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NASA Spaceline Current Awareness List #863 30 August 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, August 30, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

  

Papers deriving from NASA support:

 

1

Prisk GK.

Pulmonary challenges of prolonged journeys to space: Taking your lungs to the moon.

Med J Aust. 2019 Aug 16. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31420881

PI: G.K. Prisk

Journal Impact Factor: 5.332

Funding: "Many of the studies were funded by the National Aeronautics and Space Administration (NASA) and the National Space Biomedical Research Institute under various contracts and grants. G Kim Prisk is currently funded by the National Institutes of Health under R01 HL119263."

 

2

Padaki A, Police Reddy A, Lehnhardt K.

The utility of hyperbaric oxygen therapy for human spaceflight – Past, present, and future.

Acta Astronaut. 2019 Nov 1;164:192-6. Epub 2019 Aug 20.

http://www.sciencedirect.com/science/article/pii/S0094576519311865

Note: The use of hyperbaric oxygen therapy for decompression illness during space exploration beyond Low Earth Orbit is discussed.

Journal Impact Factor: 2.482

Funding: No funding cited. K. Lehnhardt is affiliated with NASA Johnson Space Center.

 

3

Lee MD.

GToTree: A user-friendly workflow for phylogenomics.

Bioinformatics. 2019 Mar 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30865266

PI: M.D. Lee

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.531

Funding: "This work was funded in part by NASA Space Biology under [grant NNH16ZTT001N-MOBE] and by NASA’s Planetary Science Division (Astrobiology Program). Part of the computational component of this work was performed on cloud-computing resources made available by the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number ACI-1548562, via JetStream through allocation TG-BCS180020 (Towns et al., 2014)."

 

4

Lee MD.

Applications and considerations of GToTree: A user-friendly workflow for phylogenomics.

Evol Bioinform Online. 2019 Jul 25;15:1176934319862245.

https://www.ncbi.nlm.nih.gov/pubmed/31384124

PI: M.D. Lee

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.203

Funding: "The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded in part by NASA Space Biology under grant NNH16ZTT001N-MOBE and by NASA’s Planetary Science Division (Astrobiology Program)."

 

5

Wostyn P.

Optic disc swelling in astronauts: A manifestation of "glymphedema?"

J Glaucoma. 2019 Aug 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31425337

Note: The author comments on the article: Huang AS, Stenger MB, Macias BR. Gravitational influence on intraocular pressure: Implications for spaceflight and disease. J Glaucoma. 2019 Aug;28(8):756-764. Epub 2019 May 31. https://www.ncbi.nlm.nih.gov/pubmed/31162175, which appeared in SPACELINE Current Awareness List #853, 14 June 2019.

 

6

Huang AS, Stenger MB, Macias BR.

Response to: Optic disc swelling in astronauts: A manifestation of glymphedema.

J Glaucoma. 2019 Aug 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31425338

PIs: M.B. Stenger, B.R. Macias

Note: The authors reply to #4 above: Wostyn P. Optic disc swelling in astronauts: A manifestation of "glymphedema?" J Glaucoma. 2019 Aug 14. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31425337.

Journal Impact Factor: 1.661

Funding: From the original paper: "Funding for this work came from NASA Human Research Program #NNJ11ZSA002NA [MBS and BRM]; NASA Ocular Health Study [MBS and BRM]; 80JSC017N0001-BPBA [BRM]; National Institutes of Health, Bethesda, MD (Grant Numbers K08EY024674 [ASH]; Research to Prevent Blindness Career Development Award 2016 [ASH]; an unrestricted grant from Research to Prevent Blindness [UCLA] (New York, NY)."

 

7

Goulette TR, Zhou J, Dixon WR, Normand MD, Peleg M, McClements DJ, Decker E, Xiao H.

Kinetic parameters of thiamine degradation in NASA spaceflight foods determined by the endpoints method for long-term storage.

Food Chem. 2019 Aug 13;302:125365.

https://www.ncbi.nlm.nih.gov/pubmed/31442703

PI: H. Xiao

Journal Impact Factor: 5.399

Funding: "This work was funded in part by U.S NASA Grant NNX14AP32G. William R. Dixon was supported in part by UMass PepsiCo Fellowship and Initiative for Maximizing Student Development (IMSD) NIH Fellowship."

 

8

Bond DK, Goddard B, Singleterry RC Jr, Bilbao y Leóna S.

Evaluating the effectiveness of common aerospace materials at lowering the whole body effective dose equivalent in deep space.

Acta Astronaut. 2019 Aug 22. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576519311853

Journal Impact Factor: 2.482

Funding: No funding cited. R.C. Singleterry, Jr. is affiliated with NASA Langley Research Center.

 

9

Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA. 

Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice.

Sci Rep. 2019 Aug 20;9(1):12118.

https://www.ncbi.nlm.nih.gov/pubmed/31431669

PI: C.A. Lemere

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "This work was supported by NASA Grant NNX14AI07G (Lemere)."

 

10

Overbey EG, Paul AM, da Silveira WA, Tahimic CGT, Reinsch SS, Szewczyk N, Stanbouly S, Wang C, Galazka JM, Mao XW.

Mice exposed to combined chronic low-dose irradiation and modeled microgravity develop long-term neurological sequelae.

Int J Mol Sci. 2019 Aug 22;20(17):E4094.

https://www.ncbi.nlm.nih.gov/pubmed/31443374

PIs: X.W. Mao; A.M Paul, NASA Postdoctoral Fellowship Program

Note: Hindlimb unloading study. GeneLab: Raw data are available at NASA GeneLab (www.genelab.nasa.gov, accession GLDS-202). This article may be obtained online without charge.

Journal Impact Factor: 4.183

Funding: "This research was funded in part by NASA grant No. 80NSSC17K0693 and NNX13AL97G to XWM and by the NASA Space Biology Program and NASA Space Life and Physical Sciences Research and Applications Division through the GeneLab Project. This research was funded in part by the NASA Space Biology Program to AMP, the BBSRC (BB/N015894/1) to NS, and the NIHR Nottingham Biomedical Research Centre to NS. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The genomic work was carried out at the LLU Center for Genomics which was funded in part by the National Institutes of Health (NIH) grant S10OD019960 (CW), the Ardmore Institute of Health (AIH) grant 2150141 (CW) and a Charles A. Sims’ gift (CW). WDAS acknowledges support from the MUSC Center for Genomics Medicine Bioinformatics. The APC (article processing charge) was funded by the NASA Space Biology Program and NASA Space Life and Physical Sciences Research and Applications Division through the GeneLab Project."

 

11

Chua EC, Sullivan JP, Duffy JF, Klerman EB, Lockley SW, Kristal BS, Czeisler CA, Gooley JJ.

Classifying attentional vulnerability to total sleep deprivation using baseline features of Psychomotor Vigilance Test performance.

Sci Rep. 2019 Aug 20;9(1):12102.

https://www.ncbi.nlm.nih.gov/pubmed/31431644

PIs: C.A. Czeisler, S.W. Lockley

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: "This work was supported by the Defense Advanced Research Projects Agency, USA (N66001–13-C-4035); the Office of Naval Research, USA (N00014-15-1-2408); and the Duke-NUS Signature Research Program funded by the Agency for Science, Technology and Research, Singapore, and the Ministry of Health, Singapore. Studies used in the analysis were supported by the National Institutes of Health (NIH), USA (NIMH R01 MH45130; NCCAM R01 AT002129; NHLBI K24HL105664); the National Space Biomedical Research Institute through NASA NCC 9-58; and the Brigham and Women’s General Clinical Research Center (M01 RR02635). J.J.G. was supported by an NIH Institutional Training Grant (T32-HL07901)."

 

12

Pagnini F, Phillips D, Bercovitz K, Langer E.

Mindfulness and relaxation training for long duration spaceflight: Evidences from analog environments and military settings.

Acta Astronaut. 2019 Aug 23. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576519312111

Journal Impact Factor: 2.482

Funding: "This study was funded by NASA, with the contract NNJ16HK02P."

 

13

Sun L, Ge Y, Sparks JA, Robinson ZT, Cheng X, Wen J, Blancaflor EB.

TDNAscan: A software to identify complete and truncated T-DNA insertions.

Front Genet. 2019 Jul 25;10:685.

https://www.ncbi.nlm.nih.gov/pubmed/31428129

PI: E.B. Blancaflor

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.517

Funding: "This work was supported by ESI Innovation Project of Noble Research Institute and in part by National Aeronautics and Space Administration (NASA grant numbers 80NSSC18K1462 and 80NSSC19KO129) to EB."

 

14

Alula KM, Resau JH, Patel OV.

Impact of g-load shift on temporal expression pattern of apoptosis-linked proteins in the rat mammary gland.

Gravit Space Res. 2019;7(1):13-21.

https://content.sciendo.com/view/journals/gsr/7/1/article-p13.xml

Note:  Centrifugation was used. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "A debt of gratitude is owed to Dr. Karen Plaut (Purdue University) and her collaborators for sharing tissue collected through their NASA grant NNA05CP91A." 

_____________________________________________________

 

 

Other papers of interest:

 

1

Przystupski D, Górska A, Rozborska P, Bartosik W, Michel O, Rossowska J, Szewczyk A, Drag-Zalesińska M, Kasperkiewicz P, Górski J, Kulbacka J.

The cytoprotective role of antioxidants in mammalian cells under rapidly varying UV conditions during stratospheric balloon campaign.

Front Pharmacol. 2019 Aug 2;10:851.

https://www.ncbi.nlm.nih.gov/pubmed/31427965

Note: Balloon flight results. This article may be obtained online without charge.

 

2

Llanos PJ, Andrijauskaite K, Duraisamy VV, Pastrana F, Seedhouse EL, Gangadharan S, Bunegin L, Rico M.

Challenges of ERAU’s first suborbital flight aboard Blue Origin’s New Shepard M7 for the Cell Research Experiment In Microgravity (CRExIM).

Gravit Space Res. 2019;7(1):1-12.

https://content.sciendo.com/view/journals/gsr/7/1/article-p1.xml

Note: Blue Origin New Shepard suborbital Mission 7 results. This article may be obtained online without charge.

 

3

Chen L, Selimovic EA, Daunis M, Bayers TA, Vargas LJ, O’Brien IT, McEnroe CB, Kozerski AE, Vanhoover AC, Gray WD, Caruso JF.

Musculoskeletal outcomes from chronic high-speed high-impact resistive exercise.

Gravit Space Res. 2019;7(1):22–32.

https://content.sciendo.com/view/journals/gsr/7/1/article-p22.xml

Note: A high-speed high-impact device, called an Inertial Exercise Trainer, was used. This article may be obtained online without charge.

 

4

Cho HJ, Baek MO, Khaliq SA, Chon SJ, Son KH, Lee SH, Yoon MS.

Microgravity inhibits decidualization via decreasing Akt activity and FOXO3a expression in human endometrial stromal cells.

Sci Rep. 2019 Aug 20;9(1):12094.

https://www.ncbi.nlm.nih.gov/pubmed/31431660

Note: A clinostat was used. This article may be obtained online without charge.

 

5

Lopez JV, Peixoto RS, Rosado AS.

Inevitable future: Space colonization beyond Earth with microbes first.

FEMS Microbiol Ecol. 2019 Aug 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31437273

 

6

Liang L, Yuan W, Qu L, Li H, Zhang L, Fan GC, Peng T.

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression.

J Transl Med. 2019 Aug 22;17(1):279.

https://www.ncbi.nlm.nih.gov/pubmed/31438970

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

7

Liu H, Guo D, Kong Y, Rui Q, Wang D.

Damage on functional state of intestinal barrier by microgravity stress in nematode Caenorhabditis elegans.

Ecotoxicol Environ Saf. 2019 Aug 18;183:109554.

https://www.ncbi.nlm.nih.gov/pubmed/31434019

Note: A Rotary Cell Culture System was used.

 

8

Liu KC, Fleischman D, Lee AG, Killer HE, Chen JJ, Bhatti MT.

Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: A paradigm of optic disc disease.

Surv Ophthalmol. 2019 Aug 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31449832

Note: Spaceflight associated neuro-ocular syndrome (SANS) is discussed in the review. C. Robert Gibson, OD, of NASA's Spaceflight Optometry Clinic is acknowledged for fundus photographs of SANS.

 

9

Tomiya S, Tamura Y, Kouzaki K, Kotani T, Wakabayashi Y, Noda M, Nakazato K.

Cast immobilization of hindlimb upregulates sarcolipin expression in atrophied skeletal muscles and increases thermogenesis in C57BL/6J mice.

Am J Physiol Regul Integr Comp Physiol. 2019 Aug 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31433681

Note: Hindlimb cast immobilization was used.

 

10

Bergmann PJ.

Change in bone density and reduction in fracture risk: A meta-regression of published trials.

J Bone Miner Res. 2019 Aug 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31433513      

Note: The author comments on the article: Bouxsein ML, Eastell R, Lui LY, Wu LA, de Papp AE, Grauer A, Marin F, Cauley JA, Bauer DC, Black DM. Change in bone density and reduction in fracture risk: A meta-regression of published trials. J Bone Miner Res.  2019 Apr;34(4):632-642. Epub 2019 Jan 23.https://www.ncbi.nlm.nih.gov/pubmed/30674078. The original article was cited in SPACELINE Current Awareness List #835, 1 Feb 2019.

 

11

Bouxsein ML, Eastell R, Liu LY, Wu LA, de Papp AE, Grauer A, Marin F, Cauley JA, Bauer DC, Black DM.

Reply to: Change in bone density and reduction in fracture risk: A meta-regression of published trials.

J Bone Miner Res. 2019 Aug 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31433861      

Note: The authors reply to #11 above: Bergmann PJ. Change in bone density and reduction in fracture risk: A meta-regression of published trials. J Bone Miner Res. 2019 Aug 21. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31433513.

 

12

Chen X, Yang J, Dong D, Lv H, Zhao B, Xue Y, Shang P.

Iron overload as a high risk factor for microgravity-induced bone loss.

Acta Astronaut. 2019 Aug 20. [Article in Press] Review.

http://www.sciencedirect.com/science/article/pii/S0094576519312068

Note: Spaceflight, bed rest, and hindlimb unloading studies are reviewed.

 

13

Corry KA, Zhou H, Brustovetsky T, Himes ER, Bivi N, Horn MR, Kitase Y, Wallace JM, Bellido T, Brustovetsky N, Li J.

Stat3 in osteocytes mediates osteogenic response to loading.

Bone Rep. 2019 Dec;11:100218. Epub 2019 Jul 29.

https://www.ncbi.nlm.nih.gov/pubmed/31440530

Note: Axial ulnar loading was used. This article may be obtained online without charge.

 

14

Durand M, Collombet JM, Frasca S, Sarilar V, Lataillade JJ, Le Bousse-Kerdilès MC, Holy X.

Separate and combined effects of hypobaric hypoxia and hindlimb suspension on skeletal homeostasis and hematopoiesis in mice.

Hypoxia (Auckl). 2019 Jul 25;7:41-52.

https://www.ncbi.nlm.nih.gov/pubmed/31440522

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

15

Nishimori S, O'Meara MJ, Castro C, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Jüppner H, Kronenberg HM, Wein MN. 

Salt-inducible kinases dictate parathyroid hormone receptor action in bone development and remodeling.

J Clin Invest. 2019 Aug 20. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31430259

Note: This article may be obtained online without charge.

 

16

Marques FG, Poli E, Rino J, Pinto MT, Diegues I, Pina F, Santos SCR.

Low doses of ionizing radiation enhance the angiogenic potential of adipocyte conditioned medium.

Radiat Res. 2019 Aug 23. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31442107

 

17

Abe C, Yamaoka Y, Maejima Y, Mikami T, Morita H.

Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex.

J Physiol Sci. 2019 Aug 21. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31435871

Note: Centrifugation was used.

 

18

Anderton R, Posselt B, Komorowski M, Hodkinson P.

Medical considerations for a return to the Moon.

Occup Med (Lond). 2019 Jul;69(5):311-3.

https://www.ncbi.nlm.nih.gov/pubmed/31436819

Note: This editorial is one of several published in the July issue of Occupational Medicine that commemorates the 50th anniversary of the Apollo 11 mission.

 

19

Martyn Y.

Changes in space medicine over the last 50 years.

Occup Med (Lond). 2019 Jul;69(5):314-5.

https://www.ncbi.nlm.nih.gov/pubmed/31436818

Note: This editorial is one of several published in the July issue of Occupational Medicine that commemorates the 50th anniversary of the Apollo 11 mission.

 

20

Moser R.

Occupational medicine's essential contributions to winning the race to the Moon.

Occup Med (Lond). 2019 Jul;69(5):308-10.

https://www.ncbi.nlm.nih.gov/pubmed/31436817

Note: This editorial is one of several published in the July issue of Occupational Medicine that commemorates the 50th anniversary of the Apollo 11 mission.

 

21

Al-Hijab L, Gregg A, Davies R, Macdonald H, Ladomery M, Wilson I.

Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii.

Sci Rep. 2019 Aug 19;9(1):12063.

https://www.ncbi.nlm.nih.gov/pubmed/31427663

Note: This article may be obtained online without charge.

 

22

Nakamura M, Nishimura T, Morita MT.

Bridging the gap between amyloplasts and directional auxin transport in plant gravitropism.

Curr Opin Plant Biol. 2019 Dec;52:54-60. Epub 2019 Aug 22.

https://www.ncbi.nlm.nih.gov/pubmed/31446250

Note: This article may be obtained online without charge.

 

23

Powers SK, Holehouse AS, Korasick DA, Schreiber KH, Clark NM, Jing H, Emenecker R, Han S, Tycksen E, Hwang I, Sozzani R, Jez JM, Pappu RV, Strader LC.

Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana.

Mol Cell. 2019 Jul 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31421981

 

24

Abe T, Dar F, Amnattrakul P, Aydin A, Raison N, Shinohara N, Khan MS, Ahmed K, Dasgupta P.

The effect of repeated full immersion simulation training in ureterorenoscopy on mental workload of novice operators.

BMC Med Educ. 2019 Aug 22;19(1):318.

https://www.ncbi.nlm.nih.gov/pubmed/31438934

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

 

25

Prottengeier J, Keunecke JG, Gall C, Eiche C, Moritz A, Birkholz T.

Single mission workload and influencing factors in German prehospital emergency medicine - A nationwide prospective survey of 1361 emergency missions.

Scand J Trauma Resusc Emerg Med. 2019 Aug 16;27(1):75.

https://www.ncbi.nlm.nih.gov/pubmed/31419996

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

 

 

26

Zhang X, Sun Y, Qiu Z, Bao J, Zhang Y.

Adaptive neuro-fuzzy fusion of multi-sensor data for monitoring a pilot's workload condition.

Sensors (Basel). 2019 Aug;19(16):E3629.

https://www.ncbi.nlm.nih.gov/pubmed/31434346

Note: The NASA Task Load Index was used.  This article may be obtained online without charge.

 

// end //

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