NASA Spaceline Current Awareness List #833 25 January 2019 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, January 25, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Choi WG, Barker RJ, Kim SH, Swanson SJ, Gilroy S.

Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight.

Am J Bot. 2019 Jan;106(1):123-36.

PI: S. Gilroy

Note: ISS results. GeneLab: "The FASTQ files of the transcriptomic data sets used for the ecotypic analysis can be obtained from the GeneLab data repository ( through accession number GLDS-37." This article may be obtained online without charge.

Journal Impact Factor: 2.788

Funding: "This work was supported by NASA NNX12AK79G, NNX13AM50G, NNX14AT25G, NNX17AD52G with additional funding from the International Space Station Research Integration Office to the Space Biology GeneLab Project. S.G. was also supported by a Vilas Associates award from the Graduate School of the University of Wisconsin-Madison."



Tirumalai MR, Karouia F, Tran Q, Stepanov VG, Bruce RJ, Ott CM, Pierson DL, Fox GE.

Evaluation of acquired antibiotic resistance in Escherichia coli exposed to long-term low-shear modeled microgravity and background antibiotic exposure.

MBio. 2019 Jan 15;10(1):e02637-18.

Note: A rotary cell culture system was used. This article may be obtained online without charge.

Journal Impact Factor: 6.689

Funding: "Funding was provided in part by the Institute of Space Systems Operations at the University of Houston." F. Karouia is affiliated with NASA Ames Research Center. R.J. Bruce, C.M. Ott, and D.L. Pierson are affiliated with NASA Johnson Space Center.



Belcaid M, Casaburi G, McAnulty SJ, Schmidbaur H, Suria AM, Moriano-Gutierrez S, Pankey MS, Oakley TH, Kremer N, Koch EJ, Collins AJ, Nguyen H, Lek S, Goncharenko-Foster I, Minx P, Sodergren E, Weinstock G, Rokhsar DS, McFall-Ngai M, Simakov O, Foster JS, Nyholm SV.

Symbiotic organs shaped by distinct modes of genome evolution in cephalopods.

Proc Natl Acad Sci U S A. 2019 Jan 11. [Epub ahead of print]

PI: J.S. Foster

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.504

Funding: "This work was supported in part by NIH Grant R01-AI50661 (to M.M.-N. and E. G. Ruby, co-Principal Investigator); NIH Grant R01-OD11024 (to E. G. Ruby, co-Principal Investigator, and M.M.-N.); the University of Wisconsin (M.M.-N.); NASA Space Biology Grant NNX13AM44G (to J.S.F.); NSF Integrative Organismal Systems 1557914 and the Office of the Vice President for Research, UCONN (to S.V.N.); and the Molecular Genetics Unit of OIST Graduate University (to D.S.R.). O.S. and H.S. were supported by a grant from the Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) P30686-B29."



Rettig TA, Bye BA, Nishiyama NC, Hlavacek S, Ward C, Pecaut MJ, Chapes SK.

Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

PLoS One. 2019 Jan 17;14(1):e0210284.

PIs: S.K. Chapes, M.J. Pecaut

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 2.766

Funding: "This work was supported by NNX13AN34G and NNX15AB45G from National Aeronautics and Space Administration ( (SKC and MJP); GM103418 from the National Institute of Health ( (SKC); College of Veterinary Medicine at Kansas State University (; and Kansas State University Johnson Cancer Research Center ("



Jones CB, Mange A, Granata L, Johnson B, Hienz RD, Davis CM.

Short and long-term changes in social odor recognition and plasma cytokine levels following oxygen (16O) ion radiation exposure.

Int J Mol Sci. 2019 Jan 15;20(2):E339.

PI: C.M. Davis

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.687

Funding: "This research was funded by the National Aeronautics and Space Administration (NASA), grant numbers NNX15AC71G and 80NSSC18K1080."



Kiffer F, Alexander T, Anderson JE, Groves T, Wang J, Sridharan V, Boerma M, Allen AR.

Late effects of 16O-particle radiation on female social and cognitive behavior and hippocampal physiology.

Radiat Res. 2019 Jan 21. [Epub ahead of print]

PI: M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.53

Funding: "This work was supported by the National Space Biomedical Research Institute (NSBRI), grant no. RE03701 through NASA cooperative agreement NCC 9-58. This work was also supported by Core Facilities of the Center for Translational Neuroscience IDeA program award no. P30 GM110702."



Tang S, Liu B, Liu J, Wang J, Wang Y.

A protein-mRNA feedback exists in miR-21-associated E-Selectin expression.

Int J Radiat Biol. 2019 Jan 11. [Epub ahead of print]


Journal Impact Factor: 1.97

Funding: "This work is supported by grants from the National Aeronautics and Space Administration (NNX11AC30G to Y.W.) and the National Cancer Institute (CA186129, CA185882 to Y.W. and P30CA138292 to the Institute)."



Connaboy C, Johnson CD, LaGoy AD, Pepping GJ, Simpson RJ, Deng Z, Ma L, Bower JL, Eagle SR, Flanagan SD, Alfano CA.

Intersession reliability and within-session stability of a novel perception-action coupling task.

Aerosp Med Hum Perform. 2019 Feb 1;90(2):77-83.

PI: C.A. Alfano

Journal Impact Factor: 0.899

Funding: "This study was funded by the National Aeronautics and Space Administration; grant number NNX15AC13G."



Makowski MS, Norcross JR, Alexander D, Sanders RW, Conkin J, Young M.

Carbon monoxide levels in the extravehicular mobility unit by modeling and operational testing.

Aerosp Med Hum Perform. 2019 Feb 1;90(2):84-91.

Journal Impact Factor: 0.899

Funding: No funding cited. D. Alexander, M. Young, and R.W. Sanders are affiliated with NASA Johnson Space Center.




Other papers of interest:



Li H, Zhu H, Zhang F, Dong X, Hao T, Jiang XX, Zheng W, Zhang T, Chen X, Wang P, Na J, Wang C, Zhou J.

Spaceflight promoted myocardial differentiation of induced pluripotent stem cells - Results from Tianzhou-1 Mission.

Stem Cells Dev. 2019 Jan 18. [Epub ahead of print]

Note: Tianzhou-1 results.



Yu Y, Chang, Guo Q, Wang J, Liu C.

LCT-EF258 with S17I mutation in dpra exhibits horizontal gene transfer deficiency after spaceflight.

Aerosp Med Hum Perform. 2019 Feb 1;90(2):116-22.

Note: Shenzhou-8 results.



Braddock M.

From target identification to drug development in space: Using the microgravity assist.

Curr Drug Discov Technol. 2019 Jan 12. [Epub ahead of print] Review.

Note: Space Shuttle, ISS, and other spaceflight missions are discussed.



Bart MC, de Vet SJ, de Bakker DM, Alexander BE, van Oevelen D, van Loon EE, van Loon J, de Goeij JM.

Spiculous skeleton formation in the freshwater sponge Ephydatia fluviatilis under hypergravity conditions.

PeerJ. 2019 Jan 4;6:e6055.

Note: A long-arm centrifuge was used. This article may be obtained online without charge.



Rice GM, Snider D, Drollinger S, Greil C, Bogni F, Phillips J, Raj A, Marco K, Linnville S.

Dry-EEG manifestations of acute and insidious hypoxia during simulated flight.

Aerosp Med Hum Perform. 2019 Feb 1;90(2):92-100.

Note: Altitude was simulated by using a Naval aviation mask that provides varying concentrations of oxygen and nitrogen. 



Dayal A, Ng SFJ, Grabner M.

Ca2+-activated Cl- channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration.

Nat Commun. 2019 Jan 10;10(1):115.

Note: This article may be obtained online without charge.



Dirks ML, Smeets JSJ, Holwerda AM, Kouw IWK, Marzuca-Nassr GN, Gijsen AP, Holloway GP, Verdijk LB, van Loon LJC.

Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest.

Am J Physiol Endocrinol Metab. 2019 Jan 15. [Epub ahead of print]

Note: Bed rest study.



Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP. 

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.

Am J Physiol Endocrinol Metab. 2019 Jan 15. [Epub ahead of print]



Zhang D, Miranda M, Li X, Han J, Sun Y, Rojas N, He S, Hu M, Lin L, Li X, Ke HZ, Qin YX.

Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model.

Ann N Y Acad Sci. 2019 Jan 15. [Epub ahead of print]

Note: Hindlimb unloading study.



Das D, Chakraborty A, Santra SC.

Assessment of lead tolerance in gamma exposed Aspergillus niger Van Tieghem. and Penicillium cyclopium Westling.

Int J Radiat Biol. 2019 Jan 16. [Epub ahead of print]



Repin M, Pampou S, Garty G, Brenner DJ.

RABiT-II: A fully-automated micronucleus assay system with shortened time to result.

Radiat Res. 2019 Jan 18. [Epub ahead of print]



Schuemann J, McNamara AL, Ramos-Mendez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B.

TOPAS-nBio: An extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology.

Radiat Res. 2019 Jan 4. [Epub ahead of print]



Zhang R, Yu Y, Manaenko A, Bi H, Zhang N, Zhang L, Zhang T, Ye Z, Sun X.

Effect of helium preconditioning on neurological decompression sickness in rats.

J Appl Physiol (1985). 2019 Jan 17. [Epub ahead of print]



La Scaleia B, Lacquaniti F, Zago M.

Body orientation contributes to modeling the effects of gravity for target interception in humans.

J Physiol. 2019 Jan 15. [Epub ahead of print]



Horstman MJ, Salas E.

Inpatient notes - Caregiver engagement in hospital medicine-the next frontier.

Ann Intern Med. 2019 Jan 15;170(2):HO2-HO3.

Note: This "Annals for Hospitalists" section relates information needs for home caregivers to medical needs of astronauts on long-duration spaceflights.



Kamal KY, van Loon J, Medina FJ, Herranz R.

Differential transcriptional profile through cell cycle progression in Arabidopsis cultures under simulated microgravity.

Genomics. 2019 Jan 11. [Epub ahead of print]

Note: A Random Positioning Machine was used.

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