NASA Spaceline Current Awareness List # 961 6 August 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, August 6, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Arbeille P, Zuj KA, Macias BR, Ebert DJ, Laurie SS, Sargsyan AE, Martin DS, Lee SMC, Dulchavsky SA, Stenger MB, Hargens AR.
Lower body negative pressure reduces jugular and portal vein volumes, and counteracts the cerebral vein velocity elevation during long-duration spaceflight.
J Appl Physiol (1985). 2021 Jul 29. Online ahead of print.
PIs: S.A. Dulchavsky, M.B. Stenger, A.R. Hargens
Note: ISS results. From the abstract: "Data were collected from 14 subjects (11 male) before and during long-duration ISS spaceflights. Ultrasound measures of JVvol [jugular vein volume], PV [portal vein cross-sectional area], and MCV [middle cerebral vein velocity] were acquired while seated and supine before flight and early during spaceflight at days 45 (FD45) and late (FD150) with and without LBNP [lower body negative pressure]."
Journal Impact Factor: 3.044
Funding: "We thank our research collaborators and technical assistants at NASA JSC and KBR, Houston, Texas. We also thank the ISS crew members who volunteered for these studies. Supported by NASA grants NNX13AJ12G "Fluid Distribution before, during and after Prolonged Space Flight," NSSC19K0301 "Venous Congestion and Directed Countermeasures," 80NSSC19K0409 "Self-Generated LBNP for Deep-Space Missions." NNJ11ZSA002NA, "Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance," to M.B. Stenger, Doug/Dulchavsky FS NASA grant # is NNX13AK30G, and CNES (French Space agency) grants (P Arbeille) is, DAR: 480000510."
Bailey JF, Nyayapati P, Johnson GTA, Dziesinski L, Scheffler AW, Crawford R, Scheuring R, O'Neill CW, Chang D, Hargens AR, Lotz JC.
Biomechanical changes in the lumbar spine following spaceflight 1 and factors associated with post2 spaceflight disc herniation.
Spine J. 2021 Aug 2;S1529-9430(21)00845-7. Online ahead of print.
PI: A.R. Hargens
Note: ISS results. From the abstract: "To examine the relationship between prolonged exposure to microgravity and the elevated incidence of post-flight disc herniation, we conducted a longitudinal study to track the spinal health of twelve NASA astronauts before and after approximately 6-months in space." This article may be obtained online without charge.
Journal Impact Factor: 3.191
Funding: "This research was supported by NASA grants NNX10AM18G and NNX13AM89G."
Whitelaw BS, Tanny S, Johnston CJ, Majewska AK, O'Banion MK, Marples B.
In vivo imaging of the microglial landscape after whole brain radiation therapy.
Int J Radiat Oncol Biol Phys. 2021 Jul 24;S0360-3016(21)00908-1. Online ahead of print.
PI: M.K. O'Banion
Journal Impact Factor: 2.368
Funding: "This work was supported by NIH grants F30 MH120974 (BSW), R01 NS114480 (AKM), and R01 AA02711 (AKM); NASA grant NNX16AE07G (MKO); and institutional funding."
Kusuma P, Westmoreland FM, Zhen S, Bugbee B.
Photons from NIR LEDs can delay flowering in short-day soybean and Cannabis: Implications for phytochrome activity.
PLoS One. 2021 Jul 27;16(7):e0255232.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.740
Funding: "This work was supported by the Utah Agricultural Experiment Station (, Utah State University [journal paper number 9398]. The soybean portion of this work was supported by the NASA-CUBES project award number NNX17AJ31G."
Other papers of interest:
Kobel MJ, Wagner AR, Merfeld DM.
Impact of gravity on the perception of linear motion.
J Neurophysiol. 2021 Jul 28. Online ahead of print.
Note: From the abstract: "Previous studies have reported that perceptual thresholds for Earth-vertical (i.e., parallel to gravity) and Earth-horizontal (i.e., perpendicular to gravity) translations are equivalent in healthy adults, suggesting that the nervous system compensates for the presence of gravity. However, past study designs were not able to fully separate the effect of gravity from the potential effects of motion direction and body orientation…. In contrast to prior reports, our data suggest that the nervous system does not universally compensate for the effects of gravity during translation, instead, we showed that the co-linear effect of gravity significantly decreases the sensitivity to stimuli and this effect was larger for motions sensed by the utricles (inter-aural and naso-occipital translation) than for the saccules (superior-inferior translations)."
Brisendine MH, Bond JM.
A glimpse into the early window of muscle unloading.
J Physiol. 2021 Jul 27. Online ahead of print.
Lehder EF, Ashcroft IA, Wildman RD, Ruiz-Cantu LA, Maskery I.
A multiscale optimisation method for bone growth scaffolds based on triply periodic minimal surfaces.
Biomech Model Mechanobiol. 2021 Jul 27. Online ahead of print.
Note: From the abstract: "In this study, we examine six TPMS [triply periodic minimal surfaces] scaffold types for use as tissue growth scaffolds and propose a general methodology to optimise their geometry." This article may be obtained online without charge.
Ahmadi M, Barnard S, Ainsbury E, Kadhim M.
Early responses to low-dose ionizing radiation in cellular lens epithelial models.
Radiat Res. 2021 Jul 29. Online ahead of print.
Note: From the abstract: "The goal of this study was to investigate mechanisms of cataract induction in isolated lens epithelial cells (LEC) exposed to ionizing radiation."
Benković V, Borojević N, Šikić D, Horvat Knežević A, Milić M.
DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo.
Int J Radiat Biol. 2021 Jul 30;1-29. Online ahead of print.
Dawood A, Mothersill C, Seymour C.
Low dose ionizing radiation and the immune response: What is the role of non-targeted effects?
Int J Radiat Biol. 2021 Jul 30;1-60. Review. Online ahead of print.
Jin Y, Li J, Li J, Zhang N, Guo K, Zhang Q, Wang X, Yang K.
Visualized analysis of heavy ion radiotherapy: Development, barriers and future directions.
Front Oncol. 2021 Jul 9;11:634913. Review. Online ahead of print.
Note: This article is part of Research Topic "Evaluation, Prediction and Sparing of Radiation-Induced Normal Tissue Damage in Head and Neck Cancer" ( This article may be obtained online without charge.
Lai YH, Bäumer W, Meneses C, Roback DM, Robertson JB, Mishra SK, Lascelles BDX, Nolan MW.
Irradiation of the normal murine tongue causes upregulation and activation of transient receptor potential (TRP) ion channels.
Radiat Res. 2021 Jul 29. Online ahead of print.
Tack N, Wamelink GWW, Denkova AG, Schouwenburg M, Hilhorst H, Wolterbeek HT, Goedhart PW.
Influence of Martian radiation-like conditions on the growth of Secale cereale and Lepidium sativum.
Front Astron Space Sci. 2021 Aug 02;8:665649.
Note: This article is part of Research Topic "Bioregenerative Life-Support Systems for Crewed Missions to the Moon and Mars" ( The Research Topic also includes articles from previous Current Awareness List #960,,,,,, Additional articles may be found in the link to the Research Topic.
Laitano O, Pindado J, Valera I, Spradlin RA, Murray KO, Villani KR, Alzahrani JM, Ryan TE, Efron PA, Ferreira LF, Barton ER, Clanton TL.
The impact of hindlimb disuse on sepsis-induced myopathy in mice.
Physiol Rep. 2021 Jul 26;9(14):e14979.
Note: Hindlimb unloading study. This article may be obtained online without charge.
Manganotti P, Buoite Stella A, Ajčević M, di Girolamo FG, Biolo G, Franchi MV, Monti E, Sirago G, Marusic U, Šimunič B, Narici M, Pišot R.
Peripheral nerve adaptations to 10 days of horizontal bed rest in healthy young adult males.
Am J Physiol Regul Integr Comp Physiol. 2021 Jul 28. Online ahead of print.
Note: Bed rest study.

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