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NASA Spaceline Current Awareness List #864 6 September 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 6, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.


Papers deriving from NASA support:

 

1

Passero FC Jr, Ravi D, McDonald JT, Beheshti A, David KA, Evens AM.

Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma.

Br J Haematol. 2019 Aug 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31452195

Journal Impact Factor: 5.206

Funding: "A.M.E funding supported by Takeda." A. Beheshti is affiliated with NASA Ames Research Center.

 

2

Pendleton MM, Emerzian SR, Liu J, Tang SY, O'Connell GD, Alwood JS, Keaveny TM.

Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae.

Bone. 2019 Aug 21;128:115043.

https://www.ncbi.nlm.nih.gov/pubmed/31445224

PI: J.S. Alwood, 2012 Presidential Early Career Award for Scientist and Engineers (PECASE)

Journal Impact Factor: 4.360

Funding: "This study was supported by NASA Science & Technology Research Fellowship NNX14AM56H (MMP), National Science Foundation Graduate Research Fellowship Program #1752814 (SRE), a NASA Space Biology PECASE (JSA), and grants from the National Institutes of Health (K01AR069116, R21AR069804, R01AR07444) (SYT). This research used resources of the Advanced Light Source, which is a DOE Office of Science User Facility under contract No. DE-AC02-05CH11231. Computational resources were made available through the National Science Foundation via XSEDE, Grant TG-MCA00N019 (TMK)."

 

3

Werner E, Alter A, Deng Q, Dammer EB, Wang Y, Yu DS, Duong DM, Seyfried NT, Doetsch PW.

Ionizing radiation induction of cholesterol biosynthesis in lung tissue.

Sci Rep. 2019 Aug 29;9(1):12546.

https://www.ncbi.nlm.nih.gov/pubmed/31467399

PIs: Y. Wang/P.W. Doetsch/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "This research project was supported in part by the Emory University Integrated Cellular Imaging Microscopy Core of the Winship Cancer Institute comprehensive cancer center grant, P30CA138292, the Emory Integrated Proteomics Core and the Winship Research Pathology Core. This work was funded by NASA-NSCOR grant NNX11AC3OG (Y.W.), DoD grant W81XWH-17-1-0187 to P.D./E.W. This work was also supported by the US National Institute of Health Intramural Research Program Projects Z1AES103328 to (P.D.)."

 

4

Vimal VP, DiZio P, Lackner JR.

Learning and long-term retention of dynamic self-stabilization skills.

Exp Brain Res. 2019 Aug 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31444539

PI: V.P. Vimal, TRISH Postdoctoral Fellowship Program

Journal Impact Factor: 1.878

Funding: "VPV was supported by the Translational Research Institute for Space Health through NASA NNX16AO69A."

 

5

Arsintescu L, Kato KH, Hilditch CJ, Gregory KB, Flynn-Evans E.

Collecting sleep, circadian, fatigue, and performance data in complex operational environments.

J Vis Exp. 2019 Aug 8(150):e59851.

https://www.ncbi.nlm.nih.gov/pubmed/31449253

Journal Impact Factor: 1.108

Funding: "This research was supported by the NASA Systemwide Safety Program."

 

6

Swanson CM, Kohrt WM, Wolfe P, Wright KP Jr, Shea SA, Cain SW, Munch M, Vujović N, Czeisler CA, Orwoll ES, Buxton OM.

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Osteoporos Int. 2019 Aug 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31446439

PI: C.A. Czeisler

Journal Impact Factor: 3.819

Funding: "Data collection was supported by NIA (P01 AG009975), NHLBI (K24 HL76446), and NSBRI through NASA NCC 9-58 (HFP01601), and was conducted in the BWH’s General Clinical Research Center supported by the NCRR (M01 RR02635), and the CCI of the Harvard Clinical and Translational Science Center (1 UL1 RR025758-01). This work was further supported by K23AR070275 (Swanson), P50 HD073063 (Kohrt), and the National Center for Advancing Translational Sciences of the NIH under award number UL1TR000128. CMS is supported by K23AR070275. SAS received support from The Oregon Institute of Occupational Health Sciences at Oregon Health & Science University via funds from the Division of Consumer and Business Services of the State of Oregon, and NIH grants R01 HL142064, R01 HL125893, HL125893-03A1, and R01 HL140577 (to SA Shea); DoD grant PT150133 (to L Hammer); and CDC grant U19 OH010154 (To WK Anger). NV was supported by the following NIH grants: F32AG051325, R01DK099512, R01HL118601, and R01DK105072. OMB was supported in part by the NHLBI (R01HL107240). ESO as overall PI for the Osteoporotic Fractures in Men (MrOS) Study is supported by NIH funding via the following institutes: the National Institute on Aging, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Center for Advancing Translational Sciences, and NIH Roadmap for Medical Research, under the following grant numbers: U01AG027810, U01AG042124, U01AG042139, U01AG042140, U01 AG042143, U01 AG042145, U01 AG042168, and U01 AR066160."

 

7

Shinojima A, Kakeya I, Tada S.

Lamina cribrosa pore diameter and spaceflight-associated neuro-ocular syndrome.

JAMA Ophthalmol. 2019 Aug 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31465096

Note: The authors comment on: Scott JM, Tucker WJ, Martin D, Crowell JB, Goetchius E, Ozgur O, Hamilton S, Otto C, Gonzales R, Ritter M, Newby N, DeWitt J, Stenger MB, Ploutz-Snyder R, Ploutz-Snyder L, Morgan WH, Haykowsky MJ. Association of exercise and swimming goggles with modulation of cerebro-ocular hemodynamics and pressures in a model of spaceflight-associated neuro-ocular syndrome. JAMA Ophthalmol. 2019 Apr 18. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30998818 which appeared in SPACELINE Current Awareness List #846, 20 April 2019.

 

8

Scott JM, Tucker WJ, Haykowsky MJ.

Lamina cribrosa pore diameter and spaceflight-associated neuro-ocular syndromeReply.

JAMA Ophthalmol. 2019 Aug 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31465098

PI: J.M. Scott

Note: The authors reply to #7 above: Shinojima A, Kakeya I, Tada S. Lamina Cribrosa Pore Diameter and Spaceflight-Associated Neuro-ocular Syndrome. JAMA Ophthalmol. 2019 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/31465096.

Journal Impact Factor: 6.667

Funding: "The authors were funded by National Aeronautics and Space Administration Human Research Program Grant and in part through a National Cancer Institute Cancer Center Support Grant (P30 CA008748)."

______________________________________________________

 

 

Other papers of interest:

 

1

Gao R, Duff W, Chizen D, Zello GA, Chilibeck PD.

The effect of a low glycemic index pulse-based diet on insulin sensitivity, insulin resistance, bone resorption and cardiovascular risk factors during bed rest.

Nutrients. 2019 Aug 27;11(9):E2012.

https://www.ncbi.nlm.nih.gov/pubmed/31461862

Note: Bed rest study. This article may be obtained online without charge.

 

2

Sokolovskaya A, Korneeva EA, Virus ED, Kolesov DV, Moskovtsev AA, Kubatiev AA.

Inhibition of cell cycle progression, induction of apoptosis, and changes in surface markers of MEG-01 megakaryoblastic cells exposed to a random positioning machine.

Microgravity Sci Technol. 2019 Aug 28. [Article in Press]

https://link.springer.com/article/10.1007%2Fs12217-019-09737-3

Note: A random positioning machine was used.

 

3

Chazarin B, Ziemianin A, Evans AL, Meugnier E, Loizon E, Chery I, Arnemo JM, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Lefai E, Bertile F.

Limited oxidative stress favors resistance to skeletal muscle atrophy in hibernating brown bears (Ursus arctos).

Antioxidants (Basel). 2019 Aug 22;8(9):E334.

https://www.ncbi.nlm.nih.gov/pubmed/31443506

Note: This article may be obtained online without charge.

 

4

Dang K, Gao Y, Yu H, Xu S, Jiang S, Zhang W, Wang H, Li Z, Gao Y.

Regular alteration of protein glycosylation in skeletal muscles of hibernating Daurian ground squirrels (Spermophilus dauricus).

Comp Biochem Physiol B Biochem Mol Biol. 2019 Nov;237:110323. Epub 2019 Aug 24.

https://www.ncbi.nlm.nih.gov/pubmed/31454680

 

5

Dáttilo M, Antunes HKM, Nunes-Galbes NM, Mônico-Neto M, Souza HS, Quaresma M, Lee KS, Ugrinowitsch C, Tufik S, de Mello MT.

Effects of sleep deprivation on the acute skeletal muscle recovery after exercise.

Med Sci Sports Exerc. 2019 Aug 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31469710

 

6

Lim JY, Choi SJ, Widrick JJ, Phillips EM, Frontera WR.

Passive force and viscoelastic properties of single fibers in human aging muscles.

Eur J Appl Physiol. 2019 Aug 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31468173

 

7

Maffiuletti NA, Green DA, Vaz MA, Dirks ML.

Neuromuscular electrical stimulation as a potential countermeasure for skeletal muscle atrophy and weakness during human spaceflight.

Front Physiol. 2019 Aug 13;10:1031. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31456697

Note: This article may be obtained online without charge.

 

8

Rosa-Caldwell ME, Greene NP.

Muscle metabolism and atrophy: Let's talk about sex.

Biol Sex Differ. 2019 Aug 28;10(1):43. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31462271

Note: This article may be obtained online without charge.

 

9

Ethiraj P, Ottinger AM, Singh T, Singh A, Haire KM, Reddy SV.

Proteasome inhibition suppress microgravity elevated RANK signaling during osteoclast differentiation.

Cytokine. 2019 Aug 27;125:154821.

https://www.ncbi.nlm.nih.gov/pubmed/31470364

Note: A Rotary Cell Culture System was used.

 

10

Gillies M, Haylock R, Hunter N, Zhang W.

Risk of leukemia associated with protracted low-dose radiation exposure: Updated results from the National Registry for Radiation Workers Study.

Radiat Res. 2019 Aug 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31449440

 

11

Roenneberg T, Winnebeck EC, Klerman EB.

Daylight Saving Time and artificial time zonesA battle between biological and social times. 

Front Physiol. 2019 Aug 7;10:944.

https://www.ncbi.nlm.nih.gov/pubmed/31447685

Note: This article may be obtained online without charge.

 

12

Vijayakumar S, Jones SM, Jones TA, Tian C, Johnson KR.

Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.

Sci Rep. 2019 Aug 27;9(1):12430.

https://www.ncbi.nlm.nih.gov/pubmed/31455802

Note: This article may be obtained online without charge.

 

13

Elbin RJ, Kontos AP, Sufrinko A, McElroy M, Stephenson-Brown K, Mohler S, D'Amico NR, Collins MW.

Motion sickness susceptibility and baseline vestibular and ocular-motor performance in adolescent athletes.

J Athl Train. 2019 Aug 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31454287

 

14

Gálvez-Garcia G, Aldunate N, Bascour-Sandoval C, Barramuno M, Fonseca F, Gómez-Milán E.

Decreasing motion sickness by mixing different techniques.

Appl Ergon. 2020 Jan;82:102931. Epub 2019 Aug 21.

https://www.ncbi.nlm.nih.gov/pubmed/31445459

 

15

Javaid A, Chouhna H, Varghese B, Hammam E, Macefield VG.

Changes in skin blood flow, respiration and blood pressure in participants reporting motion sickness during sinusoidal galvanic vestibular stimulation.

Exp Physiol. 2019 Aug 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31468621

 

16

Nowadly CD, Trapp BD, Robinson SK, Richards JR.

Resuscitation and evacuation from Low Earth Orbit: A systematic review.

Prehosp Disaster Med. 2019 Aug 29. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31462335

 

17

Shi HZ, Fan QC, Bai GE, Gao JY, Liu JL, Mi T, Zhao S, Liu Y, Guo LG, Xu D, Li YZ, Chen KX.

Syndrome differentiation of Chinese Medicine in Mars 500 long-term closed environment.

Chin J Integr Med. 2019 Aug 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31456137

Note: Data are from the Mars500 Project.

 

18

Agostinelli D, Lucantonio A, Noselli G, DeSimone A.

Nutations in growing plant shoots: The role of elastic deformations due to gravity loading.

J Mech Phys Solids. 2019 Aug 26. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0022509619306106

Note: From the abstract: The authors present a "discrete model (a gravitropic spring-pendulum system) and then a continuous rod model which is analyzed both analytically (under the assumption of small deformations) and numerically (in the large deformation regime)." This article may be obtained online without charge.

 

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