SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #967 17 September 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 17, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Cahill T, Cope H, Bass JJ, Overbey EG, Gilbert R, da Silveira WA, Paul AM, Mishra T, Herranz R, Reinsch SS, Costes SV, Hardiman G, Szewczyk NJ, Tahimic CGT.
Mammalian and invertebrate models as complementary tools for gaining mechanistic insight on muscle responses to spaceflight.
Int J Mol Sci. 2021 Sep;22(17):9470.
Note: ISS and hindlimb unloading results. This article and the article below (Kumar et al.) belong to Special Issue "Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment" (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). The Special Issue also includes articles from previous Current Awareness Lists #944 https://doi.org/10.3390/ijms22063070, #947 https://doi.org/10.3390/ijms22073668, and #965 https://doi.org/10.3390/ijms22169020. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.556
Funding: "T.C. was supported by the NI Department for the Economy (DfE) Research Studentship. H.C. is supported by the Horizon Centre for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). R.H. is supported by the Spanish Plan Estatal de Investigación Científica y Desarrollo Tecnológico Grant RTI2018-099309-B-I00. S.S.R. is supported by the NASA Ames Space Biology Program."
 
2
Kumar A, Tahimic CGT, Almeida EAC, Globus RK.
Spaceflight modulates the expression of key oxidative stress and cell cycle related genes in heart.
Int J Mol Sci. 2021 Aug 23;22(16):9088.
PIs: E.A.C. Almeida, R.K. Globus
Note: Space Shuttle Discovery STS-131 mission results. This article and the article above (Cahill et al.) belong to Special Issue "Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment" (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.556
Funding: "This work was supported by a NASA Human Research Program grant (NNH04ZUU005N/RAD 2004-0000-0110) to R.K.G. and a NASA Space Biology grant (NNH08ZTT003N) to E.A.C.A. A.K. was a recipient of a NASA Space Biology Postdoctoral Fellowship award."
 
3
Petersen E, Pattarini JM, Mulcahy RA, Beger SB, Mitchell MR, Hu YD, Middleton KN, Frazier W, Mormann B, Esparza H, Asadi A, Musk ER, Alter G, Nilles E, Menon AS.
Adapting disease prevention protocols for human spaceflight during COVID-19.
Aerosp Med Hum Perform. 2021 Jul 1;92(7):597-602.
PI: A.S. Menon
Note: SpaceX Crew Demo-2 mission results. This HSP [Health Stabilization Program] was implemented during the COVID-19 pandemic. From the abstract: "This article details and discusses the first commercial implementation and adaptation of the HSP prior to the Crew Demo-2 launch."
Journal Impact Factor: 0.889
Funding: "This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A."
 
4
Douglas GL, Wheeler RM, Fritsche RF.
Sustaining astronauts: Resource limitations, technology needs, and parallels between spaceflight food systems and those on Earth.
Sustainability. 2021 Aug 22;13(16):9424.
Note: From the abstract: "Here, we provide a potential approach toward sustainability with the phased addition of bioregenerative foods over the course of NASA's current mission plans." This article belongs to Special Issue "Technologies for Developing Sustaining Foods for Specialized Missions" (https://www.mdpi.com/journal/sustainability/special_issues/SustainingFoods). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: "Support for this manuscript was provided by NASA Advanced Exploration Systems."
 
5
Mahadevan AD, Hupfeld KE, Lee JK, De Dios YE, Kofman IS, Beltran NE, Mulder E, Bloomberg JJ, Mulavara AP, Seidler RD.
Head-down-tilt bed rest with elevated CO2: Effects of a pilot spaceflight analog on neural function and performance during a cognitive-motor dual task.
Front Physiol. 2021 Aug 25;12:654906.
PI: R.D. Seidler
Note: Head-down-tilt bed rest study. This article is part of Research Topic "Brains in Space: Effects of Spaceflight on the Human Brain and Behavior" (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes an article from previous Current Awareness List #956 https://doi.org/10.3389/fncir.2021.659557. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: "This work was supported by grants from the National Aeronautics and Space Administration (NASA; NNX11AR02G and 80NSSC17K0021) and from the National Space Biomedical Research Institute (NSBRI; SA02802) to RS, APM, and JB. During this work, KH received support from a National Science Foundation Graduate Research Fellowship under Grant nos. DGE-1315138 and DGE-1842473, training grant NINDS T32- NS082128, and fellowship NIA F99 AG068440-01."
 
6
Paul A-L, Haveman N, Califar B, Ferl RJ.
Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis.
Front Plant Sci. 2021 Sep 13;12:691790.
PI: A-L. Paul
Note: This article is part of Research Topic "DNA Methylation in Plants Associated with Abiotic Stress" (https://www.frontiersin.org/research-topics/12797/dna-methylation-in-plants-associated-with-abiotic-stress#articles). This article may be obtained online without charge.
Journal Impact Factor: 5.753
Funding: "This work was supported by the National Aeronautics and Space Administration–Space Life and Physical Sciences (NNX14AT24G awarded to A-LP and RF)."
 
7
Smith TG, Buckey JC Jr.
Anaesthetists and aerospace medicine in a new era of human spaceflight.
Anaesthesia. 2021 Sep 8. Online ahead of print.
Note: From the abstract: "Fewer than 600 people have been to space, mostly very fit and healthy professional astronauts who have undergone careful medical screening and selection, but this is about to change. Two billionaires recently took maiden flights on their companies' respective suborbital spacecraft, opening the way for private citizens to fly as paying customers. How will they cope with spaceflight? What should the medical approach to passengers involve? What does this have to do with anaesthetists?"
Journal Impact Factor: 5.739
Funding: "TS is an advisor in aerospace medicine to the Medical Research Council and a Member of Council of the Aerospace Medical Association (USA). He has received research grants or in-kind support from the UK Space Agency, UK Civil Aviation Authority, Royal Air Force and NASA, and has received payments from Caeli Nova for consultancy work. JB is a former payload specialist astronaut and has received funding from NASA, the Office of Naval Research, DARPA and the US National Institutes of Health."
 
8
Wood JM, Peres JB, Bateh J, Singh NK, Aronson HS, Hendrickson R, Mason CE, Venkateswaran K.
Draft genome sequences of heat shock-tolerant microbes isolated from a spacecraft assembly facility.
Microbiol Resour Announc. 2021 Sep 9;10(36):e0065321.
PI: N.K. Singh
Note: From the abstract: "Heat shock-tolerant microorganisms belonging to the orders Bacillales and Micrococcales were isolated from the Spacecraft Assembly Facility at the Jet Propulsion Laboratory, and 63 draft genome sequences were assembled and identified. Further analyses of these genomes can provide insight into methods for preventing forward contamination." This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with NASA. This research was funded by project M2020, administered at JPL in 2018. This project also funded a postdoctoral fellowship for J.M.W. and JPL student fellowships for J.B. and J.B.P."
 
9
Cornforth MN, Bedford JS, Bailey SM.
Destabilizing effects of ionizing radiation on chromosomes: Sizing up the damage.
Cytogenet Genome Res. 2021 Sep 6;1-24. Review. Online ahead of print.
PIs: M.N. Cornforth, S.M. Bailey
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.636
Funding: "Studies were supported by the National Aeronautics and Space Administration (NASA): NNX15AG747G (M.N.C) and 80NSSC19K0434 (S.M.B.)."
 
10
Sides MB, Johnston SL 3rd, Sirek A, Lee PH, Blue RS, Antonsen EL, Basner M, Douglas GL, Epstein A, Flynn-Evans EE, Gallagher MB, Hayes J, Lee SMC, Lockley SW, Monseur B, Nelson NG, Sargsyan A, Smith SM, Stenger MB, Stepanek J, Zwart SR.
Bellagio II Report: Terrestrial applications of space medicine research.
Aerosp Med Hum Perform. 2021 Aug 1;92(8):650-69.
Note: From the abstract: "Teams identified published human spaceflight research and applied translational science models to define mature products for terrestrial clinical practice."
Journal Impact Factor: 0.889
Funding: No funding cited. S.L. Johnston 3rd, G.L. Douglas, S.M.C. Lee, A. Sargsyan, S.M. Smith, M.B. Stenger, and S.R. Zwart are affiliated with NASA Johnson Space Center; E.E. Flynn-Evans is affiliated with NASA Ames Research Center.
 
11
Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM.
Dichotomous effects on lymphatic transport with loss of caveolae in mice.
Acta Physiol (Oxf). 2021 Aug;232(4):e13656. Available online 1 April 2021.
PI: W.E. Cromer
Journal Impact Factor: 5.542
Funding: "The authors thank the Texas A&M University College of Medicine Departments of MCM and MPIM for use of their IVIS scanners. This work was funded in part by Texas A&M University College of Medicine and Department of Medical Physiology. JMR and WEC received support from the Lipedema Foundation. DZ and WW received support in part from the National Heart, Lung And Blood Institute of the National Institutes of Health (U01 HL123420). HAC, RMD, and/or JMR were supported in part by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health (R01 DK119497; DK120493). JMR also received support from the American Heart Association (17GRNT33671220)." PI reports additional funding from NASA grant 80NSSC19K0438.
 
12
Casale CE, Yamazaki EM, Brieva TE, Antler CA, Goel N.
Raw scores on subjective sleepiness, fatigue, and vigor metrics consistently define resilience and vulnerability to sleep loss.
Sleep. 2021 Sep 9;zsab228. Online ahead of print.
PI: N. Goel
Journal Impact Factor: 5.849
Funding: "This work was primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361) to N.G. Other support provided by National Aeronautics and Space Administration (NASA) grant NNX14AN49G and grant 80NSSC20K0243 (to N.G.), National Institutes of Health grant NIH R01DK117488 (to N.G.) and Clinical and Translational Research Center grant UL1TR000003."
 
13
Polutchko SK, Glime GNE, Demmig-Adams B.
Synergistic action of membrane-bound and water-soluble antioxidants in neuroprotection.
Molecules. 2021 Sep;26(17):5385. Review.
PI: B. Demmig-Adams
Note: This article belongs to the Special Issue "Neuroprotective Effect of Food and Natural Bioactive Compounds" (https://www.mdpi.com/journal/molecules/special_issues/natural_bioactives). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.411
Funding: "This work was funded by the University of Colorado and the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A."
 
14
Vahlensieck C, Thiel CS, Zhang Y, Huge A, Ullrich O.
Gravitational force-induced 3D chromosomal conformational changes are associated with rapid transcriptional response in human T cells.
Int J Mol Sci. 2021 Sep;22(17):9426.
Note: Parabolic flight and suborbital ballistic rocket flight results. From the abstract: "To pinpoint potential underlying mechanisms, we compared gene expression and three-dimensional (3D) chromosomal conformational changes in human Jurkat T cells during the short-term gravitational changes in parabolic flight and suborbital ballistic rocket flight experiments." This article belongs to the Collection "21st Anniversary of IJMS: Advances in Biochemistry" (https://www.mdpi.com/journal/ijms/special_issues/21st_Biochem). Additional articles will be forthcoming and may be found in the link to the Collection. This article may be obtained online without charge.
Journal Impact Factor: 5.923
Funding: "The 23rd DLR Parabolic Flight Campaign and the TEXUS-54 mission were funded by the DLR Space Administration on behalf of the Federal Ministry for Economic Affairs and Energy (BMWi; grant numbers: 50WB1219 and 50WB1519). The 4th Swiss Parabolic Flight Campaign was funded by the Swiss SkyLab Foundation and the Swiss Space Office (SSO) of the State Secretariat for Education, Research and Innovation (SBFI; grant number: REF-1131-61001)." Y. Zhang is affiliated with NASA Kennedy Space Center.
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Johannes B, Bronnikov SV, Bubeev JA, Kotrovskaya TI, Shastlivtseva DV, Piechowski S, Hoermann HJ, Jordan J.
Operator's reliability during spacecraft docking training on board Mir and ISS.
Aerosp Med Hum Perform. 2021 Jul;92(7):541-9.
Note: ISS and Mir results.
 
2
Lee I, Barh D, Podolich O, Brenig B, Tiwari S, Azevedo V, Góes-Neto A, Reva O, Kozyrovska N, de Vera JP, Kim BS.
Metagenome-assembled genome sequences obtained from a reactivated kombucha microbial community exposed to a Mars-like environment outside the International Space Station.
Microbiol Resour Announc. 2021 Sep 9;10(36):e0054921.
Note: ISS results. This article may be obtained online without charge.
 
3
Javad Mortazavi SM, Mortazavi SA, Sihver L.
Risk of severe COVID-19 infection in International Space Station astronauts despite routine pre-mission measures.
J Allergy Clin Immunol Pract. 2021 Sep;9(9):3527.
Note: This is a comment on an article that appeared in previous Current Awareness List #918 https://doi.org/10.1016/j.jaip.2020.08.064. This article may be obtained online without charge.
 
4
Pollock RD, Jolley CJ, Abid N, Couper JH, Estrada-Petrocelli L, Hodkinson PD, Leonhardt S, Magor-Elliott S, Menden T, Rafferty G, Richmond G, Robbins PA, Ritchie GAD, Segal MJ, Stevenson AT, Tank HD, Smith TG.
Pulmonary effects of sustained periods of high-G acceleration relevant to suborbital spaceflight.
Aerosp Med Hum Perform. 2021 Aug ;92(8):633-41.
Note: A long-arm human centrifuge was used in this study.
 
5
Tang JW, Henriques A, Loh TP.
Microbes and space travel - hope and hazards.
Future Microbiol. 2021 Sep 7;16:1023-8. Commentary.
 
6
Winnard A, Caplan N, Bruce-Martin C, Swain P, Velho R, Meroni R, Wotring V, Damann V, Weber T, Evetts S, Laws J.
Developing, implementing, and applying novel techniques during systematic reviews of primary space medicine data.
Aerosp Med Hum Perform. 2021 Aug;92(8):681-8.
 
7
Li Y, Huang L, Iqbal J, Deng Y.
Investigation on P-glycoprotein function and its interacting proteins under simulated microgravity.
Space: Science & Technology. 2021 Jun 17;2021:9835728.
Note: Hindlimb unloading study. Press release for this article from the SpaceRef website: "It should come as no surprise that astronauts resort to various drugs to ameliorate the symptoms caused by microgravity. Unfortunately for them, microgravity has been noted to have a significant impact on the pharmacokinetics of certain drugs, which could lead to altered efficacy and unexpected outcomes. In particular, delivering an accurate amount of a drug to the brain has become a key problem in space health. In a recent effort to shed some light onto this issue, a team of scientists from Beijing Institute of Technology, China, studied the effects that microgravity has on P-glycoprotein (P-gp), an important efflux transporter. Their results are detailed in their paper published in Space: Science and Technology, on 17 Jun 2021." For the full press release go to http://spaceref.com/space-medicine/cardiac-atrophy-findings-may-set-course-for-preventing-harm-from-long-space-flights.html. This article may be obtained online without charge.
 
8
Fukunaga H.
Stem cell migration: A possible mechanism for the tissue-sparing effect of spatially fractionated radiation.
Radiat Res. 2021 Sep 8. Online ahead of print.
 
9
Wang Q, Lee Y, Pujol-Canadell M, Perrier JR, Smilenov L, Harken A, Garty G, Brenner DJ, Ponnaiya B, Turner HC.
Cytogenetic damage of human lymphocytes in humanized mice exposed to neutrons and x rays 24 h after exposure.
Cytogenet Genome Res. 2021 Sep 6;1-10. Online ahead of print.
 
10
Coleman K, Phillips J, Sciarini M, Stubbs B, Jackson O, Kernagis D.
A metabolic intervention for improving human cognitive performance during hypoxia.
Aerosp Med Hum Perform. 2021 Jul;92(7):556-62.
 
11
Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B.
Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration.
J Physiol. 2021 Sep 10. Online ahead of print.
Note: Bed rest study.
 
12
Duffield GE, Robles-Murguia M, Hou TY, McDonald KA.
Targeted disruption of the inhibitor of DNA binding 4 (Id4) gene alters photic entrainment of the circadian clock.
Int J Mol Sci. 2021 Sep;22(17):9632.
Note: This article and the article below (Öztürk et al.) belong to the Special Issue "Molecular and Cellular Mechanisms of Synchronization within the Mammalian Circadian System" (https://www.mdpi.com/journal/ijms/special_issues/Synchronization_Circadian). This article may be obtained online without charge.
 
13
Öztürk M, Ingenwerth M, Sager M, von Gall C, Ali AAH.
Does a red house affect rhythms in mice with a corrupted circadian system?
Int J Mol Sci. 2021 Feb 25;22(5):2288.
Note: This article and the article above (Duffield et al.) belong to the Special Issue "Molecular and Cellular Mechanisms of Synchronization within the Mammalian Circadian System" (https://www.mdpi.com/journal/ijms/special_issues/Synchronization_Circadian). This article may be obtained online without charge.
 
...

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

NanoRacks