NASA Spaceline Current Awareness List #785 9 February 2018 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, February 9, 2018

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support: 


Reschke MF, Wood SJ, Clément G.

Effect of spaceflight on the spatial orientation of the vestibulo-ocular reflex during eccentric roll rotation: A case report.

J Vestib Res. 2018;27(5-6):243-9.

PI: M.F. Reschke

Note: STS results. Rotation was used.

Journal Impact Factor: 0.900

Funding: "The experiment was supported by NASA and CNES. Current NASA efforts are funded by the Human Health Countermeasures Element of the Human Research Program."



Nair MA, Mulavara AP, Bloomberg JJ, Sangi-Haghpeykar H, Cohen HS.

Visual dependence and spatial orientation in benign paroxysmal positional vertigo.

J Vestib Res. 2018;27(5-6):279-86.

PI: A. Mulavara

Journal Impact Factor: 0.900

Funding: "Supported by National Institutes of Health grant R01DC009031 (HSC), and by a grant from the National Space Biomedical Research Institute through NASA NCC 9–58 (APM, JJB)."



Perry JL.

Trace contaminant control during the International Space Station’s on-orbit assembly and outfitting.

Huntsville, AL: NASA Marshall Space Flight Center, 2017 Oct. 242 p. NASA/TP—2017–219689.

Note: This report may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. J.L. Perry is affiliated with NASA Marshall Space Flight Center.



Other papers of interest:



Cui Y, Han J, Xiao Z, Qi Y, Zhao Y, Chen B, Fang Y, Liu S, Wu X, Dai J.

Systematic analysis of mRNA and miRNA expression of 3D-cultured neural stem cells (NSCs) in spaceflight.

Front Cell Neurosci. 2018 Jan 11;11:434.

Note: Chinese satellite SJ-10 results. This article may be obtained online without charge.



Green DA, Scott JPR.

Spinal health during unloading and reloading associated with spaceflight.

Front Physiol. 2018 Jan 18;8:1126. Review.

Note: ISS results. This article may be obtained online without charge.



Fischer JP, Wininger AE, Himes E, Chakraborty N, Hammamieh R, Kacena MA.

Fixation of whole mouse hindlimbs using NASA spaceflight fixation kit.

J Histotechnol. 2017;40(4):115-20.

Note: ISS preparation. From the abstract: "Here, the hindlimb fixation technique currently used by NASA was examined to determine whether it could be altered to yield sufficient histological quality while decreasing astronaut time." Funded in part by grant GA-2015-217 from the Center for the Advancement of Sciences in Space (CASIS, MAK).



Hekmat A, Hajebrahimi Z, Motamedzade A.

Structural changes of human serum albumin (HSA) in simulated microgravity.

Protein Pept Lett. 2017;24(11):1030-9.

Note: A 2D clinostat was used.



Strewe C, Zeller R, Feuerecker M, Hoerl M, Matzel S, Kumprej I, Crispin A, Johannes B, Debevec T, Mekjavic IB, Eiken O, Thiel M, Schelling G, Choukèr A.

PlanHab study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics.

Sci Rep. 2018 Jan 29;8(1):1762.

Note: Bed rest study. This article may be obtained online without charge.



Ebnerasuly F, Hajebrahimi Z, Tabaie SM, Darbouy M.

Effect of simulated microgravity conditions on differentiation of adipose derived stem cells towards fibroblasts using connective tissue growth factor.

Iran J Biotechnol. 2017 Autumn;15(4):241-51.

Note: A 2D clinostat was used.



Kraus A, Luetzenberg R, Abuagela N, Hollenberg S, Infanger M.

Spheroid formation and modulation of tenocyte-specific gene expression under simulated microgravity.

Muscles Ligaments Tendons J. 2017 Jul-Sep;7(3):411-7.

Note: A Random Positioning Machine was used. This article may be obtained online without charge.



Van Houdt, Kokkonen E, Lehtimäki M, Pasanen P, Leys N, Kulmala I.

Requirements for modeling airborne microbial contamination in space stations.

Acta Astronaut. 2018 Mar;144:380-7. Epub 2018 Jan 4.



D'Souza RF, Zeng N, Figueiredo VC, Markworth JF, Durainayagam BR, Mitchell SM, Fanning AC, Poppitt SD, Cameron-Smith D, Mitchell CJ.

Dairy protein supplementation modulates the human skeletal muscle microRNA response to lower limb immobilization.

Mol Nutr Food Res. 2018 Jan 29. [Epub ahead of print]

Note: Immobilization was achieved via a unilateral knee brace.



Seaborne RA, Strauss J, Cocks M, Shepherd S, O'Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples AP.

Human skeletal muscle possesses an epigenetic memory of hypertrophy.

Sci Rep. 2018 Jan 30;8(1):1898.

Note: Resistance exercises were used to induce muscle hypertrophy. This article may be obtained online without charge.



Ethiraj P, Link JR, Sinkway JM, Brown GD, Parler WA, Reddy SV.

Microgravity modulation of syncytin-A expression enhance osteoclast formation.

J Cell Biochem. 2018 Feb 1. [Epub ahead of print]

Note: The Rotary Cell Culture Systems (RCCS) was used.



Mladenov E, Li F, Zhang L, Klammer H, Iliakis G.

Intercellular communication of DNA damage and oxidative status underpin bystander effects.

Int J Radiat Biol. 2018 Jan 29. [Epub ahead of print]



Pereira MA, Federico CA, Gonçalez OL.

Determination of the response to the atmospheric cosmic radiation of a neutron dosimeter assisted by Monte Carlo simulation.

Radiat Prot Dosimetry. 2018 Jan 25. [Epub ahead of print]



Obri A, Khrimian L, Karsenty G, Oury F.

Osteocalcin in the brain: From embryonic development to age-related decline in cognition.

Nat Rev Endocrinol. 2018 Jan 29. [Epub ahead of print] Review.



Sengiku A, Ueda M, Kono J, Sano T, Nishikawa N, Kunisue S, Tsujihana K, Liou LS, Kanematsu A, Shimba S, Doi M, Okamura H, Ogawa O, Negoro H.

Circadian coordination of ATP release in the urothelium via connexin43 hemichannels.

Sci Rep. 2018 Jan 31;8(1):1996.

Note: This article may be obtained online without charge.



Canales J, Henriquez-Valencia C, Brauchi S.

The integration of electrical signals originating in the root of vascular plants.

Front Plant Sci. 2018 Jan 10;8:2173.

Note: This article may be obtained online without charge.



Aronowsky LV.

Of astronauts and algae: NASA and the dream of multispecies spaceflight.

Environ Humanit. 2017 Nov;9(2):359-77.

Note: From the abstract: "This article uses the history of an unrealized technology to rethink conventional accounts of American spaceflight that cast the space cabin as the ultimate expression of human's capacity to technologically master their environments. Drawing on archival and published sources, I detail the history of the bioregenerative life-support system, a system in which simple organisms–most commonly algae–would inhabit the spacecraft and, through a series of interspecies symbioses, maintain cabin conditions and sustain astronaut life."



Dong C, Chu Z, Wang M, Qin Y, Yi Z, Liu H, Fu Y.

Influence of nitrogen source and concentrations on wheat growth and production inside "Lunar Palace-1."

Acta Astronaut. 2018 Mar;144:371-9. Epub 2018 Jan 3.

Note: The study was conducted in China’s Lunar Palace 1, a bioregenerative life support system.



Taylor ER.

If technological intelligent extraterrestrials exist, what biological traits are de rigueur.

Life Sci Space Res. 2018 May;17:15-22. Epub 2018 Feb 2.

Note: The author examines "the biological nature of any ETIs that may exist out in the vast depths of the cosmos who have the biological and technological development to engage in electromagnetic communications."

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