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NASA Spaceline Current Awareness List # 959 23 July 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, July 23, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Bailey SM, Luxton JJ, McKenna MJ, Taylor LE, George KA, Jhavar SG, Swanson GP.
Ad Astra - Telomeres in space!
Int J Radiat Biol. 2021 Jul 16:1-26. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34270368
PI: S.M. Bailey
Note: ISS results. From the abstract: "Here, I review findings from our NASA Twins Study and Telomeres investigations, highlighting potential mechanistic roles of chronic space radiation exposure in changes in telomere length and persistent DNA damage responses associated with long-duration spaceflight." This article may be obtained online without charge.
Journal Impact Factor: 2.368
Funding: "Astronaut studies were supported by NASA: NNX14AH51G [all Twins Study principal investigators (PIs)]; NNX14AB02G and 80NSSC19K0434 (S.M.B.). Funding for the prostate cancer studies was provided through a philanthropic gift to the Baylor Scott & White Central Texas Foundation, Temple, TX, USA, and the Colorado Office of Economic Development and International Trade (OEDIT) Advanced Industry (AI) Bioscience Proof of Concept (POC) award program, Colorado State University (CSU) Ventures. Graduate student fellowships awarded by CSU’s Program of Research and Scholarly Excellence (PRSE), and the Cancer Biology and Comparative Oncology (CB&CO) PRSE to support quantitative Cell and Molecular Biology (qCMB) studies, are also gratefully acknowledged."
 
2
Gurubhagavatula I, Barger LK, Barnes CM, Basner M, Boivin DB, Dawson D, Drake CL, Flynn-Evans EE, Mysliwiec V, Patterson PD, Reid KJ, Samuels C, Shattuck NL, Kazmi U, Carandang G, Heald JL, Van Dongen HPA.
Guiding principles for determining work shift duration and addressing the effects of work shift duration on performance, safety, and health.
Sleep. 2021 Jul 15;zsab161. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34263305
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.805
Funding: E.E. Flynn-Evans is affiliated with NASA Ames Research Center.
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Mitrikas VG.
[Some aspects of the radiation exposure of cosmonauts traversing the Earth's magnetosphere.]
Aviakosm Ekolog Med. 2021;55(3):51-56. Russian.
https://elibrary.ru/item.asp?id=46184710
Note: From the abstract: "Dose loading of cosmonaut's representative body organs beyond the Earth's magnetosphere was calculated for various scenarios of departure from a reference orbit in space vehicles of different design. Calculation of contribution to the equivalent doses from protons and electrons of Earth's radiations belts and galactic cosmic rays (GCR) demonstrated that, irrespective of vehicle design, during solar minimum and growing activity the equivalent dose does not exceed the established limit for a single exposure to 150 mSv. However, radiation exposure may vary at times depending on the traverse trajectory."
 
2
Tzetlin VV, Bersenev EY, Stepanova GP, Degterenkova NV, Anikeev DAA.
[Monitoring of the effects of isolation factors on human physiological functions within the SIRIUS-19 project.]
Aviakosm Ekolog Med. 2021;55(3):36-44. Russian.
https://elibrary.ru/item.asp?id=46184708
Note: SIRIUS 19 isolation and confinement analog mission results. From the abstract: "The paper presents the results of examination of 6 volunteers (3 males and 3 females) in a 120-day isolation study aimed to simulate a mission to the Moon."
 
3
Ilyin VK, Komissarova DV, Usanova NА, Morozova YA.
[Investigations of microflora from professional test-subjects and volunteers for isolation studies of up to 20 days in duration.]
Aviakosm Ekolog Med. 2021;55(3):57-61. Russian.
https://elibrary.ru/item.asp?id=46184711
Note: From the abstract: "Microbiocenosis in the upper respiration tracts and intestine was investigated in experienced test-subjects who could, possibly, have adapted to stresses during chamber studies of 8 to 10 days in duration faster than first-timers. The eubiotic index was used to assess positive and negative shifts in microbiota. The intestinal microflora in experienced subjects turned out to be more plastic and adapted much faster compared to the inexperienced counterparts. In both groups, the microbiota composition was compromised slightly at the end of acute adaptation and then stabilized."
 
4
Nakajima S, Nagata M, Ikehata A.
Mechanism for enhancing the growth of mung bean seedlings under simulated microgravity.
npj Microgravity. 2021 Jul 15;7(1):26.
https://pubmed.ncbi.nlm.nih.gov/34267213
Note: A clinostat was used in this study. This article may be obtained online without charge.
 
5
Tyrina GЕА, Bobyleva PI, Andreeva ER, Buravkova LB.
[Strome-dependent expansion of hematopoietic precursors during 7-day modeling of the effects of microgravity.]
Aviakosm Ekolog Med. 2021;55(3):28-35. Russian.
https://elibrary.ru/item.asp?id=46184707
Note: The microgravity modeling method was not identified in the English abstract. From the abstract: "In this investigation, we used several optimized models of co-culturing mesenchymal stromal cells (MSCs) and hematopoietic stem and progenitor cells (HSPCs) to analyze the HSPCs suspension fractions following 7-day modeling of the effects of microgravity."
 
6
MacLean MK, Ferris DP.
Human muscle activity and lower limb biomechanics of overground walking at varying levels of simulated reduced gravity and gait speeds.
PLoS One. 2021 Jul 14;16(7):e0253467.
https://pubmed.ncbi.nlm.nih.gov/34260611
Note: A low-cost bodyweight support system was used in this study. This article may be obtained online without charge.
 
7
Pashchenko PS, Sukhoterin AF, Shapovalov PA.
[Structural and functional manifestations of acute and chronic gravitational stress in the adrenal.]
Aviakosm Ekolog Med. 2021;55(3):66-73. Russian.
https://elibrary.ru/item.asp?id=46184713
 
8
Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N.
Mechanical load regulates bone growth via periosteal Osteocrin.
Cell Rep. 2021 Jul 13;36(2):109380.
https://pubmed.ncbi.nlm.nih.gov/34260913
Note: Hindlimb unloading study. This article may be obtained online without charge.
 
9
Ayoub R, Lau K, Yuen N, Fernandes D, Elder M, Yeung J, Wong SC, Nieman BJ.
Spatiotemporal mapping of early volume loss in the mouse brain after cranial irradiation.
Radiat Res. 2021 Jul 16. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34270782
 
10
Shafirkin AV, Grigoriev YG, Ushakov IB, Shurshakov VA.
[Biological effectiveness of fast neutrons and accelerated multicharged ions for derivation of a new dependence of space radiation quality coefficients on linear energy transfer.]
Aviakosm Ekolog Med. 2021;55(3):5-15. Russian.
https://elibrary.ru/item.asp?id=46184705
Note: From the abstract: "The authors review recent experimental data about relative biological effectiveness (RBE) of low absorbed doses (0.01–0.5 Gy) from fast neutrons and accelerated multicharged ions currently accepted as career limits for cosmonauts from the standpoint of late effects risk mitigation."
 
11
Tabocchini MA.
A forty-year journey from "classical" biophysics and radiobiology to hadrontherapy, space radiation and low dose rate underground radiobiology.
Int J Radiat Biol. 2021 Jul 14;1-12. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34259611
 
12
Parihar VK, Syage A, Flores L, Lilagan A, Allen BD, Angulo MC, Song J, Smith SM, Arechavala RJ, Giedzinski E, Limoli CL.
The cannabinoid receptor 1 reverse agonist AM251 ameliorates radiation-induced cognitive decrements.
Front Cell Neurosci. 2021 Jun 28;15:668286.
https://pubmed.ncbi.nlm.nih.gov/34262437
Note: This article may be obtained online without charge.
 
13
Satyamitra MM, Cassatt DR, Taliaferro LP.
A poly-pharmacy approach to mitigate Acute Radiation Syndrome (ARS).
Radiat Res. 2021 Jul 16. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34270773
 
14
Wang Q, Wang Y, Du L, Xu C, Liu Y, Liu Q, Fan S.
Quantitative proteomic analysis of the effects of melatonin treatment for mice suffered from small intestinal damage induced by γ- ray radiation.
Int J Radiat Biol. 2021 Jul 15;1-26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34264173
 
15
Fernandez-Gonzalo R, McDonnell AC, Simpson EJ, Macdonald IA, Rullman E, Mekjavic IB.
Substantial and reproducible individual variability in skeletal muscle outcomes in the cross-over designed Planica bed rest program.
Front Physiol. 2021 Jul 16;12:1101.
https://doi.org/10.3389/fphys.2021.676501
Note: Data and results from three bed rest studies performed at the Planica facility are presented. This article is part of the Research Topic "Investigation of the Inter-individual Variability of Physiological Responses to Changes in Activity Levels-, Gravity Loading-, Nutritional Status, Pharmaceuticals and Exposure to Radiation" (https://www.frontiersin.org/research-topics/14100/investigation-of-the-inter-individual-variability-of-physiological-responses-to-changes-in-activity#articles). The Research Topic also includes articles from previous Current Awareness Lists #921 https://doi.org/10.3389/fphys.2020.573581, #937 https://doi.org/10.3389/fphys.2021.614619, #952 https://doi.org/10.3389/fphys.2021.685473. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
16
Richardson MES, Brown D, Honore D, Labossiere A.
Fragmented day-night cycle induces period lengthening, lowered anxiety, and anhedonia in male mice.
Behav Brain Res. 2021 Sep 10;413:113453.
https://pubmed.ncbi.nlm.nih.gov/34252503
 
17
Schastlivtseva DV, Kalmanov AS, Kotrovskaya TI, Bubeev YA.
[Individual and typological characteristics of operator's EEG reactions to time deviations in the work/rest cycle.]
Aviakosm Ekolog Med. 2021;55(3):45-50. Russian.
https://elibrary.ru/item.asp?id=46184709
 
18
Weenink RP, Wingelaar TT.
The circulatory effects of increased hydrostatic pressure due to immersion and submersion.
Front Physiol. 2021 Jul 19;12:1157.
https://doi.org/10.3389/fphys.2021.699493
Note: Immersion and submersion studies. This article is part of the Research Topic "Cardio-vascular Dysfunction and Physiological Manifestations Induced by Environmental Conditions, Volume II" (https://www.frontiersin.org/research-topics/17903/cardio-vascular-dysfunction-and-physiological-manifestations-induced-by-environmental-conditions-vol#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
19
Bubeev YA, Usov VM, Kryuchkov BI, Syrkin LD, Mikhaylyuk MV.
[Operator's spatial orientation ability during control of remotely-piloted aircraft in virtual reality.]
Aviakosm Ekolog Med. 2021;55(3):16-27. Russian.
https://elibrary.ru/item.asp?id=46184706
Note: From the abstract: "The paper analyzes approaches used in cognitive sciences to explore imagination of 2D and 3D virtual scenes and thus to get insight into the psychological aspects of spatial orientation."
 
20
Soldatov PE, Shulaguin YA, Tyurin-Kuzmin АY, Dyachenko AI.
[Endurance of hypoxic hypoxia after preliminary breathing of normoxic mixtures containing argon or krypton.]
Aviakosm Ekolog Med. 2021;55(3):74-80. Russian.
https://elibrary.ru/item.asp?id=46184714
 

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