NASA Spaceline Current Awareness List #633 - 30 January 2015

Status Report From: Spaceline
Posted: Friday, January 30, 2015


Papers deriving from NASA support:



Dib LH, Ortega MT, Melgarejo T, Chapes SK.

Establishment and characterization of DB-1: A leptin receptor-deficient murine macrophage cell line.

PI: S.K. Chapes

Journal Impact Factor: 1.449

Funding: “This project has been supported by the American Heart Association Grant 0950036G, NIH Grants AI088070, RR17686, RR17708, NASA grant NNX08BA91G and The Kansas State Agricultural Experiment Station.”



Burrell CG, Gridley DS, Ortloff LS, Charles SM, Green LM.

Effect of radiation and repeated sub-culturing on the transforming growth factor-β1 signaling pathway in FRTL-5 cells.

In Vivo. 2015 01-02;29(1):5-15.

PI: L.M. Green

Note: From the Acknowledgements: “...this paper is dedicated to the memory of Dr. Lora Green who passed away on January 11, 2010. She will forever be in our thoughts.”

Journal Impact Factor: 1.148

Funding: “This work was supported by the Department of Energy (DOE) (grant number DE-FG02-02ER63448); and the National Aeronautics and Space Administration (NASA) (grant number NAG 9-1452 to L.M.G.).”



Sokolova IV, Schneider CJ, Bezaire M, Soltesz I, Vlkolinsky R, Nelson GA.

Proton radiation alters intrinsic and synaptic properties of CA1 pyramidal neurons of the mouse hippocampus.

Radiat Res. 2015 Jan 26. [Epub ahead of print]

PIs: G.A. Nelson/I. Soltesz/R. Vlkolinsky/NSCOR

Journal Impact Factor: 2.445

Funding: “This work was supported by NASA (NNX10AD59G).”




In case you missed it:

The January 24th broadcast of The Splendid Table radio program featured an interview by Noelle Carter of the Los Angeles Times with Canadian astronaut Chris Hadfield about eating in space. The episode can be found online at:



Other papers of interest:



Rioux D, Lagacé M, Cohen LY, Beaulieu J.

Variation in stem morphology and movement of amyloplasts in white spruce grown in the weightless environment of the International Space Station.

Life Sci Space Res. 2015 Jan 23. [Article in Press]

Note: ISS results.



Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO.

Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.

Proc Natl Acad Sci U S A. 2015 Jan 20. [Epub ahead of print]



Goody MF, Sher RB, Henry CA.

Hanging on for the ride: Adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease.

Dev Biol. 2015 Jan 12. [Epub ahead of print]



Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.



Zhou Y, Mohan A, Moore DC, Lin L, Zhou FL, Cao J, Wu Q, Qin YX, Reginato AM, Ehrlich MG, Yang W.

SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.

FASEB J. 2015 Jan 15. [Epub ahead of print]



Coupaud S, McLean AN, Purcell M, Fraser MH, Allan DB.

Decreases in bone mineral density at cortical and trabecular sites in the tibia and femur during the first year of spinal cord injury.



Rocca A, Marino A, Rocca V, Moscato S, de Vito G, Piazza V, Mazzolai B, Mattoli V, Ngo-Anh TJ, Ciofani G.

Barium titanate nanoparticles and hypergravity stimulation improve differentiation of mesenchymal stem cells into osteoblasts.

Int J Nanomedicine. 2015 Jan 8;10:433-45.

Note: A large-diameter centrifuge was used. This article may be obtained online without charge.



Bramlitt ET, Shonka JJ.

Radiation exposure of aviation crewmembers and cancer.

Health Phys. 2015 Jan;108(1):76-86.



Barger LK, Rajaratnam SM, Wang W, O'Brien CS, Sullivan JP, Qadri S, Lockley SW, Czeisler CA.

Common sleep disorders increase risk of motor vehicle crashes and adverse health outcomes in firefighters.

J Clin Sleep Med. 2015 Jan 12. [Epub ahead of print]



Hancock PA, Sawyer BD, Stafford S.

The effects of display size on performance.



Czupalla M, Zhukov A, Schnaitmann J, Olthoff C, Deiml M, Plötner P, Walter U.

The Virtual Habitat – A tool for dynamic life support system simulations.

Adv Space Res. 2015 Jan 20. Epub [Article in Press]

Note: From the abstract: “In this paper we present the Virtual Habitat (V-HAB) model, which simulates on a system level the dynamics of entire mission scenarios for any given life support system (LSS) including a dynamic representation of the crew…We thus show that V-HAB is able to support LSS design processes, giving LSS designers a set of dynamic decision parameters (e.g. stability, robustness, effective crew time) at hand that supplement or even substitute the common Equivalent System Mass (ESM) quantities as a proxy for LSS hardware costs.”



Grones P, Friml J.

Auxin transporters and binding proteins at a glance.

J Cell Sci. 2015 Jan 1;128(1):1-7.



Xie L, Wang X, Peng M, Meng F, Zhou Y, Chen L, Liu L, Gao Y, Guo Y.

Isolation and detection of differential genes in hot pepper (Capsicum annuum L.) after space flight using AFLP markers.

Biochem Syst Ecol. 2014 Dec;57:27-32.

Note: Ground-raised, space-induced mutants were used; the specific space flight is not mentioned.



Booth IR, Miller S, Müller A, Lehtovirta-Morley L.

The evolution of bacterial mechanosensitive channels.

Cell Calcium. 2014 Dec 25. [Epub ahead of print] Review.

Note: This article may be obtained online without charge.



François A, Schüetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, Mantilleri A, Nargeot J, Noël J, Wood JN, Moqrich A, Pongs O, Bourinet E.

The low-threshold calcium channel Cav3.2 determines low-threshold mechanoreceptor function.

Cell Rep. 2015 Jan 14;10(3):370-82.

Note: This article may be obtained online without charge at the journal website: 



Zelenski NA, Leddy HA, Sanchez-Adams J, Zhang J, Bonaldo P, Liedtke W, Guilak F.

Collagen VI regulates pericellular matrix properties, chondrocyte swelling, and mechanotransduction in articular cartilage.

Arthritis Rheumatol. 2015 Jan 20. [Epub ahead of print]



Heureaux J, Chen D, Murray VL, Deng CX, Liu AP.

Activation of a bacterial mechanosensitive channel in mammalian cells by cytoskeletal stress.

Cell Mol Bioeng. 2014 Sep;7(3):307-19.

Note: This article may be obtained online without charge.



Badawi O, Brennan T, Celi LA, Feng M, Ghassemi M, Ippolito A, Johnson A, Mark RG, Mayaud L, Moody G, Moses C, Naumann T, Pimentel M, Pollard TJ, Santos M, Stone DJ, Zimolzak A.

Making big data useful for health care: A summary of the inaugural MIT Critical Data Conference.

JMIR Med Inform. 2014 Aug 22;2(2):e22.

Note: This article may be obtained online without charge. 

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