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NASA Spaceline Current Awareness List #794 13 April 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, April 13, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

 

Papers deriving from NASA support:

 

1

Mulavara AP, Peters BT, Miller CA, Kofman IS, Reschke MF, Taylor LC, Lawrence EL, Wood SJ, Laurie SS, Lee SMC, Buxton RE, May-Phillips TR, Stenger MB, Ploutz-Snyder LL, Ryder JW, Feiveson AH, Bloomberg JJ.

Physiological and functional alterations after spaceflight and bed rest.

Med Sci Sports Exerc. 2018 Apr 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29620686

PI: J.J. Bloomberg

Note: ISS and head-down tilt bed rest study results.

Journal Impact Factor: 4.141

Funding: "This study was conducted with the support from NASA’s Human Research Program and the Institute for Translational Sciences at the University of Texas Medical Branch, supported in part by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health."

 

2

Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa, KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah F, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA.

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.

J Clin Invest. 2018 Apr 3. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29613856

PI: S. Burma

Note: This article may be obtained online without charge.

Journal Impact Factor: 12.794

Funding: "This work was supported in part by NIH grants R01 NS062080 and by the Office of Medical Research at the Departments of Veterans Affairs, a Lung Cancer SPORE Career Enhancement Program Award, and support from the Dallas VA Research Corporation to AAH. This work was also supported by NCI Lung Cancer SPORE (P50CA70907), U01CA176284, and CPRIT (RP110708) to JDM. This work was also supported by NIH grant 1R01CA194578 to DZ and by NIH grants R01CA169338 and U54CA224081 to TGB. DEG is supported by a National Cancer Institute (NCI) Midcareer Investigator Award in Patient-Oriented Research, K24CA201543-01. SB is supported by grants from the National Institutes of Health (RO1CA197796, RO1CA149461 and R21CA202403) and the National Aeronautics and Space Administration (NNX16AD78G)."

 

3

Dillon EL, Sheffield-Moore M, Durham WJ, Ploutz-Snyder LL, Ryder JW, Danesi CP, Randolph KM, Gilkison CR, Urban RJ.

Efficacy of testosterone plus NASA exercise countermeasures during head-down bed rest.

Med Sci Sports Exerc. 2018 Mar 26. [Epub ahead of print]

https://insights.ovid.com/crossref?an=00005768-900000000-96943  

PI: R.J. Urban

Note: Head-down tilt bed rest study.

Journal Impact Factor: 4.141

Funding: "This study was funded by the National Aeronautics and Space Administration (#NNX10AP86G, RJU/MSM) and conducted with the support of the Institute for Translational Sciences at the University of Texas Medical Branch, supported in part by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health."

 

4

Kim M-HY, Blattnig SR, Clowdsley MC, Norman RB.

Using spectral shape and predictor fluence to evaluate temporal dependence of exposures from solar particle events.

Space Weather. 2017;15(2):374-91.

https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1002/2016SW001552

PI: S.R. Blattnig

Journal Impact Factor: 2.581

Funding: "The authors acknowledge the support from the NASA risk assessment project NNJ15HK11B under the Human Research Program."

 

5

Prasad B, Saxena R, Goel N, Patel SR.

Genetic ancestry for sleep research: Leveraging health inequalities to identify causal genetic variants.

Chest. 2018 Mar 28. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/29604255

PI: N. Goel

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.044

Funding: "Preparation of this review was supported by VA CSR and D (1IK2CX001026-01; B. Prasad), National Institutes of Health (NIH R01 DK117488; N. Goel, NIH R01 DK107859; R. Saxena, NIH HL127307; S.R. Patel), and National Aeronautics and Space Administration (NNX14AN49G; N. Goel)."

 

6

Bilbao A, Patel AK, Rahman M, Vanapalli SA, Blawzdziewicz J.

Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media.

Proc Natl Acad Sci U S A. 2018 Apr 4. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29618610

PI: S.A. Vanapalli

Journal Impact Factor: 9.661

Funding: "A.B. acknowledges financial support from NSF Grant CBET 1059745 and a Texas Tech University Doctoral Dissertation Completion Fellowship. J.B. was partially supported by NSF Grant CBET 1603627. S.A.V. and M.R. acknowledge partial support from Grants NIH 1R21AG050503-01 and NASA NNX15AL16G."

______________________________________________________

 

 

Other papers of interest:

 

1

Markina E, Andreeva E, Andrianova I, Sotnezova E, Buravkova L.

Stromal and hematopoietic progenitors from C57/BI/6N murine bone marrow after 30-day "BION-M1" space flight.

Stem Cells Dev. 2018 Apr 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29609526

Note: Bion M-1 results.

 

2

Magana M, Sereti C, Ioannidis A, Mitchell CA, Ball AR, Magiorkinis E, Chatzipanagiotou S, Hamblin MR, Hadjifrangiskou M, Tegos GP.

Options and limitations in clinical investigation of bacterial biofilms.

Clin Microbiol Rev. 2018 Jul;31(3):e00084-16. Epub 2018 Apr 4.

https://www.ncbi.nlm.nih.gov/pubmed/29618576

 

3

Chanon S, Chazarin B, Toubhans B, Durand C, Chery I, Robert M, Vieille-Marchiset A, Swenson JE, Zedrosser A, Evans AL, Brunberg S, Arnemo JM, Gauquelin-Koch G, Storey KB, Simon C, Blanc S, Bertile F, Lefai E.

Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells.

Sci Rep. 2018 Apr 3;8(1):5525.

https://www.ncbi.nlm.nih.gov/pubmed/29615761

Note: This article may be obtained online without charge.

 

4

Gao Y, Arfat Y, Wang H, Goswami N.

Muscle atrophy induced by mechanical unloading: Mechanisms and potential countermeasures.

Front Physiol. 2018 Mar 20;9:235. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29615929

Note: Spaceflight, bed rest, immobilization, and hindlimb unloading studies are included in the review. This article may be obtained online without charge.

 

5

Guo N, Fan X, Wu Y, Li Z, Liu S, Wang L, Yao J, Li Y.

Effect of constraint loading on the lower limb muscle forces in weightless treadmill exercise.

J Healthc Eng. 2018 Apr 3;2018:8487308.

https://www.hindawi.com/journals/jhe/2018/8487308/

Note: From the abstract: "This study aims to investigate the influence of the constraint loading mode on the lower limb muscle force in treadmill training at weightlessness. An inverse dynamic musculoskeletal model was applied to simulate the treadmill exercise." This article may be obtained online without charge.

 

6

Xie Y, Gao Y, Zhang L, Chen Y, Ge W, Tang P.

Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins.

Aging Cell. 2018 Mar 30. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29603567

 

7

Yang X, Sun L-W, Du C-F, Wu X-T, Fan Y-B.

Finite element analysis of osteocytes mechanosensitivity under simulated microgravity.

Microgravity Sci Technol. 2018 Apr 11. [Article in Press]

https://link.springer.com/article/10.1007/s12217-018-9613-x

Note: A clinostat was used.

 

8

Zhang YN, Shi WG, Li H, Hua JR, Feng X, Wei WJ, Wang JF, He JP, Lei SW.

Bone loss induced by simulated microgravity, ionizing radiation and/or ultradian rhythms in the hindlimbs of rats.

Biomed Environ Sci. 2018 Feb;31(2):126-35.

https://www.ncbi.nlm.nih.gov/pubmed/29606191

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

9

Cacao E, Parihar VK, Limoli CL, Cucinotta FA.

Stochastic modeling of radiation-induced dendritic damage on in silico mouse hippocampal neurons.

Sci Rep. 2018 Apr 3;8(1):5494.

https://www.ncbi.nlm.nih.gov/pubmed/29615729

Note: This article may be obtained online without charge.

 

10

Mulinacci N, Valletta A, Pasqualetti V, Innocenti M, Giuliani C, Bellumori M, De Angelis G, Carnevale A, Locato V, Di Venanzio C, De Gara L, Pasqua G.

Effects of ionizing radiation on bio-active plant extracts useful for preventing oxidative damages.

Nat Prod Res. 2018 Apr 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29607691

 

11

Castle KD, Daniel AR, Moding EJ, Luo L, Lee CL, Kirsch DG.

Mice lacking RIP3 kinase are not protected from acute radiation syndrome.

Radiat Res. 2018 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29634408

 

12

Daudee R, Gonen R, German U, Orion I, Alfassi ZB, Priel E.

DNA topoisomerase IB as a potential ionizing radiation exposure and dose biomarker.

Radiat Res. 2018 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29633912

 

13

Fukunaga H, Kaminaga K, Sato T, Usami N, Watanabe R, Butterworth KT, Ogawa T, Yokoya A, Prise KM.

Application of an ex vivo tissue model to investigate radiobiological effects on spermatogenesis.

Radiat Res. 2018 Mar 29. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29595376

 

14

Testa A, Ballarini F, Giesen U, Gil OM, Carante MP, Tello J, Langner F, Rabus H, Palma V, Pinto M, Patrono C.

Analysis of radiation-induced chromosomal aberrations on a cell-by-cell basis after alpha-particle microbeam irradiation: Experimental data and simulations.

Radiat Res. 2018 Apr 6. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29624483

 

15

Khan S, Duan P, Yao L, Hou H.

Shiftwork-mediated disruptions of circadian rhythms and sleep homeostasis cause serious health problems.

Int J Genomics. 2018 Jan 21;2018:8576890. Review.

https://www.ncbi.nlm.nih.gov/pubmed/29607311

Note: This article may be obtained online without charge.

 

16

Roda A, Mirasoli M, Guardigli M, Zangheri M, Caliceti C, Calabria D, Simoni P.

Advanced biosensors for monitoring astronauts' health during long-duration space missions.

Biosens Bioelectron. 2018 Mar 31;111:18-26.

https://www.ncbi.nlm.nih.gov/pubmed/29631159

 

Note: The following articles were published in the Russian aerospace journal Aviakosmicheskaia i Ekologicheskaia Meditsina in 2015 and 2016; they were republished in English in the December 2017 issue of Human Physiology.

 

17

Agureev AN, Afonin BV, Sedova EA, Solovieva AA, Valuev VA, Sidorenko LA.

Nutritional status in the experiment with 105-day isolation as the first phase of the Mars-500 Project.

Hum Physiol. 2017 Dec;43(7):793-801.

https://link.springer.com/article/10.1134%2FS0362119717070027

Note: Mars-500 Project results. Originally published in Russian in published in Aviakosm Ekolog Med. 2015;49(6):19-28.

 

18

Berendeeva TA, Ponomarev SA, Antropova EN, Rykova MP.

Toll-like receptors in peripheral blood cells of cosmonauts after long-term missions on board the International Space Station.

Hum Physiol. 2017 Dec;43(7):802-7.

https://link.springer.com/article/10.1134%2FS0362119717070039

Note: ISS results. Originally published in Russian in in Aviakosm Ekolog Med. 2015;49(6):49-54.

 

19

Bogomolov VV, Kuzmin MP, Danilichev SN.

On the problem of intracranial hypertension in astronauts under the conditions of long-term microgravity.

Hum Physiol. 2017 Dec;43(7):765-8.

https://link.springer.com/article/10.1134%2FS0362119717070040

Note: ISS results. Originally published in Russian in Aviakosm Ekolog Med. 2015;49(4):54-8.

 

20

Builov SP, Voronkov YI, Stepanova GP, Filatova LM.

Prognostic values of some cardiovascular risk factors in cosmonauts.

Hum Physiol. 2017 Dec;43(7):774-6.

https://link.springer.com/article/10.1134%2FS0362119717070052

Note: Originally published in Russian in Aviakosm Ekolog Med. 2016;50(2):21-7.

 

21

Davydov BV, Stepanova GP, Krivitsina ZA, Vorontsov AL, Voronkov YI.

Investigation of blood biochemical indices during bicycle ergometry.

Hum Physiol. 2017 Dec;43(7):826-8.

https://link.springer.com/article/10.1134%2FS0362119717070064

Note: Originally published in Russian in Aviakosm Ekolog Med. 2015;49(5):17-20.

 

22

Fomina EV, Uskov KV.

Effectiveness of different training programs for physical performance maintenance under the condition of low motor activity.

Hum Physiol. 2017 Dec;43(7):818-25.

https://link.springer.com/article/10.1134%2FS0362119717070076

Note: Mars-500 Project results. Originally published in Russian in Aviakosm Ekolog Med. 2016;50(5):47-55.

 

23

Kotovskaya AR, Fomina GA, Salnikov AV.

Variation of the state of lower limb veins in cosmonauts during long-term missions.

Hum Physiol. 2017 Dec;43(7):769-73.

https://link.springer.com/article/10.1134%2FS036211971707009X

Note: ISS results. Originally published in Russian in Aviakosm Ekolog Med. 2015;49(5):5-10.

 

24

Kovaleva AA, Skedina MA, Potapov MG.

Human neurophysiological state in long-term isolation.

Hum Physiol. 2017 Dec;43(7):741-7.

https://link.springer.com/article/10.1134%2FS0362119717070106

Note: Mars-500 Project results. Originally published in Russian in Aviakosm Ekolog Med. 2016;50(4,):14-20.

 

25

Kuznetsova PG, Gushchin VI, Vinokhodova AG, Chekalina AI, Shved DM.

Interpersonal interaction under the conditions of high autonomy in interplanetary mission simulation (Mars-500 Experiment).

Hum Physiol. 2017 Dec;43(7):751-6.

https://link.springer.com/article/10.1134%2FS0362119717070118

Note: Mars-500 Project results. Originally published in Russian in Aviakosm Ekolog Med. 2016;50(2):57-63.

 

26

Naumov IA, Kornilova LN, Glukhikh DO, Pavlova AS, Khabarova EV, Ekimovsky GA, Vasin AV.

Vestibular function after repeated space flights.

Hum Physiol. 2017 Dec;43(7):757-64.

https://link.springer.com/article/10.1134%2FS036211971707012X

Note: ISS results. Originally published in Russian in Aviakosm Ekolog Med. 2015;49(6):33-40.

 

27

Ponomarev SA, Berendeeva TA, Kalinin SA, Muranova AV.

The state of the system of signaling pattern recognition receptors of monocytes and granulocytes in the cosmonauts’ peripheral blood before and after long-term flights on board the International Space Station.

Hum Physiol. 2017 Dec;43(7):808-12.

https://link.springer.com/article/10.1134%2FS0362119717070167

Note: ISS results. Originally published in Russian in Aviakosm Ekolog Med. 2016;50(5):18-23.

// end //

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