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NASA Spaceline Current Awareness List #798 11 May 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, May 11, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

1

Zwart SR, Rice BL, Dlouhy H, Shackelford LC, Heer M, Koslovsky MD, Smith SM.

Dietary acid load and bone turnover during long-duration spaceflight and bed rest.

Am J Clin Nutr. 2018 May 1;107(5):834-44.

https://www.ncbi.nlm.nih.gov/pubmed/29722847

PI: S.M. Smith

Note: ISS and bed rest study results. An editorial about this study appears in the same issue: Frassetto L. Another strategy to help counter the effects of low gravity? Am J Clin Nutr. 2018 May 1;107(5):681-2. https://www.ncbi.nlm.nih.gov/pubmed/29722853. This article may be obtained online without charge.

Journal Impact Factor: 6.926

Funding: "This study was supported by the Human Health Countermeasures Element of the NASA Human Research Program and by the Institute for Translational Sciences at the University of Texas Medical Branch, and in part by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health. The research was also funded in part by the German Aerospace Center DLR, Space Program, Grant 50WB1231."

 

2

Kunz HE, Spielmann G, Agha NH, O'Connor DP, Bollard CM, Simpson RJ.

A single exercise bout augments adenovirus-specific T-cell mobilization and function.

Physiol Behav. 2018 Oct 1;194:56-65. Epub 2018 Apr 30.

https://www.ncbi.nlm.nih.gov/pubmed/29723594

PI: R.J. Simpson

Journal Impact Factor: 2.341

Funding: "This work was supported by an American College of Sports Medicine Foundational Research Grant to H.E. Kunz and NASA grants NNX12AB48G; NNX16AB29G; NNX16AG02G, and NIH Grant R21 CA197527-01A1 to R.J. Simpson."

 

3

Craig JC, Broxterman RM, Smith JR, Allen JD, Barstow TJ.

Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise.

J Appl Physiol (1985). 2018 May 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29722627

PI: T.J. Barstow

Journal Impact Factor: 3.351

Funding: "This work was supported by National Aeronautics and Space Administration (NASA) Grant NNX10AK60G awarded to T. J. Barstow, by NASA Experimental Program to Stimulate Competitive Research Grant NNX11AM05A supporting R. M. Broxterman, and by the Kansas State University College of Veterinary Medicine Dr. Albert Borroughs Memorial Award granted to R. M. Broxterman."

 

4

Elefteriou F.

Impact of the autonomic nervous system on the skeleton.

Physiol Rev. 2018 Jul 1;98(3):1083-112. Review. Epub 2018 May 2.

https://www.ncbi.nlm.nih.gov/pubmed/29717928

PI: F. Elefteriou

Journal Impact Factor: 27.312

Funding: "The work from the author related to this review is supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK082471, National Institute on Aging Grant R01 AG055394, National Cancer Institute Grant R01 CA168717-03, and National Aeronautics and Space Administration Grant NNX12AL35G."

 

5

Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS.

Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation.

Radiat Res. 2018 May 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29738279

PI: J.S. Willey

Journal Impact Factor: 2.539

Funding: "This research was supported by the National Institutes of Health (U19 AI67798 and T35 OD010946 to JSW) and the National Aeronautics and Space Administration (NNX15AB50G to JSW)."

 

6

Kennedy EM, Powell DR, Li Z, Bell JSK, Barwick BG, Feng H, McCrary MR, Dwivedi B, Kowalski J, Dynan WS, Conneely KN, Vertino PM.

Galactic cosmic radiation induces persistent epigenome alterations relevant to human lung cancer.

Sci Rep. 2018 Apr 30;8(1):6709.

https://www.ncbi.nlm.nih.gov/pubmed/29712937

PIs: W.S. Dynan; Y. Wang/W.S. Dynan/P.M. Vertino/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: "Supported by the US National Aeronautics and Space Administration NSCOR Program grant NNX11AC30G (to PMV and WSD) and NNX15AD63G (to WSD). This project was supported in part by the Winship Biostatistics and Bioinformatics Shared Resource and the Emory Integrated Genomics Shared Resource with support of the NCI Cancer Center Support Grant 1P30- CA0138292 to the Winship Cancer Institute of Emory University."

 

7

Mao XW, Boerma M, Rodriguez D, Campbell-Beachler M, Jones T, Stanbouly S, Sridharan V, Wroe A, Nelson GA.

Acute effect of low-dose space radiation on mouse retina and retinal endothelial cells.

Radiat Res. 2018 May 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29741442

PIs: M. Boerma/X.W. Mao/G.A. Nelson/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.539

Funding: "This study was supported by National Space Biomedical Research Institute (NSBRI) grant no. RE03701 through NASA cooperative agreement NCC 9-5884."

 

8

Golden SJ, Chang C-H, Kozlowski SWJ.

Teams in isolated, confined, and extreme (ICE) environments: Review and integration.

J Organ Behav. 2018 Apr 19. [Epub ahead of print] Review.

https://onlinelibrary.wiley.com/doi/abs/10.1002/job.2288

PI: S.W.J. Kozlowski

Journal Impact Factor: 3.607

Funding: "We gratefully acknowledge the National Aeronautics and Space Administration (NASA; NNX13AM77G and NNX16AR52G, S.W.J. Kozlowski, Principal Investigator, C.‐H. Chang, Co‐Investigator) for support that contributed to the composition of this article."

 

9

Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW.

Functional decoupling of melatonin suppression and circadian phase resetting in humans.

J Physiol. 2018 Apr 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29707782

PIs: C.A. Czeisler, E.B. Klerman, S.W. Lockley

Note: This article may be obtained online without charge until May 31, 2018.

Journal Impact Factor: 4.739

Funding: "This work was supported by NASA NAG 5-3952, NSBRI HFP02801, HFP02802, and NIH P01-AG09975, R01-HL114088 (E.B.K.), RC2-HL101340-0 (E.B.K., S.W.L., S.A.R.), K02-HD045459 (E.B.K.), K24-HL105664 (E.B.K.), T32-HL07901 (M.S.H., S.A.R.), HL094654 (C.A.C.). The project described was supported by grants from the National Centre for Research Resources to the General Clinical Research Centre GCRC-M01-RR02635, NIH Grant Number 1UL1 TR001102-01, 8UL1TR000170-05, UL1 RR 025758, Harvard Clinical and Translational Science Centre, from the National Centre for Advancing Translational Science."

 

10

Angelos E, Ruberti C, Kim SJ, Brandizzi F.

Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants.

Plant J. 2017 May;90(4):671-82. Review.

https://www.ncbi.nlm.nih.gov/pubmed/27943485

PI: F. Brandizzi

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.901

Funding: "We acknowledge support by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, US Department of Energy (award number DE-FG02-91ER20021) for infrastructure, NASA (award NNX12AN71G), NIH R01-GM101038, the DOE Great Lakes Bioenergy Research Center [DOE Office of Science BER DE-FC02-07ER64494], AgBioResearch, and a fellowship from Michigan State University, USA, under the Training Program in Plant Biotechnology for Health and Sustainability (T32-GM110523)."

 

11

Lionheart G, Vandenbrink JP, Hoeksema JD, Kiss JZ.

The impact of simulated microgravity on the growth of different genotypes of the model legume plant Medicago truncatula.

Microgravity Sci Technol. 2018 May 8. [Article in Press]

https://link.springer.com/article/10.1007%2Fs12217-018-9619-4

PI: J.Z. Kiss

Note: A rotating clinostat was used.

Journal Impact Factor: 1.188

Funding: No funding cited. The PI reports funding under NASA grant “Novel Explorations into the Interactions between Light and Gravity Sensing in Plants” (80NSSC17K0546).

 

12

Mulugeta L, Drach A, Erdemir A, Hunt CA, Horner M, Ku JP, Myers JG Jr, Vadigepalli R, Lytton WW.

Credibility, replicability, and reproducibility in simulation for biomedicine and clinical applications in neuroscience.

Front Neuroinform. 2018 Apr 16;12:18. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29713272

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This research was supported by NIH R01GM104139, R01EB024573, and USAMRMC W81XWH-15-1-0232 (AE); NIH R01 GM107340, U54 EB020405, P2C HD065690; USAMRMC W81XWH-15-1-0232 (JK); NIBIB U01 EB023224, NHLBI U01 HL133360, NIH OT2 OD023848 (RV); and NIH R01-EB022903, U01-EB017695, R01-MH086638, NYS DOH01-C32250GG-3450000 (WL)." J.G. Myers Jr. is affiliated with NASA Glenn Research Center.

______________________________________________________

 

 

Other papers of interest:

 

1

Barabanov VM, Gulimova VI, Berdiev RK, Saveliev SV.

Attachment of Turner's thick-toed geckos (Chondrodactylus turneri GRAY 1864) during weightlessness and their responses to flotation.

Life Sci Space Res. 2018 May 5. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552417300925

Note: Bion-M1 results.

 

2

Beck P, Tank J, Gauger P, Beck LEJ, Zirngibl H, Jordan J, Limper U.

Modeling human orthostatic responses on the Moon and on Mars.

Clin Auton Res. 2018 Apr 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29700646

Note: Parabolic flight results.

 

3

Avan P, Normand H, Giraudet F, Gerenton G, Denise P.

Noninvasive in-ear monitoring of intracranial pressure during microgravity in parabolic flights.

J Appl Physiol (1985). 2018 May 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29722618

Note: Parabolic flight results.

 

4

Vista SSEP Mission 11 Team, Hagstrom D, Bartee C, Collins E-MS.

Studying planarian regeneration aboard the International Space Station within the Student Space Flight Experimental Program.

Front Astron Space Sci. 2018 May 7;5:12.

https://www.frontiersin.org/article/10.3389/fspas.2018.00012

Note:  ISS results. This article may be obtained online without charge.

 

5

Bimpong-Buta NY, Jirak P, Wernly B, Lichtenauer M, Masyuk M, Muessig JM, Braun K, Kaya S, Kelm M, Jung C.

Analysis of human microcirculation in weightlessness: Study protocol and pre-study experiments.

Clin Hemorheol Microcirc. 2018 Apr 14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29710687

Note: The paper presents the protocol for a parabolic flight study.

 

6

Chibalin AV, Benziane B, Zakyrjanova GF, Kravtsova VV, Krivoi, II.

Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension.

J Cell Physiol. 2018 May 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29719042

Note: Hindlimb unloading study.

 

7

Frassetto L.

Another strategy to help counter the effects of low gravity?

Am J Clin Nutr. 2018 May 1;107(5):681-2.

https://www.ncbi.nlm.nih.gov/pubmed/29722853

Note: Comment on Zwart SR, Rice BL, Dlouhy H, Shackelford LC, Heer M, Koslovsky MD, Smith SM. Dietary acid load and bone turnover during long-duration spaceflight and bed rest. Am J Clin Nutr. 2018 May 1;107(5):834-44. https://www.ncbi.nlm.nih.gov/pubmed/29722847, which is cited in the NASA section above.

 

8

Hughes JM, Gaffney-Stomberg E, Guerriere KI, Taylor KM, Popp KL, Xu C, Unnikrishnan G, Staab JS, Matheny RW Jr, McClung JP, Reifman J, Bouxsein ML.

Changes in tibial bone microarchitecture in female recruits in response to 8 weeks of U.S. Army Basic Combat Training.

Bone. 2018 Apr 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29709620

Note: This article may be obtained online without charge.

 

9

Sfeir JG, Drake MT, Atkinson EJ, Achenbach SJ, Camp JJ, Tweed AJ, McCready LK, Yu L, Adkins MC, Amin S, Khosla S.

Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography.

Bone. 2018 Apr 25;112:145-52.

https://www.ncbi.nlm.nih.gov/pubmed/29704696

Note: This article may be obtained online without charge.

 

10

Jin X, Li F, Liu B, Zheng X, Li H, Ye F, Chen W, Li Q.

Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis.

Biochem Biophys Res Commun. 2018 May 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29709476

 

11

Goetzke R, Sechi A, De Laporte L, Neuss S, Wagner W.

Why the impact of mechanical stimuli on stem cells remains a challenge.

Cell Mol Life Sci. 2018 May 4. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/29728714

 

12

Javaheri B, Carriero A, Wood M, De Souza R, Lee PD, Shefelbine S, Pitsillides AA.

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response.

Sci Rep. 2018 Apr 27;8(1):6636.

https://www.ncbi.nlm.nih.gov/pubmed/29703931

Note: This article may be obtained online without charge.

 

13

Meng F, Murray GF, Kurgan L, Donahue HJ.

Functional and structural characterization of osteocytic MLO-Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro.

Sci Rep. 2018 Apr 30;8(1):6716.

https://www.ncbi.nlm.nih.gov/pubmed/29712973

Note: This article may be obtained online without charge.

 

14

Bérut A, Chauvet H, Legué V, Moulia B, Pouliquen O, Forterre Y.

Gravisensors in plant cells behave like an active granular liquid.

Proc Natl Acad Sci U S A. 2018 Apr 30. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29712863

Note: This article may be obtained online without charge.

 

15

Elhakeem A, Markovic D, Broberg A, Anten NPR, Ninkovic V.

Aboveground mechanical stimuli affect belowground plant-plant communication.

PLoS One. 2018 May 2;13(5):e0195646.

https://www.ncbi.nlm.nih.gov/pubmed/29718944

Note: This article may be obtained online without charge.

 

16

Nugroho WD, Nakaba S, Yamagishi Y, Begum S, Rahman MH, Kudo K, Marsoem SN, Funada R.

Stem gravitropism and tension wood formation in Acacia mangium seedlings inclined at various angles.

Ann Bot. 2018 May 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29726920

 

17

Mansikka H, Virtanen K, Harris D.

Comparison of NASA-TLX scale, Modified Cooper-Harper scale and mean inter-beat interval as measures of pilot mental workload during simulated flight tasks.

Ergonomics. 2018 Apr 30:1-22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29708054

Note: The NASA Task Load Index was used.

// end //

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