F.)."
Prelich MT, Matar M, Gokoglu SA, Gallo CA, Schepelmann A, Iqbal AK, Lewandowski BE, Britten RA, Prabhu RK, Myers JG Jr.
Predicting space radiation single ion exposure in rodents: A machine learning approach.
Funding:"VPV was supported by the Translational Research Institute for Space Health through NASA NNX16AO69A. The MARS device was provided by Air Force Office of Scientific Research AFOSR FA9550-12-1-0395."
Taibbi G, Young M, Vyas RJ, Murray MC, Lim S, Predovic M, Jacobs NM, Askin KN, Mason SS, Zanello SB, Vizzeri G, Theriot CA, Parsons-Wingerter P.
Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity.
Note:Head-down-tilt bed rest study. This article may be obtained online without charge.
Journal Impact Factor:4.415
Funding:"The research was supported by Grant NNJ12ZSA002N from the Human Health and Countermeasures, Human Research Program (HRP), U. S. National Aeronautics and Space Administration (NASA) to PPW, GV, GT, MY, and SZ. Additional support to PPW was provided by NASA’s HRP and Space Radiation Programs, Vascular Centennial Challenge, Game-Changing Development, and Ames Center Innovation Fund. The authors gratefully acknowledge Rob Ploutz-Snyder (RPS below), University of Michigan, for the original power design of the study. We thank Terry Condrich and Lorie Passe, NASA Publications (LTID) for original art work and layout editing, respectively."
The following and two citations below in the "Other" section (Herranz et al. and Soga et al.) are part of the Methods in Molecular Biology book series (MIMB, volume 2368),Plant Gravitropism: Methods and Protocols.
Basu P, Kruse CPS, Luesse DR, Wyatt SE.
Plant proteomic data acquisition and data analyses: Lessons from spaceflight.
Methods Mol Biol. 2022;2368:199-214. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Note:U.S. Space Shuttle, ISS, and former Russian Space Station Mir results. From the abstract: "One of the authors (JZK) has been a principal investigator on eight spaceflight projects. These experiences include using the U.S. Space Shuttle, the former Russian Space Station Mir, and the International Space Station, utilizing the Space Shuttle and Space X as launch vehicles. While there are several ways to fly an experiment into space and to obtain a spaceflight opportunity, this review focuses on using the NASA peer-reviewed sciences approach to get an experiment manifested for flight."
Journal Impact Factor:1.17
Funding:"Thanks to NASA for continued financial support of our spaceflight research and to ESA for providing excellent research laboratories for space research. Over the years, we have had fine support from NASA centers (ARC, KSC, JSC, and MSFC) and European facilities (ESTEC and N-USOC). We also wish to acknowledge our colleagues, friends, students, and the many astronauts who have contributed to the successes of our spaceflight projects."
Blueprints for constructing microgravity analogs.
Methods Mol Biol. 2022;2368:215-32. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Funding:"This chapter is the result of many years of continuous improvement of a variety of specialized clinostats that enabled research supported by NASA. Especially the effect of high gradient magnetic fields, mechanostimulation and longevity of stimulus retention were supported by NASA grants 80NSSC17K0344, NAG10-0190, NNX10AP91G."
Cannon AE, Sabharwal T, Roux SJ.
Spore preparation and protoplast isolation to study gravity perception and response inCeratopteris richardii.
Methods Mol Biol. 2022;2368:53-60. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PIs:C.M. Johnson, S. Neelam, NASA Postdoctoral Program Fellowship
Note:This chapter discusses microgravity simulators that include, but are not limited to, 2D clinostats, 3D clinostats, random positioning machines, and rotating wall vessels. From the abstract: "In this chapter, we will discuss current MSSF capabilities, development concepts, and the physical characteristics of these microgravity simulators."
Journal Impact Factor:1.17
Funding:"The KSC MSSF facility is supported by NASA’s Biological and Physical Science Division within the NASA Science Mission Directorate. We greatly appreciate the LASSO MSSF science support team, especially Jason Fischer and Stephanie E. Richards for logistic support, Jacob J. Torres, Jonathan R. Gleeson, Lawrence L. Koss, as well as Randall I. Wade and Michael A. Lane from NASA KSC, and Bill Wells from the Bionetics Corporation for hardware design support. We also thank Caesar Udave, Audrey Lee, Antonina Tsinman, Jessica L. Hellein, Julia Woodall, Tait Sorenson, and Emily N. Keith, for their dedication and excellent internship work to improve MSSF operations. Srujana Neelam contributed greatly to the establishment of the MSSF when she was a NASA postdoctoral fellow at KSC through the Universities Space Research Association."
Chin S, Blancaflor EB.
Plant gravitropism: From mechanistic insights intoplant function on Earth to plants colonizing other worlds.
Methods Mol Biol. 2022;2368:1-41. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Note:From the abstract: "In this chapter, we review the field of gravitropism by highlighting recent landmark studies that have provided unique insights into this classic research topic while also discussing potential contributions to agriculture on Earth and beyond."
Journal Impact Factor:1.17
Funding:"Research on gravitropism in the authors' laboratory is supported by the National Aeronautics and Space Administration (NASA grants 80NSSC19K0129 and 80NSSC18K1462)."
Funding:"Work in the authors' labs was supported by NASA Grant NNX15AG55G. The authors wish to thank the EMCS support team at NASA Ames Research Center for their work developing the specialized hardware and growth system from which this technique was modified."
Fitzgerald C, Vens CS, Miller N, Barker R, Westphall M, Lombardino J, Miao J, Swanson SJ, Gilroy S.
Using the Automated Botanical Contact Device (ABCD) todeliver reproducible, intermittent touch stimulation to plants.
Methods Mol Biol. 2022;2368:81-94. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Shin WG, Sakata D, Lampe N, Belov O, Tran NH, Petrovic I, Ristic-Fira A, Dordevic M, Bernal MA, Bordage MC, Francis Z, Kyriakou I, Perrot Y, Sasaki T, Villagrasa C, Guatelli S, Breton V, Emfietzoglou D, Incerti S.
A Geant4-DNA evaluation of radiation-induced DNA damage on a human fibroblast.