NASA Spaceline Current Awareness List #608 25 July 2014


Papers deriving from NASA support:
 
1
Crucian BE, Zwart SR, Mehta S, Uchakin P, Quiriarte HD, Pierson D, Sams CF, Smith SM.
Plasma cytokine concentrations indicate that in vivo hormonal regulation of immunity is altered during long-duration spaceflight.
J Interferon Cytokine Res. 2014 Apr 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/24702175
(PI: S.M. Smith)
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.297
 
2
Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG, Lawler JM.
MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart.
J Gerontol A Biol Sci Med Sci. 2014 Jul 11. pii: glu090. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25016531
(PI: J.M. Lawler)
Journal Impact Factor: 4.314
Funding: “This study was supported by the American Heart Association (0555064Y and 0855158F), National Institutes of Health (AR054084), National Aeronautics and Space Administration (NASA; NNX12AR62G), and the Sydney and J. L. Huffines Institute for Sports Medicine.”
 
3
Sá RC, Asadi AK, Theilmann RJ, Hopkins SR, Prisk GK, Darquenne C.
Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging.
J Appl Physiol (1985). 2014 Apr 15;116(8):1048-56. Epub 2014 Feb 6.
http://www.ncbi.nlm.nih.gov/pubmed/24505099
(PI: R.C. Sá)
Journal Impact Factor: 3.484
Funding: “This work was supported by National Heart, Lung, and Blood Institute (NHLBI) Grants R01 HL-080203, R01 HL-081171, and R01 HL-104118. R. C. Sá’s work was supported by the National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant NCC 9–58. A. K. Asadi was supported by NHLBI Grant F30 HL-110755.”
 
4
Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak EJ, Barton ER.
Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle.
Skelet Muscle. 2014 Jul 1;4:13.
http://www.ncbi.nlm.nih.gov/pubmed/25024843
(PI: E.R. Barton)
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal.
Funding: “This work was supported by grants from NASA (NNX09AH44G) and NIH (U54 AR052646) to ERB. CM was supported by the Paul D Wellstone Muscular Dystrophy Cooperative Research Center Training Grant (U54 AR052646). AP was supported by NNX09AH44G. JS is supported by the Pennsylvania Muscle Institute Training Grant (NRSA T32-AR053461). BK was supported by a School of Dental Medicine Summer Research Fellowship. EJM was supported by NNX09AH44G and P50 DK52620.”
 
5
Cho Y, Turner ND, Davidson LA, Chapkin RS, Carroll RJ, Lupton JR.
Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.
Exp Biol Med (Maywood). 2014 Mar;239(3):302-10. Epub 2014 Feb 4.
http://www.ncbi.nlm.nih.gov/pubmed/24495951
(PI: J.R. Lupton)
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.803
Funding: “This study was supported by NSBRI NASA NCC 9-58 (JRL, NDT), NASA NAG-9-1523 (JRL, NDT) and NIH [CA59034 (RSC), CA129444 (RSC), CA90301 (RJC), CA057030 (RJC), CA168312 (RSC, NDT), and CA61750 (JRL)].”
 
6
Krigsfeld GS, Savage AR, Billings PC, Lin L, Kennedy AR.
Evidence for radiation-induced disseminated intravascular coagulation as a major cause of radiation-induced death in ferrets.
Int J Radiat Oncol Biol Phys. 2014 Mar 15;88(4):940-6. Epub 2014 Feb 1.
http://www.ncbi.nlm.nih.gov/pubmed/24495588
(PI: A.R. Kennedy)
Journal Impact Factor: 4.524
Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) in the form of an NSBRI Center of Acute Radiation research grant through National Aeronautics and Space Administration project NCC 9-58. Dr Krigsfeld was supported by National Institutes of Health training grant 2T32CA09677.”
 
7
Ponomarev AL, George K, Cucinotta FA.
Generalized time-dependent model of radiation-induced chromosomal aberrations in normal and repair-deficient human cells.
Radiat Res. 2014 Mar;181(3):284-92. Epub 2014 Mar 10.
http://www.ncbi.nlm.nih.gov/pubmed/24611656
(PI: F.A. Cucinotta)
Journal Impact Factor: 2.698
Funding: “Funding was provided through the NASA Space Radiation Risk Assessment Project.”
 
8
Maier I, Berry DM, Schiestl RH.
Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons.
Radiat Res. 2014 Jan;181(1):45-53. Epub 2014 Jan 7.
http://www.ncbi.nlm.nih.gov/pubmed/24397477
(PI: R.H. Schiestl)
Journal Impact Factor: 2.698
Funding: “This work has been funded by NASA grant NNX11AB44G.”
 
9
Trani D, Nelson SA, Moon BH, Swedlow JJ, Williams EM, Strawn SJ, Appleton PL, Kallakury B, Näthke I, Fornace AJ Jr.
High-energy particle-induced tumorigenesis throughout the gastrointestinal tract.
Radiat Res. 2014 Feb;181(2):162-71. Epub 2014 Feb 10.
http://www.ncbi.nlm.nih.gov/pubmed/24512616
(PIs: A.J. Fornace/NSCOR, D. Trani)
Journal Impact Factor: 2.698
Funding: “This work was supported by NASA Grants no. NNX07AH70G and NNX09AU95G, and DOE Grant DE-PS02-08ER08. S. Nelson, J.J. Swedlow and I. Näthke were supported by a program grant from Cancer Research UK to I. Näthke. D. Trani was supported by the National Space Biomedical Research Institute (NSBRI) through NCC9-58.”
 
10
Rabin BM, Shukitt-Hale B, Carrihill-Knoll KL, Gomes SM.
Comparison of the effects of partial- or whole-body exposures to 16O particles on cognitive performance in rats.
Radiat Res. 2014 Mar;181(3):251-7. Epub 2014 Mar 10.
http://www.ncbi.nlm.nih.gov/pubmed/24611658
(PI: B.M. Rabin)
Journal Impact Factor: 2.698
Funding: “This work was made possible with the following grants from NASA: NNX08AM66G and NNX13AB73G.”
 
11
Davis CM, DeCicco-Skinner KL, Roma PG, Hienz RD.
Individual differences in attentional deficits and dopaminergic protein levels following exposure to proton radiation.
Radiat Res. 2014 Mar;181(3):258-71. Epub 2014 Mar 10.
http://www.ncbi.nlm.nih.gov/pubmed/24611657
(PIs: C.M. Davis, R.D. Hienz)
Journal Impact Factor: 2.698
Funding: “This research was supported by NASA cooperative agreement NCC 9-58 with the National Space Biomedical Research Institute through NASA NCC 9-58-PF02602 and 9-58-NBPF02802.”
 
12
Rahman SA, Flynn-Evans EE, Aeschbach D, Brainard GC, Czeisler CA, Lockley SW.
Diurnal spectral sensitivity of the acute alerting effects of light.
http://www.ncbi.nlm.nih.gov/pubmed/24501435
(PI: S.W. Lockley)
Note: This article may be obtained online without charge on 1 Aug 2014.
Journal Impact Factor: 5.051
Funding: “This work was supported by the National Space Biomedical Research Institute (HPF01301) and the National Institute of Mental Health (R01MH45130). SAR, EEF, GCB, CAC, and SWL are supported in part by the National Space Biomedical Research Institute through NASA NCC 9-58. The project described was supported by Brigham and Women’s Hospital General Clinical Research Center grant M01 RR02635. The project described was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital from the National Center for Research Resources.”
 
13
Committee to Review NASA’s Evidence Reports on Human Health Risks; Board on Health Sciences Policy; IOM (Institute of Medicine). Scott-Conner CEH, Masys DR, Liverman CT, McCoy MA, Editors.
Review of NASA’s evidence reports on human health risks: 2013 letter report.
Washington, DC: The National Academies Press. 2014; 63 p.
http://www.ncbi.nlm.nih.gov/pubmed/25032405
Note: From an excerpt: “This report builds on the 2008 IOM report Review of NASA's Human Research Program Evidence Books: A Letter Report, which provided an initial and brief review of the evidence reports.” This monograph may be obtained online without charge.
Funding: “This project was supported by Contract NNH13CK19B, Task Order NNH13CK20D, between the National Academy of Sciences and the National Aeronautics and Space Administration.”
_________________________________________________________________________
 
Other papers of interest:
 
1
Guo Y, Li Y, Su L, Chang D, Liu W, Wang T, Yuan Y, Fang X, Wang J, Li T, Fang C, Dai W, Liu C.
Comparative genomic analysis of Klebsiella pneumonia (LCT-KP214) and a mutant strain (LCT-KP289) obtained after spaceflight.
BMC Genomics. 2014 Jul 12;15(1):589.
http://www.ncbi.nlm.nih.gov/pubmed/25015528
Note: Shenzhou-8 results. This article may be obtained online without charge.
 
2
Lowrey CR, Perry SD, Strzalkowski ND, Williams DR, Wood SJ, Bent LR.
Selective skin sensitivity changes and sensory reweighting following short-duration space flight.
J Appl Physiol (1985). 2014 Mar 15;116(6):683-92. Epub 2014 Jan 23.
http://www.ncbi.nlm.nih.gov/pubmed/24458748
Note: STS results.
 
3
Venemans-Jellema A, Schreijer AJ, Le Cessie S, Emmerich J, Rosendaal FR, Cannegieter SC.
No effect of isolated long-term supine immobilization or profound prolonged hypoxia on blood coagulation.
J Thromb Haemost. 2014 Jun;12(6):902-9.
http://www.ncbi.nlm.nih.gov/pubmed/24641328
Note: Bed rest study. Studies were performed in collaboration with the European Space Agency/European Space Research and Technology Center.
 
4
Crescio C, Orecchioni M, Ménard-Moyon C, Sgarrella F, Pippia P, Manetti R, Bianco A, Delogu LG.
Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions.
http://www.ncbi.nlm.nih.gov/pubmed/25029354
Note: A random positioning machine was used to simulate microgravity.
 
5
Tanaka M, Hirayama Y, Fujita N, Fujino H.
Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat.
Acta Histochem. 2014 Jul 12. pii: S0065-1281(14)00174-3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25028130
Note: Hindlimb unloading study.
 
6
Mehta RK, Agnew MJ.
Subjective evaluation of physical and mental workload interactions across different muscle groups.
J Occup Environ Hyg. 2014 Jul 15:0. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25025738
Note: From the abstract: “…the aim of this study was to determine the sensitivity of the NASA Task Load Index (NASA TLX) and Ratings of Perceived Exertion (RPE) to evaluate physical and mental workload during muscle-specific tasks.”
 
7
Sapir-Koren R, Livshits G.
Osteocyte control of bone remodeling: Is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?
Osteoporos Int. 2014 Jul 17. [Epub ahead of print] Review.
http://www.ncbi.nlm.nih.gov/pubmed/25030653
 
8
Mayer-Wagner S, Hammerschmid F, Redeker JI, Schmitt B, Holzapfel BM, Jansson V, Betz OB, Müller PE.
Simulated microgravity affects chondrogenesis and hypertrophy of human mesenchymal stem cells.
Int Orthop. 2014 Jul 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25030964
Note: A rotating wall vessel bioreactor was used.
 
9
Pachnerová Brabcová K, Sihver L, Yasuda N, Matuo Y, Stĕpán V, Davídková M.
Clustered DNA damage on subcellular level: Effect of scavengers.
Radiat Environ Biophys. 2014 Jul 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25034012
 
10
Marie PJ, Haÿ E, Saidak Z.
Integrin and cadherin signaling in bone: Role and potential therapeutic targets.
Trends Endocrinol Metab. 2014 Jul 14. pii: S1043-2760(14)00108-8. [Epub ahead of print] Review.
http://www.ncbi.nlm.nih.gov/pubmed/25034128
 
11
Cervinka T, Sievänen H, Hyttinen J, Rittweger J.
Bone loss patterns in cortical, subcortical, and trabecular compartments during simulated microgravity.
J Appl Physiol (1985). 2014 Jul 1;117(1):80-8. Epub 2014 May 8.
http://www.ncbi.nlm.nih.gov/pubmed/24812642
 
12
Sang D, Chen D, Liu G, Liang Y, Huang L, Meng X, Chu J, Sun X, Dong G, Yuan Y, Qian Q, Li J, Wang Y.
Strigolactones regulate rice tiller angle by attenuating shoot gravitropism through inhibiting auxin biosynthesis.
Proc Natl Acad Sci U S A. 2014 Jul 15. pii: 201411859. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25028496
Note: This article may be obtained online without charge.

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