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NASA Spaceline Current Awareness List # 957 9 July 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, July 9, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Chen Z, Stanbouly S, Nishiyama NC, Chen X, Delp MD, Qiu H, Mao XW, Wang C.
Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina.
Precis Clin Med. 2021 Jun;4(2):93-108.
https://pubmed.ncbi.nlm.nih.gov/34179686
PI: M.D. Delp
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: "The genomic work carried out at the Loma Linda University Center for Genomics was funded in part by the National Institutes of Health (NIH) (Grant No. S10OD019960) (CW), the Ardmore Institute of Health (Grant No. 2150141) (CW) and Dr. Charles A. Sims’ gift to LLU Center for Genomics. This project was partially supported by NASA Space Biology (Grant No. NNX15AE86G) (MDD and XWM), and American Heart Association (AHA) (Grant No. 18IPA34170301) (CW); and also partially supported by NIH grants HL115195- 06 (HQ)/subcontract (GSU) # SP00013920-02 (CW), and HL137962 (HQ)/subcontract (GSU) # SP00013696-01 (CW)."
 
2
Manian V, Orozco-Sandoval J, Diaz-Martinez V.
Detection of genes in Arabidopsis thaliana L. responding to DNA damage from radiation and other stressors in spaceflight.
Genes (Basel). 2021 Jun 19;12(6):938.
https://pubmed.ncbi.nlm.nih.gov/34205326
Note: ISS results. This article is part of Special Section "Molecular Genetics and Genomics" (https://www.mdpi.com/journal/genes/sections/molecular_genetics). GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 4.096
Funding: "This research was funded by NASA EPSCoR, grant number 80NSSC19M0167. The APC is funded by 80NSSC19M0167."
 
3
Rubinstein L, Schreurs A-S, Torres SM, Steczina S, Lowe MG, Kiffer F, Allen AR, Ronca AE, Sowa MB, Globus RK, Tahimic CGT.
Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.
npj Microgravity. 2021 Jul 6;7(1):24.
https://pubmed.ncbi.nlm.nih.gov/34230490
PIs: C.G.T. Tahimic, R. Globus
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 4.415
Funding: "This work was funded by a grant from the NASA Space Biology Program (R.K.G., C.G.T.T.). L.R. was supported by a fellowship from the NASA Postdoctoral Program (NPP)."
 
4
Pesacreta TC, Acharya A, Hasenstein KH.
Endogenous nutrients are concentrated in specific tissues in the Zea mays seedling.
Protoplasma. 2021 Jul;258(4):863-78.
https://pubmed.ncbi.nlm.nih.gov/33582844
PI: K.H. Hasenstein
Journal Impact Factor: 2.751
Funding: "The research was partially supported by NASA grant 80NSSC17K0344 to KHH." (From Correction https://pubmed.ncbi.nlm.nih.gov/33651220: "The acknowledgment text was omitted from the original version in error.")
 
5
Stewart JJ, Adams WW 3rd, López-Pozo M, Doherty Garcia N, McNamara M, Escobar CM, Demmig-Adams B.
Features of the duckweed Lemna that support rapid growth under extremes of light intensity.
Cells. 2021 Jun 12;10(6):1481.
https://pubmed.ncbi.nlm.nih.gov/34204703
PI: B. Demmig-Adams
Note: This article is part of Special Issue "Photosynthesis under Biotic and Abiotic Environmental Stress." See this link for other articles in this issue: https://www.mdpi.com/journal/cells/special_issues/Photosynthesis_Biotic_Abiotic_Environmental_Stress. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 1.983
Funding: "This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, the National Science Foundation award number IOS-1907338, and the University of Colorado."
 
6
Zimmerman B, Kundu P, Rooney WD, Raber J.
The effect of high fat diet on cerebrovascular health and pathology: A species comparative review.
Molecules. 2021 Jun 4;26(11):3406. Review.
https://pubmed.ncbi.nlm.nih.gov/34199898
PIs: J. Raber; M. Weil/J. Raber NSCOR; J. Baker
Note: This article is part of Special Issue "Nutrition and the Ageing Brain." See this link for other articles in this issue: https://www.mdpi.com/journal/molecules/special_issues/nutrition_ageing_brain. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.267
Funding: "Support for B.Z. was provided by a Beckman Postdoctoral Fellowship with funding provided by the Arnold and Mabel Beckman Foundation and a Burroughs Wellcome Fund Collaborative Research Travel Grant (1018797). Support for PK was provided by NIA T32 AG055378. Support for WDR was provided by Conrad N Hilton Foundation, NIH/NINDS [R01-NS40801, R01-EB007258]. Support for WDR and BZ was provided by NIH/NIA R56AG066634. Support for JR was provided by NIH/NIA RF1 AG059088, R21 AG065914, R21AG065681, RF1AG058273, NIH/NCI R21 CA223461, NASA 80NSSC19K0498–P00001, and a grant from the Brightfocus Foundation." J. Raber reports funding under NASA grant NNX13AD60G and M. Weil NSCOR project, grant NNX15AK13G.
 
7
Zamuruyev K, Ferreira Santos MS, Mora MF, Kurfman EA, Noell AC, Willis PA.
Automated capillary electrophoresis system compatible with multiple detectors for potential in situ spaceflight missions.
Anal Chem. 2021 Jun 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34184887
Note: From the abstract: "For detection of any ionizable species, including organic compounds that do not participate in terrestrial biology (i.e., 'unknown unknowns'), mass spectrometry (MS) is essential. Inorganic ions, or any dissolved charged species present, can be analyzed using capacitively coupled contactless conductivity detection (C4D). Additionally, for the trace analysis of compounds of key interest to astrobiology (particularly, amino acids), laser-induced fluorescence (LIF) detection holds unique promise, due to the fact that it has the highest demonstrated sensitivity of any form of detection. Here, we demonstrate a fully automated, portable capillary electrophoresis analyzer that is capable of all these modes of detection. The prototype system developed here addresses the three most significant challenges for doing electrophoretic separations: precise sample injection, HV isolation, and automation of all operational steps. These key challenges were successfully addressed with the use of custom-designed rotor-stator valves with optimized operational sequences incorporating gas purging steps, rinses, and HV application."
Journal Impact Factor: 6.785
Funding: "The research described in this paper was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Financial support for this project was provided by JPL internal research programs. Emily Kurfman was funded by the NIH Graduate Training Program in Dynamic Aspects of Chemical Biology Grant T32GM008545 from the National Institutes of General Medical Sciences. The authors are grateful to Jed Harrison from University of Alberta and Anthony Ricco from NASA Ames Research Center for hardware design discussions."
 
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Other papers of interest:
 
1
Chakraborty N, Zamarioli A, Gautam A, Campbell R, Mendenhall SK, Childress PJ, Dimitrov G, Sowe B, Tucker A, Zhao L, Hammamieh R, Kacena MA.
Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight.
Comput Struct Biotechnol J. 2021 Jun 8;19:3507-20.
https://pubmed.ncbi.nlm.nih.gov/34194674
Note: ISS results. This article may be obtained online without charge.
 
2
Xu P, Chen H, Hu J, Cai W.
Potential evidence for transgenerational epigenetic memory in Arabidopsis thaliana following spaceflight.
Commun Biol. 2021 Jul 2;4(1):835.
https://pubmed.ncbi.nlm.nih.gov/34215844
Note: Chinese satellite SJ-10 results. From the abstract: "Here, using the offspring of the seedlings grown in microgravity environment in the SJ-10 [Shijian 10] satellite for 11 days and returned to Earth, we systematically studied the potential effects of spaceflight on DNA methylation, transcriptome, and phenotype in the offspring." This article may be obtained online without charge.
 
3
Yarmanova EN.
Development and improvement of countermeasures against negative effects of weightlessness in long-term space flights on board International Space Station.
Hum Physiol. 2021 May;47:328-34.
https://doi.org/10.1134/S036211972103018X
Note: ISS results.
 
4
Degan P, Cortese K, Pulliero A, Bruno S, Gagliani MC, Congiu M, Izzotti A.
Simulated microgravity effects on human adenocarcinoma alveolar epithelial cells: Characterization of morphological, functional, and epigenetic parameters.
Int J Mol Sci. 2021 Jul;22(13):6951.
https://pubmed.ncbi.nlm.nih.gov/34203322
Note: A random positioning machine was used in this study. This article is part of Special Issue "Recent Advances in Microgravity and Cell Adherence" (https://www.mdpi.com/journal/ijms/special_issues/Microgravity_Cell). The Special Issue also includes an article from previous Current Awareness List #948 https://doi.org/10.3390/ijms22094550. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
5
Gao Y, Han H, Du J, He Q, Jia Y, Yan J, Dai H, Cui B, Yang J, Wei X, Yang L, Wang R, Long R, Ren Q, Yang X, Lu J.
Early changes to the extracellular space in the hippocampus under simulated microgravity conditions.
Sci China Life Sci. 2021 Jun 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34185240
Note: Hindlimb unloading study.
 
6
ElGindi M, Ibrahim IH, Sapudom J, Garcia-Sabate A, Teo JCM.
Engineered microvessel for cell culture in simulated microgravity.
Int J Mol Sci. 2021 Jun;22(12):6331.
https://pubmed.ncbi.nlm.nih.gov/34199262
Note: A random positioning machine was used in this study. From the abstract: "In this work, a microvessel for commercial cell culture plates was designed. Four 3D printable (polycarbonate (PC), polylactic acid (PLA) and resin) and castable (polydimethylsiloxane (PDMS)) materials were assessed for biocompatibility with adherent and suspension cell types." This article is part of Special Issue "Molecular Mechanobiology in Space and on Earth" (https://www.mdpi.com/journal/ijms/special_issues/Molecular_Mechanobiology). The Special Issue also includes an article from previous Current Awareness List #928 https://doi.org/10.3390/ijms21238908 and Thiel et al. listed below. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
7
Thiel CS, Vahlensieck C, Bradley T, Tauber S, Lehmann M, Ullrich O.
Metabolic dynamics in short- and long-term microgravity in human primary macrophages.
Int J Mol Sci. 2021 Jul;22(13):6752.
https://pubmed.ncbi.nlm.nih.gov/34201720
Note: ISS and sounding rocket results. From the introduction: "To gain insights into the underlying gravity-dependent mechanisms, we applied metabolomics analyses to two experiments performed on different platforms: a suborbital ballistic rocket flight and an ISS microgravity experiment." This article is part of Special Issue "Molecular Mechanobiology in Space and on Earth" (https://www.mdpi.com/journal/ijms/special_issues/Molecular_Mechanobiology). The Special Issue also includes an article from previous Current Awareness List #928 https://doi.org/10.3390/ijms21238908 and ElGindi et al. listed above. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
8
Grimm D.
Microgravity and space medicine.
Int J Mol Sci. 2021 Jul;22(13):6697.
https://pubmed.ncbi.nlm.nih.gov/34206630
Note: This article is an introductory article to Special Issue "Microgravity and Space Medicine" (https://www.mdpi.com/journal/ijms/special_issues/microgravity). The Special Issue also includes articles from previous Current Awareness Lists #902 https://doi.org/10.3390/ijms21103638, #910 https://doi.org/10.3390/ijms21145054, #917 https://doi.org/10.3390/ijms21186762, #920 https://doi.org/10.3390/ijms21197345, #924 https://doi.org/10.3390/ijms21218205, #930 https://doi.org/10.3390/ijms21249596, #934 https://doi.org/10.3390/ijms22020862, #940 https://doi.org/10.3390/ijms22042132 and https://doi.org/10.3390/ijms22052333, #944 https://doi.org/10.3390/ijms22063252 and https://doi.org/10.3390/ijms22073577, #948 https://doi.org/10.3390/ijms22094585. This article may be obtained online without charge.
 
9
Bacci G, Mengoni A, Emiliani G, Chiellini C, Cipriani EG, Bianconi G, Canganella F, Fani R.
Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: The Mars500 mission.
Microbiome. 2021 Jun 30;9(1):152.
https://pubmed.ncbi.nlm.nih.gov/34193273
Note: Mars500 space simulation results. From the abstract: "Here, we report the characterization of the salivary microbiota from 88 samples taken during and after Mars500 mission for a total of 720 days." This article may be obtained online without charge.
 
10
Ding Y, Cui Y, Yang X, Wang X, Tian G, Peng J, Wu B, Tang L, Cui CP, Zhang L.
Anti-RANKL monoclonal antibody and bortezomib prevent mechanical unloading-induced bone loss.
J Bone Miner Metab. 2021 Jul 1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34212247
Note: Hindlimb unloading study.
 
11
Mladenova V, Mladenov E, Scholz M, Stuschke M, Iliakis G.
Strong shift to ATR-dependent regulation of the G2-checkpoint after exposure to high-LET radiation.
Life (Basel). 2021 Jun;11(6):560.
https://pubmed.ncbi.nlm.nih.gov/34198619
Note: This article is part of Special Issue "Radiobiology in Space" (https://www.mdpi.com/journal/life/special_issues/radiobio_space). The Special Issue also includes articles from previous Current Awareness Lists #914 https://doi.org/10.3390/life10090161, #917 https://doi.org/10.3390/life10090187, #925 https://doi.org/10.3390/life10110274, #927 https://doi.org/10.3390/life10110298, #930 https://doi.org/10.3390/life10120341, #934 https://doi.org/10.3390/life11010054, #936 https://doi.org/10.3390/life11020115. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
12
Pacelli C, Alessia C, Siong LM, Lorenzo A, Moeller R, Fujimori A, Igor S, Silvano O.
Insights into the survival capabilities of Cryomyces antarcticus hydrated colonies after exposure to Fe particle radiation.
J Fungi (Basel). 2021 Jul;7(7):495.
https://pubmed.ncbi.nlm.nih.gov/34206448
Note: This article is part of Special Issue "Ecology and Evolution of Black Fungi" (https://www.mdpi.com/journal/jof/special_issues/black_fungi). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
 
13
De Martino E, Salomoni SE, Hodges PW, Hides J, Lindsay K, Debuse D, Winnard A, Elliott JM, Hoggarth M, Beard D, Cook JA, Ekman R, Hinterwaldner L, Scott J, Weber T, Caplan N.
Intermittent short-arm centrifugation is a partially effective countermeasure against upright balance deterioration following 60-day head-down tilt bed rest.
J Appl Physiol (1985). 2021 Jul 1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34197228
Note: Head-down tilt bed rest study.
 
14
Fomina EV, Lysova NY, Savinkina AO, Zhedyaev RY, Senatorova NA, Kukoba TB.
Role of support receptor stimulation in locomotor training for the prevention of hypogravitational disorders.
Hum Physiol. 2021 May;47:320-7.
https://doi.org/10.1134/S0362119721030051
Note: From the abstract: "The time of stimulation of support receptors in locomotor training was analyzed individually for 13 cosmonauts for each day of a long-term space flight."
 
15
Hettinger ZR, Hamagata K, Confides AL, Lawrence MM, Miller BF, Butterfield TA, Dupont-Versteegden EE.
Age-related susceptibility to muscle damage following mechanotherapy in rats recovering from disuse atrophy.
J Gerontol A Biol Sci Med Sci. 2021 Jun 28;glab186. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34181006
Note: Hindlimb unloading study.
 
16
Nosikova IN, Ryabova AM, Dmitrieva LE, Zakirova AZ, Kitov VV, Tomilovskaya ES, Kozlovskaya IB.
Specific features of the motor potentials of the leg muscles induced by magnetic stimulation under the conditions of a five-day “dry” immersion in healthy volunteers.
Hum Physiol. 2021 May;47:282-8.
https://doi.org/10.1134/S0362119721030130
Note: Dry immersion study.
 
17
Tomilovskaya E, Amirova L, Nosikova I, Rukavishnikov I, Chernogorov R, Lebedeva S, Saveko A, Ermakov I, Ponomarev I, Zelenskaya I, Shigueva T, Shishkin N, Kitov V, Riabova A, Brykov V, Abu Sheli N, Vassilieva G, Orlov O.
The first female dry immersion (NAIAD-2020): Design and specifics of a 3-Day study.
Front Physiol. 2021 Jun 14;12:661959.
https://pubmed.ncbi.nlm.nih.gov/34194336
Note: Dry immersion study. This article may be obtained online without charge.
 
18
Alexander P, Vsevolod L, Elena B, Oleg G, Daria K, Natalia M, Pavel M.
The role of the load-dependent sensory input in control of balance during gait.
J Exp Biol. 2021 Jun 28;jeb.242138. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34180518
Note: Hindlimb unloading study.
 

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