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NASA Spaceline Current Awareness List #850 24 May 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 24, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Thiel CS, Tauber S, Lauber B, Polzer J, Seebacher C, Uhl R, Neelam S, Zhang Y, Levine H, Ullrich O.

Rapid morphological and cytoskeletal response to microgravity in human primary macrophages.

Int J Mol Sci. 2019 May 15;20(10):E2402.

https://www.ncbi.nlm.nih.gov/pubmed/31096581

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.687

Funding: "This research was funded by the DLR Space Administration on behalf of the Federal Ministry for Economic Affairs and Energy (BMWi), grant no. 50WB1519." S. Neelam, Y. Zhang, H. Levine, and O. Ullrich are affiliated with NASA Kennedy Space Center. 

 

2

Xu Y, Safari MS, Ma W, Schafer NP, Wolynes PG, Vekilov PG.

Steady, symmetric, and reversible growth and dissolution of individual amyloid-beta fibrils.

ACS Chem Neurosci. 2019 May 17. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31099555

PI: P.G. Vekilov

Journal Impact Factor: 4.21

Funding: "This work was supported by NASA (Grants NNX14AE79G and NNX14AD68G to PGV), NSF (Grants MCB-1518204 and DMR-1710354 to PGV). Additional support was provided by the Center for Theoretical Biological Physics at Rice University sponsored by NSF (Grant PHY-1427654 to PGW)."

 

3

Zhang X, Alexander N, Leonardi I, Mason C, Kirkman LA, Deitsch KW.

Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum.

PLoS Biol. 2019 May 13;17(5):e3000271.

https://www.ncbi.nlm.nih.gov/pubmed/31083650

PI: C. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.163

Funding: "The Department of Microbiology and Immunology at Weill Medical College of Cornell University acknowledges the support of the William Randolph Hearst Foundation. This work was supported by the National Institutes of Health (AI 52390 to KWD, AI 99327 to KWD and LAK, AI76635 to LAK). KWD is a Stavros S. Niarchos Scholar and a recipient of a William Randolf Hearst Endowed Faculty Fellowship. LAK received support from the William Randolph Hearst Foundation as a Clinical Scholar in Microbiology and Infectious Diseases. We would also like to thank funding from the Bert L and N Kuggie Vallee Foundation to CM, the WorldQuant Foundation to CM, The Pershing Square Sohn Cancer Research Alliance to CM, NASA (NNX14AH50G) to CM, the National Institutes of Health (R01ES021006, 1R21AI129851,1R01MH117406) to CM, TRISH (NNX16AO69A:0107, NNX16AO69A:0061) to CM, the Bill and Melinda Gates Foundation (OPP1151054) to CM, and the Leukemia and Lymphoma Society (LLS) grants (LLS 9238-16, LLS-MCL-982) to CM."

 

4

Ade CJ, Bemben DA.

Differential microRNA expression following head-down tilt bed rest: Implications for cardiovascular responses to microgravity.

Physiol Rep. 2019 May;7(9):e14061.

https://www.ncbi.nlm.nih.gov/pubmed/31087541

PI: C.J. Ade

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This study was supported by a National Aeronautics and Space Administration (NASA) research grant (NNX16AR26G) awarded to C.J Ade and D.A. Bemben."

 

5

DeFina LF, Radford NB, Levine BD.

Risks of high coronary artery calcium—Reply.

JAMA Cardiol. 2019 May 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31090884

PI: B.D. Levine

Note: The authors reply to the letters: Kuller LH. Risks of High Coronary Artery Calcium. JAMA Cardiol. 2019 May 15. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31090872, and Shaikh K, Budoff MJ. Risks of High Coronary Artery Calcium. JAMA Cardiol. 2019 May 15.  [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31090871. (See #5 and #6 in the Other section of this List.) The letters and author reply are in reference to DeFina LF, Radford NB, Barlow CE, Willis BL, Leonard D, Haskell WL, Farrell SW, Pavlovic A, Abel K, Berry JD, Khera A, Levine BD. Association of all-cause and cardiovascular mortality with high levels of physical activity and concurrent coronary Artery Calcification. JAMA Cardiol. 2019 Jan 30. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30698608, which appeared in SPACELINE Current Awareness List #835, 8 Feb 2019.

Journal Impact Factor: 10.1

Funding: From the original paper: "This study was supported in part by the National Space Biomedical Research Institute through NASA Cooperative Agreement NCC 9-58."

 

6

Lenarczyk M, Kronenberg A, Mader M, North PE, Komorowski R, Cheng Q, Little MP, Chiang IH, LaTessa C, Jardine J, Baker JE.

Age at exposure to radiation determines severity of renal and cardiac disease in rats.

Radiat Res. 2019 May 16. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31095446

PI: J.E. Baker

Journal Impact Factor: 1.691

Funding: "Support for this work was provided by the National Aeronautical and Space Administration (NASA grant nos. NNX15AD69G and 80NSSC19K0498), the Greater Milwaukee Foundation, the Foundation for Heart Science, and the We Care Fund."

 

7

Moreno-Villanueva M, Zhang Y, Feiveson A, Mistretta B, Pan Y, Chatterjee S, Wu W, Clanton R, Nelman-Gonzalez M, Krieger S, Gunaratne P, Crucian B, Wu H.

Single-cell RNA-sequencing identifies activation of TP53 and STAT1 pathways in human T lymphocyte subpopulations in response to ex vivo radiation exposure.

Int J Mol Sci. 2019 May 10;20(9):E2316.

https://www.ncbi.nlm.nih.gov/pubmed/31083348

PIs: B. Crucian, H. Wu

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.687

Funding: "This project was supported by the Office of the Chief Technologist of NASA Johnson Space Center." The PIs also report funding through NASA’s Human Research Program.

 

8

Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S. 

Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas.

Cancer Res. 2019 May 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31088835

PI: S. Burma

Journal Impact Factor: 9.130

Funding: "SB is supported by grants from the National Institutes of Health (RO1CA197796) and the National Aeronautics and Space Administration (NNX16AD78G). This work was supported in part by the Office of Medical Research, Departments of Veteran Affairs (AAH)."

 

9

Bell ST, Brown SG, Mitchell T.

What we know about team dynamics for long-distance space missions: A systematic review of analog research.

Front Psychol. 2019 May 15;10:811. Review.

https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00811/full

Note: From the abstract: "To anticipate the dynamics of future long-distance space exploration mission (LDSEM) teams, research is conducted in analog environments (e.g., Antarctic expeditions, space chamber simulations), or environments that share key contextual features of LDSEM such as isolation and confinement. We conducted a systematic review of research conducted on teams in LDSEM-analog environments to identify which factors have been examined with quantitative research, and to summarize what the studies reveal about team dynamics in LDSEM-analog environments." This article may be obtained online without charge.

Journal Impact Factor: 2.089

Funding: "This work was supported by contract NNJ15HK18P awarded to the first author from the National Aeronautics and Space Administration (NASA)."

 

10

Gradini R, Chen F, Tan R, Newlin L.

A summary on cutting edge advancements in sterilization and cleaning technologies in medical, food, and drug industries, and its applicability to spacecraft hardware.

Life Sci Space Res. 2019 May 15. [Article in Press] Review.

http://www.sciencedirect.com/science/article/pii/S2214552419300069

Journal Impact Factor: 1.97

Funding: "The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration."

 

11

Hernandez Y, Kim KH, Benson E, Jarvis SP, Meginnis I, Rajulu S.

Underwater space suit performance assessments part 1: Motion capture system development and validation.

Int J Ind Ergon. 2019 Jul;72:119-27. Epub 2019 May 14.

http://www.sciencedirect.com/science/article/pii/S0169814118305900

Journal Impact Factor: 1.429

Funding: "This study was partially funded by NASA HHPC NNJ15HK11B, USA."

______________________________________________________

 

 

Other papers of interest:

 

1

Kashirina DN, Pastushkova LK, Percy AJ, Borchers CH, Brzhozovsky AG, Larina IM.

Changes in the plasma protein composition in cosmonauts after space flight and its significance for endothelial functions.

Hum Physiol. 2019 Jan 1;45(1):75-82.

https://link.springer.com/article/10.1134%2FS0362119719010092

Note: ISS results. Originally published in Russian in Fiziologiya Cheloveka, 2019;45(1):88–96.

 

2

Miglis MG, Muppidi S.

Do astronauts get postural tachycardia syndrome? And other updates on recent autonomic research.

Clin Auton Res. 2019 May 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31089931

Note: The author discusses NASA Twins Study results of interest to autonomic specialists. This article may be obtained online without charge.

 

3

Vishvkarma R.

Is telomere shortening reversible? A clue from NASA’s twins mission.

Polymorphism. 2019 Jan 1;2:118-21.

http://www.peerpublishers.com/index.php/snp/article/view/22

Note: The author discusses NASA Twins Study results related to telomere dynamics. This article may be obtained online without charge.

 

4

Russell TL, Zhang J, Okoniewski M, Franke F, Bichet S, Hierlemann A.

Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation.

Front Neurosci. 2019 Apr 26;13:376. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31080399

Note: This article may be obtained online without charge.

 

5

Kuller LH.

Risks of high coronary artery calcium.

JAMA Cardiol. 2019 May 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31090872

Note: The author comments on the article: DeFina LF, Radford NB, Barlow CE, Willis BL, Leonard D, Haskell WL, Farrell SW, Pavlovic A, Abel K, Berry JD, Khera A, Levine BD. Association of all-cause and cardiovascular mortality with high levels of physical activity and concurrent coronary artery calcification. JAMA Cardiol. 2019 Jan 30. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30698608, which appeared in SPACELINE Current Awareness List #835, 8 Feb 2019. (See #5 in the NASA section of this List for the authors’ reply.)

 

6

Shaikh K, Budoff MJ.

Risks of high coronary artery calcium.

JAMA Cardiol. 2019 May 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31090871

Note: The authors comment on the article: DeFina LF, DeFina LF, Radford NB, Barlow CE, Willis BL, Leonard D, Haskell WL, Farrell SW, Pavlovic A, Abel K, Berry JD, Khera A, Levine BD. Association of all-cause and cardiovascular mortality with high levels of physical activity and concurrent coronary artery calcification. JAMA Cardiol. 2019 Jan 30. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30698608, which appeared in SPACELINE Current Awareness List #835, 8 Feb 2019. (See #5 in the NASA section of this List for the authors’ reply.)

 

7

Surgent OJ, Dadalko OI, Pickett KA, Travers BG.

Balance and the brain: A review of structural brain correlates of postural balance and balance training in humans.

Gait Posture. 2019 May 6;71:245-52. Review.

https://www.ncbi.nlm.nih.gov/pubmed/31082657

 

8

Chazarin B, Storey KB, Ziemianin A, Chanon S, Plumel M, Chery I, Durand C, Evans AL, Arnemo JM, Zedrosser A, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Lefai E, Bertile F. 

Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle.

Front Zool. 2019 May 6;16:12.

https://www.ncbi.nlm.nih.gov /pubmed/31080489

Note: This article may be obtained online without charge.

 

9

Seaborne RA, Hughes DC, Turner DC, Owens DJ, Baehr LM, Gorski P, Semenova EA, Borisov OV, Larin AK, Popov DV, Generozov EV, Sutherland H, Ahmetov I, Jarvis JC, Bodine SC, Sharples AP. 

UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy.

J Physiol. 2019 May 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31093990

 

10

Martin M, Sansalone V, Cooper DML, Forwood MR, Pivonka P.

Mechanobiological osteocyte feedback drives mechanostat regulation of bone in a multiscale computational model.

Biomech Model Mechanobiol. 2019 May 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31087221

 

11

Pannkuk EL, Laiakis EC, Girgis M, Dowd SE, Dhungana S, Nishita D, Bujold K, Bakke J, Gahagen J, Authier S, Chang PY, Fornace AJ.

Temporal effects on radiation responses in nonhuman primates: Identification of biofluid small molecule signatures by gas chromatography-mass spectrometry metabolomics.

Metabolites. 2019 May 15;9(5):E98.

https://www.ncbi.nlm.nih.gov/pubmed/31096611

Note: This article may be obtained online without charge.

 

12

Werner M, Van De Water TR, Stenlund H, Berggren D.

Ultrastructural characterization of stem cell derived replacement vestibular hair cells within ototoxin-damaged rat utricle explants.

Anat Rec (Hoboken). 2019 May 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31090209

 

13

Jaskolowski A, Iñigo S, Arellano SM, Arias LA, Fiol DF, Sede AR, Oldra MB, Lorenzi H, Muschietti JP, Pagnussat GC, Cerdán PD.

The MED30 subunit of mediator complex is essential for early plant development and promotes flowering in Arabidopsis thaliana.

Development. 2019 May 16;146(10):dev175224.

https://www.ncbi.nlm.nih.gov/pubmed/31097434

 

14

Meroz Y, Bastien R, Mahadevan L.

Spatio-temporal integration in plant tropisms.

J R Soc Interface. 2019 May 31;16(154):20190038.

https://www.ncbi.nlm.nih.gov/pubmed/31088258

Note: This article may be obtained online without charge.

 

15

Primo C, Pizzio GA, Yang J, Gaxiola RA, Scholz-Starke J, Hirschi KD.

Plant proton pumping pyrophosphatase: The potential for its pyrophosphate synthesis activity to modulate plant growth.

Plant Biol (Stuttg). 2019 May 12. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/31081197

 

16

Sampathkumar A, Peaucelle A, Fujita M, Schuster C, Persson S, Wasteneys GO, Meyerowitz EM.

Primary wall cellulose synthase regulates shoot apical meristem mechanics and growth.

Development. 2019 May 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31076488

 

17

Xue S, Zou J, Liu Y, Wang M, Zhang C, Le J.

Involvement of BIG5 and BIG3 in BRI1 trafficking reveals diverse functions of BIG-subfamily ARF-GEFs in plant growth and gravitropism.

Int J Mol Sci. 2019 May 11;20(9):E2339.

https://www.ncbi.nlm.nih.gov/pubmed/31083521

Note: This article may be obtained online without charge.

 

18

Sampson JB, Lee BH, Koka R, Chima AM, Jackson EV, Ogbuagu OO, Tran TP, Rosen MA.

Human factors evaluation of the Universal Anaesthesia Machine: Assessing equipment with high-fidelity simulation prior to deployment in a resource-constrained environment.

J Natl Med Assoc. 2019 May 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/31078287

Note: The NASA Task Load Index was used.

...

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