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NASA Spaceline Current Awareness List #948 7 May 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 7, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
Papers deriving from NASA support:
 
1
Macias BR, Ferguson CR, Patel N, Gibson C, Samuels BC, Laurie SS, Lee SMC, Ploutz-Snyder R, Kramer L, Mader TH, Brunstetter T, Alferova IV, Hargens AR, Ebert DJ, Dulchavsky SA, Stenger MB.
Changes in the optic nerve head and choroid over 1 year of spaceflight.
JAMA Ophthalmol. 2021 Apr 29;e210931. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33914020
PIs: B.R. Macias, S.A. Dulchavsky, M.B. Stenger
Note: ISS results. From the article: "In support of our hypothesis, this study documents the late development of optic disc edema in 1 crew member and progressive development of choroidal folds and optic disc edema in another crew member throughout the duration of 1 year in low Earth orbit aboard the International Space Station. As spaceflight missions increase in duration, quantitative analyses of ocular structural and functional changes are important to monitor astronaut health and the efficacy of potential SANS countermeasures."
Journal Impact Factor: 6.198
Funding: "This work was supported by the National Aeronautics and Space Administration Human Research Program as part of the Fluid Shifts (NNJ11ZSA002NA) and Ocular Health studies."
 
2
Schuerger AC, Amaradasa BS, Dufault NS, Hummerick ME, Richards JT, Khodadad CL, Smith TM, Massa GD.
Fusarium oxysporum as an opportunistic fungal pathogen on Zinnia hybrida plants grown on board the International Space Station.
Astrobiology. 2021 Apr 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33926205
Note: ISS results.
Journal Impact Factor: 4.091
Funding: "The authors would like to thank the National Aeronautics and Space Administration for providing the Zinnia hybridatissues from the VEG-01C flight experiment for this study. The VEG-01C validation test flight was funded by NASA's Space Biology program. The flight experiment would not have been possible without help from the VEG and Veggie teams at KSC and SNC-ORBITEC, the ISS program, the Payload Operations and Integration Center and Marshall Space Flight Center, and the tireless efforts of the astronauts on the ISS. We also wish to thank K. Venkateswaran at the Jet Propulsion Laboratory, Pasadena, California, for graciously providing cultures of the ISS-F3 and ISS-F4 strains of Fusarium oxysporum for these studies; and C.S. Cockell at the University of Edinburgh, Scotland—and a second anonymous reviewer—for their helpful suggestions during the review process."
 
3
Simpson AC, Urbaniak C, Singh NK, Wood JM, Debieu M, O'Hara NB, Mason CE, Venkateswaran K.
Draft genome sequences of various bacterial phyla isolated from the International Space Station.
Microbiol Resour Announc. 2021 Apr 29;10(17):e00214-21.
https://pubmed.ncbi.nlm.nih.gov/33927037
PI: C. Jaing
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 0.486
Funding: "Part of the research described was carried out at the Jet Propulsion Laboratory of the California Institute of Technology under a contract with NASA. This research was funded by a 2014 Space Biology NNH14ZTT002N award (grant 80NSSC18K0113) to Crystal Jaing and K.V., which also partially funded postdoctoral fellowships for C.U. and J.M.W. Additionally, A.C.S. was supported by grant 80NM0018D0004, funded to K.V. We thank astronauts Colonel Jack Fischer, Colonel Mark Vande Hei, Norishige Kanai, and Alexander Gerst for collecting samples aboard the ISS, the implementation team (Fathi Karouia) at NASA Ames Research Center for coordinating this effort, and Crystal Jaing (Lawrence Livermore National Laboratory), principal investigator of the team. …The Jet Propulsion Laboratory supercomputing facility staff is acknowledged, notably, Narendra J. Patel (Jimmy) and Edward Villanueva, for continuous support in providing the best possible infrastructure for BIG-DATA analysis."
 
4
Lan M, Phillips SD, Archambault-Leger V, Chepko AB, Lu R, Anderson AP, Masterova KS, Fellows AM, Halter RJ, Buckey JC.
Proposed mechanism for reduced jugular vein flow in microgravity.
Physiol Rep. 2021 Apr;9(8):e14782.
https://pubmed.ncbi.nlm.nih.gov/33931957
PI: J.C. Buckey
Note: From the article: "The cause of reduced IJV flow in space is not well understood, but understanding it is important for preventing in-flight vein thromboses. To explore possible causes, we used a novel numerical model of the cranial circulation. The model was created using MATLAB® Simscape Fluids™ (MathWorks®, Natick, MA). The model simulates changes in body fluid distribution and pressures in various body positions (supine, prone, head down tilt), different gravity conditions (0-g, 1-g, etc.), different body sizes (neck, chest, waist circumference), and the presence of an external pressure device (lower body negative pressure (LBNP), lower body positive pressure (LBPP)) used on the lower extremities." This article may be obtained online without charge.
Journal Impact Factor: 1.535
Funding: "The development of the numerical models was supported by grant CA03401 from the National Space Biomedical Research Institute through NCC 9–58 and by NASA EPSCoR Cooperative Agreement NNX13AD35A."
 
5
Rubinstein L, Paul AM, Houseman C, Abegaz M, Tabares Ruiz S, O'Neil N, Kunis G, Ofir R, Cohen J, Ronca AE, Globus RK, Tahimic CGT.
Placenta-expanded stromal cell therapy in a rodent model of simulated weightlessness.
Cells. 2021 Apr 19;10(4):940.
https://pubmed.ncbi.nlm.nih.gov/33921854
PIs: L. Rubinstein, R.K. Globus, A.M. Paul, NASA Postdoctoral Program Fellowship
Note: Hindlimb unloading study.
Journal Impact Factor: 3.748
Funding: "This work was supported by an Ames Research Innovation Award (ARIA) to R.K.G., L.R. and A.M.P. were supported by a fellowship from the NASA Space Biology Postdoctoral Program (NPP)."
 
6
Sater SH, Sass AM, Seiner A, Natividad GC, Shrestha D, Fu AQ, Oshinski JN, Ethier CR, Martin BA.
MRI-based quantification of ophthalmic changes in healthy volunteers during acute 15° head-down tilt as an analogue to microgravity.
J R Soc Interface. 2021 Apr;18(177):20200920.
https://pubmed.ncbi.nlm.nih.gov/33906382
PIs: C.R. Ethier, B.A. Martin
Note: Head-down tilt study.
Journal Impact Factor: 3.748
Funding: "This study was funded by NASA grant nos 80NSSC20K0920, NNX16AT06G and 80NSSC19K1298; NASA Idaho Space Grant Consortium grant no. NNX10AM75H; National Institute of Neurological Disorders and Stroke grant no. 1R01NS11128301; the Georgia Research Alliance and the NASA Human Research Program."
 
7
Zwart SR, Mulavara AP, Williams TJ, George K, Smith SM.
The role of nutrition in space exploration: Implications for sensorimotor, cognition, behavior and the cerebral changes due to the exposure to radiation, altered gravity, and isolation/confinement hazards of spaceflight.
Neurosci Biobehav Rev. 2021 Apr 26;S0149-7634(21)00185-8. Review.
https://pubmed.ncbi.nlm.nih.gov/33915203
PI: S.M. Smith
Note: From the abstract: "Here we review the nutritional perspective of how these spaceflight hazards affect the astronaut’s brain, behavior, performance, and sensorimotor function. We also assess potential nutrient/nutritional countermeasures that could prevent or mitigate spaceflight risks and ensure that crewmembers remain healthy and perform well during their missions. Just as history has taught us the importance of nutrition in terrestrial exploration, we must understand the role of nutrition in the development and mitigation of spaceflight risks before humans can successfully explore beyond low-Earth orbit."
Journal Impact Factor: 8.330
Funding: "Funding was provided by the NASA Human Research Program’s Human Factors and Behavior and Performance, the Human Health Countermeasures, and Space Radiation Elements for this effort."
 
8
Whittle RS, Diaz-Artiles A.
Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis.
J Appl Physiol (1985). 2021 Apr 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33914657
PI: A. Diaz-Artiles
Journal Impact Factor: 3.044
Funding: "80NSSC20K1521/NASA Human Research Program."
 
 
Please Note: The following articles belong to the Special Issue "Overcoming the Challenges of Space Environment" edited by M. Boerma and I. Koturbash. The articles are available at https://www.tandfonline.com/toc/lesc21/39. Additional articles will be forthcoming and may be found in the link to the Special Issue.
 
9
Boerma M, Koturbash I.
Manned space travel: From a race between nations to a race against the environmental stressors beyond Earth.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):109-12. Editorial.
https://pubmed.ncbi.nlm.nih.gov/33902390
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.552
Funding: No funding cited. M. Boerma is PI on the 80NSSC19K0437 "Gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects" project.
 
10
Willey JS, Britten RA, Blaber E, Tahimic CGT, Chancellor J, Sanford LD, Kubik AJ, Delp MD, Mao XW.
The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):129-79.
https://pubmed.ncbi.nlm.nih.gov/33902391
PIs: J.S. Willey, R.A. Britten, M.D. Delp, X.W. Mao, C.L. Limoli/R.A. Britten/NSCOR, S. Rutkove
Note: Hindlimb unloading study.
Journal Impact Factor: 2.552
Funding: "This project was supported by Willey – NASA Space Biology grant no. NNX15AB50G, NIH/NIAMS 1R21AR072806-01, and the Translational Research Institute for Space Health through NASA NNX16AO69A for award EO005. Britten – NASA grant nos. NNX16AC40G, NNX15AI22G, and NNX14AE73G. Mortreux – NASA grant nos. NNX16AL36G and 80NSSC19K1598. Delp - NASA grant nos. NNX16AC28G, NNX15AE86G, 80NSSC19K1322, and 80NSSC19K1599. Mao-NASA Space Biology grant no. NNX15AB41G, NASA 80NSSC18K0310, 80NSSC20K0986 and LLU Department of Basic Sciences."
 
11
Chancellor J, Nowadly C, Williams J, Aunon-Chancellor S, Chesal M, Looper J, Newhauser W.
Everything you wanted to know about space radiation but were afraid to ask.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):113-28.
https://pubmed.ncbi.nlm.nih.gov/33902392
PI: J. Chancellor
Note: Hindlimb unloading study.
Journal Impact Factor: 2.552
Funding: "The National Institute of Health R01 CA220467 R01 HL127001JCC acknowledges support by the Translational Research Institute for Space Health (TRISH) through NASA NNX16AO69A. JCC and MEC acknowledges support from LaSPACE/NASA Grant Number 80NSSC20M0110. JPW acknowledges support from the National Institute of Health through grants R01 CA220467 and R01 HL127001."
 
12
Davis CM, Allen AR, Bowles DE.
Consequences of space radiation on the brain and cardiovascular system.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):180-218.
https://pubmed.ncbi.nlm.nih.gov/33902387
PIs: C.M. Davis, A.R. Allen, D.E. Bowles
Journal Impact Factor: 2.552
Funding: "This work was supported by NASA research grant 80NSSC18K1080 (CMD), Translational Research Institute through NASA cooperative agreement NNX16AO69A (ARA, DEB) and NASA research grant NNX16AK20G (DEB)."
 
13
Dissmore T, DeMarco AG, Jayatilake M, Girgis M, Bansal S, Li Y, Mehta K, Sridharan V, Gill K, Bansal S, Tyburski JB, Cheema AK.
Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):219-33.
https://pubmed.ncbi.nlm.nih.gov/33902389
PI: M. Boerma, M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Journal Impact Factor: 2.552
Funding: "This study was supported by a grant from the National Space Biomedical Research Institute [RE03701 through NCC 9-58] and NASA [80NSSC17K0425 and 80NSSC19K0437] to Dr. Cheema. The authors would like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008."
 
14
Girgis M, Li Y, Jayatilake M, Gill K, Wang S, Makambi K, Sridharan V, Cheema AK.
Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation.
J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):234-49.
https://pubmed.ncbi.nlm.nih.gov/33902388
PI: M. Boerma, M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Journal Impact Factor: 2.552
Funding: "This study was supported by the National Space Biomedical Research Institute [RE03701 through NCC 9–58] and 1U01AI133561-01 funding from NIH/NIAID to AKC and National Institute of Allergy and Infectious Diseases. The authors would like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Kesserwani H.
Space flight-associated neuroocular syndrome, idiopathic intracranial hypertension, and pseudotumor cerebri: Phenotypic descriptions, pathogenesis, and hydrodynamics.
Cureus. 2021 Mar 25;13(3):e14103. Review.
https://pubmed.ncbi.nlm.nih.gov/33907644
Note: From the abstract: "Recent data from astronauts who have returned to Earth from a long-duration space flight have unequivocally distinguished spaceflight-associated neuro-ocular syndrome (SANS) from idiopathic intracranial hypertension (IIH) and pseudotumor cerebri (PTC). We review the semiology and pathogenesis of these three entities, noting that optic disc edema is what unites them, and this where the similarities between SANS and IIH/PTC end. We distinguish between PTC and IIH and between SANS and IIH/PTC and review the medical and surgical therapy of IIH/PTC." This article may be obtained online without charge.
 
2
Walsh L, Hafner L, Straube U, Ulanowski A, Fogtman A, Durante M, Weerts G, Schneider U.
A bespoke health risk assessment methodology for the radiation protection of astronauts.
Radiat Environ Biophys. 2021 Apr 30. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33929575
 
3
Genah S, Monici M, Morbidelli L.
The effect of space travel on bone metabolism: Considerations on today's major challenges and advances in pharmacology.
Int J Mol Sci. 2021 Apr 27;22(9):4585. Review.
https://pubmed.ncbi.nlm.nih.gov/33925533
Note: This article may be obtained online without charge.
 
4
Simon Á, Smarandache A, Iancu V, Pascu ML.
Stability of antimicrobial drug molecules in different gravitational and radiation conditions in view of applications during outer space missions.
Molecules. 2021 Apr 12;26(8):2221. Review.
https://pubmed.ncbi.nlm.nih.gov/33921448
Note: This article may be obtained online without charge.
 
5
Ho CNQ, Tran MT, Doan CC, Hoang SN, Tran DH, Le LT.
Simulated microgravity inhibits the proliferation of Chang liver cells by attenuation of the major cell cycle regulators and cytoskeletal proteins.
Int J Mol Sci. 2021 Apr 27;22(9):4550.
https://pubmed.ncbi.nlm.nih.gov/33925309
Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
 
6
Restier-Verlet J, El-Nachef L, Ferlazzo ML, Al-Choboq J, Granzotto A, Bouchet A, Foray N.
Radiation on Earth or in space: What does it change?
Int J Mol Sci. 2021 Apr 3;22(7)3739. Review.
https://pubmed.ncbi.nlm.nih.gov/33916740
Note: From the abstract: "This review summarizes the specificities of space radiobiology and opens the debate as regards refinements of current radiation protection concepts that will be useful for the better estimation of risks." This article may be obtained online without charge.
 
7
Useinova AN, Kaliberdenko V, Sapegin ID, Kulanthaivel S, Shterenshis MV, Dmitriyevskaya MI, Balasundaram K.
Influence of inosine on cerebral hemodynamics in space motion sickness in experimental animals.
Cent Nerv Syst Agents Med Chem. 2021 Apr 27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33913407
 
8
Simões MF, Antunes A.
Microbial pathogenicity in space.
Pathogens. 2021 Apr 9;10(4):450. Review.
https://pubmed.ncbi.nlm.nih.gov/33918768
Note: This article may be obtained online without charge.
 
9
Peyroteo MMA, Belinha J, Natal Jorge RM.
Load adaptation through bone remodeling: A mechanobiological model coupled with the finite element method.
Biomech Model Mechanobiol. 2021 Apr 26. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33900492
 
10
Bourdillon N, Jeanneret F, Nilchian M, Albertoni P, Ha P, Millet GP.
Sleep deprivation deteriorates heart rate variability and photoplethysmography.
Front Neurosci. 2021 Apr 8;15:642548.
https://pubmed.ncbi.nlm.nih.gov/33897355
Note: This article may be obtained online without charge.
 

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