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NASA Spaceline Current Awareness List # 969 1 October 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 1, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
In case you missed it: STAT, a media company focused on finding and telling compelling stories about health, medicine, and scientific discovery, recently ran an article by members of the Scientific Advisory Board for the Translational Research Institute for Space Health. Collins A, Suennen L, Kherlopian AR. "Space-bound billionaires can help make the world a healthier place through research." STAT. 2021 Sep 24 can be found at https://www.statnews.com/2021/09/24/billionaires-spaceflight-research-improve-earthlings-health/?fbclid=IwAR0ToGjNazlwtTsiFvIx3gReZRH5HWJafHy-nmwGBUQxoT49q4NWmSnP0_M.
 
Papers deriving from NASA support:
 
1
Urbaniak C, Grams T, Mason CE, Venkateswaran K.
Simulated microgravity promotes horizontal gene transfer of antimicrobial resistance genes between bacterial genera in the absence of antibiotic selective pressure.
Life (Basel). 2021 Sep;11(9):960.
https://pubmed.ncbi.nlm.nih.gov/34575109
PIs: C. Urbaniak, K. Venkateswaran
Note: A high aspect ratio vessel was used in this study. ISS results. This article and an article directly below (Sheppard et al.) and two articles below in the "Other" section (Siddiqui et al. and Keller et al.) are part of Special Issue "Space Life Sciences" (https://www.mdpi.com/journal/life/special_issues/space_bio). The Special Issue also includes articles from previous Current Awareness Lists #917 https://doi.org/10.3390/life10090196;
#920 https://doi.org/10.3390/life10100235; #933 https://doi.org/10.3390/life11010033 and https://doi.org/10.3390/life11020109; #953 https://doi.org/10.3390/life11060492 and https://doi.org/10.3390/life11050449; and #965 https://doi.org/10.3390/life11080829,https://doi.org/10.3390/life11080770, and https://doi.org/10.3390/life11080741. Additional articles may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: "This study was funded by the National Aeronautics and Space Administration 2020 Space Biology (NNH18ZTT001N-FG2) grant (80NSSC21K0320) awarded to CU and a 2012 Space Biology NNH12ZTT001N Grant No. 19-12829-26 under Task Order NNN13D111T awarded to KV."
 
2
Sheppard J, Land ES, Toennisson TA, Doherty CJ, Perera IY.
Uncovering transcriptional responses to fractional gravity in Arabidopsis roots.
Life (Basel). 2021 Sep;11(10):1010.
https://doi.org/10.3390/life11101010
PI: I.Y. Perera
Note: ISS results. This article and the article above (Urbaniak et al.) and two articles below (Siddiqui et al. and Keller et al.) are part of Special Issue "Space Life Sciences" (https://www.mdpi.com/journal/life/special_issues/space_bio).
Additional articles may be found in the link to the Special Issue. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: "This work was supported by funding from NASA (Award # NNX10AM72G to I.Y.P.)."
 
3
Raber J, Holden S, Sudhakar R, Hall R, Glaeser B, Lenarczyk M, Rockwell K, Nawarawong N, Sterrett J, Perez R, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen CM, Willey JS, Bobe G, Baker J.
Effects of 5-ion beam irradiation and hindlimb unloading on metabolic pathways in plasma and brain of behaviorally tested WAG/Rij rats.
Front Physiol. 2021 Sep 27;12:746509.
https://www.frontiersin.org/article/10.3389/fphys.2021.746509
PI: J. Baker
Note: Hindlimb unloading study. This article is part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557 and #967 https://doi.org/10.3389/fphys.2021.654906. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 5.6
Funding: "This study was supported by grants from NASA (80NSSC19K0498–P00001 and 80NSSC19K0498)."
 
4
Weiss H, Liu A, Byon A, Blossom J, Stirling L.
Comparison of display modality and human-in-the-loop presence for on-orbit inspection of spacecraft.
Hum Factors. 2021 Sep 24;187208211042782. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34558994
PI: L. Stirling
Note: From the abstract: "Participants (n = 19) performed telerobotic inspection of a virtual spacecraft during two degrees of temporal communication, a Synchronous Inspection task and an Asynchronous Inspection task. Participants executed the two tasks while using three distinct visual displays (2D, 3D, AR) and accompanying control systems." This article may be obtained online without charge.
Journal Impact Factor: 2.888
Funding: "This study was supported by the National Aeronautics and Space Administration (NASA) Human Research Program Award 80NSSC20K0409."
 
5
Beheshti A, McDonald JT, Hada M, Takahashi A, Mason CE, Mognato M.
Genomic changes driven by radiation-induced DNA damage and microgravity in human cells.
Int J Mol Sci. 2021 Sep;22(19):10507. Review.
https://doi.org/10.3390/ijms221910507
PI: A. Beheshti
Note: This article is part of Special Issue "Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment" (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). The Special Issue also includes articles from previous Current Awareness Lists #944 https://doi.org/10.3390/ijms22063070, #947 https://doi.org/10.3390/ijms22073668, #965 https://doi.org/10.3390/ijms22169020, and #967 https://doi.org/10.3390/ijms22179470. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.556
Funding: "This research was funded by University of Padova (BIRD-DOR 2020) to M.M. A.B. was supported and funded by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and The Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404)."
 
6
Wostyn P, Gibson CR, Mader TH.
Optic nerve sheath stiffness as a predictive biomarker for optic disc edema in astronauts.
J Mech Behav Biomed Mater. 2021 Dec;124:104846. Available online 20 September 2021. Letter.
https://pubmed.ncbi.nlm.nih.gov/34555625
Journal Impact Factor: 3.902
Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division (Johnson Space Center).
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Gómez X, Sanon S, Zambrano K, Asquel S, Bassantes M, Morales JE, Otáñez G, Pomaquero C, Villarroel S, Zurita A, Calvache C, Celi K, Contreras T, Corrales D, Naciph MB, Peña J, Caicedo A.
Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions.
npj Microgravity. 2021 Sep 23;7:35. Review.
https://pubmed.ncbi.nlm.nih.gov/34556658
Note: This article may be obtained online without charge.
 
2
[No authors listed]
Open science in space. Editorial.
Nat Med. 2021 Sep 14;27:1485.
https://www.nature.com/articles/s41591-021-01508-1
Note: From the article: "Scientific and medical research conducted in space can bring benefits for all humankind, but this will require commercial space flight companies to embrace open data principles." This article may be obtained online without charge.
 
3
Chai S, Guo S, Yang J, Lu S, Yue Y, Li H, Sun P, Zhang T, Xu B, Sun H, Si S, Zhou J, Yang J, Yang H, Li Z, Cui Y.
Inflammation is involved in response of gastric mucosal epithelial cells under simulated microgravity by integrated transcriptomic analysis.
Am J Transl Res. 2021 Aug 15;13(8):9195-207.
https://pubmed.ncbi.nlm.nih.gov/34540035
Note: A Rotary Cell Culture System was used in this study. This article may be obtained online without charge.
 
4
Chen W, Chen ZQ, Xiang Y, Deng CH, Zhang H, Wang JM.
Analogs of microgravity: The function of Schlemm's canal, intraocular pressure and autonomic nervous during the head-down tilt test in healthy subjects.
Int J Ophthalmol. 2021 Sep 18;14(9):1419-23.
https://pubmed.ncbi.nlm.nih.gov/34540620
Note: Head-down tilt test study. This article may be obtained online without charge.
 
5
Siddiqui R, Qaisar R, Goswami N, Khan NA, Elmoselhi A.
Effect of microgravity environment on gut microbiome and angiogenesis.
Life (Basel). 2021 Sep;11(10):1008.
https://doi.org/10.3390/life11101008
Note: From the abstract: "Here, the potential association of angiogenesis with visual impairment, skeletal muscle and gut microbiome is proposed and explored." This article and two articles above in the "NASA" section (Urbaniak et al. and Sheppard et al.) and an article below (Keller et al.) are part of Special Issue "Space Life Sciences" (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.
 
6
Keller RJ, Porter W, Goli K, Rosenthal R, Butler N, Jones JA.
Biologically-based and physiochemical life support and in situ resource utilization for exploration of the solar systemReviewing the current state and defining future development needs.
Life (Basel). 2021 Aug;11(8):844. Review.
https://doi.org/10.3390/life11080844
Note: This article and two articles above in the "NASA" section (Urbaniak et al. and Sheppard et al.) and (Keller et al. directly above) are part of Special Issue "Space Life Sciences" (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.
 
7
Takahashi H, Nakamura A, Shimizu T.
Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level.
Biochem Biophys Res Commun. 2021 Nov 12;578:115-21. Available online 20 September 2021.
https://pubmed.ncbi.nlm.nih.gov/34562651
Note: The method of simulated microgravity is not evident in the available abstract.
 
8
Wang D, Bai P, Zhang B, Su X, Jiang X, Fang T, Wang J, Liu C.
Decreased biofilm formation in Proteus mirabilis after short-term exposure to a simulated microgravity environment.
Braz J Microbiol. 2021 Sep 23. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34558030
Note: A high-aspect rotating vessel bioreactor was used in this study.
 
9
Wingelaar-Jagt YQ, Wingelaar TT, Riedel WJ, Ramaekers JG.
Fatigue in aviation: Safety risks, preventive strategies and pharmacological interventions.
Front Physiol. 2021 Sep 6;12:712628. Review.
https://pubmed.ncbi.nlm.nih.gov/34552504
Note: This article is part of Research Topic "Aerospace Health and Safety: Today and the Future" (https://www.frontiersin.org/research-topics/10667/aerospace-health-and-safety-today-and-the-future#articles). The Research Topic also includes articles from previous Current Awareness Lists #873 https://doi.org/10.3389/fphys.2019.01366, #893 https://doi.org/10.3389/fphys.2020.00299, #897 https://doi.org/10.3389/fpubh.2020.00119, #907 https://doi.org/10.3389/fphys.2020.00837, #910 https://doi.org/10.3389/fphys.2020.00781, #911 https://doi.org/10.3389/fphys.2020.00960, #918 https://doi.org/10.3389/fpubh.2020.00327, #936 https://doi.org/10.3389/fphys.2020.577325, #940 https://doi.org/10.3389/fphys.2021.643943, and #942 https://doi.org/10.3389/fphys.2021.651977. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
10
Jaster JH, Ottaviani G.
Gravitational ischemia in the brain - may be exacerbated by high altitude and reduced partial pressure of oxygen, inducing lung changes mimicking neurogenic pulmonary edema.
Int J Cardiol. 2021 Sep 21. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34555443
 
11
Chen G, Liang B, Bawa G, Chen H, Shi K, Hu Y, Chen P, Fan Y, Pu T, Sun X, Yong T, Liu W, Liu J, Du J, Yang F, Wang X, Yang W.
Gravity reduced nitrogen uptake via the regulation of brace unilateral root growth in maize intercropping.
Front Plant Sci. 2021 Sep 6;12:724909.
https://pubmed.ncbi.nlm.nih.gov/34552608
Note: This article may be obtained online without charge.
 
12
Wakabayashi H, Matsuda O, Fujita T, Kume A.
Practical application of proximal sensing for monitoring the growth of Physcomitrium patens.
Biological Sciences in Space. 2021;35:32-40.
https://doi.org/10.2187/bss.35.32
Note: From the abstract: "Plant culture experiments in space require non-destructive and automated assessment of growth that is efficient and unattended. Currently, plant growth conditions in spacecraft are often captured by ordinary RGB (red, green blue) cameras. In addition to images in the RGB wavelengths, near-infrared (NIR) images that are not affected by plant pigments, such as chlorophylls, could be used to improve the quality of growth-related information. In this study, we examined the possibility of using NIR to assess the growth status of a model moss plant, Physcomitrium (Physcomitrella) patens." This article may be obtained online without charge.
 
13
Averhoff B, Kirchner L, Pfefferle K, Yaman D.
Natural transformation in Gram-negative bacteria thriving in extreme environments: From genes and genomes to proteins, structures and regulation.
Extremophiles. 2021 Sep 20. Online ahead of print. Review.
https://pubmed.ncbi.nlm.nih.gov/34542714
Note: This article may be obtained online without charge.
 
14
Zhang D, Deng T, Luo Z, Zhu A, Yang B, Zhong H, Li S, Yang X.
[Surface modification of titanium implant with hBMP-2/hIGF-1 for promoting biocompatibility and osteogenesis].
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 20;41(8):1277-82. Chinese.
https://pubmed.ncbi.nlm.nih.gov/34549722
 
15
Benderitter M, Herrera-Reyes E, Gigov Y, Souleau B, Huet JC, Trompier F, Fagot T, Grégoire E, Malfuson JV, Konopacki-Potet J, Buglova E, Lataillade JJ, Tamarat R, Gourmelon P, de Revel T.
Hematopoietic recovery using multi-cytokine therapy in 8 patients presenting radiation-induced myelosuppression after radiological accidents.
Radiat Res. 2021 Sep 23. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34554263
 
16
Goh VST, Takebayashi K, Nakayama R, Fujishima Y, Yoshida MA, Kasai K, Ariyoshi K, Miura T.
Cytokinesis-block micronucleus assay performed in 0 and 2 Gy irradiated whole blood and isolated PBMCs in a six-well transwell co-culture system.
Int J Radiat Biol. 2021 Sep 27;1-10. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34554021
 
17
Singh VK, Fatanmi OO, Wise SY, Carpenter A, Nakamura-Peek S, Serebrenik AA, Kaytor MD.
A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice.
Int J Radiat Biol. 2021 Sep 23:1-27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34554032
 
18
Szojka ARA, Li DX, Sopcak MEJ, Ma Z, Kunze M, Mulet-Sierra A, Adeeb SM, Westover L, Jomha NM, Adesida AB.
Mechano-hypoxia conditioning of engineered human meniscus.
Front Bioeng Biotechnol. 2021 Sep 3;9:739438.
https://pubmed.ncbi.nlm.nih.gov/34540817
Note: From the abstract: "Meniscus fibrochondrocytes (MFCs) experience simultaneous hypoxia and mechanical loading in the knee joint. Experimental conditions based on these aspects of the native MFC environment may have promising applications in human meniscus tissue engineering. We hypothesized that in vitro 'mechano-hypoxia conditioning' with mechanical loading such as dynamic compression (DC) and cyclic hydrostatic pressure (CHP) would enhance development of human meniscus fibrocartilage extracellular matrix in vitro." This article may be obtained online without charge.
 
19
Takata R, Kanehira M, Kato Y, Matsuura T, Kato R, Maekawa S, Obara W.
Improvement of three-dimensional motion sickness using a virtual reality simulator for robot-assisted surgery in undergraduate medical students: A prospective observational study.
BMC Med Educ. 2021 Sep 21;21(1):498.
https://pubmed.ncbi.nlm.nih.gov/34548032
Note: This article may be obtained online without charge.
 
20
Mao T, Dinges D, Deng Y, Zhao K, Yang Z, Lei H, Fang Z, Yang FN, Galli O, Goel N, Basner M, Rao H.
Impaired vigilant attention partly accounts for inhibition control deficits after total sleep deprivation and partial sleep restriction.
Nat Sci Sleep. 2021 Sep 16;13:1545-60.
https://pubmed.ncbi.nlm.nih.gov/34557048
Note: This article may be obtained online without charge.
 
21
Zhou L, Fitzpatrick K, Olker C, Vitaterna MH, Turek FW.
Casein kinase 1 epsilon and circadian misalignment impact affective behaviors in mice.
Eur J Neurosci. 2021 Sep 12. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34514665
 
22
Shokravi S, Bahavar N.
Growth and photosynthesis acclimated response of the cyanobacterium Fischerella sp. FS 18 exposed to extreme conditions: Alkaline pH, limited irradiance, and carbon dioxide concentration.
Extremophiles. 2021 Sep 20. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34545451
Note: From the abstract: "This investigation tested the hypothesis that the cyanobacterium can acclimatize under the combined effect of extreme environmental conditions. Here, we analyzed the physiological response of the cyanobacterium under extremely limited irradiance (2 μmol photon m-2 s-1); limited carbon dioxide concentration (no aeration) at alkaline pHs (9 and 11) for up to 96 h."
 
23
Wang C, Sang W, Chen Y, Song D.
[Electrospun PLGA scaffold loaded with osteogenic growth peptide accelerates cranial bone repair in rats].
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 20;41(8):1183-90. Chinese.
https://pubmed.ncbi.nlm.nih.gov/34549709
 

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