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NASA Spaceline Current Awareness List #964 27 August 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, August 27, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Crucian B, Valentine R, Calaway K, Miller R, Rubins K, Hopkins M, Salas Z, Krieger S, Makedonas G, Nelman-Gonzalez M, McMonigal K, Perusek G, Lehnhardt K, Easter B.
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions.
Life Sci Space Res. 2021 Nov;31:29-33. Available online 15 July 2021.
https://doi.org/10.1016/j.lssr.2021.07.003
Note: ISS results. From the abstract: "We performed ground and flight validation of a device designed to monitor WBC and differential within minutes from a fingerstick blood sample." This article may be obtained online without charge.
Journal Impact Factor: 2.082
Funding: "The authors wish to thank both ISS astronauts for their important contributions to making this technical evaluation successful. The authors also thank both the Exploration Medical Capability Element and Research Operations and Integration at NASA JSC, for their role in selection, funding, and enabling this flight evaluation. In particular, the authors are grateful to Mr. Scott Humbert in ROI at NASA JSC for his work to make this project successful."
 
2
Hupfeld KE, McGregor HR, Koppelmans V, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Reuter-Lorenz PA, Wood SJ, Bloomberg JJ, Mulavara AP, Seidler RD.
Brain and behavioral evidence for reweighting of vestibular inputs with long-duration spaceflight.
Cereb Cortex. 2021 Aug 20;bhab239. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34416764
PI: R.D. Seidler
Note: ISS results.
Journal Impact Factor: 5.043
Funding: "The National Aeronautics and Space Administration (NASA NNX11AR02G) to R.S., A.M., S.W., P.A.R.L., and J.B; National Space Biomedical Research Institute (#NCC 9–58) to R.S., A.M., S.W., P.A.R.L., and J.B. During completion of this work, A National Science Foundation Graduate Research Fellowship under grant nos DGE-1315138, DGE-1842473 to K.H.; National Institute of Neurological Disorders and Stroke training grant no. T32-NS082128 to K.H.; National Institute on Aging fellowship 1F99AG068440 to K.H.; A Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship and a NASA Human Research Program augmentation grant to H.M."
 
3
Casale CE, Brieva TE, Yamazaki EM, Antler CA, Goel N.
Acute sleep deprivation in humans.
In: Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, 2021.
https://doi.org/10.1016/B978-0-12-822963-7.00005-0
PI: N. Goel
Note: From the abstract: "This article provides a comprehensive overview of the impact of acute total sleep deprivation in humans on various biological processes and on neurobehavioral performance, relative to robust interindividual differences. It reviews a number of promising biomarkers to predict responses to total sleep deprivation including genetic, omic (e.g., transcriptomic, epigenomic and metabolomic) and neuroimaging markers, as well as describes several biomathematical models of sleep-wake regulation and their role in research in this field. Additionally, this article offers effective strategies, including napping and caffeine administration, to combat subsequent deficits following total sleep deprivation."
Journal Impact Factor: Not applicable to this publication.
Funding: "PI reports funding under NASA 80NSSC20K0243."
 
4
Casale CE, Goel N.
Genetic markers of differential vulnerability to sleep loss in adults.
Genes. 2021 Aug 26;12(9):1317. Review.
https://doi.org/10.3390/genes12091317
PI: N. Goel
Note: The article belongs to the Special Issue "Genetics of Sleep, Sleep Loss, and Cognitive Impairment" (https://www.mdpi.com/journal/genes/special_issues/Genetics_Sleep). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.096
Funding: "This review was supported by National Aeronautics and Space Administration (NASA) grant NNX14AN49G and grant 80NSSC20K0243 (to N.G.), and National Institutes of Health grant NIH R01DK117488 (to N.G.). The APC was funded by a research account from Rush University Medical Center (to N.G.)."
 
5
Brieva TE, Casale CE, Yamazaki EM, Antler CA, Goel N.
Cognitive throughput and working memory raw scores consistently differentiate resilient and vulnerable groups to sleep loss.
Sleep. 2021 Aug 1;zsab197. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34333658
PI: N. Goel
Journal Impact Factor: 4.805
Funding: "This work was primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361) to N.G. Other support provided by National Aeronautics and Space Administration (NASA) NNX14AN49G and grant 80NSSC20K0243 (to N.G.), National Institutes of Health grant NIH R01DK117488 (to N.G.) and Clinical and Translational Research Center grant UL1TR000003."
 
6
Matula EE, Nabity JA, McKnight DM.
Supporting simultaneous air revitalization and thermal control in a crewed habitat with temperate Chlorella vulgaris and eurythermic Antarctic Chlorophyta.
Front Microbiol. 2021 Aug 24;12:709746.
https://doi.org/10.3389/fmicb.2021.709746
Note: This article and an article listed below in the "Other" section (Poughon et al.) are part of Research Topic "Bioregenerative Life-Support Systems for Crewed Missions to the Moon and Mars" (https://www.frontiersin.org/research-topics/16705/bioregenerative-life-support-systems-for-crewed-missions-to-the-moon-and-mars#articles). The Research Topic also includes articles from previous Current Awareness Lists #960 https://doi.org/10.3389/fspas.2021.699688, https://pubmed.ncbi.nlm.nih.gov/34276632, https://doi.org/10.3389/fspas.2021.700370, https://doi.org/10.3389/fspas.2021.711550, https://doi.org/10.3389/fmicb.2021.700010, https://doi.org/10.3389/fspas.2021.700579,https://doi.org/10.3389/fspas.2021.699097, and #961 https://doi.org/10.3389/fspas.2021.665649, #962 https://doi.org/10.3389/fspas.2021.700270. Additional articles may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.235
Funding: "This work was funded by a NASA Space Technology Research Fellowship (NNX15AP52H). …Cultures for this study were provided by the McMurdo Long-Term Ecological Research (MCM-LTER) group, which is supported by NSF Grant #OPP-1637708."
 
7
Kennedy Z, Newberg J, Goelzer M, Judex S, Fitzpatrick CK, Uzer G.
Modeling stem cell nucleus mechanics using confocal microscopy.
Biomech Model Mechanobiol. 2021 Aug 23.
https://pubmed.ncbi.nlm.nih.gov/34424419
Note: From the abstract: "Nuclear mechanics is emerging as a key component of stem cell function and differentiation. While changes in nuclear structure can be visually imaged with confocal microscopy, mechanical characterization of the nucleus and its sub-cellular components require specialized testing equipment. …Here, we developed a computational framework for generating finite element models of isolated cell nuclei from multiple confocal microscopy scans and simple atomic force microscopy (AFM) tests."
Journal Impact Factor: 2.527
Funding: "NASA ISGC NNX15AI04H, NIH awards R01AG059923, 5P2CHD086843-03, P20GM109095, P20GM103408 and NSF awards 1929188 & 2025505."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Stahn AC, Kühn S.
Brains in space: The importance of understanding the impact of long-duration spaceflight on spatial cognition and its neural circuitry.
Cogn Process. 2021 Aug 18. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34409546
Note: From the abstract: "We provide examples from historic spaceflight missions, spaceflight analogs, and extreme environments suggesting that spatial cognition and its neural circuitry could be impaired during long-duration spaceflight, and identify recommendations and future steps to mitigate these risks." This article may be obtained online without charge.
 
2
Poughon L, Creuly C, Godia F, Leys N, Dussap C-G.
Photobioreactor Limnospira indica growth model: Application from the MELiSSA plant pilot scale to ISS flight experiment.
Front Astron Space Sci. 2021 Aug 25;8:700277.
https://doi.org/10.3389/fspas.2021.700277
Note: This article and an article listed above in the "NASA" section (Matula et al.) are part of Research Topic "Bioregenerative Life-Support Systems for Crewed Missions to the Moon and Mars" (https://www.frontiersin.org/research-topics/16705/bioregenerative-life-support-systems-for-crewed-missions-to-the-moon-and-mars#articles). From the abstract: "The present work concerns the fourth MELiSSA compartment (C4a), which is the photosynthetic microalgae compartment in charge of producing part of oxygen for the LSS [Life Support System] and converts part of waste nitrogen into consumable biomass material." This article may be obtained online without charge.
 
3
Genchi GG, Degl'Innocenti A, Martinelli C, Battaglini M, De Pasquale D, Prato M, Marras S, Pugliese G, Drago F, Mariani A, Balsamo M, Zolesi V, Ciofani G.
Cerium oxide nanoparticle administration to skeletal muscle cells under different gravity and radiation conditions.
ACS Appl Mater Interfaces. 2021 Aug 19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34410709
Note: The methods of simulated microgravity are not specified in the available abstract.
 
4
Hartel C, Nasonova E, Ritter S, Friedrich T.
Alpha-particle exposure induces mainly unstable complex chromosome aberrations which do not contribute to radiation-associated cytogenetic risk.
Radiat Res. 2021 Aug 19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34411274
 
5
Kim SH, Kim SY, Ryu J, Jo YD, Choi HI, Kim JB, Kang SY.
Suggested doses of proton ions and gamma-rays for mutation induction in 20 plant species.
Int J Radiat Biol. 2021 Aug 17;1-21. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34402731
 
6
Singh VK, Seed TM.
Radiation countermeasures for hematopoietic acute radiation syndrome: Growth factors, cytokines and beyond.
Int J Radiat Biol. 2021 Aug 17;1-67. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34402734
 
7
Verma S, Keshri GK, Karmakar S, Mani KV, Chauhan S, Yadav A, Sharma M, Gupta A.
Effects of microwave 10 GHz radiation exposure in the skin of rats: An insight on molecular responses.
Radiat Res. 2021 Aug 18. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34407201
 
8
Wu X, Zhu T, Zhang H, Lu L, He X, Liu C, Fan SJ.
Identification of odor biomarkers in irradiation injury urine based on headspace SPME-GC-MS.
Int J Radiat Biol. 2021 Aug 17;1-26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34402727
Note: From the abstract: "This study confirmed the 'special odor' induced by irradiation injury, and identified biomarkers through urine VOCs [volatile organic compounds] analysis for the first time, which can provide a novel approach and insight to evaluate irradiation injury noninvasively, accurately, and conveniently."
 
9
Montgomery LD, Oloff C.
Segmental volume and circulatory changes that occur in humans and Rhesus monkeys during 4 hour, -6 degree head down tilt.
J Electr Bioimpedance. 2021 Jan;12(1):11-6. Available online 17 April 2021.
https://pubmed.ncbi.nlm.nih.gov/34413918
Note: Head-down tilt study. This article may be obtained online without charge.
 
10
Kawashima T, Ji RC, Itoh Y, Agata N, Sasai N, Murakami T, Sokabe M, Hamada F, Kawakami K.
Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading.
Muscle Nerve. 2021 Aug 19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34409627
Note: Hindlimb unloading study.
 
11
Yao D, He Q, Bai S, Zhao H, Yang J, Cui D, Yu Y, Fei X, Mei Y, Cheng Y, Yan S, Huang N, Di Y, Cai X, Wang R, Gao Y, Cheng F, Zhao S, Yang X, Cai X, Han H, Lyu J, Tong Z.
Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading.
Commun Biol. 2021 Aug 19;4(1):933.
https://pubmed.ncbi.nlm.nih.gov/34413463
Note: Hindlimb unloading study. This article may be obtained online without charge.
 
12
Ånell R, Grönkvist M, Gennser M, Eiken O.
High-altitude decompression strain can be reduced by an early excursion to moderate altitude while breathing oxygen.
Eur J Appl Physiol. 2021 Aug 19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34410475
 

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