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NASA Spaceline Current Awareness List #853 14 June 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, June 14, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Drew A, Sridharan V, Boerma M, Tackett AJ, Zawieja D, Willey JS, Delp M, Pecaut MJ.

Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

Sci Rep. 2019 Jun 3;9(1):8215.

https://www.ncbi.nlm.nih.gov/pubmed/31160660

PIs: X.W. Mao, J.S. Willey

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: "This study was supported by NASA Space Biology grant # NNX15AB41G, National Institutes of Health grant P20GM121293, UL1TR000039, P20GM103625, S10OD018445 and P20GM103429, NNX15AB50G, and LLU Department of Basic Sciences."

 

2

McNamara KP, Greene KA, Moore AM, Lenchik L, Weaver AA.

Lumbopelvic muscle changes following long-duration spaceflight.

Front Physiol. 2019 May 21;10:627.

https://www.ncbi.nlm.nih.gov/pubmed/31164840

PI: A.A. Weaver

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.394

Funding: "This study is supported by the NASA Human Research Program (Award No. NNX16AP89G) and the contributions by Nisha Subramanian were made possible by the National Science Foundation [REU Site: Imaging and Mechanics-based Projects on Accidental Cases of Trauma (IMPACT), Award No. 1559700]."

 

3

Blachowicz A, Chiang AJ, Elsaesser A, Kalkum M, Ehrenfreund P, Stajich JE, Torok T, Wang CCC, Venkateswaran K.

Proteomic and metabolomic characteristics of extremophilic fungi under simulated Mars conditions.

Front Microbiol. 2019 May 15;10:1013.

https://www.ncbi.nlm.nih.gov/pubmed/31156574

PI: K. Venkateswaran

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.019

Funding: "This research was funded by a JPL Internal Development Program awarded to KV and also funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T awarded to KV and a student fellowship to AB. AC and MK were supported through JPL subcontract 1574847. The use of the City of Hope Mass Spectrometry and Proteomics core facility was partially supported by NIH, National Cancer Institute Grant P30 CA33572."

 

4

Huang AS, Stenger MB, Macias BR.

Gravitational influence on intraocular pressure: Implications for spaceflight and disease.

J Glaucoma. 2019 May 31. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31162175

PIs: M.B. Stenger, B.R. Macias

Journal Impact Factor: 1.742

Funding: "Funding for this work came from NASA Human Research Program #NNJ11ZSA002NA [MBS and BRM]; NASA Ocular Health Study [MBS and BRM]; 80JSC017N0001-BPBA [BRM]; National Institutes of Health, Bethesda, MD (Grant Numbers K08EY024674 [ASH]; Research to Prevent Blindness Career Development Award 2016 [ASH]; an unrestricted grant from Research to Prevent Blindness [UCLA] (New York, NY)."

 

5

Asadi AK, Sá RC, Arai TJ, Theilmann RJ, Hopkins SR, Buxton RB, Prisk GK.

Regional pulmonary perfusion patterns in humans are not significantly altered by inspiratory hypercapnia.

J Appl Physiol (1985). 2019 Jun 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31169470

PI: G.K. Prisk

Journal Impact Factor: 3.256

Funding: "This work was supported by the National Institutes of Health through grants NIH R01 HL104118, HL 119263, HL 129990, R21HL118539 F30 HL110755 and by the National Space Biomedical Research Institute through NASA NCC 9-58. We thank Dr. David Dubowitz for technical assistance with the MRI compatible breathing circuit."

 

6

Blue RS, Bayuse TM, Daniels VR, Wotring VE, Suresh R, Mulcahy RA, Antonsen EL.

Supplying a pharmacy for NASA exploration spaceflight: Challenges and current understanding.

npj Microgravity. 2019 Jun 13;5(1):14. Review.

https://www.nature.com/articles/s41526-019-0075-2 

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.00

Funding: No funding cited. R.A. Mulcahy and E.L. Antonsen are affiliated with NASA Johnson Space Center.

______________________________________________________

 

 

Other papers of interest:

 

1

Ritzmann R, Freyler K, Helm M, Holubarsch J, Gollhofer A.

Stumbling reactions in partial gravity—Neuromechanics of compensatory postural responses and inter-limb coordination during perturbation of human stance.

Front Physiol. 2019 May 21;10:576.

https://www.ncbi.nlm.nih.gov/pubmed/31164834

Note: Parabolic flight results. This article may be obtained online without charge.

 

2

Camberos V, Baio J, Bailey L, Hasaniya N, Lopez LV, Kearns-Jonker M.

Effects of spaceflight and simulated microgravity on YAP1 expression in cardiovascular progenitors: Implications for cell-based repair.

Int J Mol Sci. 2019 Jun 4;20(11):E2742.

https://www.ncbi.nlm.nih.gov/pubmed/31167392

Note: ISS results. A clinostat was used for ground studies. This article may be obtained online without charge.

 

3

Gambacurta A, Merlini G, Ruggiero C, Diedenhofen G, Battista N, Bari M, Balsamo M, Piccirillo S, Valentini G, Mascetti G, Maccarrone M.

Human osteogenic differentiation in space: Proteomic and epigenetic clues to better understand osteoporosis.

Sci Rep. 2019 Jun 6;9(1):8343.

https://www.ncbi.nlm.nih.gov/pubmed/31171801

Note: ISS results. This article may be obtained online without charge.

 

4

Ilgrande C, Mastroleo F, Christiaens MER, Lindeboom REF, Prat D, Van Hoey O, Ambrozova I, Coninx I, Heylen W, Pommerening-Roser A, Spieck E, Boon N, Vlaeminck SE, Leys N, Clauwaert P. 

Reactivation of microbial strains and synthetic communities after a spaceflight to the International Space Station: Corroborating the feasibility of essential conversions in the MELiSSA loop.

Astrobiology. 2019 Jun 4. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31161957

Note: ISS results.

 

5

Kang H, Wu C, Qu Y, Gao M, Zhang W, Sun A, Deng X.

Adaptation of glycocalyx, nitric oxide synthase expression and vascular cell apoptosis in conduit arteries of tail-suspended rats.

Clin Exp Pharmacol Physiol. 2019 Jun 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31175664

Note: Hindlimb unloading study.

 

6

Koaykul C, Kim MH, Kawahara Y, Yuge L, Kino-Oka M.

Alterations in nuclear lamina and the cytoskeleton of bone marrow-derived human mesenchymal stem cells cultured under simulated microgravity conditions.

Stem Cells Dev. 2019 Jun 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31169056

Note: A 3D clinostat was used.

 

7

Cervaens M, Lumini-Oliveira J, Ascensao A, Magalhaes J, Camacho O, Barata P.

The influence of hyperbaric environment on the skeletal muscle mitochondrial energetic of rats after induced muscle contusion.

Undersea Hyperb Med. 2018 Nov-Dec;45(6):653-62.

https://www.ncbi.nlm.nih.gov/pubmed/31158932

 

8

Jones TW, Petersen N, Howatson G.

Optimization of exercise countermeasures for human space flight: Operational considerations for concurrent strength and aerobic training.

Front Physiol. 2019 May 16;10:584. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31156461

Note: This article may be obtained online without charge.

 

9

Bagherian A, Baghani M, George D, Rémond Y, Chappard C, Patlazhan S, Baniassadi M.

A novel numerical model for the prediction of patient-dependent bone density loss in microgravity based on micro-CT images.

Continuum Mech Therm. 2019 Jun 8. [Article in Press]

https://link.springer.com/article/10.1007/s00161-019-00798-8

 

10

McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E, Boerckel JD.

Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration.

Sci Transl Med. 2019 Jun 5;11(495):eaav7756.

https://www.ncbi.nlm.nih.gov/pubmed/31167930

 

11

Negishi-Oshino R, Ohgami N, He T, Ohgami K, Li X, Kato M.

cVEMP correlated with imbalance in a mouse model of vestibular disorder.

Environ Health Prev Med. 2019 Jun 1;24(1):39.

https://www.ncbi.nlm.nih.gov/pubmed/31153359

Note: This article may be obtained online without charge.

 

12

Booker LA, Sletten TL, Alvaro PK, Barnes M, Collins A, Chai-Coetzer CL, Naqvi A, McMahon M, Lockley SW, Rajaratnam SMW, Howard ME.

Exploring the associations between shift work disorder, depression, anxiety and sick leave taken amongst nurses.

J Sleep Res. 2019 May 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31144389

 

13

Phillips AJK, Vidafar P, Burns AC, McGlashan EM, Anderson C, Rajaratnam SMW, Lockley SW, Cain SW.

High sensitivity and interindividual variability in the response of the human circadian system to evening light.

Proc Natl Acad Sci U S A. 2019 Jun11;116(24):12019-24.

https://www.ncbi.nlm.nih.gov/pubmed/31138694

Note: This article may be obtained online without charge.

 

14

Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE, Willett WC, Schernhammer E.

Shift work, chronotype, and melatonin rhythm in nurses.

Cancer Epidemiol Biomarkers Prev. 2019 May 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31142495

 

15

Roenneberg T, Wirz-Justice A, Skene DJ, Ancoli-Israel S, Wright KP, Dijk DJ, Zee P, Gorman MR, Winnebeck EC, Klerman EB.

Why should we abolish daylight saving time?

J Biol Rhythms. 2019 Jun;34(3):227-30.

https://www.ncbi.nlm.nih.gov/pubmed/31170882

Note: The Position Paper from the Society for Research on Biological Rhythms (SRBR) favors the abolition of Daylight Saving Time (DST). This article may be obtained online without charge.

 

16

Almahdi EM, Zaidan AA, Zaidan BB, Alsalem MA, Albahri OS, Albahri AS.

Mobile-based patient monitoring systems: A prioritisation framework using multi-criteria decision-making techniques.

J Med Syst. 2019 Jun 6;43(7):219.

https://www.ncbi.nlm.nih.gov/pubmed/31172296

Note: The Yale-NASA patient monitoring system is compared to other mobile patient monitoring systems based on multi-criteria analysis in architectural components.

 

17

Berman E, Eyal S.

Drug interactions in space: A cause for concern?

Pharm Res. 2019 May 31;36(8):114.

https://www.ncbi.nlm.nih.gov/pubmed/31152244

Note: From the Introduction: "...the aim of the current study was to evaluate the type of alerts generated by Lexi-Interact [drug interaction software] which involve medications aboard the ISS based on publically-available medication lists."

 

18

Morley SA, Peralta-Castro A, Brieba LG, Miller J, Ong KL, Ridge PG, Oliphant A, Aldous S, Nielsen BL.

Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B.

BMC Plant Biol. 2019 Jun 6;19(1):241.

https://www.ncbi.nlm.nih.gov/pubmed/31170927

Note: This article may be obtained online without charge.

 

19

Yuan M, Custaud MA, Xu Z, Wang J, Yuan M, Tafforin C, Treffel L, Arbeille P, Nicolas M, Gharib C, Gauquelin-Koch G, Arnaud L, Lloret JC, Li Y, Navasiolava N.

Multi-system adaptation to confinement during the 180-day Controlled Ecological Life Support System (CELSS) experiment.

Front Physiol. 2019 May 21;10:575.

https://www.ncbi.nlm.nih.gov/pubmed/31164833

Note: Results are reported from a 180-day study in the Chinese Controlled Ecological Life Support System (CELSS). This article may be obtained online without charge.

 

20

Zhang R, Wang Z, Zhang Y.

A person-following nanosatellite for in-cabin astronaut assistance: System design and deep-learning-based astronaut visual tracking implementation.

Acta Astronaut. 2019 Sep;163:121-34. Epub 2019 Jun 5.

https://www.sciencedirect.com/science/article/pii/S0094576519300025

 

21

Alleblas CCJ, Vleugels MPH, Stommel MWJ, Nieboer TE.

Performance of a haptic feedback grasper in laparoscopic surgery: A randomized pilot comparison with conventional graspers in a porcine model.

Surg Innov. 2019 Jun 4. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31161876

Note: The NASA Task Load Index was used.

 

22

Delliaux S, Delaforge A, Deharo JC, Chaumet G.

Mental workload alters heart rate variability, lowering non-linear dynamics.

Front Physiol. 2019 May 14;10:565.

https://www.ncbi.nlm.nih.gov/pubmed/31156454

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

 

23

Georgsson M.

NASA RTLX as a novel assessment for determining cognitive load and user acceptance of expert and user-based evaluation methods exemplified through a mHealth diabetes self-management application evaluation.

Stud Health Technol Inform. 2019;261:185-90.

https://www.ncbi.nlm.nih.gov/pubmed/31156113

Note: The NASA Raw Task Load Index was used.

...

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