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NASA Spaceline Current Awareness List #941 19 March 2021 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 19, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
 
 
Papers deriving from NASA support:
 
1
Hong X, Ratri A, Choi SY, Tash JS, Ronca AE, Alwood JS, Christenson LK.
Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression.
npj Microgravity. 2021 Mar 12;7(1):11.
https://pubmed.ncbi.nlm.nih.gov/33712627
PIs: J.S. Tash, L.K. Christenson
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: "Rodent Research 1 was a joint operation between NASA and the ISS National Lab. This work was supported by the NASA Space Biology Program, Spaceflight Research Opportunities in Space Biology—NNX15AB48G to L.K. Christenson and University of Kansas Medical School research funds to L.K. Christenson."
 
2
Cortesão M, Siems K, Koch S, Beblo-Vranesevic K, Rabbow E, Berger T, Lane M, James L, Johnson P, Waters SM, Verma SD, Smith DJ, Moeller R.
MARSBOx: Fungal and bacterial endurance from a balloon-flown analog mission in the stratosphere.
Front Microbiol. 2021 Feb 22;12:601713.
https://pubmed.ncbi.nlm.nih.gov/33692763
PIs: D.J. Smith, S.M. Waters, NASA Postdoctoral Program Fellowship
Note: Balloon flight of MARSBOx experiment (Microbes in Atmosphere for Radiation, Survival, and Biological Outcomes Experiment). This article may be obtained online without charge.
Journal Impact Factor: 4.235
Funding: "KS, KB-V, TB, and RM were supported by the DLR grant FuEProjekt “ISS LIFE” (Programm RF-FuW, Teilprogramm 475). MC was supported by the DLR/DAAD Research Fellowship Doctoral Studies in Germany, 2017 (57370122). DS funding was from NASA Space Biology and NASA Planetary Protection Research grants. SW was supported by the NASA Postdoctoral Program (NPP) as a fellow."
 
3
Bijlani S, Singh NK, Eedara VVR, Podile AR, Mason CE, Wang CCC, Venkateswaran K.
Methylobacterium ajmalii sp. nov., isolated from the International Space Station.
Front Microbiol. 2021 Mar 15;12(534).
https://www.frontiersin.org/article/10.3389/fmicb.2021.639396
PIs: C.C.C. Wang, K. Venkateswaran
Note: ISS results. This article, available online without charge, belongs to the Special Issue "Extremophiles: Microbial Genomics and Taxogenomics" (https://www.frontiersin.org/research-topics/15100/extremophiles-microbial-genomics-and-taxogenomics#articles). Another microbial genomics- and taxogenomics-related article is listed within this Current Awareness list. Additional articles will be forthcoming and may be found in the link to the special issue.
Journal Impact Factor: 4.235
Funding: "The research described in this manuscript was funded by a 2012 Space Biology NNH12ZTT001N Grant No. 19-12829- 26 under Task Order NNN13D111T awarded to KV, and NASA’s 2018 Space Biology (ROSBio) NNH18ZTT001N-FG App B: Flight and Ground Space Biology Research Grant No. 80NSSC19K1501 awarded to CCCW."
 
4
Eller KA, Aunins TR, Courtney CM, Campos JK, Otoupal PB, Erickson KE, Madinger NE, Chatterjee A.
Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria.
Commun Biol. 2021 Mar 12;4(1):331.
https://pubmed.ncbi.nlm.nih.gov/33712689
PI: A. Chatterjee
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.165
Funding: "We acknowledge financial support from W. M. Keck Foundation and DARPA Young Faculty Award (D17AP00024) and National Aeronautics and Space Administration (NASA) Cooperative Agreement Notice––Translational Research Institute (TRISH) award number NNX16A069A to A.C., NSF Graduate fellowship (DGE 1144083) to C.M.C."
 
5
Rahman SA, Brainard GC, Czeisler CA, Lockley SW.
Spectral sensitivity of circadian phase resetting, melatonin suppression and acute alerting effects of intermittent light exposure.
Biochem Pharmacol. 2021 Mar 9:114504. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33711285
PIs: C.G. Brainard, C.A. Czeisler, S.W. Lockley
Journal Impact Factor: 4.960
Funding: "This work was supported by the National Space Biomedical Research Institute (HPF01301) and the National Institute of Mental Health (R01MH45130). SAR, GCB, CAC, and SWL were supported in part by the National Space Biomedical Research Institute through NASA NCC 9-58. The project was supported by Brigham and Women’s Hospital General Clinical Research Center grant M01 RR02635 and by the Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital."
 
6
Zheng M, Domanskyi S, Piermarocchi C, Mias GI.
Visibility graph based temporal community detection with applications in biological time series.
Sci Rep. 2021 Mar 11;11(1):5623.
https://pubmed.ncbi.nlm.nih.gov/33707481
PI: G.I. Mias
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: "This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (project T0412). S.D. acknowledges support by the NIH under R01GM122085."
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Karlin JN, Farajzadeh J, Stacy S, Esfandiari M, Rootman DB.
The effect of zero gravity on eyelid and brow position.
Ophthalmic Plast Reconstr Surg. 2021 Mar 8. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33710037
Note: From the abstract: "Images of astronauts on earth and in space were collected from a National Aeronautics and Space Administration image library. For each astronaut, front facing portraits captured within a 5-year period were obtained. At least 6 photos were collected per astronaut, 3 taken on earth, and 3 in zero gravity. Measurements from the center of the pupil to the upper eyelid margin (MRD1) and center of the pupil to the inferior eyebrow margin [pupil-to-brow (PTB)] were performed digitally for each image and averaged for each condition and each individual. Differences in mean MRD1 and PTB were assessed to illustrate the effects of zero gravity on eyelid and eyebrow position respectively. Linear-mixed effects modeling, analysis of variance and post hoc power analysis were performed."
 
2
Kim DS, Vaquer S, Mazzolai L, Roberts LN, Pavela J, Watanabe M, Weerts G, Green DA.
The effect of microgravity on the human venous system and blood coagulation: A systematic review.
Exp Physiol. 2021 Mar 11. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33704837
Note: From the abstract: "Whilst data is limited, our systematic review suggests that microgravity and its analogues may induce an enhanced coagulation state due to venous changes most prominent in the cephalad venous system, as a consequence of changes in venous flow, distension, pressures, endothelial damage, and possibly hypercoagulability in microgravity and its analogues. However, whether such changes precipitate an increased VTE risk in spaceflight remains to be determined."
 
3
Marusic U, Narici M, Šimunič B, Pišot R, Ritzmann R.
Non-uniform loss of muscle strength and atrophy during bed rest: A systematic review.
J Appl Physiol (1985). 2021 Mar 11. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33703945
Note: Bed rest study. 
 
4
Zhang G, Li X, Wu L, Qin YX.
Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells.
Bone Res. 2021 Mar 10;9(1):16.
https://pubmed.ncbi.nlm.nih.gov/33692342
Note: This article may be obtained online without charge.
 
5
Harrison MF, Butler WP, William P, Murad MH, Toups GN.
Decompression sickness risk assessment and awareness in general aviation.
Aerosp Med Hum Perform. 2021 Mar 2;92(3):138-45.
https://www.ingentaconnect.com/contentone/asma/amhp/2021/00000092/00000003/art00003
 
6
Schultzhaus Z, Chen A, Shuryak I, Wang Z.
The transcriptomic and phenotypic response of the melanized yeast Exophiala dermatitidis to ionizing particle exposure.
Front Microbiol. 2021 Jan 12;11:609996.
https://pubmed.ncbi.nlm.nih.gov/33510728
Note: This article, available online without charge, belongs to the Special Issue "Extremophiles: Microbial Genomics and Taxogenomics" (https://www.frontiersin.org/research-topics/15100/extremophiles-microbial-genomics-and-taxogenomics#articles). The other microbial genomics- and taxogenomics-related article is NASA article number 3 within this Current Awareness list. Additional articles will be forthcoming and may be found in the link to the special issue.
 
7
Grant LK, Kent BA, Mayer MD, Stickgold R, Lockley SW, Rahman SA.
Daytime dxposure to short wavelength-enriched light improves cognitive performance in sleep-restricted college-aged adults.
Front Neurol. 2021;12:624217.
https://pubmed.ncbi.nlm.nih.gov/33692742
Note: This article may be obtained online without charge.
 
8
Chua KWD, Kek TL.
A preliminary study: Central vestibular sensitivity affects motion sickness susceptibility through the efficacy of the velocity storage mechanism.
Audiol Res. 2020 Aug 19;10(2):21-30.
https://pubmed.ncbi.nlm.nih.gov/33704147
Note: This article may be obtained online without charge.
 
9
Rosen MA, Romig M, Demko Z, Barasch N, Dwyer C, Pronovost PJ, Sapirstein A.
Smart agent system for insulin infusion protocol management: A simulation-based human factors evaluation study.
BMJ Qual Saf. 2021 Mar 10. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33692190
Note: This article may be obtained online without charge.
 
10
Illingworth DA, Feigh KM.
Impact mapping for geospatial reasoning and decision making.
Hum Factors. 2021 Mar 7:18720821999021. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33682462
 
11
Kappert KDR, Voskuilen L, Smeele LE, Balm AJM, Jasperse B, Nederveen AJ, van der Heijden F.
Personalized biomechanical tongue models based on diffusion-weighted MRI and validated using optical tracking of range of motion.
Biomech Model Mechanobiol. 2021 Mar 7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33682028
 

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