NASA Spaceline Current Awareness List #818 5 October 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 5, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Romsdahl J, Blachowicz A, Chiang AJ, Singh N, Stajich JE, Kalkum M, Venkateswaran K, Wang CCC.

Characterization of Aspergillus niger isolated from the International Space Station.

mSystems. 2018 Sep-Oct;3(5):e00112-18.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 5.750

Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with NASA. This research was supported by the JPL Advanced Concept Development fund awarded to K.V. that funded a student fellowship for A.B. Research at USC was supported by a subcontract from JPL."



Walker SC, Garbino A, Ray K, Hardwick R, Fitzpatrick DT, Sanders RW.

Oxygen exposures at NASA's Neutral Buoyancy Lab: A 20-year experience.

Undersea Hyperb Med. 2018 Jul-Aug;45(4):427-36.

Note: From the abstract: "The data from the NBL suited dive operations provide a foundation of evidence that can help inform the expert discussion on dive-related neurologic oxygen toxicity performance and overnight recovery in young, healthy males."

Journal Impact Factor: 0.636

Funding: "This project reviewed work and was completed with funding from the Human Health and Performance Contract and the Bioastronautics Contract."



Hammond TG, Allen PL, Birdsall HH.

Gene pathways analysis of the effects of suspension culture on primary human renal proximal tubular cells.

Microgravity Sci Technol. 2018 Oct 2. [Article in Press]

PI: T.G. Hammond

Note: A rotating wall vessel was used.

Journal Impact Factor: 1.357

Funding: "NASA Grants NNX13AN32G, NNX12AM93G, and NNX10AP01G supported these studies."



Morrison MD, Nicholson WL.

Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial "spaceflight response."

Sci Rep. 2018 Sep 26;8(1):14403.

PI: W.L. Nicholson

Note: GeneLab: The spaceflight biology experiment datasets used were from NASA’s GeneLab Data System (GLDS) ( This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: "This work was supported by grant NNX17AD51G from NASA Research Opportunities in Space Biology."



Gerber B, Singh JL, Zhang Y, Liou W.

A computer simulation of short-term adaptations of cardiovascular hemodynamics in microgravity.

Comput Biol Med. 2018 Sep 18;102:86-94.

Journal Impact Factor: 2.115

Funding: "This material is based upon work supported by the National Aeronautics and Space Administration (NASA), United States, through the North Dakota NASA Established Program to Stimulate Competitive Research (EPSCoR) Research Infrastructure Development Funding."



Goodhead DT.

Track structure and the quality factor for space radiation cancer risk (REID).

THREE. 2018 Sep 28.

Note: A corrected version of the article was posted on 28 September 2018. The article originally appeared in SPACELINE Current Awareness List #813, 31 Aug 2018. This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.



Kumar S, Suman S, Fornace AJ Jr, Datta K.

Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine.

Proc Natl Acad Sci U S A. 2018 Oct 1. [Epub ahead of print]

PIs: K. Datta; A.J. Fornace Jr/K. Datta/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.504

Funding: "This study is funded through NASA Grants NNX13AD58G and NNX15AI21G. The Histopathology and Tissue Shared Resource is partially supported by NIH/National Cancer Institute (NCI) Grant P30-CA051008."



Ruitenberg MFL, Koppelmans V, De Dios YE, Gadd NE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, Seidler RD.

Neural correlates of multi-day learning and savings in sensorimotor adaptation.

Sci Rep. 2018 Sep 24;8(1):14286.

PIs: R.D. Seidler, A.P. Mulavara, J.J. Bloomberg

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA; grant number NNX11AR02G), and in part by the National Space Biomedical Research Institute through NASA NCC 9–58 (grant numbers SA03801, SA02801). MR was supported in part by a postdoctoral fellowship from Ghent University (BOF 15/PDO/135)."



Flynn-Evans EE, Arsintescu L, Gregory K, Mulligan J, Nowinski J, Feary M.

Sleep and neurobehavioral performance vary by work start time during non-traditional day shifts.

Sleep Health. 2018 Oct;4(5):476-84.

Journal Impact Factor: Not available for this journal

Funding: "This study was funded by the NASA Airspace Operations and Safety Program."



Cramer A, Hecla J, Wu D, Lai X, Boers T, Yang K, Moulton T, Kenyon S, Arzoumanian Z, Krull W, Gendreau K, Gupta R.

Stationary computed tomography for space and other resource-constrained environments.

Sci Rep. 2018 Sep 21;8(1):14195.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: "A.C. supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), of the National Institutes of Health under award number 5T32EB1680; by the US Army Medical Research Contract Acquisition Activity under award number W81XWH-15-C-0052; and by the Eran Broshy Fellowship in Medical Engineering and Science. R.G. was supported in part by the following contracts: (a) DoD W81XWH-13-2-0067, (b) DoD CDMRP Air Force Contract FA8650-17-C-9113, (c) USAMRAA W81XWH-15-C-0052, and (d) USAMRAA W81XWH-17-C-0068. We received additional support from the Consortia for Improving Medicine with Innovation and Technology (CIMIT)." S. Kenyon and K. Gendreau are affiliated with NASA Goddard Space Flight Center.



Reed RD, Antonsen EL.

Should NASA collect astronauts' genetic information for occupational surveillance and research?

AMA J Ethics. 2018 Sep 1;20(9):E849-56.

Note: This article may be obtained online without charge.

Journal impact Factor: 0.69

Funding: No funding cited. R.D. Reed and E.L. Antonsen are affiliated with NASA Johnson Space Center.




Other papers of interest:



Kurazumi T, Ogawa Y, Morisaki H, Iwasaki K.

The effect of mild decrement in plasma volume simulating short-duration spaceflight on intracranial pressure.

npj Microgravity. 2018 Oct 2;4(1):19.

Note: Bed rest study. This article may be obtained online without charge.



Hagiwara H, Higashibata A, Ogawa S, Kanazawa S, Mizuno H, Tanaka R.

Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential.

Sci Rep. 2018 Sep 24;8(1):14239.

Note: A 3-D clinostat was used. This article may be obtained online without charge.



Guruceaga X, Ezpeleta G, Mayayo E, Sueiro-Olivares M, Abad-Diaz-de-Cerio A, Aguirre JM, Liu HG, Wiemann P, Bok JW, Filler SG, Keller NP, Hernando FL, Ramirez-Garcia A, Rementeria A. 

A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus.

Virulence. 2018 Sep 25. [Epub ahead of print]

Note: This article may be obtained online without charge.



Evanger K, Vaagbo G, Haugen OH.

Short-term effects on ocular variables immediately after hyperbaric oxygen exposures.

Undersea Hyperb Med. 2018 Jul-Aug;45(4):395-402.



Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H.

Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle.

J Physiol Sci. 2018 Sep 27. [Epub ahead of print]

Note: Hindlimb unloading study.



Frings-Meuthen P, Bernhardt G, Buehlmeier J, Baecker N, May F, Heer M.

The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: A bed rest study.

Osteoporos Int. 2018 Sep 25. [Epub ahead of print]

Note: Bed rest study.



Li K, Yang C, Zhang H, Wu F, Wang H, Cao H, Xu Z, Ding B, Li Y, Dai Z.

Screening and identification of novel mechanoresponsive microRNAs in rat femur under simulated microgravity.

Acta Astronaut. 2018 Oct 2. [Article in Press]

Note: Hindlimb unloading study. A clinostat was used.



Sun Z, Li Y, Zhou H, Cai M, Liu J, Gao S, Yang J, Tong L, Wang J, Zhou S, Hu Z, Wang Y, Wang K, Zhang L, Wang H, Zhang L, Shi F, Cao X, Zhang S, Ji Y, Zhao J.

Simulated microgravity reduces intracellular-free calcium concentration by inhibiting calcium channels in primary mouse osteoblasts.

J Cell Biochem. 2018 Sep 27. [Epub ahead of print]

Note: A clinostat was used.



Hamada N, Salomaa S, Dörr W.

Toward tailoring radiation protection strategies at an individual level.

Int J Radiat Biol. 2018 Sep 27:1-4. [Epub ahead of print]



Leavitt RJ, Limoli CL, Baulch JE.

miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: A safe cell-free treatment to ameliorate radiation-induced brain injury.

Int J Radiat Biol. 2018 Sep 25:1-8.



Macaeva E, Mysara M, De Vos WH, Baatout S, Quintens R.

Gene expression-based biodosimetry for radiological incidents: assessment of dose and time after radiation exposure.

Int J Radiat Biol. 2018 Sep 24. [Epub ahead of print]

Note: This article may be obtained online without charge.



Rummel C.

Perhaps women are better astronauts?

Brain Behav Immun. 2018 Sep 23. [Epub ahead of print]

Note: This is a Comment on the article: Krukowski K, Grue K, Frias ES, Pietrykowski J, Jones T, Nelson G, Rosi S. Female mice are protected from space radiation-induced maladaptive responses. Brain Behav Immun. 2018 Aug 11. [Epub ahead of print], which appeared in SPACELINE Current Awareness List #812, 24 August 2018.



Muntaseer Mahfuz M, Schubert MC, Figtree WVC, Todd CJ, Migliaccio AA.

Human vestibulo-ocular reflex adaptation training: Time beats quantity.

J Assoc Res Otolaryngol. 2018 Sep 24. [Epub ahead of print]



Dietz AS, Salas E, Pronovost PJ, Jentsch F, Wyskiel R, Mendez-Tellez PA, Dwyer C, Rosen MA.

Evaluation of a measurement system to assess ICU team performance.

Crit Care Med. 2018 Sep 21. [Epub ahead of print]



Blecher R, Heinemann-Yerushalmi L, Assaraf E, Konstantin N, Chapman JR, Cope TC, Bewick GS, Banks RW, Zelzer E.

New functions for the proprioceptive system in skeletal biology.

Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759):20170327.



Ettinger L, Ostrander T.

Gravitational torque partially accounts for proprioceptive acuity.

Hum Mov Sci. 2018 Sep 17;62:41-7.



Berkovich YA, Konovalova IO, Erokhin AN, Smolyanina SO, Smolyanin VG, Yakovleva OS, Tarakanov IG, Ivanov TM.

LED lighting optimization as applied to a vitamin space plant growth facility.

Life Sci Space Res. 2018 Sep 27. [Article in Press]



Lai YS, Stefano G, Zemelis-Durfee S, Ruberti C, Gibbons L, Brandizzi F.

Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum.

Nat Commun. 2018 Sep 25;9(1):3918.

Note: This article may be obtained online without charge.



Lowndes BR, Forsyth KL, Blocker RC, Dean PG, Truty MJ, Heller SF, Blackmon S, Hallbeck MS, Nelson H.

NASA-TLX assessment of surgeon workload variation across specialties.

Ann Surg. 2018 Sep 20. [Epub ahead of print]

Note: The NASA Task Load Index was used.

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