NASA Spaceline Current Awareness List #806 6 July 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, July 6, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Valbuena MA, Manzano A, Vandenbrink JP, Pereda-Loth V, Carnero-Diaz E, Edelmann RE, Kiss JZ, Herranz R, Medina FJ.

The combined effects of real or simulated microgravity and red-light photoactivation on plant root meristematic cells.

Planta. 2018 Jun 8. [Epub ahead of print]

PI: J.Z. Kiss

Note: ISS results. A random positioning machine was used for simulation studies.

Journal Impact Factor: 3.361

Funding: "Funding for this study was provided mainly by the Spanish National Plan for Research and Development (MINECOERDF co-funding) Grant ESP2015-64323-R to FJM. The access to ISS and RPM facilities was granted by ESA-ELIPS ILSRA-2009-0932 to FJM and GBF Program GIA Project (contract# 4000105761) to RH. This research was supported also by grants (NNX12A0656 and 80NSSC17K0546) from NASA to JZK and the French Space Agency—CNES to ECD and VPL. MAV and AM were recipients of grants of the Spanish National Program for Young Researchers Training (Refs. BES-2010-035741 and BES-2013-063933, respectively)."



Urbaniak C, Dadwal S, Bagramyan K, Venkateswaran K.

Draft genome sequence of a clinical isolate of Fusarium fujikuroi isolated from a male patient with acute myeloid leukemia.

Genome Announc. 2018 Jun 21;6(25)e00476-18.

PIs: K. Venkateswaran; C. Urbaniak, NASA Postdoctoral Program

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.18

Funding: "This research was funded by a 2012 Space Biology NNH12ZTT001N grant 19-12829-26 under Task Order NNN13D111T award to K.V. Funding for C.U. was supported by the NASA Postdoctoral Program."



Miousse IR, Ewing LE, Kutanzi KR, Griffin RJ, Koturbash I.

DNA methylation in radiation-induced carcinogenesis: Experimental evidence and clinical perspectives.

Crit Rev Oncog. 2018;23(1-2):1-11. Review.

PIs: M. Boerma/I. Koturbash/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.58

Funding: "Research reported in this publication was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number 1P20GM109005, the National Space Biomedical Research Institute through the National Aeronautics and Space Administration NCC 9-58 grant number RE03701, and the Winthrop P. Rockefeller Cancer Institute at UAMS."



Norbury JW, Whitman K, Lee K, Slaba TC, Badavi FF.

Comparison of space radiation GCR models to recent AMS data.

Life Sci Space Res. 2018 Aug;18:64-71. Epub 2018 Jun 28.

PI: J.W. Norbury

Journal Impact Factor: 1.97

Funding: "This work was supported by the Advanced Exploration Systems (AES) Division under the Human Exploration and Operations Mission Directorate of NASA."



McHill AW, Hull JT, McMullan CJ, Klerman EB.

Chronic insufficient sleep has a limited impact on circadian rhythmicity of subjective hunger and awakening fasted metabolic hormones.

Front Endocrinol (Lausanne). 2018 Jun 12;9:319.

PIs: E.B. Klerman, D. Schreckenghost

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Funding for this project was provided by NIH (KL2TR002370, F32DK107146, T32HL007901, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392) and NSBRI (HFP02802, HFP04201, HDP0006)."


Please Note: A special issue of Journal of Organizational Behavior entitled "Teamwork in Extreme Environments" includes two articles by NASA-funded PIs. The remaining articles from the special issue are listed in the "Other papers of interest" section. From the Editors: "Our hope is that this special issue serves as a resource for readers of the Journal of Organizational Behavior and teams researchers from other disciplines to gain insights into the lessons learned from studying teamwork in extreme environments. Additionally, beyond emphasizing these lessons, our intent with this special issue was to also highlight the challenges and opportunities for researching teams in such contexts in the future. These papers highlight the benefits and need for more research studying teams in the wild where insights into inputs, processes, emergent states, and outputs might otherwise be missed in more conventional environments. We are confident that the findings and implications provided by the authors will help to guide the development of new theory and empirical studies, and to generate actionable knowledge for practitioners working with teams in both extreme and more traditional contexts."




Golden SJ, Chang C-H, Kozlowski SWJ.

Teams in isolated, confined, and extreme (ICE) environments: Review and integration.

J Organ Behav. 2018 Jul;39(6):701-15. Review. Epub 2018 Apr 19.

PI: S.W.J. Kozlowski

Note: This citation originally appeared in SPACELINE Current Awareness List #798, May 11, 2018. This article may be obtained online without charge.

Journal Impact Factor: 4.229

Funding: "We gratefully acknowledge the National Aeronautics and Space Administration (NASA; NNX13AM77G and NNX16AR52G, S.W.J. Kozlowski, Principal Investigator, C.‐H. Chang, Co‐Investigator) for support that contributed to the composition of this article."



Burke CS, Shuffler ML, Wiese CW.

Examining the behavioral and structural characteristics of team leadership in extreme environments.

J Organ Behav. 2018;39(6):716-30.

PI: C.S. Burke

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.229

Funding: "This work was supported by a NASA grant (NNX14AK54G) to Dr. Shawn Burke, Principal Investigator, Dr. Eduardo Salas and Dr. Marissa Shuffler, Co‐Principal Investigators."




Other papers of interest:



Lützenberg R, Solano K, Buken C, Sahana J, Riwaldt S, Kopp S, Krüger M, Schulz H, Saar K, Huebner N, Hemmersbach R, Bauer J, Infanger M, Grimm D, Wehland M.

Pathway analysis hints towards beneficial effects of long-term vibration on human chondrocytes.

Cell Physiol Biochem. 2018 Jun 28;47(4):1729-41.

Note: Parabolic flight results. This article may be obtained online without charge.



Xu D, Guo Y-B, Zhang M, Sun Y-Q.

The subsequent biological effects of simulated microgravity on endothelial cell growth in HUVECs.

Chinese J Traumatol. 2018 June 28. [Article in Press]

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Koç A, Elçin AE, Elçin YM.

Osteogenic differentiation of encapsulated rat mesenchymal stem cells inside a rotating microgravity bioreactor: In vitro and in vivo evaluation.

Cytotechnology. 2018 Jun 25. [Epub ahead of print]

Note: A Rotating Wall Vessel was used.



Salmela A, Kokkonen E, Kulmala I, Veijalainen AM, van Houdt R, Leys N, Berthier A, Viacheslav I, Kharin S, Morozova J, Tikhomirov A, Pasanen P.

Production and characterization of bioaerosols for model validation in spacecraft environment.

J Environ Sci (China). 2018 Jul;69:227-38.

Note: A computational fluid dynamics model was used to test aerosol dispersion in confined space habitats.



Andreev-Andrievskiy AA, Popova AS, Lagereva EA, Vinogradova OL.

Fluid shift vs. body size: Changes of hematological parameters and body fluid volumes in hindlimb-unloaded mice, rats and rabbits.

J Exp Biol. 2018 Jun 27. [Epub ahead of print]

Note: Hindlimb unloading study.



Koschate J, Thieschäfer L, Drescher U, Hoffmann U.

Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: Efficacy of a reactive sledge jump countermeasure.

Eur J Appl Physiol. 2018 Jun 26. [Epub ahead of print]

Note: Bed rest study.



Apte S, Plooij M, Vallery H.

Influence of body weight unloading on human gait characteristics: A systematic review.

J Neuroeng Rehabil. 2018 Jun 20;15(1):53. Review.

Note: This article may be obtained online without charge.



Khoddam-Khorasani P, Arjmand N, Shirazi-Adl A.

Trunk hybrid passive-active musculoskeletal modeling to determine the detailed T12-S1 response under in vivo loads.

Ann Biomed Eng. 2018 Jun 26. [Epub ahead of print]



Xu H, Ren X, Lamb GD, Murphy RM.

Physiological and biochemical characteristics of skeletal muscles in sedentary and active rats.

J Muscle Res Cell Motil. 2018 Jun 15. [Epub ahead of print]



Yoshiko A, Yamauchi K, Kato T, Ishida K, Koike T, Oshida Y, Akima H.

Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf.

Skeletal Radiol. 2018 Jun 9. [Epub ahead of print]

Note: Cast immobilization was used.



Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM.

Role of pannexin 1 channels in load-induced skeletal response.

Ann N Y Acad Sci. 2018 Jun 28. [Epub ahead of print]



Bevelacqua JJ, Mortazavi SMJ.

Commentary regarding: "The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1".

Electrophoresis. 2018 Jun 27. [Epub ahead of print]

Note: The authors comment on the article: Szarka M, Szilasi S, Donczo B, Sarkozy D, Rajta I, Guttman A. The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1. Electrophoresis. 2018 May 18. [Epub ahead of print], which appeared in SPACELINE Current Awareness List #801, June 1, 2018.



El-Missiry MA, Othman AI, El-Sawy MR, Lebede MF.

Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus.

Int J Radiat Biol. 2018 Jun 25. [Epub ahead of print]



Gandhi NM.

Cellular adaptive response and regulation of HIF after low dose gamma-radiation exposure.

Int J Radiat Biol. 2018 Jun 26. [Epub ahead of print]



Velegzhaninov IO, Ermakova AV, Klokov DY.

Low dose ionizing irradiation suppresses cellular senescence in normal human fibroblasts.

Int J Radiat Biol. 2018 Jun 28. [Epub ahead of print]



Bury N, Bock O.

The habitual motor vertical of humans depends on gravicentric and egocentric cues, but only little on visual cues.

Exp Brain Res. 2018 Jun 22. [Epub ahead of print]



Lakshminarasimhan KJ, Petsalis M, Park H, DeAngelis GC, Pitkow X, Angelaki DE.

A dynamic Bayesian observer model reveals origins of bias in visual path integration.

Neuron. 2018 Jun 20. [Epub ahead of print]



Gimmon Y, Migliaccio AA, Todd CJ, Figtree WVC, Schubert MC.

Simultaneous and opposing horizontal VOR adaptation in humans suggests functionally independent neural circuits.

J Neurophysiol. 2018 Jun 27. [Epub ahead of print]



Bao Y, Pu Y, Yu X, Gregory BD, Srivastava R, Howell SH, Bassham DC.

IRE1B degrades RNAs encoding proteins that interfere with the induction of autophagy by ER stress in Arabidopsis thaliana.

Autophagy. 2018 Jun 25. [Epub ahead of print]



Dietrich D, Dekova R, Davy S, Fahrni G, Geissbühler A.

Applications of space technologies to global health: Scoping review.

J Med Internet Res. 2018 Jun 27;20(6):e230. Review.

Note: This article may be obtained online without charge.



Mackaill C, Sponchiado G, Leite AK, Dias P, Da Rosa M, Brown EJ, de Lima JCM, Rehnberg L, Russomano T.

A new method for the performance of external chest compressions during hypogravity simulation.

Life Sci Space Res. 2018 Jun 30. [Article in Press]

Note: A body suspension device with counterweights was used to simulate microgravity.



Edelmann HG.

Graviperception in maize plants: Is amyloplast sedimentation a red herring?

Protoplasma. 2018 Jun 11. [Epub ahead of print]

Note: This article may be obtained online without charge.



Rüede A-M, Ivanov AA, Leonardi C, Volkova T.

Systems engineering and design of a Mars Polar Research Base with a human crew.

Acta Astronaut. 2018 Jun 30. [Article in Press]



Liu M, Sharma AK, Shaevitz J, Leifer AM.

Temporal processing and context dependency in C. elegans response to mechanosensation.

Elife. 2018 Jun 26;7:e36419.

Note: This article may be obtained online without charge.



Pletser V.

Gravity, Weight and Their Absence.

Singapore: Springer, 2018. 98 p.

Note: From the publisher: "The book introduces readers to the concept of weightlessness and microgravity, and presents several examples of microgravity research in fluid physics, the material sciences and human physiology. Further, it explains a range of basic physical concepts (inertia, reference frames, mass and weight, accelerations, gravitation and weightiness, free fall, trajectories, and platforms for microgravity research) in simple terms. The last section addresses the physiological effects of weightlessness." Chapters are: Can inertia make us move?, Is weightlessness without gravity?, Weighing in on microgravity?, and Physiological effects of microgravity.


Please Note: The rest of the articles from the Journal of Organizational Behavior special issue, "Teamwork in Extreme Environments," appear below.



Maynard MT, Kennedy DM, Resick CJ.

Teamwork in extreme environments: Lessons, challenges, and opportunities.

J Organ Behav. 2018 Jul;39(6):695-700.

Note: This article may be obtained online without charge.



Uitdewilligen S, Waller MJ.

Information sharing and decision-making in multidisciplinary crisis management teams.

J Organ Behav. 2018 Jul;39(6):731-48.

Note: This article may be obtained online without charge.



Schmutz JB, Lei Z, Eppich WJ, Manser T.

Reflection in the heat of the moment: The role of in-action team reflexivity in health care emergency teams.

J Organ Behav. 2018 Jul;39(6):749-65.

Note: This article may be obtained online without charge.



Van Thielen T, Decramer A, Vanderstraeten A, Audenaert M.

When does performance management foster team effectiveness? A mixed-method field study on the influence of environmental extremity.

J Organ Behav. 2018 Jul;39(6):766-82.

Note: This article may be obtained online without charge.



Rauter S, Weiss M, Hoegl M.

Team learning from setbacks: A study in the context of start-up teams.

J Organ Behav. 2018 Jul;39(6):783-95.

Note: This article may be obtained online without charge.



Hong W, Gajendran RS.

Explaining dyadic expertise use in knowledge work teams: An opportunity–ability–motivation perspective.

J Organ Behav. 2018 Jul;39(6):796-811.

Note: This article may be obtained online without charge.



Skaggs BC, Manz CC, Lyle MCB, Pearce CL.

On the folly of punishing A while hoping for A: Exploring punishment in organizations.

J Organ Behav. 2018 Jul;39(6):812-5.

Note: This article may be obtained online without charge.

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