Note:Some of the experiments and research missions discussed in this article were performed at NASA Extreme Environment Mission Operations (NEEMO), NASA Human Exploration Research Analog (HERA), the Russian facility Nezemnyy Eksperimental’nyy Kompleks (NEK), the European Astronaut Centre (EAC) facility, and Concordia Research Station in Antarctica—to mention a few.From the abstract: "In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over." This article may be obtained online without charge.
Journal Impact Factor:7.561
Funding:B. Crucian is affiliated with NASA Johnson Space Center.
Ding LH, Yu Y, Edmondson EF, Weil MM, Pop LM, McCarthy M, Ullrich RL, Story MD.
Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes.
Funding:"This work was funded by HATCH award #WIS10338 from the College of Agriculture and Life Sciences, Fall Competition Award #MSN226688 from Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison, and grant #80NSSC19K1483 from the National Aeronautics and Space Administration. …Tecan Infinite M1000 Pro data were obtained at the University of Wisconsin-Madison Biophysics Instrumentation Facility, which was established with support from the University of Wisconsin-Madison and grants BIR-9512577 (NSF) and S10RR13790 (NIH). …Instrument acquisition and lipidomics method development was supported by National Science Foundation (EPS 0236913, MCB 1413036, DBI 0521587, DBI1228622), Kansas Technology Enterprise Corporation, K-IDeA Networks of Biomedical Research Excellence (INBRE) of National Institute of Health (P20GM103418), and Kansas State University."
Silverman JD, Bloom RJ, Jiang S, Durand HK, Dallow E, Mukherjee S, David LA.
Measuring and mitigating PCR bias in microbiota datasets.
PLoS Comput Biol. 2021 Jul 6;17(7):e1009113. Online ahead of print.
Note:From the abstract: "Here we present a paired modeling and experimental approach to characterize and mitigate PCR NPM-bias (PCR bias from non-primer-mismatch sources) in microbiota surveys." This article may be obtained online without charge.
Journal Impact Factor:4.700
Funding:"JDS was supported in part by the Duke University Medical Scientist Training Program (GM007171). JDS and LAD were supported in part by the Global Probiotics Council, a Searle Scholars Award, the Hartwell Foundation, an Alfred P. Sloan Research Fellowship, the Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, the Hartwell Foundation, and NIH 1R01DK116187-01. SM would like to acknowledge the support of grants NSF IIS-1546331, NSF DMS-1418261, NSF IIS-1320357, NSF DMS-1045153, and NSF DMS1613261."
Zhen S, van Iersel M, Bugbee B.
Why far-red photons should be included in the definition of photosynthetic photons and the measurement of horticultural fixture efficacy.
Note:From the abstract: "The future of mankind is tied to the exploration and eventual colonization of space. Currently, people have resided in orbit at a space station. In the future, we will have opportunities to stay on the moon, Mars, or in deeper space, where astronauts are exposed to the hypomagnetic field (HMF), which refers to an extremely weak magnetic field environment compared with the geomagnetic field. However, the potential risks of HMF exposure to human health are often overlooked. Here, we summarize the literature related to the biological effects of HMF and calculate the magnitude of the effect."
Riwaldt S, Corydon TJ, Pantalone D, Sahana J, Wise P, Wehland M, Krüger M, Melnik D, Kopp S, Infanger M, Grimm D.
Role of apoptosis in wound healing and apoptosis alterations in microgravity.
Front Bioeng Biotechnol. 2021 June 17;9:679650. Review.
Note:This article is part of the Research Topic "Wound Management and Healing in Space." See this link for other articles in this issue:https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles. Additional articles will be forthcoming and may be found in the link to the Research Topic.From the abstract: "In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies." This article may be obtained online without charge.
Swaminathan V, Bechtel G, Tchantchaleishvili V.
Artificial tissue creation under microgravity conditions: Considerations and future applications.
Artif Organs. 2021 Jul 5. Review. Online ahead of print.
Note:From the abstract: "We report the case of a diffuse non-aneurysmal subarachnoid hemorrhage due to sudden gravitational changes encountered during complex airflight maneuvers, complicated by hydrocephalus and cerebral vasospasm. This case illustrates a rare phenomenon that may again be encountered in the future with the advent and advancement of civilian spaceflight."
Obata Y, Nakaue H, Hirasaki K, Akimitsu N, Yokoya A.
Expression of an x-ray irradiated EGFP-expressing plasmid transfected into nonirradiated human cells.